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Regulation of endogenous nitric oxide synthase inhibitors on the expression of endothelial SK3 channel

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Regulation of endogenous nitric oxide synthase inhibitors on...

乳腺癌患者术后切口感染致病菌病原学特点及危险因素分析

湖南省生理科学会2008年度学术年会

作者： Zhou Zhi,Jiang De-jian,Jia Su-Jie,Xiao hong-bo,li Yuan-Jian~* (Department of Pharmacology,School of Pharmaceutical Sciences,Central South University, Changsha 410078)

Objective To investigate role of endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine(ADMA)in downregulation of the expression of endothelial SK3 induced by *** C57BL/6J mice and apolipop rotein E deficient(apoE)mice were treated with ADMA(Smg/kg/day,subcutaneous injection)for 4 *** human umbilical

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中国医学前沿杂志（电子版） 2016年第11期8卷 109-112页

作者：田宏窦丽波哈尔滨医科大学附属第一临床医学院乳腺外科哈尔滨150001

目的研究乳腺癌患者术后切口感染的病原菌分类及感染相关危险因素,为预防术后切口感染提供参考依据。方法选取本院2012年10月至2015年10月收治的1242例行乳腺癌手术的患者为研究对象,对发生切口感染38例患者感染部位的分泌物进行细菌学... 详细信息

目的研究乳腺癌患者术后切口感染的病原菌分类及感染相关危险因素,为预防术后切口感染提供参考依据。方法选取本院2012年10月至2015年10月收治的1242例行乳腺癌手术的患者为研究对象,对发生切口感染38例患者感染部位的分泌物进行细菌学培养。统计患者术后切口感染发生率并对相关危险因素进行统计学分析。结果乳腺癌患者术后切口感染发生率为3.06%;切口感染部位检出43株病原菌,其中革兰阴性菌24株(55.8%),革兰阳性菌19株(44.2%);耐药发生以革兰阴性菌为主。统计显示:年龄≥60岁(P=0.044)、临床分期Ⅲ期以上(c TNM)(P=0.013)、行标准根治术或扩大根治术(P=0.032)、营养水平差(血清白蛋白<35 g/L)(P=0.012)、伴有糖尿病(P=0.006)、外周血白细胞计数<4×10~9个/L(P=0.001)、细胞免疫功能低下(外周血T细胞总数及CD4^+T细胞数降低)(P=0.012)、手术时间≥3小时(P=0.004)、引流时间≥15天(P=0.032)及术前接受辅助化疗(P=0.022)是乳腺癌患者术后发生切口感染的危险因素。结论乳腺癌术后切口感染原因复杂,术中加强感染控制,围术期加强营养支持、积极控制血糖,并给予患者免疫治疗及合理使用抗生素均有助于降低术后切口感染发生率。

关键词：乳腺癌切口感染病原菌危险因素

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端氨基聚醚/环氧树脂的固化行为及声性能

热固性树脂 2018年第2期33卷 39-42页

作者：孙卫红刘波李阳彭茂林中国人民解放军91872部队

在环氧树脂E44/端氨基聚醚D-2000体系中加入丙烯酸丁酯（BA）改性的二乙烯三胺（BA-DETA）及四乙烯五胺（BA-TEPA）固化剂,通过粘度和声学性能测试对比了加入DETA,BA-DETA及BA-TEPA的体系的粘度,固化物的表观特性及水声性能。结果表明... 详细信息

在环氧树脂E44/端氨基聚醚D-2000体系中加入丙烯酸丁酯（BA）改性的二乙烯三胺（BA-DETA）及四乙烯五胺（BA-TEPA）固化剂,通过粘度和声学性能测试对比了加入DETA,BA-DETA及BA-TEPA的体系的粘度,固化物的表观特性及水声性能。结果表明：加入BA-DETA的E44/端氨基聚醚D-2000体系2~25 k Hz频率下透声系数均值为0.879,反射系数均值为0.069,尤其是在中低频（2-10 k Hz）时,其透声系数均在0.9以上,具有良好的透声性能。

