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Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 207-215页

作者： Wei hong Kai WANG Yi-ping ZHANG Jun-yan kou Dan hong Dan SU Wei-min MAO Xin-min YU Fa-jun XIE Xiao-jian WANG Department of Medical Oncology Zhejiang Cancer Hospital Zhejiang Key Laboratory of the Diagnosis and Treatment Technology on Thoracic Oncology Department of Respiratory Medicine the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Medical Oncology Hangzhou Cancer Hospital Institute of Immunology School of MedicineZhejiang University

Objective： The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase （MTHFR） C677T excision repair cross-complementation group 1 （ERCC1） genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer （NSCLC）. Methods： A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regi- mens. The polymorphisms of MTHFR C677T, ERCC1 C8092A, and ERCC1 Cl18T were genotyped using the TaqMan methods. Results： The overall response rate was 28.9%. Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype （TT or CT）（41.2% versus 19.1%, P=0.01 ）. Median time to progression （TTP） of patients with MTHFR CC genotype was longer than that of patients with variant genotype （7.6 months versus 5.0 months, P=0.003）. No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival. Conclusions： Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.

关键词： Non-small cell lung cancer Single nucleotide polymorphism Methylenetetrahydrofolate reductase Gemcitabine Excision repair cross-complementation group 1

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The Claustrum Controls Motor Activity Through Anterior Cingulate Cortex Input and Local Circuit Synchronization in a Preparatory Manner

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Neuroscience Bulletin 2023年第10期39卷 1591-1594页

作者： Zi-Qi kou Chun-Yan Chen Mamatsali Abdurahman Xu-Chu Weng Chun Hu hong-Yan Geng Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationSouth China Normal UniversityGuangzhou 510631China Institute for Brain Research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou 510631China

Motor control has evolved in the nervous systems of animals and motor output is the final result of neural *** previous studies have focused on the classical brain regions for motor coordination,including the cerebell... 详细信息

关键词： Cortex neural processing

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Genetic Algorithms for Auto-Clustering in KDD

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Journal of Systems Engineering and Electronics 2000年第3期11卷 53-58页

作者： Li, Minqiang Li, Jianwu kou, Jisong Tianjin Univ Tianjin China

In solving the clustering problem in the context of knowledge discovery in databases (KDD), the traditional methods, for example, the K-means algorithm and its variants, usually require the users to provide the number of clusters in advance based on the pro-information. Unfortunately, the number of clusters in general is unknown to the users who are usually short of pro-information. Therefore, the clustering calculation becomes a tedious trial-and-error work, and the result is often not global optimal especially when the number of clusters is large. In this paper, a new dynamic clustering method based on genetic algorithms (GA) is proposed and applied for auto-clustering of data entities in large databases. The algorithm can automatically cluster the data according to their similarities and find the exact number of clusters. Experiment results indicate that the method is of global optimization by dynamically clustering logic.

关键词： Data reduction Database systems Error analysis Optimization

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Rank-One Cross Commutators on Backward Shift Invariant Subspaces on the Bidisk

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Acta Mathematica Sinica,English Series 2009年第5期25卷 693-714页

作者： Kei Ji IZUCHI kou Hei IZUCHI Department of Mathematics Niigata University Graduate School of Science and Technology Niigata University Department of Mathematics Graduate School of ScienceHokkaido University

For a backward shift invariant subspace N in H^2（Г^2）, the operators Sz and Sw on N are defined by Sz = PNTz｜N and Sw, = PNTw｜N, where PN is the orthogonal projection from L^2（Г^2） onto N. We give a characteri... 详细信息

关键词： backward shift invariant subspace invariant subspace Hardy space cross commutator rank-one operator

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Detection approach for unusable shared bikes enabled by reinforcement learning and PageRank algorithm

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Journal of Safety Science and Resilience 2023年第2期4卷 220-227页

作者： Yu Zhou Ran Zheng Gang kou Colege of Economics and Management Inner Mongolia UniversityHohhot 010021China School of Business Administration Southwestern University of Finance and EconomicsChengdu 611130China

Existing research models can neither indicate the availability of shared bikes nor detect unusable ones owing to a lack of information on bike maintenance and *** improve awareness regarding the availability of shared bikes,we propose an innovative approach for detecting unusable shared bikes based on reinforcement learning and the PageRank *** proposed method identifies unusable shared bikes depending on the local travel data and provides a ranking of the shared bikes according to their availability *** a sliding time window,the value function for the reinforcement learning model was determined by considering the cumulative number of unavailable shared bikes,the proportion of rental cancelations at the same stations,and the mean time between the *** learning was then used to identify shared bikes with the worst *** availability ranking for the shared bikes below the reward threshold was performed using the PageRank *** proposed detection approach was applied to a trip dataset of a real-world bike-sharing system to illustrate the modeling process and its *** detection results of unusable shared bikes in the absence of failure and feedback data can provide essential information to support the maintenance management decisions regarding shared bikes.

