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Pharmacokinetics and bioequivalence of ranitidine and bismuth derived from two compound preparations

World Journal of Gastroenterology 2006年第17期12卷 2742-2748页

作者： Quan Zhou Zou-Rong Ruan hong Yuan bo Jiang dong-Hang Xu Department of Clinical Pharmacology the 2^th Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM： To evaluate the bioequivalence of ranitidine and bismuth derived from two compound preparations. METHODS： The bioavailability was measured in 20 healthy male Chinese volunteers following a single oral dose （equivalent to 200 mg of ranitidine and 220 mg of bismuth） of the test or reference products in the fasting state. Then blood samples were collected for 24 h. Plasma concentrations of ranitidine and bismuth were analyzed by high-performance liquid chromatography and inductively coupled plasma-mass spectrometry （ICPMS）, respectively. The non-compartmental method was used for pharmacokinetic analysis. Log-transformed Cmax, AUC（0-t） and AUC（0-∞） were tested for bioequivalence using ANOVA and Schuirmann two-one sided t-test. Tmax was analyzed by Wilcoxon＇s test. RESULTS： Various pharmacokinetic parameters of ranitidine derived from the two compound preparations, including Cmax, AUC（0-t）, AUC（0-∞）, Tmax and T1/2, were nearly consistent with previous observations. These parameters derived from test and reference drug were as follows： Cmax（0.67 ± 0.21 vs 0.68 ± 0.22 mg/L）, AUC（0-t）（3.1 ± 0.6 vs 3.0 ± 0.7 mg/L per hour）, AUC（0-∞）（3.3 ± 0.6 vs 3.2 ± 0.8 mg/L per hour）, Tmax （2.3 ± 0.9 VS 2.1 ± 0.9 h） and T1/2 （2.8 ± 0.3 vs 3.1 ± 0.4 h）. In addition, double-peak absorption profiles of ranitidine were found in some Chinese volunteers. For bismuth, those parameters derived from test and reference drug were as follows： Cmax （11.80 ± 7.36 vs 11.40 ± 6.55 μg/L）, AUC（0-t）（46.65 ± 16.97 vs 47.03 ± 21.49 μg/L per hour）, Tmax （0.50 ± 0.20 vs 0.50 ± 0.20 h） and T1/2 （10.2 ± 2.3 vs 13.0 ± 6.9 h）. Ninety percent of confidence intervals for the test/reference ratio of Cmax, AUC（0-t） and AUC（0-∞） derived from both ranitidine and bismuth were found within the bioequivalence acceptable range of 80%-125%. No significant difference was found in Tmax derived from both ranitidine and bismuth. CONCLUSION： The two compound preparations are bioequivalent and may be prescribed intercha

关键词： Ranitidine Bismuth Compound preparation Bioequivalence Pharmacokinetics Healthy volunteers High-performanace liquid chromatography Inductively coupled plasma-mass spectrometry

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Study on Inclusions in Large Sapphire Optical Crystal Grown by SAPMAC Method

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Chinese Journal of Aeronautics 2006年第B12期19卷 31-35页

作者： WANG Gui-gen ZHANG Ming-fu ZUO hong-bo HE Xiao-dong HAN Jie-cai Center for Composite Structure Harbin Instime of Technology Harbin 150080 China

The sapphire （Al2O3） single crystal is a kind of excellent infrared transmission window materials. A large-sized sapphire （Ф225 mm×205 mm, 27.5 kg） was grown by SAPMAC method （sapphire growth technique with micro-pulling and shoulder-expanding at cooled center）. Several kinds of inclusion in the large sapphire crystal were investigated by means of an optical microscopy （OM）, scanning electron microscopy （SEM） and electron probe microanalysis （EPMA）. The experimental results show that most inclusions are consisted of solid metallic and non-metallic particles as well as gas pores caused by the impurity of alumina as the raw material, the thermal dissociation of aluminum oxide melt and the reaction of the melt to the crucible material （Mo） at high temperatures. It is also found that in different crystal regions the inclusions are of varied sizes, morphology and chemical compositions. Finally, the measures to reduce and eliminate the inclusions are proposed to improve the crystal quality.

关键词： sapphire single crystal inclusions bubbles SAPMAC method

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Development of a High Sound Absorption Material CEMCOM

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Journal of Wuhan University of Technology(Materials Science) 2002年第4期17卷 5-8页

作者：马保国 School of Materials Science and Engineering Whan University of Technology Wuhan China

Based on sound absorption mechanism of material,the special sound absorption material CEMCOM for road sound insulation is *** high sound absorption material is mainly composed of expanded *** multiple sound absorption structure can improve sound absorption property of *** to the preparation principle and durability design of material,a new kind of material with low cost and high durability is developed.

关键词： sound absorption coefficient sound absorption structure porous material

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Prevalence of hypertension and its associations with body composition across Chinese and American children and adolescents

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World Journal of Pediatrics 2024年第4期20卷 392-403页

作者： Li-Wang Gao Yi-Wen Huang hong Cheng Xi Wang hong-bo dong Pei Xiao Yin-Kun Yan Xin-Ying Shan Xiao-Yuan Zhao Jie Mi Center for Non-Communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthNo.56 Nanlishi RoadXicheng DistrictBeijing100045China Department of Epidemiology Capital Institute of PediatricsNo.2 Yabao RoadChaoyang DistrictBeijing100020China Key Laboratory of Major Diseases in Children Ministry of EducationBeijingChina

Background The age of onset of hypertension(HTN)is decreasing,and obesity is a significant risk *** prevalence and racial disparities in pediatric HTN and the association between body composition and blood pressure are insufficiently *** study aimed to evaluate the prevalence of HTN in Chinese and American children and adolescents and to assess the relationship between various body composition indices and *** Seven thousand,five hundred and seventy-three Chinese and 6239 American children and adolescents aged 8–18 years from the 2013–2015 China Child and Adolescent Cardiovascular Health study and the 2011–2018 National Health and Nutrition Examination Surveys were *** pressure and body composition(fat and muscle)were measured by trained *** crude prevalence and age-standardized prevalence rate(ASPR)of primary HTN and its subtypes[isolated systolic hypertension(ISH)and isolated diastolic hypertension(IDH)]were calculated based on 2017 American Academy of Pediatrics ***-adjusted linear regression coefficients and odds ratios(ORs)were calculated to assess the associations of body composition indicators with HTN,ISH and *** The ASPR of HTN was 18.5%in China(CN)and 4.6%in the United States(US),whereas the obesity prevalence was 7.4%and 18.6%,and the population attributable risk of HTN caused by overweight and obesity was higher in the US than in *** fat mass,muscle mass and body fat percentage mass were associated with a higher risk of HTN in both *** percent of muscle body mass had a protective effect on HTN and ISH in both countries[HTN(CN:OR=0.83,95%CI=0.78–0.88;US:OR=0.72,95%CI=0.64–0.81);ISH(CN:OR=0.87,95%CI=0.80–0.94;US:OR=0.71,95%CI=0.62–0.81)],and the protective effect was more common among children and adolescents with high levels of physical *** The burden of HTN in Chinese children and adolescents was substantial and much greater than that in the US,and th

关键词： body composition Children and adolescents China Child and Adolescent Cardiovascular Health Hypertension National Health and Nutrition Examination Surveys

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Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures

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World Journal of Psychiatry 2025年第1期15卷 83-92页

作者： bo Wang Da Shi Yin-Di Sun bo dong Joint Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Pain Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar *** kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation *** patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative *** To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation *** This study retrospectively analyzed 100 patients admitted to the orthopedic department of honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June *** general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social *** Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on *** According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)*** significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety *** depression(r=0

关键词： Patients with thoracolumbar fractures Anxiety Depression Social pressure Social support

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两种有机酸对铀和^(241)Am污染土壤植物修复影响的比较研究

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安全与环境学报 2016年第6期16卷 287-291页

作者：王萍杜良苏容波谭昭怡李涛文郭洪波张东中国工程物理研究院核物理与化学研究所四川绵阳621900

为了实现放射性核素污染土壤植物修复的工程化应用,在前期植物筛选的基础上,选取对铀富集能力较强的芥菜和对^(241)Am富集能力较强的大麦进行盆栽试验,研究不同含量的柠檬酸和苹果酸对铀、^(241)Am污染土壤植物修复效果的影响。从转移系... 详细信息

为了实现放射性核素污染土壤植物修复的工程化应用,在前期植物筛选的基础上,选取对铀富集能力较强的芥菜和对^(241)Am富集能力较强的大麦进行盆栽试验,研究不同含量的柠檬酸和苹果酸对铀、^(241)Am污染土壤植物修复效果的影响。从转移系数(TFs)、富集系数(BFs)、盆栽植物生物量及提取效率等方面对有机酸作用下两种核素的去除效果进行了研究。结果表明,与柠檬酸相比,苹果酸也能促进植物对土壤中铀和^(241)Am的吸收,并能促进铀和^(241)Am在植物体内的运输,但其促进能力较弱。在相同的土壤条件下,芥菜地上部的铀富集系数高于大麦地上部的^(241)Am富集系数,铀在植物体内的转移系数也远高于^(241)Am,表明在试验给定的条件下,铀比^(241)Am更容易在植物体内运输迁移。当有机酸含量在20 mmol/kg及以上时,盆栽植物的生物量大大降低,降低幅度在20%以上,表明土壤中有机酸含量太高会严重影响植物的正常生长发育。在环境条件相同的情况下,盆栽芥菜的铀提取率远高于盆栽大麦的^(241)Am提取率。

