检索结果-南通市图书馆

Compositional modeling and simulation of dimethyl ether (DME)-enhanced waterflood to investigate oil mobility improvement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2018年第2期15卷 297-304页

作者： Jinhyung cho Tae hong Kim Kun Sang Lee Department of Earth Resources and Environmental Engineering Hanyang University

Dimethyl ether （DME） is a widely used industrial compound, and Shell developed a chemical EOR technique called DME- enhanced waterflood （DEW）. DME is applied as a miscible solvent for EOR application to enhance the performance of conventional waterflood. When DME is injected into the reservoir and contacts the oil, the first-contact miscibility process occurs, which leads to oil swelling and viscosity reduction. The reduction in oil density and viscosity improves oil mobility and reduces residual oil saturation, enhancing oil production. A numerical study based on compositional simulation has been developed to describe the phase behavior in the DEW model. An accurate compositional model is imperative because DME has a unique advantage of solubility in both oil and water. For DEW, oil recovery increased by 34% and 12% compared to conventional waterflood and CO2 flood, respectively. Compositional modeling and simulation of the DEW process indicated the unique solubility effect of DME on EOR performance.

关键词： Dimethyl ether (DME) DME-enhanced waterflood (DEW) Solubility Oil mobility

Global parameter estimation of the Cochlodinium polykrikoides model using bioassay data

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2016年第2期35卷 39-45页

作者： cho hong-Yeon PARK Kwang-Soon KIM Sung Coastal and Environmental Engineering Division Korea Institute of Ocean Science and Technology Coastal Disaster Research Center Korea Institute of Ocean Science and Technology Biological Oceanography and Marine Biology Division Korea Institute of Ocean Science and Technology

Cochlodinium polykrikoides is a notoriously harmful algal species that inflicts severe damage on the aquacultures of the coastal seas of Korea and Japan. Information on their expected movement tracks and boundaries of influence is very useful and important for the effective establishment of a reduction plan. In general, the information is supported by a red-tide（a.k.a algal bloom） model. The performance of the model is highly dependent on the accuracy of parameters, which are the coefficients of functions approximating the biological growth and loss patterns of the C. polykrikoides. These parameters have been estimated using the bioassay data composed of growth-limiting factor and net growth rate value pairs. In the case of the C. polykrikoides, the parameters are different from each other in accordance with the used data because the bioassay data are sufficient compared to the other algal species. The parameters estimated by one specific dataset can be viewed as locally-optimized because they are adjusted only by that dataset. In cases where the other one data set is used, the estimation error might be considerable. In this study, the parameters are estimated by all available data sets without the use of only one specific data set and thus can be considered globally optimized. The cost function for the optimization is defined as the integrated mean squared estimation error, i.e., the difference between the values of the experimental and estimated rates. Based on quantitative error analysis, the root-mean squared errors of the global parameters show smaller values, approximately 25%–50%, than the values of the local parameters. In addition, bias is removed completely in the case of the globally estimated parameters. The parameter sets can be used as the reference default values of a red-tide model because they are optimal and representative. However, additional tuning of the parameters using the in-situ monitoring data is highly *** opposed to the bioassay d

关键词： global and local estimation gain and loss parameters Cochlodinium polykrikoides bioassay data model performance

All-in-one glycol chitosan nanoparticles for co-delivery of doxorubicin and anti-PD-L1 peptide in cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第10期28卷 358-375页

作者： Sukyung Song Man Kyu Shim Suah Yang Jaewan Lee Wan Su Yun Hanhee cho Yujeong Moon Jin Young Min Eun Hee Han hong Yeol Yoon Kwangmeyung Kim College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul03760Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Bioengineering Korea UniversitySeoul02841Republic of Korea Research Center for Bioconvergence Analysis Korea Basic Science Institute(KBSI)Cheongju28119Republic of Korea Department of Toxicology College of PharmacyChungnam National UniversityDaejeon34134Republic of Korea

Synergistic immunotherapy of immune checkpoint blockade (ICB) and immunogenic cell death (ICD) has shown remarkable therapeutic efficacy in various cancers. However, patients show low response rates and undesirable outcomes to these combination therapies owing to the recycling mechanism of programmed death-ligand 1 (PD-L1) and the systemic toxicity of ICD-inducing chemotherapeutic drugs. Herein, we propose all-in-one glycol chitosan nanoparticles (CNPs) that can deliver anti-PD-L1 peptide (PP) and doxorubicin (DOX) to targeted tumor tissues for a safe and more effective synergistic immunotherapy. The PP-CNPs, which are prepared by conjugating ᴅ-form PP (NYSKPTDRQYHF) to CNPs, form stable nanoparticles that promote multivalent binding with PD-L1 proteins on the targeted tumor cell surface, resulting in effective lysosomal PD-L1 degradation in contrast with anti-PD-L1 antibody, which induces recycling of endocytosed PD-L1. Consequently, PP-CNPs prevent subcellular PD-L1 recycling and eventually destruct immune escape mechanism in CT26 colon tumor-bearing mice. Moreover, the ICD inducer, DOX is loaded into PP-CNPs (DOX-PP-CNPs) for synergistic ICD and ICB therapy, inducing a large number of damage-associated molecular patterns (DAMPs) in targeted tumor tissues with minimal toxicity in normal tissues. When the DOX-PP-CNPs are intravenously injected into CT26 colon tumor-bearing mice, PP and DOX are efficiently delivered to the tumor tissues via nanoparticle-derived passive and active targeting, which eventually induce both lysosomal PD-L1 degradation and substantial ICD, resulting in a high rate of complete tumor regression (CR: 60%) by a strong antitumor immune response. Collectively, this study demonstrates the superior efficacy of synergistic immunotherapy using all-in-one nanoparticles to deliver PP and DOX to targeted tumor tissues.