关键词： Bike-sharing system Bike availability Maintenance Failure Shared bike Intelligent transportation Reinforcement learning PageRank algorithm Detection

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Diffuse axonal injury after traumatic cerebral microbleeds: an evaluation of imaging techniques

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Neural Regeneration Research 2014年第12期9卷 1222-1230页

作者： Jun Liu Zhifeng kou Yongquan Tian Department of Radiology Second Xiangya Hospital Central South University Department of Biomedical Engineering and Radiology School of Medicine Wayne State University School of Public Administration Central South University

Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intrace- rebral hematoma, and epidural and subdural hematoma. In fact, many smaller injuries can also lead to severe neurological disorders. For example, cerebral microbleeds result in the dysfunc- tion of adjacent neurons and the disassociation between cortex and subcortical structures. These tiny changes cannot be adequately visualized on CT or conventional MRI. In contrast, gradient echo sequence-based susceptibility-weighted imaging is very sensitive to blood metabolites and microbleeds, and can be used to evaluate traumatic cerebral microbleeds with high sensitivity and accuracy. Cerebral microbleed can be considered as an important imaging marker for dif- fuse axonal injury with potential relevance for prognosis. For this reason, based on experimental and clinical studies, this study reviews the role of imaging data showing traumatic cerebral microbleeds in the evaluation of cerebral neuronal injury and neurofunctional loss.

关键词： nerve regeneration neuroimaging traumatic brain injury cerebral microbleeds diffuse axonal injury gradient-recalled-echo susceptibility weighted imaging review neural regeneration

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Non-Hermitian Ising model at finite temperature

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Communications in Theoretical Physics 2023年第4期75卷 123-130页

作者： Qian Du Kui Cao Su-Peng kou Center for Advanced Quantum Studies Department of PhysicsBeijing Normal UniversityBeijing 100875China

As a very simple model,the Ising model plays an important role in statistical *** the paper,with the help of quantum Liouvillian statistical theory,we study the one-dimensional nonHermitian Ising model at finite temperature and give its analytical *** find that the nonHermitian Ising model shows quite different properties from those of its Hermitian *** example,the‘pseudo-phase transition’is explored between the‘topological’phase and the‘nontopological’phase,at which the Liouvillian energy gap is closed rather than the usual energy *** particular,we point out that the one-dimensional non-Hermitian Ising model at finite temperature can be equivalent to an effective anisotropic XY model in the transverse *** work will help people understand quantum statistical properties of non-Hermitian systems at finite temperatures.

关键词： non-Hermitian quantum system Ising model quantum statistical mechanics thermodynamics

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Quasilinear Elliptic Equations with Neumann Boundary and Singularity

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Acta Mathematicae Applicatae Sinica 2009年第4期25卷 631-646页

作者： Bing-yu kou Shuang-jie Peng School of Mathematics and Statistics Central China Normal University Wuhan 430079 China Institute of Science PLA University of Science and Technology Nanjing 210007 China

Let Ω be a bounded domain with a smooth C2 boundary in RN（N ≥ 3）, 0 ∈Ω, and n denote the unit outward normal to ЭΩ.We are concerned with the Neumann boundary problems： -div（｜x｜α｜△u｜p-2△u）=｜x｜βup（α,β）-1-λ｜x｜γup-1,u（x）〉0,x∈Ω,Эu/Эn=0 on ЭΩ,where 1〈p〈N and α〈0,β〈0 such that p（α,β）△=p（N＋β）/N-p＋α〉p,y〉α-*** various parameters α,βorγ,we establish certain existence results of the solutions in the case 0∈Ω or 0∈ЭΩ.

关键词： Singular equations Caffarelli-Kohn-Nirenberg inequalities critical exponents ground state sloutions

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Vibration analysis of maglev three-span continuous guideway considering control system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 8-14页

作者： Yan-feng TENG Nian-guan TENG Xinojian kou School of Naval Ocean Architecture and Civil Engineering Shanghai Jiao Tong University Shanghai 200240 China

The dynamic interaction between maglev vehicle and three-span continuous guideway is discussed. With the consideration of control system, the dynamic interaction model has been developed. Numerical simulation has been performed to study dynamic characteristics of the guideway. The results show that bending rigidity, vehicle speed, span ratio and primary frequency all have important influences on the dynamic characteristics of the guideway and there is no distinct trend towards resonance vibration when fl/（v/l） equals 1.0. The definite way is to control impact coefficient and acceleration of the guideway. The conclusions can serve the design of high-speed maglev three-span continuous guideway.

关键词： Maglev transportation system Three-span continuous guideway Coupling dynamics Feedback control Numerical simulation

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High sidelobe effects on interferometric coherence for circular SAR imaging geometry

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Journal of Systems Engineering and Electronics 2013年第1期24卷 76-83页

作者： Leilei kou Xiaoqing Wang Maosheng Xiang Minhui Zhu School of Atmospheric Physics Nanjing University of Information Science and Technology Institute of Electronics Chinese Academy of Sciences

The coherence is a measure for the accuracy of the interferometric phase, and the synthetic aperture radar （SAR） inter- ferometric coherence is affected by several sources of the decor- relation noise. For the circular SAR （CSAR） imaging geometry, the system response function is in the form of the Bessel function which brings a high sidelobe, and the high sidelobe of CSAR will be an important factor influencing the interferometric coherence. The effect of the high sidelobe on the coherence is analyzed and deduced. Based on the interferometric characteristics of the slight difference in the viewing angles and the potential pixel off- set in the interferometric SAR （InSAR） images, a relation between the radar impulse response and the coherence loss function is derived. From the relational model, the coherence loss function due to the high sidelobe of CSAR is then deduced, and compared with that of the conventional SAR. It is shown that the high sidelobe of CSAR focusing signal will severely affect the baseline decorre- lation and coregistration decorrelation. Simulation results confirm the theoretical analysis and quantitatively show the baseline and coregistration decorrelation degradation due to the high sidelobes of CSAR.

关键词： interferometric coherence circular SAR (CSAR) high sidelobe interferometric SAR (InSAR) baseline decorrelation coregistration decorrelation.

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