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Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG li WENKE JIN liFENG WU HUAN WANG XIN XIE WEI HUANG bo liU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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基于系统动力学的信息管理研究:框架与综述

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情报科学 2017年第2期35卷 164-170页

作者：李洪波熊励刘寅斌上海大学管理学院上海200444

【目的/意义】为了反映系统动力学在信息管理领域的研究进展,重点对2000年以后,发表在国内外主流学术期刊上的论文做了系统性综述。【方法/过程】分析了系统动力学的建模流程,从问题层面和模型特点两个维度,构建了基于系统动力学的信息... 详细信息

【目的/意义】为了反映系统动力学在信息管理领域的研究进展,重点对2000年以后,发表在国内外主流学术期刊上的论文做了系统性综述。【方法/过程】分析了系统动力学的建模流程,从问题层面和模型特点两个维度,构建了基于系统动力学的信息管理研究框架。分别从单一模型和混合模型的角度综述了已有研究,并简要点评了主流的系统动力学仿真软件。【结果/结论】系统动力学对信息管理领域的问题具有广泛的适用性,产生了一系列具有重要理论价值和应用前景的研究成果。未来的研究将从微观、中观和宏观层面进一步扩展与深化。

关键词：信息管理系统动力学仿真综述

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Shape phase transition in neutron-rich even-even light nuclei with Z=20-28

Shape phase transition in neutron-rich even-even light nucle...

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第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： BAI hong-bo~(1)) li Xiao-Wei~(2)) DONG hong-Fei~(3)) CAO Wan-cang (Department of Physics,Chifeng University,Chifeng,024001)

The E-Gamma Over Spin（E-GOS） analysis method is applied to study the shape phase transition of neutron-rich even-even light nuclei with Z=*** is found that the doubly magic nuclei have similar E-GOS curves at low spins,and the singly magic nuclei have characteristics of collective motion when the number of valence nucleon increases and closes to half *** isospin effect plays an important role in the shape phase transition of neutron-rich even-even light *** is also shown that Ni is a double magic nucleus.

关键词： Nuclear structure shape phase transition E-GOS curve isospin effect

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西部煤层开采覆岩垮落及矿压显现影响因素研究

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煤炭学报 2017年第2期42卷 460-469页

作者：刘洪磊杨天鸿张博华李杨侯宪港东北大学资源与土木工程学院辽宁沈阳110819 东北大学岩石破裂与失稳研究所辽宁沈阳110819

西部矿区高强度开采引起覆岩变形-移动-破断是造成顶板大面积切落、突水溃沙等地质灾害以及水土流失等环境损伤的根源。采用数值模拟、现场微震监测和理论分析相结合的方法开展西部矿区煤层覆岩垮落及矿压显现规律影响因素研究。以小纪... 详细信息

西部矿区高强度开采引起覆岩变形-移动-破断是造成顶板大面积切落、突水溃沙等地质灾害以及水土流失等环境损伤的根源。采用数值模拟、现场微震监测和理论分析相结合的方法开展西部矿区煤层覆岩垮落及矿压显现规律影响因素研究。以小纪汗煤矿为例,开展了覆岩层变形、破断、垮落、"三带"形成规律的研究,以及不同开采速度下矿压显现规律研究,揭示了不同采高和开采速度对煤岩破坏的影响规律。现场微震监测结果表明,不同的推进速度会造成工作面不同的应力调整范围和不同的应力调整完整程度。通过2者综合分析,系统揭示了西部煤层覆岩垮落特征及"三带"形成演化规律,为建立高强度开采下覆岩结构破断规律及其稳定性判据的提出提供了科学依据。

关键词：西部煤层覆岩垮落矿山压力推进速度微震监测

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang bo Yang Jiawei Zhang Haiting li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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Graphene oxide wrapped-silica microspheres humidity sensor with fast response/recovery, high sensitivity, and selectivity for pig respiratory rate monitoring

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Science China Technological Sciences 2025年

作者： Jing li bo li Ziqi liAO Yunhui DUAN Xinglan FU Yuehua HUANG Guanglin li College of Engineering and Technology Southwest University Modern Agricultural Equipment Research Institute Xihua University

Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases. Humidity sensing is an important noncontact method to monitor pig respiration, which does not cause direct harm to pigs and meets the requirements of animal welfare. This paper proposes a humidity sensor based on graphene oxide wrapped-silica microspheres （GO@SiO2）. First, the sensor shows fast response/recovery performances of0.24/0.73 s. Experiments demonstrate that the wrapped microsphere structure can inhibit water aggregation. It is speculated that the wrapped microsphere structure can inhibit the stacking of GO, and its curved surface can promote the evaporation of water molecules. Second, the sensor shows a high sensitivity of 1.2%/%RH–4.2%/%RH in 11%–95%RH range. This can be attributed to different sensing mechanisms, from hopping transport to increasing ion transport, leading to a significant change in the sensor’s resistance. Third, the sensor shows selectivity to water molecules due to the hydrophilic characteristic of GO and the significant increase in conductivity by ion transport. Finally, the sensor is applied to realize the respiratory rate monitoring of adult pigs and piglets.

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ISOSPIN EXCITATION AND MIXED SYMMETRY STATES IN SOME N=32 ISOTONES

ISOSPIN EXCITATION AND MIXED SYMMETRY STATES IN SOME N=32 IS...

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第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： ZHANG Jin-Fu~(1 1)) LV li-Jun~1 BAI hong-bo~1 li Xiao-wei~1 DONG hong-Fei~1 1(Department of Physics,Chifeng University,Chifeng 024001,China)

With the development of radioactive ion beam facilities and large detector arrays,the study of the structure of heavy nuclei（A≥60） with N（?） Z have been a subject of intense interest during the last few years. By the limited systematic information for such nuclei,we suggest that these nuclei with A≥60 have different collective behavior from the nuclei with N≥*** E（4 ）/E（2） values are closed to *** suggest that these nuclei are gamma unstable *** nuclei may be give new insights into neutron - proton（np pair） ***,we expect that np pair correlations for nuclei with N（?） Z are larger than for nuclei N≥*** experimental and theoretical works,e.g.[1-13],have been carried out recently for the investigation and understanding of the structure of the nuclei with N（?） *** this paper,we adopte the interacting boson model with isospin（IBM-3） to investigate the band structure and electromagnetic transition properties of the low-lying states in the even-even N = 32 isotones Fe,Ni,Zn and *** isospin excitation states with T = 0,1,2 and 3 are identified,and compared with available *** E2 and M1 matrix elements for the low-lying states have been *** to this study,the state is the lowest mixed symmetry state in the even-even N = 32 *** agreement between the model calculations and data is reasonably good.

关键词： energy level isospin mixed symmetry states electromagnetic matrix element transitions

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The Design of Inverted Pendulum System Based on Virtual Prototype Technology and PID Control

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Journal of Measurement Science and Instrumentation 2010年第S1期1卷 46-49页

作者： hong-bo ZHENG,An-li TAO,Guo-dong XU,lie-kun YANG,Xian-hua ZHANG (School of Information Science and Engineering,Shandong University,Qingdao,China)

A design scheme of a single Inverted Pendulum Virtual Prototype based on the combination of software and hardware is *** uses hardware platform of C8051F020 single chip and the software of Matlab,Visual Basic and *** can simulate the force and movement of Inverted Pendulum expediently and *** combination of software and hardware makes the system closer to the *** concrete scheme is introduced in the paper and the result of PID control which verifies the correctness of the scheme.

关键词： inverted pendulum virtual prototype PID

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车辆荷载下全新载重轮胎接地行为的试验研究

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武汉理工大学学报 2010年第15期32卷 99-103页

作者：李洪波邵玉丽李红涛王保良洛阳理工学院洛阳471023

在岛津AG-25TA万能试验机平台上,利用自行开发的工装,选用全新轮胎进行了车辆荷载下载重轮胎接地行为的试验研究。结果发现,同样的车辆荷载下,轮胎在刚性路面和柔性路面具有不同的接地面积和接地形状,且在柔性路面上获得较大的接地面积... 详细信息

在岛津AG-25TA万能试验机平台上,利用自行开发的工装,选用全新轮胎进行了车辆荷载下载重轮胎接地行为的试验研究。结果发现,同样的车辆荷载下,轮胎在刚性路面和柔性路面具有不同的接地面积和接地形状,且在柔性路面上获得较大的接地面积;通过对试验数据的处理,给出了轮胎在不同类型路面接地面积的计算公式和接地形状量化计算公式。

关键词：车辆工程接地面积接地形状载重轮胎量化

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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