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Effects of gastrin 17 on β-catenin/Tcf-4 pathway in Colo320WT colon cancer cells

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World Journal of Gastroenterology 2006年第46期12卷 7482-7487页

作者： Jun Cao Jie-Ping Yu chao-hong liu Lan Zhou hong-Gang Yu Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan430060 Hubei Province China State Key Laboratory of Virology Wuhan institute of Virology China Adcamy of Science Wuhan 430060Hubei Province China Traditional Chinese Medicine Experiment Center Hubei College of Traditional Chinese Medicine Wuhan 4300061Hubei Province China

AIM： To explore the effect of gastrin 17 （G17） on β-catenin/T cell factor-4 （Tcf-4） signaling in colonic cancer cell line Colo320WT. METHODS： The pCR3.1/GR plasmid, which expresses gastrin receptor, cholecystokinin-2 receptor （CCK-2R）, was transfected into a colonic cancer cell line Colo320 by Lipofectamine ^TM 2000 and the stably expressing CCK-2R clones were screened by G418. The expression levels of gastrin receptor in the Colo320 and the transfected Colo320WT cell line were assayed by RTPCR. Colo320WT cells were treated with G17 in a time-dependent manner （0, 1, 6, 12, 24 and 48 h）, then with L365,260 （Gastrin17 receptor blocker） for 30 rain, and with G17 again for 12 h or L365,260 for 12 h. Expression levels of β-catenin in a TX-100 soluble fraction and TX-100 insoluble fraction of Colo320WT cells treated with G17 were detected by co-immuniprecipation and Western blot. Immunocytochemistry was used to examine the distribution of β-catenin in CoLoWT320 cells. Expression levels of c-myc and cyclin D1 in Colo320WT cells treated with G17 were assayed by Western blot. RESULTS： Expression levels of β-catenin in the TX-100 solution fraction decreased apparently in a time- dependent fashion and reached the highest level after G17 treatment for 12 h, while expression levels of β-catenin in the TX-100 insoluble fraction were just on the contrary. Immunocytochemistry showed that β-catenin was translocated from the cell membranes into the cytoplasm and nucleus under G17 treatment. Expression levels of c-myc and cyclin D1 in the G17- treated Colo320WT cells were markedly higher compared to the untreated Colo320WT cells. In addition, the aforementioned G17-stimulated responses were blocked by L365,260.CONCLUSION： Gastrin17 activates β-catenin/Tcf-4 signaling in Colo320WT cells, thereby leading to over- expression of c-myc and cyclin D1.

关键词： Gastrin17 Cholecystokinin-2 receptor Colorectal carcinoma β-catenin/Tcf-4 pathway

Perovskite single-pixel detector for dual-color metasurface imaging recognition in complex environment

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Light(Science & Applications) 2023年第12期12卷 2723-2731页

作者： Jiahao Xiong Zhi-hong Zhang Zile Li Peixia Zheng Jiaxin Li Xuan Zhang Zihan Gao Zhipeng Wei Guoxing Zheng Shuang-Peng Wang hong-chao liu Institute of Applied Physics and Materials Engineering University of MacaoTaipaMacao SARChina State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchunChina Electronic Information School and School of MicroelectronicsWuhan UniversityWuhanChina Peng Cheng Laboratory ShenzhenChina

Highly efficient multi-dimensional data storage and extraction are two primary ends for the design and fabrication of emerging optical *** metasurfaces show great potential in information storage due to their modulation for different degrees of freedom of light,a compact and efficient detector for relevant multi-dimensional data retrieval is still a challenge,especially in complex ***,we demonstrate a multi-dimensional image storage and retrieval process by using a dual-color metasurface and a double-layer integrated perovskite single-pixel detector(DIP-SPD).Benefitting from the photoelectric response characteristics of the FAPbBr2.4l0.6 and FAPbl3 films and their stacked structure,our filter-free DIP-SPD can accurately reconstruct different colorful images stored in a metasurface within a single-round measurement,even in complex environments with scattering media or strong background *** work not only provides a compact,filter-free,and noise-robust detector for colorful image extraction in a metasurface,but also paves the way for color imaging application of perovskite-like bandgap tunable materials.