关键词： Chitosan nanoparticle Synergistic immunotherapy Immune checkpoint blockade Multivalent binding Immunogenic cell death

Antifi brotic effects of green tea on in vitro and in vivo models of liver fibrosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第41期15卷 5200-5205页

作者： Hye Kyung Kim Taik-Hoon Yang hong-Yon cho Department of Food and Biotechnology Hanseo University Seosan Chungnam 356-706 South Korea Department of Food and Bio-technology College of Science and Technology Korea University Jochiwon Chungnam 339-700 South Korea

AIM: To examine the protective effect of green tea extract (GT) on hepatic fi brosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced ***: HSC-T6, a rat hepatic stellate cell line, was used as an in vitro assay system. Cell proliferation, collagen content, and type 1 collagen expression were examined in activated HSC-T6 cells. Collagen was determined by estimating the hydroxyproline content. In rats with DMN-induced hepatic fi brosis, serum aspartate aminotransferase and alanine aminotransferase concentrations, liver hydroxyproline and lipid peroxides were determined. Pathologic changes were examined by hematoxylin & eosin ***: GT administration prevented the development of hepatic fibrosis in the rat model of DMN-induced liver fi brosis. These results were confi rmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content, a marker of liver collagen deposition. Accordingly, inhibition of proliferation, reduced collagen deposition, and type 1 collagen expression were observed in activated HSC-T6 cells following GT treatment. These results imply that GT reduced the proliferation of activated HSC and down regulated the collagen content and expression of collagen type 1, thereby ameliorating hepatic ***: This study demonstrates that greentea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic f ibrosis.

关键词：肝纤维化绿茶提取物体外体内天冬氨酸转氨酶模型二甲基亚硝胺胶原含量

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第10期12卷 1640-1647页

作者： Jisu hong Bo-yong Park Hwan-ho cho Hyunjin Park Department of Electronic Electrical and Computer EngineeringSungkyunkwan UniversitySuwonKorea Center for Neuroscience Imaging Research(CNIR) Institute for Basic ScienceSuwonKorea School of Electronic and Electrical Engineering Sungkyunkwan UniversitySuwonKorea

Attention deficit and hyperactivity disorder（ADHD） is a disorder characterized by behavioral symptoms including hyperactivity/impulsivity among children,adolescents,and *** ADHD related symptoms are influenced by the complex interaction of brain networks which were under *** explored age-related brain network differences between ADHD patients and typically developing（TD） subjects using resting state f MRI（rs-f MRI） for three age groups of children,adolescents,and *** collected rs-f MRI data from 184 individuals（27 ADHD children and 31 TD children;32 ADHD adolescents and 32 TD adolescents;and 31 ADHD adults and 31 TD adults）.The Brainnetome Atlas was used to define nodes in the network *** compared three age groups of ADHD and TD subjects to identify the distinct regions that could explain age-related brain network differences based on degree centrality,a well-known measure of nodal *** left middle temporal gyrus showed significant interaction effects between disease status（i.e.,ADHD or TD） and age（i.e.,child,adolescent,or adult）（P 0.001）.Additional regions were identified at a relaxed threshold（P 0.05）.Many of the identified regions（the left inferior frontal gyrus,the left middle temporal gyrus,and the left insular gyrus） were related to cognitive *** results of our study suggest that aberrant development in cognitive brain regions might be associated with age-related brain network changes in ADHD *** findings contribute to better understand how brain function influences the symptoms of ADHD.

