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Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism

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World Journal of Gastroenterology 2012年第25期18卷 3282-3287页

作者： Shu Zhao hong sha Zhang-Yong Li, Chao-Shi Ren Institute of BiomedicalEngineering Chinese Academy of Medical Sciences and PekingUnion Medical College Tianjin 300192 China College of Bioinformation Chongqing Univer-sity of Posts and Telecommunications Chongqing 400065 China

AIM： To introduce a bioimpedance gastric motility mea- surement method based on an electrical-mechanical composite concept and a preliminary clinical application. METHODS： A noninvasive gastric motility measure- ment method combining electrogastrograrn （EGG） and impedance gastric motility （IGM） test was used. Prelim- inary clinical application studies of patients with func- tional dyspepsia （FD） and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients （mean age 40.9±9.7 years） and 40 healthy volun- teers （mean age 30.9±7.9 years） were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients （mean age 50.5±13.0 years） and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after ***： There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency （PNF） 70.8±25.5 in healthy subjects and 28.3 =t= 16.9 in FD patients, P 〈 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not im- proved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups （PNF 70.4：1：25.5 for healthy subjects and 36.1 4- 21.8 for gastritis patients, P 〈 0.05）. The EGG rhythm of the gastritis patients returned to normal （frequency insta- bility coefficient 2.22±0.43 before treatment and 1.77 ：t： 0.19 one wk after treatment, P 〈 0.05） after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tenden- cy toward improvement but had not reached statistical si

关键词： Gastric motility Electrical bioimpedance Electrical-mechanical composite Electrogastrogram

Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 983-989页

作者： Zhang-yong LI Chao-shi REN Shu ZHAO hong sha Juan DENG College of Bioinformation Chongqing University of Posts and Telecommunications Chongqing 400065 China nstitute of Biomedical Engineering Chinese Academy of Medical Sciences ＆ Peking Union Medical College Tianjin 300192 China

For some time now,the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine,exocrine secretion,and gastric *** this paper,a noninvasive method to study gastric motility was developed,taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography(EGG).This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity(basic electric rhythm) and the mechanical gastric ***,preliminary clinical studies of healthy subjects and subjects with functional dyspepsia(FD) and gastritis were carried *** impedance gastric motility(IGM) measurements of the healthy and FD subjects were compared,along with the studies of the FD subjects before treatment and after one week and three weeks of *** also compared IGM measurements of healthy subjects and subjects with erosive gastritis,along with the studies of the subjects with erosive gastritis before treatment and after one week of *** show that FD subjects have poor gastric motility(P0.05),These results suggest the possibility of clinic application of the proposed method.

关键词： Gastric motility Electrical bioimpedance Electrogastrography Functional dyspepsia Gastritis

Conversion therapy and suitable timing for subsequent salvage surgery for initially unresectable hepatocellular carcinoma: What is new?

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World Journal of Clinical Cases 2018年第9期6卷 259-273页

作者： Ze-Feng Zhang Yu-Jun Luo Quan Lu Shi-Xue Dai Wei-hong sha Department of Gastroenterology and Hepatology Guangdong Geriatrics Institute Guangdong General Hospital Guangdong Academy of Medical Sciences

AIM To review the conversion therapy for initially unre-sectable hepatocellular carcinoma(HCC) patients and the suitable timing for subsequent salvage surgery. METHODS A Pub Med search was undertaken from 1987 to 2017 to identify articles using the keywords including "unresectable" "hepatocellular carcinoma", "hepate-ctomy", "conversion therapy", "resection", "salvage surgery" and "downstaging". Additional studies were investigated through a manual search of the references from the articles. The exclusion criteria were duplicates, case reports, case series, videos, contents unrelated to the topic, comments, and editorial essays. The main and widely used conversion therapies and the suitable timing for subsequent salvage surgery were discussed in detail. Two members of our group independently performed the literature search and data extraction. RESULTS Liver volume measurements [future liver remnant(FLR)/total liver volume or residual liver volume/bodyweight ratio] and function tests(scoring systems and liver stiffness) were often performed in order to justify whether patients were suitable candidates for surgery. Successful conversion therapy was usually defined as downstaging the tumor, increasing FLR and providing subsequent salvage surgery, without increasing com-plications, morbidity or mortality. The requirementsfor performing salvage surgery after transcatheter arterial chemoembolization were the achievement of a partial remission in radiology, the disappearance of the portal vein thrombosis, and the lack of extrahepatic metastasis. Patients with a standardized FLR(sF LR) > 20% were good candidates for surgery after portal vein embolization, while other predictive parameters like growth rate, kinetic growth rate were treated as an effective supplementary. There was probably not enough evidence to provide a standard operation time after associating liver partition and portal vein ligation for staged hepatectomy or yttrium-90 microsphere radioembolization. The i

关键词： Unresectable Hepatocellular carcinoma Hepatectomy Conversion therapy Salvage surgery Downstaging

Percutaneous ultrasound-guided coaxial core needle biopsy for the diagnosis of multiple splenic lesions: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 616-621页

作者： sha-hong Pu Wu-Yong-Ga Bao Zhen-Peng Jiang Rui Yang Qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The overlap of imaging manifestations among distinct splenic lesions gives rise to a diagnostic ***,a definitive diagnosis primarily relies on his-tological *** ultrasound(US)-guided coaxial core needle biopsy(CNB)not only procures sufficient tissue to help clarify the diagnosis,but reduces the incidence of puncture-related *** SUMMARY A 41-year-old female,with a history of pulmonary tuberculosis,was admitted to our hospital with multiple indeterminate splenic ***-scale ultrasono-graphy demonstrated splenomegaly with numerous well-defined hypoechoic *** contrast-enhanced computed tomography(CT)showed an en-larged spleen with multiple irregular-shaped,peripherally enhancing,hypodense *** emission CT revealed numerous abnormal hyperglycemia *** imaging findings strongly indicated the possibility of infectious disease as the primary concern,with neoplastic lesions requiring *** obtain the precise pathological diagnosis,the US-guided coaxial CNB of the spleen was ca-rried *** patient did not express any discomfort during the *** Percutaneous US-guided coaxial CNB is an excellent and safe option for obtaining precise splenic tissue samples,as it significantly enhances sample yield for exact pathological analysis with minimum trauma to the spleen parenchyma and sur-rounding tissue.

关键词： Spleen Splenic disease Ultrasound Biopsy Ultrasound-guided coaxial core needle biopsy Case report

Effect of Kaiyu Qingwei Jianji on the morphometry and residual strain distribution of small intestine in experimental diabetic rats

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World Journal of Gastroenterology 2006年第44期12卷 7149-7154页

作者： hong sha Jing-Bo Zhao Zhi-Yuan Zhang Shui-Ping Zhou Xiao-Lin Tong Feng-Yuan Zhuang Hans Gregersen China-Japan Friendship Hospital Beijing 100029 China Center of Excellence in Visceral Biomechanics and Pain Aalborg Hospital DK 9000 Aalborg Denmark Bioengineering Department Beijing University of Aeronautics and Astronautics 37 Xueyuan Rd. Beijing 100083 China

AIM： To investigate the effect of a Chinese medicine, Kaiyu Qingwei Jianji （KYQWJJ） used for diabetic treatment, on the morphometry and residual strain distribution of the small intestine in streptozotocin （STZ） -induced diabetic rats. Correlation analysis was also performed between the opening angle and residual strain with the blood glucose level. METHODS： Forty-two male Wistar rats weighing 220-240 g were included in this study. Thirty-two STZ- induced diabetic rats were subdivided into four groups （n = 8 in each group）, i.e. diabetic control group （DM）; high dose of KYQWJJ （T1, 36g/kg per day）; low dose of KYQWJJ （T2, 17 g/kg per day） and Gliclazide （T3, 50 mg/kg per day）. Another ten rats were used as nondiabetic control （CON）. The medicines were poured directly into stomach lumen by gastric lavage twice daily. The rats of CON and DM groups were only poured the physiological saline. Blood glucose and plasma insulin levels were measured. Experimental period was 35 d. At the end of experiment, three 5-cm long segments were harvested from the duodenum, jejunum and ileum. Three rings of 1-2 mm in length for no-load and zero-stress state tests were cut from the middle of different segments. The morphometric data, such as the circumferential length, the wall thickness and the opening angle were measured from the digitized images of intestinal segments in the no-load state and zerostress state. The residual strain was computed from the morphometry data. Furthermore, the linear regression analysis was performed between blood glucose level with morphometric and biomechanical data in the different intestinal segments. RESULTS： The blood glucose level of DM group was consistent 4-fold to 5-fold higher than those in CON group during the experiment （16.89 ± 1.11 vs 3.44 ± 0.15 mmol/L, P 〈 0.001）. The blood glucose level in the T1 （16.89 ± 1.11 vs 11.08 ± 2.67 mmol/L, P 〈 0.01） and T3 groups （16.89 ± 1.11 vs 13.54 ± 1.73 mmol/L, P 〈 0.05）, but not in T2 group （P 〉 0.05）

关键词： Diabetes Intestine Kaiyu Qingwei Jianji Residual strain Rat

Potential involvement of heat shock proteins in pancreaticduodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study

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World Journal of Gastroenterology 2018年第37期24卷 4263-4271页

作者： Juan Ma Bei-Bei Wang Xiao-Yan Ma Wei-Ping Deng Li-Shu Xu Wei-hong sha Department of Gastroenterology and Hepatology Guangdong General Hospital (Guangdong Academy of Medical Sciences) Guangdong Geriatrics Institute Forensic Identification Institute Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical University

AIM To identify functional proteins involved in pancreaticduodenal homeobox-1(PDX1)-mediated effects on gastric *** A PDX1-overexpressed model was established by transfecting gastric cancer cell line SGC7901 with pcDNA3.1(+)-PDX1 vector(SGC-PDX1). Transfection with empty pcDNA3.1 vector(SGC-pcDNA) served as control. Comparative protein profiles of the two groups were analyzed by two-dimensional electrophoresis basedproteomics(2 DE gel-based proteomics). The differential proteins identified by 2 DE were further validated by qRTPCR and immunoblotting. Finally, co-immunoprecipitation was used to determine any direct interactions between PDX1 and the differential ***2 DE gel proteomics identified seven differential proteins in SGC-PDX1 when compared with those in SGC-pcDNA. These included four heat shock proteins(HSPs; HSP70 p1 B, HSP70 p8, HSP60, HSP27) and three other proteins(ER60, laminin receptor 1, similar to epsilon isoform of 14-3-3 protein). Immunoblotting validated the expression of the HSPs(HSP70, HSP60, HSP27). Furthermore, their expressions were lowered to 80%, 20% and 24%, respectively, in SGC-PDX1, while PDX1 exhibited a 9-fold increase, compared to SGC-pcDNA. However, qRT-PCR analysis revealed that mRNA levels of the HSP s were increased in SGC-PDX1, suggesting that the expression of the HSP s was post-translationally regulated by the PDX1 protein. Finally, co-immunoprecipitation failed to identify any direct interaction between PDX1 and HSP70 *** This study demonstrates the potential involvement of HSPs in PDX1-mediated effects on the genesis of gastric cancer.

关键词： Pancreatic-duodenal homeobox-1 Heat shock proteins Gastric cancer Proteomics Two-dimensional electrophoresis

Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

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Current Medical Science 2023年第3期43卷 496-504页

作者： Ying ZHENG Jing-hong LI shan-ying LIAO Yi-ming FU Yan-jun ZHANG Jun-long LIN Xin-bin CHEN Wei-hong sha Shi-xue DAI Wen-jun MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China The First School of Clinical Medicine&Nanfang Hospital Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial Geriatrics InstituteNational Key Clinical SpecialtyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD *** study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s *** CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December *** serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before *** diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)*** The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,*** diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

关键词： Crohn’s disease vitamin D body mass index tumor necrosis factor alpha

Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet

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World Journal of Gastroenterology 2022年第34期28卷 4993-5006页

作者： Shi-Min Zheng Hao Chen Wei-hong sha Xiao-Fen Chen Jian-Bin Yin Xiao-Bo Zhu Zhong-Wen Zheng Juan Ma Department of Gastroenterology and Hepatology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Medical College Shantou UniversityShantou 515041Guangdong ProvinceChina Medical College Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Center for Orthopaedic Surgery The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Oxidized low-density lipoprotein(ox-LDL),which is abnormally increased in the serum of colorectal cancer(CRC)patients consuming a high-fat diet(HFD),may be one of the risk factors for the development of ***-LDL exerts a regulatory effect on macrophages and may influence CRC through the tumor *** role of ox-LDL in CRC remains *** To investigate the role of ox-LDL through macrophages in HFD associated *** The expression of ox-LDL and CD206 was detected in colorectal tissues of CRC patients with hyperlipidemia and HFD-fed mice by *** stimulated the macrophages with 20μg/mL ox-LDL and assessed the expression levels of CD206 and the cytokines by cell fluorescence and quantitative polymerase chain *** further knocked down LOX-1,the surface receptor of ox-LDL,to confirm the function of ox-LDL in ***,LoVo cells were co-cultured with the stimulated macrophages to analyze the CD44 and CD133 expression by western *** The expression of ox-LDL and the CD206 was significantly increased in the stroma of colorectal tissues of CRC patients with hyperlipidemia,and also upregulated in the HFD-fed ***,an increased level of CD206 and decreased level of inducible nitric oxide synthase were observed in macrophages after ox-LDL continuous *** effects were inhibited when the surface receptor LOX-1 was knocked down in ***-LDL could induce CD206+macrophages,which resulted in high expression of CD44 and CD133 in co-cultured LoVo *** Ox-LDL stimulates CD206+macrophages to upregulate CD44 and CD133 expression in HFD related CRC.

关键词： Oxidized low-density lipoprotein CD206 positive macrophages CD44 CD133

Laparoscopic radical resection of gastric carcinoma,a report of 129 cases

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Laparoscopic radical resection of gastric carcinoma,a report...