关键词：端氨基聚醚环氧树脂丙烯酸丁酯二乙烯三胺四乙烯五胺粘度透声系数

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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绿宝石茶加工过程香气变化研究

食品科技 2016年第11期41卷 78-82页

作者：谢勋何锦林杨鸿波李贵洪贵州大学贵阳550001 贵州省分析测试研究院贵阳550001

为了提升绿宝石茶叶品质,保护贵州绿宝石茶叶品牌。以贵州绿宝石茶为研究对象,采用固相微萃取技术并结合气相色谱质谱仪对其加工过程香气变化进行研究。结果表明,加工过程对香气最有影响的是炒制过程,其次是杀青过程,摊凉和揉捻过程不明... 详细信息

为了提升绿宝石茶叶品质,保护贵州绿宝石茶叶品牌。以贵州绿宝石茶为研究对象,采用固相微萃取技术并结合气相色谱质谱仪对其加工过程香气变化进行研究。结果表明,加工过程对香气最有影响的是炒制过程,其次是杀青过程,摊凉和揉捻过程不明显,但也非常重要,并且还对其主要香气成分变化进行了研究。该结果还对进一步研究与应用绿宝石茶提供了理论基础。

关键词：绿宝石茶固相微萃取香气加工气相色谱-质谱

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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旋转电弧焊缝跟踪系统的智能化研究

上海交通大学学报 2010年第S1期44卷 163-166页

作者：徐启栋洪波李湘文肖兵球李艳红湘潭大学机械工程学院湖南湘潭411105

旋转电弧焊缝跟踪系统的稳定性和可靠性是其应用推广要解决的问题,提高系统的智能化水平是解决问题的关键.对智能控制的观点进行研究,提出在自主性、主动性的基础上,建立以自我意识为控制核心的主体Agent,并以计算机为载体实现功能;分... 详细信息

旋转电弧焊缝跟踪系统的稳定性和可靠性是其应用推广要解决的问题,提高系统的智能化水平是解决问题的关键.对智能控制的观点进行研究,提出在自主性、主动性的基础上,建立以自我意识为控制核心的主体Agent,并以计算机为载体实现功能;分析了旋转电弧信号特性与数字处理方法,为其在计算机中的应用奠定基础.

关键词：旋转电弧焊缝跟踪系统数字处理智能控制

三元FeCl_3-AlCl_3-GIC的制备及其插层反应过程的研究

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新型炭材料 2002年第1期17卷 22-25页

作者：刘洪波张宝庆张红波李德意湖南大学材料科学与工程学院湖南长沙410082

采用混合熔融盐法制备以天然鳞片石墨作宿主、以FeCl3和AlCl3为插层剂的GIC。通过考察反应温度、碳与金属氯化物的摩尔比以及保温时间对产物阶结构的影响 ,探讨了FeCl3和AlCl3在石墨层间的插层反应过程。实验结果表明 :调节和控制插层... 详细信息

采用混合熔融盐法制备以天然鳞片石墨作宿主、以FeCl3和AlCl3为插层剂的GIC。通过考察反应温度、碳与金属氯化物的摩尔比以及保温时间对产物阶结构的影响 ,探讨了FeCl3和AlCl3在石墨层间的插层反应过程。实验结果表明 :调节和控制插层反应条件 ,可以得到一阶FeCl3 GIC和一阶AlCl3 GIC相对含量不同的三元FeCl3 AlCl3 GIC。插层过程中存在通过生成中间产物AlFeCl6 ,以FeCl3逐渐替换AlCl3的插层反应机制。替换量随插层反应温度的升高。

关键词：石墨层间化合物氯化铁氯化铝阶结构插层反应制备

Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-bo Xie School of Environmental and Material Engineering Yantai University bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements