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Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

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World Journal of Gastroenterology 2006年第17期12卷 2742-2748页

作者： Quan Zhou Zou-Rong Ruan hong Yuan bo jiang Dong-Hang Xu Department of Clinical Pharmacology the 2^th Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To evaluate the bioequivalence of ranitidine and bismuth derived from two compound preparations. METHODS： The bioavailability was measured in 20 healthy male Chinese volunteers following a single oral dose （equivalent to 200 mg of ranitidine and 220 mg of bismuth） of the test or reference products in the fasting state. Then blood samples were collected for 24 h. Plasma concentrations of ranitidine and bismuth were analyzed by high-performance liquid chromatography and inductively coupled plasma-mass spectrometry （ICPMS）, respectively. The non-compartmental method was used for pharmacokinetic analysis. Log-transformed Cmax, AUC（0-t） and AUC（0-∞） were tested for bioequivalence using ANOVA and Schuirmann two-one sided t-test. Tmax was analyzed by Wilcoxon＇s test. RESULTS： Various pharmacokinetic parameters of ranitidine derived from the two compound preparations, including Cmax, AUC（0-t）, AUC（0-∞）, Tmax and T1/2, were nearly consistent with previous observations. These parameters derived from test and reference drug were as follows： Cmax（0.67 ± 0.21 vs 0.68 ± 0.22 mg/L）, AUC（0-t）（3.1 ± 0.6 vs 3.0 ± 0.7 mg/L per hour）, AUC（0-∞）（3.3 ± 0.6 vs 3.2 ± 0.8 mg/L per hour）, Tmax （2.3 ± 0.9 VS 2.1 ± 0.9 h） and T1/2 （2.8 ± 0.3 vs 3.1 ± 0.4 h）. In addition, double-peak absorption profiles of ranitidine were found in some Chinese volunteers. For bismuth, those parameters derived from test and reference drug were as follows： Cmax （11.80 ± 7.36 vs 11.40 ± 6.55 μg/L）, AUC（0-t）（46.65 ± 16.97 vs 47.03 ± 21.49 μg/L per hour）, Tmax （0.50 ± 0.20 vs 0.50 ± 0.20 h） and T1/2 （10.2 ± 2.3 vs 13.0 ± 6.9 h）. Ninety percent of confidence intervals for the test/reference ratio of Cmax, AUC（0-t） and AUC（0-∞） derived from both ranitidine and bismuth were found within the bioequivalence acceptable range of 80%-125%. No significant difference was found in Tmax derived from both ranitidine and bismuth. CONCLUSION： The two compound preparations are bioequivalent and may be prescribed intercha

关键词： Ranitidine Bismuth Compound preparation Bioequivalence Pharmacokinetics Healthy volunteers High-performanace liquid chromatography Inductively coupled plasma-mass spectrometry

CRISPR-mediated mutagenesis of the odorant receptor co-receptor(Orco)gene disrupts olfaction-mediated behaviors in Bactrocera dorsalis

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Insect Science 2022年第5期29卷 1275-1286页

作者： Li Xu hong-bo jiang Kai-Yue Tang Ying Yan Marc F.Schetelig Jin-Jun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqingChina International Joint Laboratory of China-Belgium on Sustainable Crop Pest Control Academy of Agricultural SciencesSouthwest UniversityChongqingChina Department of Insect Biotechnology in Plant Protection Justus-Liebig-University GiessenInstitute for Insect BiotechnologyGiessenGermany

Olfaction plays an essential role in insect behavior such as host location,foraging,mating,and *** odorant receptor co-receptor(Orco)is an obligatory odorant receptor and indispensable in odor ***,we characterized the Orco gene from the oriental fruit fly,Bactrocera dorsalis(Hendel),a notorious agriculture *** olfactory deficiency mutants were generated by editing the BdorOrco gene using the CRISPR/Cas9 ***(EAG)and olfactory preference assays confirmed that BdorOrco^(−/−)mutant flies had reduced perception of methyl eugenol,β-caryophyllene,and ethyl *** bioassays showed that the eggs laid by BdorOrco^(−/−)females mediated by benzothiazole and 1-octen-3-ol were significantly *** addition,BdorOrco^(−/−)mutant flies took a significantly longer time to locate the food source compared with wild type(WT)***,our data indicated that Orco is essential for multiple physiological processes in ***,and it expands our understanding of the function of insect Orco.

关键词： CRISPR/Cas9 foraging olfaction oriental fruit fly oviposition

Aminooxyacetic acid improves learning and memory in a rat model of chronic alcoholism

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Neural Regeneration Research 2018年第9期13卷 1568-1574页

作者： Ai-Lin Du Hao-Zhi Qin hong-bo jiang Peng-Yan Fu Ke Lou Yu-Ming Xu Department of Neurology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province China Department of Physiology and Neurobiology Xinxiang Medical University Henan Provincial Key Laboratory of Brain Research Second Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Province China Third Affiliated Hospital of Xinxiang Medical University Xinxiang Henan Province China

Chronic alcoholism seriously damages the central nervous system and leads to impaired learning and *** damage in chronic alcoholism is strongly associated with elevated levels of hydrogen sulfide（H2S） and calcium ion *** acid is a cystathionine-β-synthase activity inhibitor that can reduce H2S formation in the *** study sought to observe the effect of aminooxyacetic acid on learning and memory in a chronic alcoholism rat *** were randomly divided into three *** in the control group were given pure water for 28 *** in the model group were given 6% alcohol for 28 days to establish an alcoholism rat *** in the aminooxyacetic acid remedy group were also given 6% alcohol for 28 days and were also intraperitoneally injected daily with aminooxyacetic acid（5 mg/kg） from day 15 to day *** and memory was tested using the Morris water maze *** ultrastructure of mitochondria in the hippocampus was observed by electron microscopy.H2S levels in the hippocampus were measured indirectly by spectrophotometry,and ATPase activity was measured using a commercial *** expression of myelin basic protein was determined by immunohistochemistry and western *** with the control group,latency and swimming distance were prolonged in the navigation test on days 2,3,and 4 in the model *** the spatial probe test on day 5,the number of platform crosses was reduced in the model *** cracks,swelling or deformation of mitochondria appeared in the hippocampus,the hippocampal H2S level was increased,the mitochondrial ATPase activity was decreased,and the expression of myelin basic protein in the hippocampus was down-regulated in the model group compared with the control *** the above indexes were ameliorated in the aminooxyacetic acid remedy group compared with the model *** findings indicate that aminooxyacetic acid can improve learning and memory in a chronic alcoholism rat model,w

关键词： nerve regeneration aminooxyacetic acid chronic alcoholism rat model hydrogen sulfide Ca2+ overload brain injury learning andmemory abilities Morris water maze myelin basic protein mitochondria ATP enzyme activity neural regeneration

Study on hepatocelluar carcinoma-associated hepatic arteriovenous shunt using multidetector CT

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World Journal of Gastroenterology 2003年第11期9卷 2455-2459页

作者： Ming-Yue Luo hong Shan Zai-bo jiang Lu-Fang Li Hui-Qing Huang, Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China Sun Yat Sen Univ Dept Radiol Affiliated Hosp 3 Guangzhou 510630 Guangdong Provi Peoples R China

AIM: To investigate multidetector CT (MDCT) findings of hepatocelluar carcinoma (HCC)-associated hepatic arteriovenous shunt (HAVS) and to evaluate their clinical significance. METHODS: Thin-slice and dynamic enhancement MDCT of HAVS was performed on 56 patients with HCC. MDCT findings, including those of portal veins, hepatic veins, superior mesenteric veins, splenic veins, HCC loci, liver parenchyma without HCC loci, spleens, and thromboses in portal veins and hepatic veins, were all confirmed by digital subtract angiography and analyzed. RESULTS: MDCT demonstrated earlier enhancement of main portal trunks and/or the first order branches than that of superior mesenteric veins or splenic veins (n=-31). One patient had strong early enhancement of left hepatic vein with thromboses in left hepatic vein and upper part of inferior vena cava and 1 patient had transient patchy enhancement peripheral to HCC loci in late hepatic arterial phase among them. It demonstrated stronger opacification of main portal trunks and/or the first order branches than that of superior mesenteric veins or splenic veins (n=18), and earlier enhancement of the second order and smaller branches of portal veins than that of main portal trunks (n=4), stronger opacification of the second order and smaller branches of portal veins than that of main portal trunks (n=3), with transient patchy enhancement (n=3) or wedge-shaped enhancement (n=4) peripheral to HCC foci in late hepatic arterial phase. Enhancement degree of HCC loci was all decreased. As for 49 patients with severe or moderate shunts, enhancement degree of liver parenchyma without HCC loci was increased with heterogeneous density, but enhancement degree of spleens was decreased. There were thromboses in main portal trunks and/or the first order branches in 32 patients. CONCLUSION: The main MDCT findings of HCC-associated HAVS are earlier enhancement and stronger opacification of portal veins and/or hepatic veins. Understanding of these fin

关键词：肝动静脉吻合流术肝细胞癌多层螺旋CT 临床意义预后诊断

爆炸处理消除大型柱壳结构环焊缝残余应力实验研究

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爆炸与冲击 2008年第3期28卷 213-219页

作者：洪江波侯海量朱锡阚于龙海军工程大学船舶与海洋工程系湖北武汉430033 华中科技大学船舶与海洋工程学院

为探讨大型耐压柱壳结构对接环焊缝焊接残余应力消除方法,根据耐压柱壳结构环焊缝焊接工艺,设计并制作了大型耐压柱壳结构对接环焊缝模拟焊接模型,并采用沿焊缝条状布药,分别进行了单、双面布药爆炸处理消除大型耐压柱壳结构对接环焊缝... 详细信息

为探讨大型耐压柱壳结构对接环焊缝焊接残余应力消除方法,根据耐压柱壳结构环焊缝焊接工艺,设计并制作了大型耐压柱壳结构对接环焊缝模拟焊接模型,并采用沿焊缝条状布药,分别进行了单、双面布药爆炸处理消除大型耐压柱壳结构对接环焊缝焊接残余应力模型实验。结果表明:大型耐压柱壳结构对接环焊缝存在较大的焊接残余应力;单、双面爆炸处理均能有效调整、消除焊接残余应力,残余应力分布明显均匀化;焊后残余应力越大,爆炸处理效果越明显,当焊接残余应力大于0.5sσ时,单面爆炸处理后残余应力σm下降幅度在40%以上,双面爆炸处理后残余应力σm下降幅度在60%以上;采用沿焊缝条状布药,爆炸处理能有效消除沿焊缝的纵向残余应力;双面爆炸处理效果优于单面爆炸处理效果。

关键词：固体力学消除残余应力爆炸处理焊接耐压

Enhanced piezoelectric properties of SOL-GEL-DERIVED epitaxial BiFe1-xWxO3+δthin films

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Enhanced piezoelectric properties of SOL-GEL-DERIVED epitaxi...

2011年全国压电和声波理论及器件应用研讨会

作者： hong-Yan Zhang bo jiang Ling Cheng Guangda-Da Hu~* School of Materials Science and Engineering,University of Jinan,Jinan 250022

The excellent piezoelectric properties of BiFeO in thin-film form make it promising in the application of microelectromechanical ***,the BiFeO thin films suffer from severe leakage and aging problems, which lead to th... 详细信息

关键词： BiFeO3 thin films Piezoelectric properties Sol-Gel Aging Defect complexes

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位置隐私保护下的连续最近邻查询

北京邮电大学学报 2016年第5期39卷 83-88页

作者：王勇董一鸿钱江波陈华辉宁波大学信息科学与工程学院浙江宁波315211

已有的位置隐私保护下的连续最近邻查询往往采用snapshot方式进行,导致较高的中央处理器开销.为此,研究了基于位置隐私的连续最近邻查询,提出了基于重用技术的位置隐私保护的连续最近邻查询算法.该算法利用相邻时刻查询结果集的相似性... 详细信息

已有的位置隐私保护下的连续最近邻查询往往采用snapshot方式进行,导致较高的中央处理器开销.为此,研究了基于位置隐私的连续最近邻查询,提出了基于重用技术的位置隐私保护的连续最近邻查询算法.该算法利用相邻时刻查询结果集的相似性来减少计算成本,从而实现答案集的快速更新,可大大加快系统响应时间.实验结果表明了该算法的有效性.

关键词：位置服务位置隐私最近邻查询连续查询重用技术

A Novel Compact Power Divider with Harmonic Suppression for Phased Array Antenna Application

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A Novel Compact Power Divider with Harmonic Suppression for ...

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

The 8th International Symposium on Antennas,Propagation and EM Theory（ISAPE2008）

作者： Fang-fang Fan,Ze-hong Yan,Jun-bo jiang KEY NATIONAL LAboRATORY OF ANTENNAS' AND MCROWAVE TECHNOLOGY XIDIAN UNIVERSITY XI'AN,SHAANXI,710071,CHINA

This paper presents a novel compact power divider with third harmonic suppression and also can provide a direct current(dc) path which could simplify the other active circuits,such as power amplifier,in the complicated phased array antenna system,so it could reduce the total phased array antenna feeding network *** proposed power divider achieves 20% size reduction compared to the conventional Wilkinson power divider and it is benificial to the miniaturation of the phased array *** the measured results,it can be seen that the simulated results can instruct the practical circuit very well.

关键词： Wilkinson A Novel Compact Power Divider with Harmonic Suppression for Phased Array Antenna Application

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-hong Tang Li jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism