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Chemical Recycling of Poly(ethylene furanoate)into Value-added Poly(ethylene-co-isosorbide furanoate)

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高分子科学:英文版 2023年第10期41卷 1533-1542页

作者： Jing Li Sheng Wang Huan-Jun Lu Ying-Jia Lan Xiao-hong Li Ying-Feng tu Jiangsu Engineering Laboratory of Novel Functional Polymeric Materials State and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China Jiangsu Key Laboratory for Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou215009China

We present here a novel strategy for the chemical recycling of bio-based poly(ethylene furanoate)s(PEF)to value-added high-performance bio-based poly(ethylene-co-isosorbide furanoate)(PEIF)copolyesters by the combination of cyclodepolymerization method with rapid cascade polycondensation-coupling ring-opening polymerization(PROP).The solution cyclodepolymerization of commercially available PEF affords cyclic oligo(ethylene 2,5-furandicarboxylate)s(COEFs),and the effects of reaction conditions on the yield of COEFs were studied.PEIF copolyesters with different isosorbide(IS)contents were synthesized via the cascade PROP of COEFs with IS,which show significant enhanced glass transition temperature.By melt spinning,PEIF fibers with different orientation factors were prepared,with excellent thermal stability and mechanical performance.The obtained PEIF fibers can lift a weight∼25000 times higher than its weight.The PEIF fibers are stable under ambient conditions but are biodegradable following the“surface erosion”mechanism.These sustainable value-added biodegradable PEIF fibers offer a solution to the environmentally friendly fibers.

关键词： Bio-based Chemical recycling Fiber PROP Sustainable

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1523-1533,F0004页

作者： Canhao Wu Qin Xu Huiyuan Wang Bin tu Jiaxin Zeng Pengfei Zhao Mingjie Shi hong Qiu Yongzhuo Huang Artemisinin Research Center First Clinical SchoolGuangzhou University of Chinese MedicineGuangzhou 510450China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Zhongshan Institute for Drug Discovery SIMMCASZhongshan 528437China Center of Clinical Pharmacology The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310009China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients Shanghai 201203China Taizhou University School of Advanced StudyInstitute of Natural Medicine and Health ProductTaizhou 318000China

The spread of coronavirus disease 2019(COVID-19)throughout the world has resulted in stressful healthcare burdens and global health crises.Developing an effective measure to protect people from infection is an urgent need.The blockage of interaction between angiotensin-converting enzyme 2(ACE2)and S protein is considered an essential target for anti-severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)drugs.A full-length ACE2 protein could be a potential drug to block early entry of SARS-Co V-2 into host cells.In this study,a therapeutic strategy was developed by using extracellular vesicles(EVs)with decoy receptor ACE2 for neutralization of SARS-Co V-2.The EVs embedded with engineered ACE2(EVs-ACE2)were prepared;the EVs-ACE2 were derived from an engineered cell line with stable ACE2 expression.The potential effect of the EVs-ACE2 on anti-SARS-Co V-2 was demonstrated by both in vitro and in vivo neutralization experiments using the pseudovirus with the S protein(S-pseudovirus).EVs-ACE2 can inhibit the infection of S-pseudovirus in various cells,and importantly,the mice treated with intranasal administration of EVs-ACE2 can suppress the entry of S-pseudovirus into the mucosal epithelium.Therefore,the intranasal EVs-ACE2 could be a preventive medicine to protect from SARS-Co V-2 infection.This EVs-based strategy offers a potential route to COVID-19 drug development.

关键词： SARS-CoV-2 COVID-19 Spike protein Pseudovirus Extracellular vesicles ACE2 Intranasal administration Neutralization

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灵活性负荷参与电网调度的经济优化运行

科学技术与工程 2024年第7期24卷 2767-2774页

作者：崔喾张新燕何广渝王志磊王显岚张洪图新疆大学电气工程学院乌鲁木齐830047

在“碳达峰、碳中和”的背景下,大规模新能源并网使系统出现了调峰压力大、新能源消纳难等问题。随着灵活性负荷占比的不断增大,根据灵活性负荷的不同特性,针对系统面临的问题提出了“源-网-荷-储”相协调的双层优化运行模型。首先,基... 详细信息

在“碳达峰、碳中和”的背景下,大规模新能源并网使系统出现了调峰压力大、新能源消纳难等问题。随着灵活性负荷占比的不断增大,根据灵活性负荷的不同特性,针对系统面临的问题提出了“源-网-荷-储”相协调的双层优化运行模型。首先,基于分时电价策略引导用户用电行为,建立提升源荷双方综合满意度以及净负荷波动最小的上层多目标模型,利用粒子群算法对上层模型进行求解得到优化后的负荷需求响应并带入下层模型中。其次,根据源荷双方的供需关系,确定参与调度灵活负荷的运行方式,构建以系统调度运行成本最小为目标的下层模型,并采用Cplex求解器求解。最后,以某地区实际系统为例,结果表明了灵活性负荷参与电网调度可缓解电网调峰压力,提高了可再生能源消纳能力,并验证了本文所提模型的有效性。

关键词：分时电价策略灵活性负荷系统调度源-网-荷-储

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激素对圆齿野鸦椿种子萌发的影响

南方农业学报 2024年第1期55卷 160-168页

作者：阳先波冉芳周宇曦涂淑萍蔡军火姜雪茹钟鑫宏江西农业大学园林与艺术学院江西南昌330045

【目的】探究激素在圆齿野鸦椿种子萌发中的作用及其与活性氧的关系,为圆齿野鸦椿种子破眠技术和种苗高效繁育技术提供理论依据。【方法】以自然层积210 d的圆齿野鸦椿种子为试验材料,去除外部硬质种壳,进行为期12 d的萌发试验,测定纯... 详细信息

【目的】探究激素在圆齿野鸦椿种子萌发中的作用及其与活性氧的关系,为圆齿野鸦椿种子破眠技术和种苗高效繁育技术提供理论依据。【方法】以自然层积210 d的圆齿野鸦椿种子为试验材料,去除外部硬质种壳,进行为期12 d的萌发试验,测定纯水、不同浓度的赤霉素(GA_(3))(20、40和60μmol/L)和脱落酸(ABA)(10、20和30μmol/L)处理下萌发率及活性氧、抗氧化物质、植物激素、可溶性糖和可溶性蛋白含量的变化,并观察记录种子的萌发形态。【结果】纯水处理萌发率最终达77.8%,GA_(3)处理萌发率最高可达82.2%,ABA处理萌发率最终均未达50.0%,而保留硬质种皮纯水处理的种子萌发率仅17.8%。3种浓度的GA_(3)处理均可有效缩短圆齿野鸦椿种子萌发率达50.0%的时间(T_(50)),促进根茎生长,但其最终萌发率均与纯水处理无显著差异(P>0.05);ABA处理浓度越高,对圆齿野鸦椿种子抑制萌发作用越强。相关分析显示,在萌发的第8和12 d,萌发率与GA_(3)、油菜素内酯(BR)和茉莉酸(JA)呈显著正相关(P<0.05,下同),且超氧阴离子(O_(2)^(-)·)与BR和JA含量呈显著负相关,与过氧化氢酶(CAT)、ABA、ABA/GA_(3)均呈显著正相关。【结论】添加GA_(3)可有效缩短圆齿野鸦椿种子萌发率达50%的时间,促进根茎生长,O_(2)^(-)·与ABA的积累对种子萌发存在抑制作用,BR和JA对种子萌发的促进作用可能与对O_(2)^(-)·的清除有关。

关键词：圆齿野鸦椿种子萌发植物激素活性氧

Inhaled heparin polysaccharide nanodecoy against SARS-CoV-2 and variants

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3187-3194页

作者： Bin tu Huiyuan Wang Xinran An Jingkun Qu Qianqian Li Yanrong Gao Mingjie Shi hong Qiu Yongzhuo Huang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China University of Michigan College of Pharmacy Ann ArborMI 48109USA School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Nanchang University College of Pharmacy Nanchang 330006China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528437China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients Shanghai 201203China Taizhou University School of Advanced StudyInstitute of Natural Medicine and Health ProductTaizhou 318000China

To the Editor:As of January 27,2022,there were 363,062,293 cases and 5,645,884deaths from the COVID-19 pandemic1.The prevalent mutated strains have aggravated the global pandemic2.SARS-Co V-2 is highly mutable,and the mutations on the spike(S)protein resulted in a high transmission of COVID-19 and vaccine breakthrough infection3.For example,there is a notable decrease in neutralizing ability of BNT162b2 vaccination-elicited antibodies against the Delta and other variants4,5,and attenuation of peak viral burden and vaccine effectiveness are reduced with Delta variant6.

关键词： SARS-CoV-2 Delta variant Heparan sulfate Spike protein Heparin nanoparticle Pulmonary delivery

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再生塑料管控政策及其智能鉴定研究综述

包装学报 2024年第2期16卷 78-86页

作者：李虹陈寿王鑫曾平张智寰涂建国深圳市八六三新材料技术有限责任公司广东深圳518117

对全球多个国家,特别是欧美国家和中日韩等亚太国家,塑料生产、回收和再利用的相关政策和法规进行了梳理;对再生塑料成分和含量的鉴定技术进行了归纳总结。研究结果表明:发达国家和发展中大国对塑料管控相对较好,既有近期规划又有远景目... 详细信息

对全球多个国家,特别是欧美国家和中日韩等亚太国家,塑料生产、回收和再利用的相关政策和法规进行了梳理;对再生塑料成分和含量的鉴定技术进行了归纳总结。研究结果表明:发达国家和发展中大国对塑料管控相对较好,既有近期规划又有远景目标;再生塑料的鉴定技术和方法正在快速发展和完善。在不远的将来,会实现塑料的高效回收和循环利用,也会开发出简便、快速、精准的再生塑料鉴定方法。

关键词：再生塑料塑料废弃物包装法律法规循环利用

基于Docker和Asterisk的软交换实验平台设计与实现

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实验室科学 2024年第3期27卷 54-58页

作者：涂继辉李李周翔邱威杜红王庆楠长江大学电子信息与电气工程学院湖北荆州434023 长江大学国家级电子电工实验教学示范中心湖北荆州434023 怀化学院机械与光电物理学院湖南怀化418000

针对软交换实验和实训平台存在教学系统不完善、部署维护困难和利用率低等问题,提出了基于Docker和Asterisk的软交换实验教学平台。该实验平台主要分为三个部分:(1)利用B/S架构实现了实验教学管理;(2)利用Docker的微服务框架来承载软交... 详细信息

针对软交换实验和实训平台存在教学系统不完善、部署维护困难和利用率低等问题,提出了基于Docker和Asterisk的软交换实验教学平台。该实验平台主要分为三个部分:(1)利用B/S架构实现了实验教学管理;(2)利用Docker的微服务框架来承载软交换平台;(3)利用改进的Asterisk作为软交换实验平台。经过实验教学实践的检验,该实验教学平台相比目前已有的系统具有方便简单的操作、灵活快速的部署维护、价格低廉和容易升级等优点,这为学生课内软交换实验和课外创新活动提供了实践平台。

关键词：软交换实验系统微服务 Docker Asterisk SIP

La^(3+)修饰对纳米ZnO/TiO_(2)复合粉体的光催化性能影响

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广州化工 2024年第8期52卷 48-50页

作者：汪鹏许应生屠后为徐茂红皖西卫生职业学院安徽六安237005

以La_(2)(SO_(4))3、Ti(SO_(4))2和ZnSO_(4)·7H_(2)O为原料,体积分数为40%的乙醇作溶剂,用共沉淀法制备La^(3+)修饰纳米ZnO/TiO_(2)复合光催化材料,初步研究了La^(3+)修饰对ZnO/TiO_(2)光催化性能的影响。有实验可知,用最佳镧掺杂量为0.2%的Zn∶Ti=3∶10的ZnO/TiO_(2)样品,La^(3+)修饰ZnO/TiO_(2)纳米复合粉体对甲基橙降解率可达到38.4%。掺入金属La^(3+)有效地抑制ZnO/TiO_(2)纳米复合粉体粒子之间的团聚,比表面积增加,光催化活性明显增强。并采用XRD等测试手段对其进行表征。

关键词： La^(3+)修饰 ZnO/TiO_(2) 光催化剂

Recent advances of bioresponsive polymeric nanomedicine for cancer therapy

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Nano Research 2023年第2期16卷 2660-2671页

作者： tu hong Xinyuan Shen Madiha Zahra Syeda Yang Zhang Haonan Sheng Yipeng Zhou JinMing Xu Chaojie Zhu hongjun Li Zhen Gu Longguang Tang International institutes of Medicine The Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Shanghai Jiaotong University School of Medicine Shanghai 200025China Department of Thoracic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Jinhua Institute of Zhejiang University Jinhua 321299China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented.

关键词： drug delivery polymer bioresponsive immunotherapy cancer therapy