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A defect recognition model for cross-section profile of hot-rolled strip based on deep learning

Journal of Iron and Steel Research International 2023年第12期30卷 2436-2447页

作者： Tian-lun Li Wen-quan Sun An-rui He Jian Shao Chao Liu Ai-bin Zhang Yi Qiang xiang-hong ma National Engineering Research Center for Advanced Rolling and Intelligent manufacturing University of Science and Technology BeijingBeijing100083China Academy of machinery Science and Technology Beijing100044China School of Engineering and Applied Science Aston UniversityBirminghamB47ETUK

The cross-section profile is a key signal for evaluating hot-rolled strip quality,and ignoring its defects can easily lead to a final *** characteristics of complex curve,significant irregular fluctuation and imperfect sample data make it a challenge of recognizing cross-section defects,and current industrial judgment methods rely excessively on human decision making.A novel stacked denoising autoencoders(SDAE)model optimized with support vector machine(SVM)theory was proposed for the recognition of cross-section ***,interpolation filtering and principal component analysis were employed to linearly reduce the data dimensionality of the profile ***,the deep learning algorithm SDAE was used layer by layer for greedy unsupervised feature learning,and its final layer of back-propagation neural network was replaced by SVM for supervised learning of the final features,and the final model SDAE_SVM was obtained by further optimizing the entire network parameters via error ***,the curve mirroring and combination stitching methods were used as data augmentation for the training set,which dealt with the problem of sample imbalance in the original data set,and the accuracy of cross-section defect prediction was further *** approach was applied in a 1780-mm hot rolling line of a steel mill to achieve the automatic diagnosis and classification of defects in cross-section profile of hot-rolled strip,which helps to reduce flatness quality concerns in downstream processes.

关键词： Hot-rolled strip cross section:Curve recognition Deep learning-Stacked denoising autoencoder Support vector machine Imperfect data

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun Fu hong-Wei Li Jian-hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Periphyton growth reduces cadmium but enhances arsenic accumulation in rice(Oryza sativa) seedlings from contaminated soil

Periphyton growth reduces cadmium but enhances arsenic accum...

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中国土壤学会土壤环境专业委员会第十九次会议暨“农田土壤污染与修复研讨会”第二届山东省土壤污染防控与修复技术研讨会

作者： Gao Ling Shi Hai Ying Lu Yong hong Wu Junzhuo Liu Lai Qing Lou hong xiang ma Institute of Food Crops Jiangsu Academy of Agricultural Sciences State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences College of Life Sciences Nanjing Agricultural University

Periphyton is ubiquitous in paddy fields, but its role in arsenic(As) and cadmium(Cd) bioavailability to rice plants remains unknown. A paddy field was simulated under controlled conditions to investigate the influences of periphyton on As and Cd accumulation in rice seedlings grown in soil contaminated with both As and Cd. The presence of periphyton significantly enhanced the growth of rice seedlings in As and Cd contaminated soil. Periphyton had significant effects on soil p H and Eh, resulting in a substantial decrease in the Cd concentration, but an increase in the total As and As(III) concentrations in soil solution. Corresponding with these changes, Cd concentrations in rice roots and shoots were significantly decreased in the presence of periphyton, while As concentrations increased. This study demonstrate that periphyton growth can significant affect soil As and Cd bioavailability and soil As speciation by change soil p H and Eh, thereby affect As and Cd accumulation in rice seedlings. These results suggest that controlling native periphyton growth may be an effective strategy to regulate As and Cd translocation to the edible organs of food crops.

关键词： Arsenic Bioavailability Cadmium Periphyton Rice

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Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun hong Guo School of materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang Lin xiang ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying ma Jia Liu xiang Xia Ning Xu Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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HPLC法测定岩青兰地上全草与不同部位中柚皮素-7-O-葡萄糖苷及北美圣草素-7-O-葡萄糖苷的含量

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天然产物研究与开发 2003年第3期15卷 229-231页

作者：任冬梅娄红祥马斌季梅山东大学药学院济南250012

建立HPLC法测定岩青兰中柚皮素 7 O 葡萄糖苷及北美圣草素 7 O 葡萄糖苷的含量的方法 ,考察岩青兰地上全草与不同部位中两种二氢黄酮类成分的含量。采用PhenomenexC18柱 ,甲醇乙腈水(32∶8∶6 0 )为流动相 ,流速 1ml/min ,紫外检测... 详细信息

建立HPLC法测定岩青兰中柚皮素 7 O 葡萄糖苷及北美圣草素 7 O 葡萄糖苷的含量的方法 ,考察岩青兰地上全草与不同部位中两种二氢黄酮类成分的含量。采用PhenomenexC18柱 ,甲醇乙腈水(32∶8∶6 0 )为流动相 ,流速 1ml/min ,紫外检测器 2 84nm波长进行检测。测得岩青兰叶中两种二氢黄酮含量最高 ,茎中含量极低 ,根中未测到。建立的方法分析简便、灵敏、准确。

关键词： HPLC法岩青兰柚皮素-7-O-葡萄糖苷北美圣草素-7-O-葡萄糖苷含量唇形科

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新鲜羊膜移植治疗急症重度眼烧伤

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眼外伤职业眼病杂志 2008年第4期30卷 305-307页

作者：孙红陈虹秦向阳马敏旺武警医学院附属医院眼科天津300162 武警山西总队医院眼科山西太原030006

目的研究早期重度眼烧伤的急症处理,联合新鲜羊膜移植的临床效果。方法急症处理15例(18眼)眼烧伤,采用新鲜羊膜治疗碱烧伤4例(5眼),酸烧伤3例(4眼),铁水烫伤5例(5眼),热水烫伤3例(4眼)。结果18眼均无羊膜移植排斥反应和继发感染。术后... 详细信息

目的研究早期重度眼烧伤的急症处理,联合新鲜羊膜移植的临床效果。方法急症处理15例(18眼)眼烧伤,采用新鲜羊膜治疗碱烧伤4例(5眼),酸烧伤3例(4眼),铁水烫伤5例(5眼),热水烫伤3例(4眼)。结果18眼均无羊膜移植排斥反应和继发感染。术后无角巩膜溶解穿孔、虹膜萎缩,视力较前提高。12眼合并不同程度的角膜斑翳,4眼出现角膜新生血管,2眼全角膜浑浊行角膜移植术。结论运用正确的急症处理联合羊膜移植治疗眼表烧伤,可促进上皮细胞分化移行,抑制局部炎症发生,能有效阻止新生血管和瘢痕形成,预防睑球粘连。

关键词：急症处理羊膜移植眼烧伤

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