检索结果-南通市图书馆

5-Hydroxytryptamine:a potential therapeutic target in amyotrophic lateral sclerosis

Neural Regeneration Research 2023年第9期18卷 2047-2055页

作者： Shi-Shi Jiang Meng-Ni Gong Wei Rao Wen Chai Wen-Zhi Chen Xiong Zhang hong-bing nie Ren-Shi Xu Medical College of Nanchang University Department of NeurologyJiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeClinical College of Nanchang Medical CollegeNanchangJiangxi ProvinceChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurology Maoming People’s HospitalMaomingGuangdong ProvinceChina

Previous studies have indicated that the pathogenesis of amyotrophic lateral sclerosis(ALS) is closely linked to 5-hydroxytryptamine(5-HT).To investigate this further,we administered 5-HT receptor antagonists to SOD1*G93A transgenic(ALS mouse model) and wide-type *** involved intraperitoneal injections of either granisetron,piboserod,or ritanserin,which inhibit the 5-HT3,5-HT4,and 5-HT2 receptors,*** transgenic mice were found to have fewer5-HT-positive cells in the spinal cord compared with wide-type *** found that the administration of granisetron reduced the body weight of the transgenic mice,while piboserod and ritanserin worsened the motor functioning,as assessed using a hanging wire ***,none of the 5-HT receptor antagonists affected the disease *** analyzed the distribution and/or expression of TAR DNA binding protein 43(TDP-43) and superoxide dismutase 1 G93A(SOD1-G93A),which fo rm abnormal aggregates in *** found that the expression of these proteins increased following the administration of all three 5-HT receptor *** addition,the disease-related mislocalization of TD P-43 to the cytoplasm increased markedly for all three *** ce rtain anatomical regions,the 5-HT receptor antagonists also led to a marked increase in the number of astrocytes and microglia and a decrease in the number of *** results indicate that 5-HT deficiency may play a role in the pathogenesis of amyotrophic lateral sclerosis by inducing the abnormal expression and/or distribution of TDP-43 and SOD1-G93A and by activating glial cells.5-HT co uld therefore be a potential therapeutic target for amyotrophic lateral sclerosis.

关键词： 5-hydroxytryptamine amyotrophic lateral sclerosis astrocytes granisetron microglia neuron piboserod ritanserin SOD1-G93A TAR DNA-binding protein 43

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic resonance spectroscopy findings of central pontine myelinolysis in an alcohol abuser

引用

Chinese Medical Journal 2020年第7期133卷 874-876页

作者： Yao-Yao Shen hong-bing nie Zhong-Bin Xia bing Bao Xiang-Bin Wu Department of Neurology The Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi 332000China

To the Editor:Central pontine myelinolysis(CPM),a form of osmotic demyelination syndrome(ODS)typically-occurring in the central pons,was first described in alcoholic and malnourished individuals by Adams et al[1]in *** is frequently associated with alcohol abuse,liver transplantation,and rapid correction of hyponatremia.[2]The clinical manifestations of CPM are variable,including dysarthria,dysphagia,oculomotor dysfunction,variable degrees of quadriparesis and even locked-in ***,some patients may be *** size of myelinolysis in the central pons on brain magnetic resonance imaging(MRI)is not always matched with the severity of clinical ***,a limited number of case reports focued on the magnetic resonance spectroscopy(MRS)findings of CPM.

关键词： myelin clinical finding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification and Characteristics Analysis of Micro-Seismic Signals in the Haima Seep Area

引用

Journal of Earth Science 2024年第1期35卷 288-291页

作者： Xiangchun Wang bing nie Zhiyu Wu Weiwei Wang Hua Chen China University of Geosciences Beijing 100083China CNOOC China Limited Shenzhen BranchShenzhen 518000China Guangzhou Marine Geological Survey Guangzhou 511458China CNOOC China Limited Shanghai BranchShanghai 200335China

*** recent years,with the steady development of offshore energy exploration technology,submarine gas seepage sites,and their products are gradually being identified and *** submarine cold seep is a seepage phenomenon in which hydrocarbon gases stored deep in the seafloor are transported to seawater by gushing or seepage under the action of tectonic compression(Roy et al.,2019;Tinivella and Giustiniani,2016).

关键词： submarine Seismic offshore

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reversible Cerebral Vasoconstriction Syndrome following Guillain-Barre Syndrome： A Rare Complication

引用

Chinese Medical Journal 2018年第18期131卷 2237-2238页

作者： Yao-Yao Shen Zhi-Juan Cheng Chen-Guang Zhou Ting-Min Dai hong-bing nie Department of Neurology The Affiliated Hospital of Jiujiang University Jiujiang Jiangxi 332000 China Department of Neurology The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Neurology The Fifth Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China

To the Editor： Reversible cerebral vasoconstriction syndrome （RCVS） is well characterized by severe headaches, with or without other acute neurological symptoms, and diffuse segmental vasoconstriction of cerebral arteries, which resolves within 3 months. It has been reported predominantly in middle age, and the syndrome is more common in women than in men. Neuroradiological features of RCVS include convexity subarachnoid hemorrhage, intracerebral hemorrhage.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combined Promoting Effects of Specific Organic Functional Groups and Alumina Surface Characteristics for the Design of a Highly Efficient NiMo/Al_(2)O_(3) Hydrodesulfurization Catalyst

引用

China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 1-11页

作者： Li Huifeng Li Mingfeng Zhang Le Wang Wei nie hong National Energy R&D Center of Petroleum Refining Technology SINOPEC Research Institute of Petroleum Processing Co.Ltd.Beijing 100083China

To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were ***,the correlation between the surface characteristics of four different alumina and the existing Mo species states was *** was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into ***,the Mo-O-Al bonds still exist at the metal-support *** introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on ***,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.

关键词： alumina Mo equilibrium adsorption capacity organic functional groups metal-support interaction hydrodesulfurization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Radial solution of the Logarithmic Laplacian system

引用

Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 114-124页

作者： ZHANG Li-hong nie Xiao-feng WANG Guo-tao Bashir Ahmad School of Mathematics and Computer Science Shanxi Normal UniversityLinfen 041004China Nonlinear Analysis and Applied Mathematics(NAAM)Research Group Department of MathematicsFaculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia.

The paper generalizes the direct method of moving planes to the Logarithmic Laplacian ***,some key ingredients of the method are discussed,for example,Narrow region principle and Decay at ***,the radial symmetry of th... 详细信息

关键词： the Logarithmic Laplacian system radial symmetry the direct method of moving planes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive spatial-temporal graph attention network for traffic speed prediction

引用

High Technology Letters 2024年第3期30卷 221-230页

作者： ZHANG Xijun ZHANG Baoqi ZHANG hong nie Shengyuan ZHANG Xianli School of Computer and Communication Lanzhou University of TechnologyLanzhou 730050P.R.China

Considering the nonlinear structure and spatial-temporal correlation of traffic network,and the influence of potential correlation between nodes of traffic network on the spatial features,this paper proposes a traffic speed prediction model based on the combination of graph attention network with self-adaptive adjacency matrix(SAdpGAT)and bidirectional gated recurrent unit(BiGRU).First-ly,the model introduces graph attention network(GAT)to extract the spatial features of real road network and potential road network respectively in spatial ***,the spatial features are input into BiGRU to extract the time series ***,the prediction results of the real road network and the potential road network are connected to generate the final prediction results of the *** experimental results show that the prediction accuracy of the proposed model is im-proved obviously on METR-LA and PEMS-BAY datasets,which proves the advantages of the pro-posed spatial-temporal model in traffic speed prediction.

关键词： traffic speed prediction spatial-temporal correlation self-adaptive adjacency ma-trix graph attention network(GAT) bidirectional gated recurrent unit(BiGRU)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Sc on Al_(3)Fe phase and mechanical properties of as-cast AA5052 aluminum alloy

引用

China Foundry 2024年第3期21卷 257-264页

作者： Yang Li Qing Yu Feng-feng Chen Jia-wen He hong-mei Yang Meng-nie Li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical *** studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the *** this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%*** results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc *** ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.

关键词： AA5052 aluminum alloy Al3Fe phase mechanical properties grain boundary

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interhemispheric Subdural Empyema Secondary to Sinusitis in an Adolescent Girl

引用

Chinese Medical Journal 2018年第24期131卷 2989-2990页

作者： Yao-Yao Shen Zhi-Juan Cheng Jing-Yan Chai Ting-Min Dai Ying Luo Yan-Qin Guan hong-bing nie Department of Neurology The Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi 332000China Department of Neurology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

To the Editor:With the advent of antibiotics application,intracranial complications of paranasal sinusitis,including meningitis, intracranial abscess,subdural empyema (SDE),epidural abscess, cavernous sinus thrombosis,and thrombosis of other dural sinuses, have become uncommon. However,SDE is still a life-threatening disease *** is defined as a purulent collection between dura mater and *** most common cause of SDE is *** causes include meningitis,otitis media,operative infection,head trauma,and bacteremic seeding of previous subdural hematoma, Here,we present a rapidly progressive case ofinterhemispheric SDE following *** should be aware of SDE when the patient presents with headache and fever,and neuroimaging manifests as a dilated subdural space especially in adolescent with sinusitis.

关键词： Interhemispheric Subdural Empyema Adolescent Girl

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization and degradation of β-Sn particles in thermal aged Pb-rich solder joint for low-temperature co-fired ceramic(LTCC) applications

引用

Rare Metals 2024年第10期43卷 5346-5361页

作者： Jin-hong Liu Zhe Zhu Qiang-Qiang nie Jun-Fu Liu Peng He Shu-Ye Zhang State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Anhui Key Laboratory of Microsystem East China Research Institute of Microelectronics School of Materials Science and Engineering Hefei University of Technology

High-lead solder joints are still playing an indispensable role in military and space ***, in-depth characterization of high-lead solder joints and the underlying degradation mechanisms remain unexplored. This research first performed aging tests on Sn10Pb90 solder joints, the shear strength at room and elevated temperatures gradually reduced, and the resistance increased. Here, a two-layered Ni–Sn intermetallic compound(IMC) structure was identified using transmission electron microscopy(TEM), which could be attributed to the change of Sn content in the solder. Moreover, the internal annealing twin of a Sn particle was discovered,which could be attributed to creeping induced by thermal expansion coefficient(CTE) difference between Sn and *** analysis of partial and whole annealing twins was conducted through high-resolution TEM(HRTEM).Finally, four degradation mechanisms were *** of the IMC layer would result in increased brittleness and resistivity. For particle coarsening, apart from diminishing the ductility and toughness of the solder joint, it would also accelerate the creeping rate by weakening the phase boundary strength. Regarding voids and cracks induced by phase boundary sliding, wedgeshaped cracking and pore-shaped cracking were discovered and their formation was analyzed. Most importantly, the consumption of Sn resulted in a depletion of wettable layer,leading to the formation of Pb streams and isolated IMC islands, also known as the spalling and delamination of IMCs. Pb diffusion followed a spiral path, which was mutually influenced by orientation misfit and concentration gradient. A technique to prevent cracking was *** research is expected to provide significant technical references for high-lead solder joints.

关键词： Aging Degradation mechanisms High-lead solder joints Properties TEM characterization

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：