关键词：环境工程学植物修复 241Am 铀有机酸

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复旦大学大学生吸烟情况及影响因素调查

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复旦学报（医学版） 2003年第5期30卷 487-490页

作者：陈静孙亮钱海红傅东波郑频频傅华复旦大学公共卫生学院预防医学教研室上海200032 复旦大学团委上海200433

目的　了解复旦大学大学生吸烟现状 ,分析该人群吸烟行为的影响因素 ,寻找有效的控烟策略以预防和矫正大学生的吸烟行为。方法　对 4 0 19名在校本科生进行了问卷调查。结果　吸烟率为 2 .3% ,现在吸烟率为 2 .3%。性别、年级、专业与... 详细信息

目的　了解复旦大学大学生吸烟现状 ,分析该人群吸烟行为的影响因素 ,寻找有效的控烟策略以预防和矫正大学生的吸烟行为。方法　对 4 0 19名在校本科生进行了问卷调查。结果　吸烟率为 2 .3% ,现在吸烟率为 2 .3%。性别、年级、专业与现在是否吸烟有关。男性是吸烟的危险因素 ;随着年级的升高 ,吸烟率呈上升趋势 ;非医学专业的吸烟率高于医学专业。结论　大学生对吸烟的态度和信念较好 ,但是吸烟率仍然处于一个比较高的水平 ,近一半的吸烟者并没有戒烟的打算 ,非吸烟者拒绝被动吸烟的意识也比较薄弱。开展控烟运动已刻不容缓 ,成为当务之急。

关键词：复旦大学大学生吸烟情况影响因素调查控烟策略预防矫正

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罐头涂料铁罐双酚A二缩水甘油醚及其衍生物迁移规律研究

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食品工业科技 2017年第1期38卷 87-91,96页

作者：黄文仇凯钟其顶吴刚孟镇高红波肖冬光天津科技大学生物工程学院天津300457 中国食品发酵工业研究院北京100015 全国食品发酵标准化中心北京100015

研究了罐头涂料铁罐双酚A二缩水甘油醚及其衍生物在特定食品模拟物中的迁移规律。采用50%(v/v)乙醇溶液为食品模拟物,应用高效液相色谱-串联质谱法进行双酚A二缩水甘油醚及其衍生物的定性定量分析,并应用基于Fick扩散第二定律的***模型... 详细信息

研究了罐头涂料铁罐双酚A二缩水甘油醚及其衍生物在特定食品模拟物中的迁移规律。采用50%(v/v)乙醇溶液为食品模拟物,应用高效液相色谱-串联质谱法进行双酚A二缩水甘油醚及其衍生物的定性定量分析,并应用基于Fick扩散第二定律的***模型和基于概率与数理统计方法的Weibull模型进行了预测。结果表明:贮存条件对迁移总量变化影响显著,温度越高越快达到平衡,迁移平衡值为1.28 mg/kg;***模型中扩散系数D与贮存温度符合阿伦尼乌斯动力学模型,该模型预测值与实验值的拟合优度(R^2)小于0.23,而Weibull模型拟合优度(R^2)能达到0.90以上。因此,Weibull模型比***模型更接近实际迁移结果,为评估涂料铁罐的安全性提供参考。

关键词：涂料铁罐双酚A二缩水甘油醚高效液相色谱-串联质谱法迁移模型

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单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

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中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler法将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②MRI成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(P<0.05),水凝胶组大鼠跟腱的拉伸强度高于手术组(P<0.05)。与假手术组比较,手术组大鼠跟腱中白细胞介素1β、白细胞介素6及肿瘤坏死因子α质量浓度及mRNA表达升高(P<0.05);与手术组比较,水凝胶组3种炎症因子水平及mRNA表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

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Nonconforming Finite Element Methods for the Constrained Optimal Control Problems Governed by Nonsmooth Elliptic Equations

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 471-481页

作者： hong-bo GUAN dong-yang SHI College of Mathematics and Information Sciences Zhengzhou University of Light IndustryZhengzhou 450002China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

In this paper,nonconforming finite element methods(FEMs)are proposed for the constrained optimal control problems(OCPs)governed by the nonsmooth elliptic equations,in which the popular EQr1 ot element is employed to approximate the state and adjoint state,and the piecewise constant element is used to approximate the ***,the convergence and superconvergence properties for the nonsmooth elliptic equation are obtained by introducing an auxiliary ***,the goal-oriented error estimates are obtained for the objective function through establishing the negative norm error ***,the methods are extended to some other well-known nonconforming elements.

关键词： nonconforming finite element supercloseness and superconvergence optimal control problems nonsmooth elliptic equations goal-oriented error estimate

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