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Drug-induced erythroderma in patients with acquired immunodeficiency syndrome

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World Journal of Emergency Medicine 2021年第4期12卷 299-302页

作者： Wei-fang Zhu De-ren fang hong fang Department of Dermatology the First Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310003China

BACKGROUND: To explore the clinical manifestations, diagnosis, and treatment of patients with acquired immunodeficiency syndrome(AIDS) complicated with drug-induced ***: The clinical data of 12 AIDS patients with drug-induced erythroderma in our hospital were retrospectively analyzed. The general information, offending medications, complications, modified severity-of-illness score for toxic epidermal necrolysis(SCORTEN) scores, and disease outcome spectrums were ***: Drug-induced erythroderma was mostly caused by antiviral drugs, antituberculosis drugs, antibiotics, traditional Chinese medicine, and immune checkpoint inhibitors. The spectrum of sensitizing drugs was broad, the clinical situation was complex, and infections were common. The affected areas were greater than 40% body surface area in all patients. The modified SCOTERN score averaged 3.01±0.99. All patients were treated with glucocorticoids, and nine patients were treated with intravenous immunoglobulin(IVIG) pulse therapy at the same time. The average time to effectiveness was 7.08±2.23 days, and the average hospital stay was 17.92±8.46 days. Eleven patients were cured, and one patient died of secondary multiple infections, who had a modified SCORTEN score of 5 points. The mortality rate in this study was 8.3%.CONCLUSIONS: The clinical situation of AIDS patients with drug-induced erythroderma in hospitalized patients is complex and the co-infection rate is high. The use of modified SCORTEN score may objectively and accurately assess the conditions, and the use of glucocorticoid combined with IVIG therapy may improve the prognosis.

关键词： Acquired immunodeficiency syndrome Drug eruption Erythroderma Modified severity-of-illness score for toxic epidermal necrolysis

Survey on skin aging status and related influential factors in Southeast China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 57-66页

作者： Yi-na WANG hong fang Wei-fang ZHU Department of Dermatology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results： Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet （UV）-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types Ⅱ, Ⅲ and Ⅳ were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type Ⅱ seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types Ⅲ and Ⅳ. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion： Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.

关键词： Skin aging Influential factor Fitzpatrick type Solar exposure Skin type Concomitant facial disease

Development of a Non-Pollution Orange Fruit Expert System Software Based on ***

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Agricultural Sciences in China 2011年第5期10卷 805-812页

作者： LI Yi-shan hong Li-fang Institute of Network Technology Beijing University of Posts and Telecommunications Beijing 100876 P.R.China Agricultural Environment and Resource Institute Yunnan Academy of Agricultural Sciences Kunming 650205 P.R.China

Based on ***,a orange fruit tree fertilizer expert system software was *** system could simulate and decide an annual fertilization plan for young and mature trees in terms of geographical position and *** paper introduced the design conditions,framework,production,and deployment of the *** exhibited characters of orange specialty and was a typical online agriculture expert *** use of the system for orange fruit management could decrease production cost,guarantee orange quality and improve economical benefit at the same *** using the system saved N input by 41-238 g/plant,P2O5 input 3-24 g/plant,and K2O input 1-36 g/plant,and got higher yield by 6-17 kg/plant.

关键词： rational fertilization expert system orange fruit tree ***

NUMERICAL ANALYSIS FOR CIRCULATION DISTRIBUTION OF PROPELLER BLADE

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Journal of Hydrodynamics 2010年第4期22卷 488-493页

作者： hong fang-wen DONG Shi-tang China Ship Scientific Research Center Wuxi 214082 China

A process for numerical analysis of radial circulation distribution of propeller blade is proposed and *** is based on the results of numerical simulation of the velocity field around propeller blades and in the *** well-known traditional method using tangential velocity data in the wake and applying Stockes＇s theorem was also examined in the *** results from two approaches are compared with each *** is found that if the traditional way is utilized,in many cases an unexpected ＂hump＂ appears in the circulation distribution at certain outer *** authors calculated the circulations directly around blade sections,and it is referred as direct *** unexpected hump of the circulation distribution disappears in the results of direct *** article also discusses the reasons of the appearance of the unexpected hump in traditional *** direct method is proposed to have a potential in analyzing or verifying the radial road distribution for designed propeller and the numerical analysis instead of experimental validation for circulation distribution can be as a tool in the propeller design process.

关键词： propeller blade circulation distribution load distribution

Modification of k-ω Turbulence Model for Predicting Airfoil Aerodynamic Performance

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Journal of Thermal Science 2015年第3期24卷 221-228页

作者： PENG Bo YAN Hao fang hong WANG Ming School of Economics and Management Beihang University National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power Engineering Beihang University Shenyang Aeroengine Research Institute

Predicting wind turbine S825 airfoil＇s aerodynamic performance is crucial to improving its energy efficiency and reducing its environmental impact. In this paper, a numerical simulation on the wind turbine S825 airfoil is con- ducted with k-to turbulence model at different attack angles. By comparing with experimental data, a new method of modifying k-to model is proposed. A modifying function is proposed to limit the production term in ω equation based on fluid rotation and deformation. This method improves turbulent viscosity and decreases separating re- gion when the airfoil works at large separating conditions. The predictive accuracy could be improved by using the modified k-to turbulence model.

关键词： S825 airfoil separation k-ω model aerodynamic performance non-equilibrium

In Vitro Interaction of Nicotine and Hemoglobin under Liver Cell Metabolizing Condition

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Chinese Chemical Letters 2001年第5期12卷 449-452页

作者： Yan WANG hong fang SUN Hai fang WANG Yuan fang LIU Department of Technical Physics Peking UniversityBeijing 100871

The in vitro interaction of nicotine and hemoglobin (Hb) in a metabolizing System was studied by spectroscopy assays. Visible spectra showed two isobestics, and fluorescence spectra showed static quenching with increasing of nicotine dose. Meanwhile, the CD spectra intensity reduced, showing the conformation of Hb varied markedly through the interaction. All these results suggested that the interaction of nicotine or its metabolites and Hb might do harm to physicological function of Hb.

关键词： Nicotine hemoglobin visible absorption fluorescence CD

The dynamic response and damage models of rebar reinforced polymer slabs subjected to contact and near-field explosions

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Defence Technology（防务技术） 2023年第10期28卷 330-342页

作者： Hao-nan Zhao hong-yuan fang Xiao-hua Zhao Yellow River Laboratory Zhengzhou UniversityZhengzhou450001China

Non aqueous reactive polymer materials produced by the reaction of isocyanate and polyol have been widely used in infrastructure construction,which may be subjected to explosion loads during complex service *** blast response of composite materials is a crucial aspect for applications in engineering structures potentially subjected to extreme *** this work,damage caused to rebar reinforced polymer slabs by surface explosive charges was studied experimentally and numerically.A total of 6 field tests were carried out to investigate the performances of the failure modes of rebar reinforced polymer slabs under contact and near-field *** influence of explosive quantity(10-40 g)and stand-off distances(0-20 cm)at the damage modes were *** results show that the failure modes of rebar reinforced polymer slabs under near-field explosion mainly were bending and surface spalling,while under the impact of contact explosion,the failure modes were craters of the top surface,spalling of the bottom surface,and middle ***,a detailed fully coupled model was developed and validated with the test *** influences of explosive quantity and slab thickness on rebar reinforced polymer slabs under contact explosion were *** on this,the calculation formula between breach diameter,explosive quantity,and slab thickness is fitted.

关键词： Reinforced polymer slab Numerical investigations Empirical prediction Damage models

Interview with Gish Jen

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Journal of Foreign Languages and Cultures 2019年第1期3卷 145-154页

作者： hong fang Nanjing University

American writer Gish Jen is best known as the author of four critically acclaimed novels:Typical American(1991),Mona in the Promised Land(1996),The Love Wife(2004),and World and Town(2010).Although this interview focuses primarily on these novels,Jen is also the author of a work of nonfiction,Tigerwriting:Art,Culture and the Interdependent Self(2013),and the short story collections Who’s Irish(1999)and The Girl at the Baggage:Explaining the East and West Cultural Gap(2017).This interview was compiled from three conversations between Gish Jen and hong fang:two in May 2009 at Jen’s home in Cambridge,Massachusetts,and one in Fall 2012 when she visited Nanjing Normal *** covers the themes of Jen’s novels as well as their different representations of issues in identity and choices of ethnicity,which are among the most important themes in contemporary American literature and *** believes that American identity is a personal choice and America is a nation made by immigrants and descendants of immigrants who have brought their different cultures to America as they settled in the land of their *** varied cultures of the American immigrants are ingredients of this nation which has been known for its *** these conversations,Jen implies that America may embrace multiculturalism again,which makes this interview’s appearance in this issue a timely commentary.

关键词： interview settled conversation

Quantum Phase Transitions in Spin Star Configuration

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Communications in Theoretical Physics 2008年第5期49卷 1353-1356页

作者： DENG hong-Liang fang Xi-Ming Key Laboratory of Quantum Structure and Quantum Control of Ministry of Education and Department of Physics Hunan Normal University Changsha 410081 China

We consider a generalized spin star configuration that can be solved exactly, with the central spin-1/2 system embedded in an outer ring of N spin-1/2 particles （denoted as spin bath）. In this model, we consider a modified version of the spin star model, by taking into account, besides the interaction of the central spin with the bath, the interactions between the spins of the bath as well. The general expressions of the eigenstates as well as the eigenvalues of the model are derived with the use of the symmetries of system. We then investigate the properties of the ground quantum phase transitions in some limiting cases in the model and show that the occurrence of quantum phase transitions and the desired ground states can be obtained by varying the external control parameters.

关键词： quantum phase transitions ground state