关键词： materials perovskite complex

Evidence for the Late Pliocene Aridification in the Eastern Tarim Basin,Northwest China

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Journal of Earth Science 2023年第5期34卷 1632-1634页

作者： Hua Zhang Feng-Lin Lü Cheng-Lin liu Peng-Cheng Jiao Hui-Jing Yin Hui Yan Bao-Cheng Ma Liang-Liang Zhao hong-chao liu Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China National Centre for Archaeology Beijing 100013China School of Earth Resources China University of GeoscienceWuhan 430074China School of Earth Sciences and Resources China University of GeoscienceBeijing 100083China State Development and Investment Corp. Xin Jiang Luobupo Potash Co.LTDHami 839000China

INTRODUCTION The vast arid regions in mid-latitude Asia(MLA)are among the most prominent landscapes on Earth’s surface and have been thought to provide a key source of global atmospheric dust(Hovan et al.,1989).Over the past decades,research on aridification of MLA have made tremendous progress and pointed large-scale aridity has prevailed in this region since the Late Pliocene despite long-term stepwise drying(Fang et al.,2020;liu et al.,2014).However,direct sedimentary records for the late Pliocene aridification is still lack,hindering our understanding of regional comparison and the behind drive *** Tarim Basin in northwest China is one of the driest and largest inland basins and is considered as an ideal candidate for aridity records of MLA(Sun et al.,2013).Although considerable studies of environmental variations have been conducted(liu et al.,2020;Zheng et al.,2015),a comprehensive picture of climatic change of the basin during the Late Pliocene is still unavailable,due to fragmentary sedimentary records,especially in the eastern Tarim *** this contribution,we report the Late Pliocene lacustrine sediments found in Lop Nur of the east of Tarim *** occurrence of abundant magnesite,their related crystal morphology and C-O isotopic signature suggested a typical brackish or even saline lake environment and arid climatic condition in eastern Tarim Basin during this interval.

关键词： Tarim sedimentary climatic

Single-celled metasurface for labeled vortex beam generator

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Journal of Materiomics 2024年第4期10卷 811-818页

作者： Congling Liang Qi Dai Tian Huang hong-chao liu Zhiqiang Guan Rao Fu Jin Tao Zile Li Shaohua Yu Guoxing Zheng Electronic Information School and School of MicroelectronicsWuhan UniversityWuhan430072China Wuhan Institute of Quantum Technology Wuhan430206China Peng Cheng Laboratory Shenzhen518055China Suzhou Institute of Wuhan University Suzhou215123China Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao SARMacao999078China State Key Laboratory of Optical Communication Technologies and Networks China Information Communication Technologies Group Corporation(CICT)Wuhan430074China

Vortex light is a unique beam characterized by a spiral phase as it propagates. A fundamental parameter of vortex light is the topological charge, which determines the amount of angular momentum and plays a crucial role in tailoring its behavior. However, conventional measurement methods for determining the topological charge, such as those based on interference and phase modulation, tend to be intricate and complex. In this regard, a labeled vortex beam generator is proposed, composed of a metasurface with a single-celled configuration. When the metasurface is illuminated by light of the designed wavelength, the outgoing light exhibits a vortex structure. Furthermore, the topological charge numbers can be directly observed with distinct labeled patterns when the metasurface is placed in an orthogonal-polarized optical path. With advantages such as ultra-compactness, high robustness, and exceptional precision, the proposed metasurface exhibits significant potential for applications in optical communication, light manipulation, optical sensing, etc.

关键词： Metasurface Vortex beam generator Topological charge

Palladium-Catalyzed One-Step Synthesis of Stereodefined Difunctionalized Glycals

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CCS Chemistry 2023年第3期5卷 741-749页

作者： Xiao-Ping Gong Yuke Li hong-chao liu Zhe Zhang Zhi-Jie Niu Ya-Nan Ding Yang An Xi Chen Yan-Chong Huang Rui-Qiang Jiao Xue-Yuan liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000 Department of Chemistry Centre for Scientific Modeling and ComputationChinese University of Hong KongShatinHong Kong 999077

Efficiently modifying glycals by directly introducing functional groups into their double bonds is a longstanding ***,the strategy of introducing two different functional groups into 1-iodoglycals to obtain modified glycals in one step through palladium catalysis was reported for the first time,and the modified glycals contained stereodefined tetrasubstituted *** this method,various difunctionalized glycals that were difficult to form by other routes were synthesized in moderate to good *** experiments and density functional theory calculations show that the palladium catalyst played dual roles in this transformation,namely,inducing nucleophilic substitution and catalyzing Suzuki *** reaction intermediate was isolated and confirmed by X-ray crystallographic ***,the gram-scale synthesis and facile deprotection of the target compound enhances the practicality of this strategy.

关键词： palladium catalysis glycals tetrasubstitute olefins difunctionalization stereodefined threecomponent

Complex-amplitude Fourier single-pixel imaging via coherent structured illumination

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Chinese Physics B 2023年第6期32卷 236-241页

作者：侯红云赵亚楠韩佳成曹德忠张素恒刘宏超梁宝来 Hebei Key Laboratory of Optic-Electronic Information and Materials College of Physics Science&TechnologyHebei UniversityBaoding 071002China Department of Physics Yantai UniversityYantai 264005China Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao SARChina

We propose a method of complex-amplitude Fourier single-pixel imaging(CFSI)with coherent structured illumination to acquire both the amplitude and phase of an *** the proposed method,an object is illustrated by a series of coherent structured light fields,which are generated by a phase-only spatial light modulator,the complex Fourier spectrum of the object can be acquired sequentially by a single-pixel *** the desired complex-amplitude image can be retrieved directly by applying an inverse Fourier *** experimentally implemented this CFSI with several different types of *** experimental results show that the proposed method provides a promising complex-amplitude imaging approach with high quality and a stable ***,it might find broad applications in optical metrology and biomedical science.

关键词： complex-amplitude imaging single-pixel imaging Fourier basis scan coherent structured illumination

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo Liang chao Wang Yunhong Zhang hong liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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离子影响水蒸气核化的分子动力学研究

工程热物理学报 2017年第10期38卷 2081-2085页

作者：宋粉红徐洪帆刘朝范晶陈奇成李勇东北电力大学能源与动力工程学院吉林132012 重庆大学动力工程学院低品位能利用技术及系统教育部重点实验室重庆400030

本文采用分子动力学模拟方法研究离子的存在对水蒸气核化过程的影响。模拟系综初始温度为600 K,达到平衡后撤去水蒸气热浴,将载气温度标定至200 K,与水蒸气进行热量交换,带走水蒸气核化释放的核化潜热。研究结果表明,离子的存在能够促... 详细信息

本文采用分子动力学模拟方法研究离子的存在对水蒸气核化过程的影响。模拟系综初始温度为600 K,达到平衡后撤去水蒸气热浴,将载气温度标定至200 K,与水蒸气进行热量交换,带走水蒸气核化释放的核化潜热。研究结果表明,离子的存在能够促使核化的发生,但离子的浓度对系综内最大团簇的生长影响较小。根据团簇分析统计系综内含20个Na^+/Cl^-时,核化率约为1.01×10^(28)cm^(-3)·s^(-1),与经典核化理论计算值4.89×10^(28)cm^(-3)·s^(-1)在同一个数量级。

关键词：离子异质核化团簇分子动力学

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板坯连铸直轧感应补热有限元分析与试验

钢铁 2017年第2期52卷 44-50页

作者：肖宏余超刘剑任忠凯刘晓燕山大学国家冷轧板带装备及工艺工程技术研究中心河北秦皇岛066004

为减少连铸与热轧工序之间坯料再加热的能源消耗,连铸直轧技术蓬勃发展,其关键技术之一在于连铸与轧制工序之间的补热工艺。针对板坯连铸直轧实际生产中对补热工艺的要求,建立了纵向磁通和横向磁通感应补热有限元模型,分析了板坯的补热... 详细信息

为减少连铸与热轧工序之间坯料再加热的能源消耗,连铸直轧技术蓬勃发展,其关键技术之一在于连铸与轧制工序之间的补热工艺。针对板坯连铸直轧实际生产中对补热工艺的要求,建立了纵向磁通和横向磁通感应补热有限元模型,分析了板坯的补热过程。结果表明,纵向磁通对板坯表面整体补热效果好,但无法解决板坯边角温度偏低的问题;横向磁通可有效地对板坯边角进行局部补热;选择合适的电流大小和板坯移动速度,可使板坯温度分布更均匀。同时,使用自制的感应补热样机做补热试验,对补热效果进行检验,所得的试验结果与模拟结果一致。分析结果对板坯连铸直轧在实际生产中的感应补热工艺具有指导意义。

关键词：连铸直轧板坯节能感应补热