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Effect of bivalirudin on myocardial microcirculation and adverse events after interventional therapy in older patients with acute coronary syndrome

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World Journal of Clinical Cases 2024年第22期12卷 4890-4896页

作者： Ya-Kun Du Li-Jun Cui hong-bo gao Cardiovascular Department Hanzhong People’s HospitalHanzhong 723000Shaanxi ProvinceChina

BACKGROUND Bivalirudin,a direct thrombin inhibitor,is used in anticoagulation therapies as a substitute for heparin,especially during cardiovascular procedures such as percutaneous coronary *** To explore the effect of bivalirudin on myocardial microcirculation following an intervention and its influence on adverse cardiac events in elderly patients with acute coronary syndrome(ACS).METHODS In total,165 patients diagnosed with acute myocardial at our hospital between June 2020 and June 2022 were enrolled in this *** June 2020 to June 2022,elderly patients with ACS with complete data were selected and treated with interventional *** study cohort was randomly divided into a study group(n=80,administered bivalirudin)and a control group(n=85,administered unfractionated heparin).Over a 6-mo follow-up period,differences in emergency processing times,including coronary intervention,cardiac function indicators,occurrence of cardiovascular events,and recurrence rates,were *** Significant differences were observed between the study cohorts,with the observation group showing shorter emergency process times across all stages:Emergency classification;diagnostic testing;implementation of coronary intervention;and conclusion of emergency treatment(P<0.05).Furthermore,the left ventricular ejection fraction in the observation group was significantly higher(P<0.05),and the creatine kinase-MB and New York Heart Association scores were CONCLUSION In elderly patients receiving interventional therapy for ACS,bivalirudin administration led to increased activated clotting time achievement rates,enhanced myocardial reperfusion,and reduced incidence of bleeding complications and adverse cardiac events.

关键词： Bivalirudin Heparin Acute coronary syndrome Corrected thrombolysis in myocardial infarction flow frame count Thrombolysis in myocardial infarction myocardial perfusion classification

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Phosphatidic Acid Regulates BZR1 Activity andBrassinosteroid Signal of Arabidopsis

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Molecular Plant 2014年第2期7卷 445-447页

作者： Ping Wu hong-bo gao Liang-Li Zhang hong-Wei Xue Wen-Hui Lin Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China University of Chinese Academy of Sciences Beijing 100049 China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200032 Shanghai China

Dear Editor, Brassinosteroid （BR） is an important hormone and playscrucial roles in plant growth and development （Kim andWang, 2010）. Genetics studies identify many componentsinvolving in BR signaling, including transcript factor BZR1（BRASSINAZOLE RESISTANT 1）. BZR1 is dephosphorylated （Heet al., 2005） to regulate expression of target genes. A sin-gle amino acid mutation in BZR1 PEST domain results inenhanced binding and dephosphorylation by PP2A （PROTEINPHOSPHATASE 2A; Tang et al., 2011）, leading to constitutivelyactivated BZR1 and enhanced BR signal in gain-of-functionmutant bzr1-1D. Although BR signal is well characterized inArabidopsis, how the components of BR signaling transduc-tion pathway are reclulated needs further illustrations.

关键词： PLANT-GROWTH TRANSDUCTION RESPONSES

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Phosphatidic Acid （PA） PP2A Activity and PIN1 Binds PP2AA1 to Regulate Polar Localization

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Molecular Plant 2013年第5期6卷 1692-1702页

作者： hong-bo gao Yu-Jia Chu hong-Wei Xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chineseacademy of Sciences 200032 Shanghai People's Republic of China

Phospholipase D （PLD） exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid （PA）. Protein kinases and phosphatases, such as mammalian target of rapa- mycin （mTOR）, Protein Phosphatase 1 （PP1） and Protein Phosphatase 2C （PP2C）, are PA-binding proteins that execute crucial regulatory functions in both animals and plants. PA participates in many signaling pathways by modulating the enzymatic activity and/or subcellular localization of bound proteins. In this study, we demonstrated that PLD-derived PA interacts with the scaffolding A1 subunit of Protein Phosphatase 2A （PP2A） and regulates PP2A-mediated PIN1 dephos- phorylation in Arabidopsis. Genetic and pharmacological studies showed that both PA and PP2A participate in the regu- lation of auxin distribution. In addition, both the phosphorylation status and polar localization of PIN1 protein were affected by PLD inhibitors, Exogenous PA triggered the membrane accumulation of PP2AA1 and enhanced the PP2A activity at membrane, while PLD inhibition resulted in the reduced endosomal localization and perinuclear aggregation of PP2AA1. These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphoryl- ation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. As PA and PP2A are conserved among eukaryotes, other organisms might use similar mechanisms to mediate multiple biological processes.

关键词： phosphatidic acid (PA) PP2A PIN1 phosphorylation polar localization.

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An Approximation Algorithm for the Parallel-Machine Customer Order Scheduling with Delivery Time and Submodular Rejection Penalties

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Journal of the Operations Research Society of China 2024年第2期12卷 495-504页

作者： hong-Ye Zheng Suo-Gang gao Wen Liu bo Hou School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024HebeiChina

In this paper,we consider the parallel-machine customer order scheduling with delivery time and submodular rejection *** this problem,we are given m dedicated machines in parallel and n customer *** order has a delivery time and consists of m product types and each product type should be manufactured on a dedicated *** order is either rejected,in which case a rejection penalty has to be paid,or accepted and manufactured on the m dedicated *** objective is to find a solution to minimize the sum of the maximum delivery completion time of the accepted orders and the penalty of the rejected orders which is determined by a submodular *** design an LP rounding algorithm with approximation ratio of n+1 for this problem.

关键词： Order scheduling Delivery time Submodular rejection penalty Approximation algorithm

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Noise-Tolerant ZNN-Based Data-Driven Iterative Learning Control for Discrete Nonaffine Nonlinear MIMO Repetitive Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 344-361页

作者： Yunfeng Hu Chong Zhang bo Wang Jing Zhao Xun Gong Jinwu gao hong Chen State Key Laboratory of Automotive Simulation and Control Jilin UniversityJilin UniversityChangchun 130025China College of Communication Engineering Jilin UniversityJilin UniversityChangchun 130025China Department of Electromechanical Engineering University of MacaoMacao 999078China School of Artificial Intelligence Jilin UniversityChangchun 130012China IEEE College of Electronics and Information Engineering Tongji UniversityShanghai 200092China

Aiming at the tracking problem of a class of discrete nonaffine nonlinear multi-input multi-output(MIMO) repetitive systems subjected to separable and nonseparable disturbances, a novel data-driven iterative learning control(ILC) scheme based on the zeroing neural networks(ZNNs) is proposed. First, the equivalent dynamic linearization data model is obtained by means of dynamic linearization technology, which exists theoretically in the iteration domain. Then, the iterative extended state observer(IESO) is developed to estimate the disturbance and the coupling between systems, and the decoupled dynamic linearization model is obtained for the purpose of controller synthesis. To solve the zero-seeking tracking problem with inherent tolerance of noise,an ILC based on noise-tolerant modified ZNN is proposed. The strict assumptions imposed on the initialization conditions of each iteration in the existing ILC methods can be absolutely removed with our method. In addition, theoretical analysis indicates that the modified ZNN can converge to the exact solution of the zero-seeking tracking problem. Finally, a generalized example and an application-oriented example are presented to verify the effectiveness and superiority of the proposed process.

关键词： Adaptive control control system synthesis data-driven iterative learning control neurocontroller nonlinear discrete time systems

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Programmable repulsive potential for tight-binding from Chen-Möbius inversion theorem

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 71-83页

作者： Jian-gao Li Jin-Kun Tang hong-Quan Song Gotthard Seifert Dong-bo Zhang College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China Department of Physics Beijing Normal UniversityBeijing 100875China College of Physics and Telecommunication Engineering Zhoukou Normal UniversityZhoukou 466001China Theoretische Chemie Technische Universität DresdenDresden D-01062Germany

An accurate total energy calculation is essential in materials *** date,many tight-binding(TB)approaches based on parameterized hopping can produce electronic structures comparable to those obtained using first-principles ***,TB approaches still have limited applicability for determining material properties derived from the total *** is,the predictive power of the TB total energy is impaired by an inaccurate evaluation of the repulsive *** complexity associated with the parametrization of TB repulsive potentials is the weak link in this *** this study,we propose a new method for obtaining the pairwise TB repulsive potential for crystalline materials by employing the Chen-Möbius inversion *** show that the TB-based phonon dispersions,calculated using the resulting repulsive potential,compare well with those obtained by first-principles calculations for various systems,including covalent and ionic bulk materials and twodimensional *** present approach only requires the first-principles total energy and TB electronic band energy as input and does not involve any *** striking feature enables us to generate repulsive potentials programmatically.

关键词： tight binding first-principles calculation total energy repulsive potential phonon dispersion

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Quantitative method to predict the energetics of helium-nanocavities interactions in metal systems based on electrophobic interaction

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Journal of Materiomics 2024年第3期10卷 725-737页

作者： Fengping Luo bowen Zhang Zhiying gao Jia Huang hong-bo Zhou Guang-hong Lu Fei gao Yugang Wang Chenxu Wang State Key Laboratory of Nuclear Physics and Technology Center for Applied Physics and TechnologyPeking UniversityBeijing100871China Department of Physics Beihang UniversityBeijing100191China Department of Nuclear Engineering and Radiological Science University of MichiganAnn ArborMI48109USA

Energetics of helium-nanocavities interactions are crucial for unveiling underlying mechanisms of nanocavity evolution in nuclear ***,it becomes intractable and even not feasible to obtain these energetics via atomic simulations with increasing nanocavity size and increasing helium content in ***,a universal scaling law of helium-induced interaction energies in nanocavities in metal systems is proposed based on electrophobic interaction of *** on this scaling law and ab-initio calculations,a predictive method for binding energies of helium and displacement defects to nanocavities of arbitrary sizes and with different helium/vacancy ratios is established for BCC iron as a representative and validated by atomic *** predictive method reveals that the critical helium/vacancy ratio for helium-enhanced vacancy binding to nanocavities in-creases with increasing nanocavity size,and the helium/vacancy ratio giving the highest stability of nanocavities is about *** Ostwald ripening of nanocavities is delayed by helium to higher temper-atures due to reduced vacancy de-trapping rates from *** proposed scaling law can be generalized to many metal systems studied in the nuclear materials *** readily coupled into mesoscale models of irradiation damages,this predictive method facilitates clarifying helium role in cavity swelling of metallic nuclear materials.

关键词： Nanocavities Helium Electrophobic interaction Predictive method

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An innovative classification system for ranking the biological effects of marine aromatic hydrocarbons based on fish embryotoxicity

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Acta Oceanologica Sinica 2024年第6期43卷 153-162页

作者： Ronghui Zheng Chao Fang Fukun hong Min Zhang Fulong gao Yusheng Zhang Jun bo Key Laboratory of Marine Ecological Conservation and Restoration Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China Observation and Research Station of Coastal Wetland Ecosystem in Beibu Gulf Ministry of Natural ResourcesBeihai 536015China

Petroleum hydrocarbon pollution is a global concern,particularly in coastal *** aromatic hydrocarbons(PAHs) are regarded as the most toxic components of petroleum *** this study,the biomonitoring and ranking effects of petroleum hydrocarbons and PAHs on the marine fish model Oryzias melastigma embryos were determined in the Jiulong River Estuary(JRE) and its adjacent waters in *** results showed that the levels of petroleum hydrocarbons from almost all sites met the primary standard for marine seawater quality,and the concentrations of the 16 priority PAHs in the surface seawater were lower compared with those in other coastal areas worldwide.A new fish expert system based on the embryotoxicity of ***(OME-FES) was developed and applied in the field to evaluate the biological effects of petroleum hydrocarbons and *** selected physiological index and molecular indicators in OME-FES were appropriate biomarkers for indicating the harmful effects of petroleum hydrocarbons and *** outcome of OME-FES revealed that the biological effect levels of the sampling sites ranged from level Ⅰ(no stress) to level Ⅲ(medium stress),which is further corroborated by the findings of nested analysis of variance(ANOVA) *** results suggest that the OME-FES is an effective tool for evaluating and ranking the biological effects of marine petroleum hydrocarbons and *** method may also be applied to evaluate other marine pollutants based on its framework.

关键词： petroleum hydrocarbons polycyclic aromatic hydrocarbons fish expert system integrated biomarker response nested one-way analysis of variance

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Backed-up or bound： Youths in US Chinatowns in Ethnic Literature and in Reality

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Sino-US English Teaching 2013年第12期10卷 979-984页

作者： YANG hong-bo gao Wei-nong Jinan University Guangzhou China

Targeting the youth group of the American Chinatowns, this paper attempts to explore the continuous interactions of the people and the community on each other. As a result of combined impact of the immigration history of Chinese Americans and the unfolding political and economical reality, a complicated relationship has developed between the growing Chinese immigrants and the Chinatown where they happen to inhabit and influence. Literature and history have captured the interesting development in their specific perspectives and paradigms, between whom the comparison is creatively presented. The great process of modern urbanization of American cities since the 1950s is given serious highlight in shaping the small community as well as the large one. The authors invite further argument on whether the youths are cushioned or bound by the traditional physical and cultural environment, or they bring change to the community in return at the end of the paper. It is suggested that they mature into a beautiful compromise and pride on creating the immigrant legacy characteristic of the great country.

关键词： ethnic Chinese literature the US Chinatowns youths

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Recovery of scandium from silicate minerals by high-pressure leaching in sulfuric acid

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Journal of Rare Earths 2024年第7期42卷 1375-1384,I0007页

作者： Peng Yan Xiaoming Chen Likun gao bo Yang Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming650093China School of Chemistry and Chemical Engineering Kunming UniversityKunming650214China

This study investigated the leaching of scandium from a Sc-bearing silicate *** Sc concentrate obtained by beneficiation pre-enrichment has 1.03×10^(−4) wt%Sc and 14.66 wt%*** main Sc-bearing minerals are limonite,chlorite,sericite,and hornblende,in the form of ***-pressure leaching(HPL)with sulfuric acid(98 wt%)and NaF was used to dispose this *** Sc leaching efficiency of 91.82%was obtained under the optimum conditions,which are pressure of 5.0×10^(5) Pa,A/O value of 1.1,L/S value of 1.8,NaF dosage of 2 wt%,at 130℃ for 6 *** X-ray diffraction(XRD)and scanning electron microscopy(SEM)results show that the residue is mainly quartz phase in the multihole *** with ordinary leaching for silicate,high-pressure leaching has significant advantages in saving acid and energy consumption.

关键词： Silicate minerals Scandium High-pressure Leaching Concentrated sulfuric acid Rare earths

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