关键词： nerve regeneration attention deficit and hyperactivity disorder cognitive function connectivity resting-state f MRI Brainnetome Atlas whole brain analysis disease-aging interaction effect neuroscience neural regeneration

Fabrication of Dual-pore Scaffolds Using a Combination of Wire-Networked Molding （WNM） and Non-solvent Induced Phase Separation （NIPS） Techniques

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2015年第4期12卷 565-574页

作者： Dong Guk Sohn Myoung Wha hong Young Yul Kim Young-Sam cho Division of Mechanical and Automotive Engineering College of Engineering Wonkwang University 460 Iksandae-ro Iksan Jeonbuk 570-749 Republic of Korea Department of Orthopedics Daejeon St. Mary's Hospital Catholic University of Korea 64 Daeheung-ro Jung-gu Daejeon 301-723 Republic of Korea

In this study, to fabricate dual-pore scaffolds with interconnected pores, Non-solvent Induced Phase Separation （NIPS） and Wire-Network Molding （WNM） techniques were combined. First, a mold with uniform slits was prepared, and needles were inserted into the mold. Subsequently, polycaprolactone （PCL） pellets were dissolved in tetrahydrofuran （THF） at a specified ratio. The slurry was mixed using hot plate stirrer at 1200 rpm for 24 hours at 40 ~C. The PCL slurry was subsequently injected into the mold. Thereafter, to exchange the THF （solvent） with the ethanol （non-solvent）, the mold was soaked in an ethanol bath. After removing the mold from the ethanol bath, the needles were removed from the mold. Consequently, dual-pore scaffold with interconnected pores was obtained. The surface morphology of the fabricated scaffolds were observed using Scanning Electron Microscope （SEM）. Moreover, cell culture experiments were performed using the CCK-8 assay, and the characteristics of cells grown on the dual-pore scaffolds were assessed and were compared with the NIPS-based 3D plotting scaffold.

关键词： tissue engineering scaffold polycaprolactone (PCL) Wire-Network Molding (WNM) Non-solvent Induced Phase Separation (NIPS)

Weave-pattern-dependent fabric piezoelectric pressure sensors based on polyvinylidene fluoride nanofibers electrospun with 50 nozzles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Flexible Electronics 2022年第1期6卷 699-707页

作者： Da Bin Kim Ju Han Sun Min Sung Min Seong Kim Bo Kyoung choi Sung Jun Park Hyae Rim hong hong Je choi Byeong Kon Kim Chung Hee Park Jong Hoo Paik Joon-Seok Lee Yong Soo cho Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Textile Engineering and Technology Yeungnam UniversityGyeongsan 38541Republic of Korea Deparment of Textile Merchandising and Fashion DesignSeoul National UniversitySeoul 08826Republic of Korea Samsung Electro-Mechanics Co.Ltd. Suwon 16674Republic of Korea Ceratorq Inc. Seoul 08511Republic of Korea Electronic Materials and Component Center Korea Institute of Ceramic Engineering and TechnologyJinju 52851Republic of Korea

Wearable pressure sensors having versatile device structures have been extensively investigated to achieve high sensitivity under mechanical ***,we introduce piezoelectric pressure sensors based on fabrics woven using polyvinylidene fluoride(PVDF)weft and polyethylene terephthalate(PET)warp yarns with different weave structures:1/1(plain),2/2,and 3/3 weft rib *** dependence of the pressure-sensing performance on the weave pattern is demonstrated with an actual large-scale fabric up to the~2 m *** optimized pressure sensor with a 2/2 weft rib pattern produced a high sensitivity of 83 mV N−1,which was 245%higher than that of the 1/1 *** detection performance of the optimal fabric was extensively evaluated with a variety of ambient input sources,such as pressing,bending,twisting,and crumpling,as well as various human ***,a large allfabric pressure sensor with arrayed touch pixel units demonstrated highly sensitive and stable sensing performance.

关键词： pattern fluoride piezoelectric

DESIGNING THE OPTIMUM CONFIGURATIONS OF CIRCULAR AND SPHERICAL PRODUCT SPECIFICATIONS FOR MULTIPLE QUALITY CHARACTERISTICS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2005年第4期14卷 385-399页

作者： Byung rae cho Michael D. PHILLIPS Jami KOVACH Department of Industrial Engineering Clemson University Clemson South Carolina 29634 USA Department of Mathematical Sciences United States Military Academy West Point NY 10996 USA

As an integral part of tolerance design in the context of design for six sigma, determining optimal product specifications has become the focus of increased activity, as manufacturing industries strive to increase productivity and improve the quality of their products. Although a number of research papers have been reported in the research community, there is room for improvement. Most existing research papers consider determining optimal specification limits for a single quality characteristic. In this paper, we develop the modeling and optimization procedures for optimum circular and spherical configurations by considering multiple quality characteristics. The concepts of multivariate quality loss function and truncated distribution are incorporated. This has never been adequately addressed, nor has been appropriately applied in industry. A numerical example is shown and comparison studies are made.

关键词： Circular and spherical specifications multivariate quality loss function truncated multivariate distribution optimization

Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

在线全文

学校读者我要写书评

暂无评论

npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk cho Jaejin Park Jung-Hoon hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In Sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin hong Min-Ho Nam Hojeong Jeon Youngmee Jung Huanyu Cheng Il-Joo cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous