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In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A

Journal of Environmental Sciences 2011年第2期23卷 315-321页

作者： Jie Cao Liang-hong guo bin Wan Yin Wei State Key Laboratory of Environmental Chemistry and Ecoloxicology Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Bisphenol A （BPA） is a chemical with high production volume and wide applications in many industries. Although BPA is known as an endocrine disruptor, its toxic mechanisms have not been fully characterized. Due to its structural similarity to thyroid hormones thyroxine （T4） and triiodothyronine （T3）, one possible mechanism of BPA toxicity is disruption of hormone transport by competitive binding with the transport proteins. In this study, the binding interactions of BPA, T4, and T3 with three thyroid hormone transport proteins, human serum albumin （HSA）, transthyretin （TTR）, and thyroxine-binding globulin （TBG） were investigated by fluorescence measurement. Using two site-specific fluorescence probes dansylamide and dansyl-L-proline, the binding constants of BPA with HSA at drug site I and site II were determined as 2.90 × 10^4 and 3.14 × 10^4 L/mol, respectively. By monitoring the intrinsic fluorescence of tryptophan, a binding constant of 4.70 ×10^3 L/mol was obtained. Similarly, by employing 8-anilino-l-naphthalenesulfonic acid as fluorescence probe, the binding affinity of BPA with TTR and TBG was measured to be 3.10 × 10^5 and 5.90× 10^5 L/mol, respectively. In general, BPA showed lower binding affinity with the proteins than T3 did, and even lower affinity than T4. Using these binding constants, the amount of BPA which would bind to the transport proteins in human plasma was estimated. These results suggest that the concentrations of BPA commonly found in human plasma are probably not high enough to interfere with T4 transport.

关键词： bisphenol A human serum albumin human transthyretin human thyroxine-binding globulin fluorescence displacement method

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Effect of AMPS(2-acrylamido-2-methylpropane sulfonic acid) content on the properties of polymer gels

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Petroleum Science 2022年第2期19卷 697-706页

作者： Tian-Ci Zhang Ji-Jiang Ge Hao Wu hong-bin guo Bao-Lei Jiao Zhen Qian School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Petroleum Engineering Institute Northwest Branch of SinopecUrumqi830011XinjiangChina

The BST oilfield in the northwestern Taklamakan Desert is a fractured carbonate reservoir,but issues of water breakthrough are becoming increasingly severe with the development of water ***,the high-temperature and high-salt conditions(130°C,71695 mg/L)of the BST oilfield pose challenges for the development of plugging *** this study,the effects of 2-acrylamido-2-methylpropane sulfonic acid(AMPS)content on AM/AMPS copolymers and gels were studied through viscosity measurements,nuclear magnetic resonance(NMR),and cryo-scanning electron microscope(Cryo-SEM).Moreover,the AMPS stabilization mechanism of the polymers and gels was *** and salt-tolerant gel systems were developed,and their gelation properties,thermal stability,injection capacity,and plugging ability were *** results showed inconsistencies between the effects of AMPS content on the polymers and *** the polymers,the thermal stability increased with increased AMPS content in the ***,excessive AMPS content resulted in poor gelation and low *** developed gel systems with S30 polymer(AMPS content is approximately 26%)exhibited excellent thermal stability,controllable gelation time,good injection capacity,and plugging *** field application results indicated that most production wells had a positive response,with reduced water-cut and increased daily oil production.

关键词： Gels 2-Acrylamido-2-methylpropane sulfonic acid Enhanced oil recovery Hydrolysis Syneresis

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Quantitative image analysis for evaluation of tumor response in clinical oncology

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Chronic Diseases and Translational Medicine 2018年第1期4卷 18-28页

作者： Wen-Li Cai guo-bin hong Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhaiGuangdong 519000China

The objective, accurate, and standardized evaluation of tumor response to treatment is an indispensable procedure in clinical oncology. Compared to manual measurement, computer-assisted linear measurement can significantly improve the accuracy and reproducibility of tumor burden quantification. For irregular-shaped and infiltrating or diffuse tumors, which are difficult to quantify by linear measurement, computer-assisted volumetric measurement may provide a more objective and sensitive quantification to evaluate tumor response to treatment than linear measurement does. In the evaluation of tumor response to novel oncologic treatments such as targeted therapy, changes in overall tumor size do not necessarily reflect tumor response to therapy due to the presence of internal necrosis or hemorrhages. This leads to a new generation of imaging biomarkers to evaluate tumor response by using texture analysis methods, also called radiomics. Computer-assisted texture analysis technology offers a more comprehensive and in-depth imaging biomarker to evaluate tumor response. The application of computer-assisted quantitative imaging analysis techniques not only reduces the inaccuracy and improves the reliability in tumor burden quantification, but facilitates the devel-opment of more comprehensive and intelligent approaches to evaluate treatment response, and hence promotes precision imaging in the evaluation of tumor response in clinical oncology. This article summarizes the state-of-the-art technical developments and clinical applications of quantitative imaging analysis in evaluation of tumor response in clinical oncology.

关键词： Quantitative image analysis Tumor imaging biomarker Response evaluation

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Coke-Resistant　Ni-based　Catayst　for　Partial　Oxidation　and　CO_2-Reforming　of　Methane　to　Syngas

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Chemical Research in Chinese Universities 1997年第1期13卷 85-87页

作者： CHEN Ping, ZHANG hong bin, LIN guo dong, guo Zhong ping, TSAI Khi rui (Department of Chemistry & State Key Laboratory for Physical Chemistry of the Solid Surface, Xiamen University, Xiamen, 361005)

Ｃｏｋｅ┐ＲｅｓｉｓｔａｎｔＮｉ┐ｂａｓｅｄＣａｔａｙｓｔｆｏｒＰａｒｔｉａｌＯｘｉｄａｔｉｏｎａｎｄＣＯ２┐ＲｅｆｏｒｍｉｎｇｏｆＭｅｔｈａｎｅｔｏＳｙｎｇａｓ＊ＣＨＥＮＰｉｎｇ，ＺＨＡＮＧＨｏｎｇ－ｂｉｎ＊＊，Ｌ... 详细信息

Ｃｏｋｅ┐ＲｅｓｉｓｔａｎｔＮｉ┐ｂａｓｅｄＣａｔａｙｓｔｆｏｒＰａｒｔｉａｌＯｘｉｄａｔｉｏｎａｎｄＣＯ２┐ＲｅｆｏｒｍｉｎｇｏｆＭｅｔｈａｎｅｔｏＳｙｎｇａｓ＊ＣＨＥＮＰｉｎｇ，ＺＨＡＮＧＨｏｎｇ－ｂｉｎ＊＊，ＬＩＮＧｕｏ－ｄｏｎｇ，ＧＵＯＺｈｏ...

关键词： Coke resistant Ni catalyst Methane Partial oxidation CO 2 reforming Syngas

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基于Petri网的企业内部活动关系整合研究

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系统工程学报 2005年第1期20卷 43-48页

作者：洪国彬郑丕谔天津大学系统工程研究所

提出一种优化整合企业内部各种活动关系的方法.首先,将一个企业的平面活动流程图转换为Petri网模型,并据此确定出企业内部的各种活动间的选择、冲突、同步和并发关系.进一步提出基于关联矩阵的重组算法并用于对确定的各种关系加以描述.... 详细信息

提出一种优化整合企业内部各种活动关系的方法.首先,将一个企业的平面活动流程图转换为Petri网模型,并据此确定出企业内部的各种活动间的选择、冲突、同步和并发关系.进一步提出基于关联矩阵的重组算法并用于对确定的各种关系加以描述.最后,对企业内部的各种活动关系进行优化和整合.通过实例阐明了文章所提的企业内部各个活动关系的整合方法可行并且有效.

关键词： Petd网关联矩阵重组算法流程优化整合

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Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan guo hong-Bo Jin Cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi guo bin Hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun hong guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： bin Xie Yuanhui guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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制备裸鼠皮下移植瘤动物模型:3种建模方法及MR成像比较

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中国医学影像技术 2010年第2期26卷 205-208页

作者：洪国斌梁碧玲沈君黄文革中山大学附属第二医院放射科广东广州510120 中山大学附属第五医院放射科广东珠海519000 中山大学实验动物中心广东广州510080

目的通过比较3种人肝癌裸鼠皮下移植瘤模型建模方法,探索适于分子影像学研究的裸鼠移植瘤建模方法。方法48只BALB/C-nu/nu裸小鼠随机分成3组,每组16只。对实验组采用2mm3大小的瘤组织块建模,对照组1采用1mm3大小的瘤组织块建模,对照组2... 详细信息

目的通过比较3种人肝癌裸鼠皮下移植瘤模型建模方法,探索适于分子影像学研究的裸鼠移植瘤建模方法。方法48只BALB/C-nu/nu裸小鼠随机分成3组,每组16只。对实验组采用2mm3大小的瘤组织块建模,对照组1采用1mm3大小的瘤组织块建模,对照组2采用瘤细胞悬液法进行建模,分别观察成瘤率、成瘤时间和成瘤数目。接种后3～6周进行常规MR扫描及T2-mapping成像。结果实验组、对照组1、对照组2的成瘤率分别为93.75%、75.00%、43.75%,实验组与对照组2差异有统计学意义(P<0.05);实验组、对照组1、对照组2的肿瘤体积达1cm3的时间分别为(21.7±2.4)天、(29.8±2.9)天、(34.6±3.9)天,组间两两比较差异均有统计学意义(P<0.05);3组形成单发肿瘤的比例分别为93.33%、75.00%、14.29%,实验组与对照组2差异有统计学意义(P<0.05)。常规T1WI和T2WI均能清晰显示肿瘤、肝脏、脾脏和脑组织等主要脏器,肿瘤在T1WI上呈等、稍低信号,在T2WI上呈高信号。利用多回波自旋回波序列(MSE)可测量肿瘤组织的T2弛豫时间,将T2-mapping成像数据输入工作站可获得T2-mapping伪彩图。结论采用体积约2mm3的改良瘤组织块法制作人肝癌移植瘤动物模型成瘤率高,成瘤时间短且较易形成单发肿瘤,可进行常规MR成像和T2-mapping成像,是一种适用于分子影像学成像研究的建模方法。

关键词：肝肿瘤模型动物磁共振成像

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