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Quantum chemical study on the thermal Diels-Alder reaction of cyclohexadiene and methyl crotonate

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Chinese Journal of Chemistry 1997年第1期15卷 21-24页

作者： Li, YH hong, sg Wang, S Peng, YY Department of Chemistry Jiangxi Normal University Nanchang Jiangxi 330027 China

AM1 molecular orbital method using the unrestricted Hartree-Fock(UHF) calculations has been applied to investigate the thermal reaction of cyclohexadiene and methyl crotonate. The calculated results indicate that the ... 详细信息

关键词： thermal Diels-Alder reaction concerted and radical pathways transition state UHF/AM1 method

Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823

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World Journal of Gastroenterology 2000年第5期6卷 676-680页

作者： Li QF Ou Yang GL Li CY hong sg Xiamen Univ Coll Life Sci Cell Biol Lab Xiamen 361005 Fujian Province Peoples R China

AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith *** Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)***-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron *** BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin *** were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in *** the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and *** microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell *** Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells.

关键词： stomach neoplasms/ultrastructure horseshoe crabs stomach neoplasms tachyplesin microscopy electron cell morphology

Quantum Chemical Study on the Thermolysis of Dicyanofuroxan

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Chinese Chemical Letters 1998年第2期9卷 187-189页

作者： Li, YH Xu, WY Peng, YY hong, sg Wang, S Jiangxi Normal Univ Dept Chem Nanchang 330027 Peoples R China Jiangxi Normal Univ Dept Chem Nanchang 330027 Peoples R China

AM1 and PM3 methods using the unrestricted Hartree-Fock (UHF) calculations have been applied to study the thermolysis of dicyanofuroxan. The results obtained show that the reaction proceeds to product through a two-st... 详细信息

关键词： transition state thermolysis dicyanofuroxan AM1 method PM3 method

Intraductalpapillarymucinousneoplasmofthebileductwithgastricand duodenalfistulas

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World Journal of Gastrointestinal Endoscopy 2014年第7期6卷 70-76,78+337-338页

作者： hong MY Yu DW hong sg Man Yong hong Dong Wook Yu Seung Goun Hong Department of Internal Medicine SAM Anyang Hospital Gyeonggi 430-733 South Korea

Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowl-edge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stom-ach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fis-tula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into cho-ledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledocho-gastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The pa-tient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved af-ter percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d.

关键词： Intraductal papillary mucinous neoplasm Bile duct Fistula Acetylcysteine

Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy

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Nano Research 2024年第9期17卷 8269-8284页

作者： Xinyi Cai Long Qiu Zhenying Diao Lintao Cai Ting Yin hong Pan Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemInstitute of Biomedicine and BiotechnologyShenzhen Institute of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen 518055China School of pharmacy Guangdong Medical UniversityDongguan 523808China Sino-Euro Center of Biomedicine and Health Shenzhen 518024China

The antitumor effects of conventional drug carriers are often attenuated and limited in application by biological barriers associated with tumor heterogeneity and resistance brought about by low tumor *** the rapid development of nanotechnology,naturally derived bioactive materials,and live cell carriers,a promising strategy emerges for targeting the tumor microenvironment(TME)for precision cancer *** unique injury-targeting properties of platelets can significantly extend functional activity,which cannot be achieved with conventional *** this review,three strategies based on platelet-engineered materials are systematically described,namely nanoparticles for platelet membrane camouflage,engineered activated platelets,and targeted-platelets ***-based nanomaterials can effectively coordinate local and distant tumor-host crosstalk with controlled active tumor site recognition and killing effects due to the presence of specific membrane proteins on the surface and the self-secretion of a large number of *** advances in platelets for effectively overcoming biological barriers and reducing immune resistance in cancer immunotherapy applications will be discussed in future clinical *** review provides an overview of recent research advances in platelet-based bioactive material-directed immunotherapy and chemotherapy to inform future antitumor combination therapies.

关键词： platelets bionic targeting immune modulation precision therapy deep penetration

Outage Probability Analysis for D2D-Enabled Heterogeneous Cellular Networks with Exclusion Zone:A Stochastic Geometry Approach

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工程与科学中的计算机建模(英文) 2024年第1期138卷 639-661页

作者： Yulei Wang Li Feng Shumin Yao hong Liang Haoxu Shi Yuqiang Chen School of Computer Science and Engineering Macao University of Science and TechnologyTaipaMacaoChina Department of Broadband Communication Peng Cheng LaboratoryShenzhenChina School of Artificial Intelligence Dongguan PolytechnicDongguanChina

Interference management is one of the most important issues in the device-to-device(D2D)-enabled heterogeneous cellular networks(HetCNets)due to the coexistence of massive cellular and D2D devices in which D2D devices reuse the cellular *** alleviate the interference,an efficient interference management way is to set exclusion zones around the cellular *** this paper,we adopt a stochastic geometry approach to analyze the outage probabilities of cellular and D2D users in the D2D-enabled *** main difficulties contain three aspects:1)how to model the location randomness of base stations,cellular and D2D users in practical networks;2)how to capture the randomness and interrelation of cellular and D2D transmissions due to the existence of random exclusion zones;3)how to characterize the different types of interference and their impacts on the outage probabilities of cellular and D2D *** then run extensive Monte-Carlo simulations which manifest that our theoretical model is very accurate.

关键词： Device-to-device(D2D)-enabled heterogeneous cellular networks(HetCNets) exclusion zone stochastic geometry(sg) Matérn hard-core process(MHCP)

Efficacy of ginseng-based Renshenguben oral solution for cancer-related fatigue among patients with advanced-stage hepatocellular carcinoma:A prospective multicenter cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 249-256页

作者： Ming-Da Wang Chen Yuan Ke-Chun Wang Nan-Ya Wang Ying-Jian Liang hong Zhu Xiang-Min Tong Tian Yang Department of Hepatobiliary and Pancreatic Surgery General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Department of Clinical Laboratory Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Department of Hepatobiliary Surgery First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDepartment of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Background:Cancer-related fatigue(CRF)is a common and debilitating symptom experienced by patients with advanced-stage cancer,especially those undergoing antitumor *** study aimed to evaluate the efficacy and safety of Renshenguben(RsgB)oral solution,a ginseng-based traditional Chinese medicine,in alleviating CRF in patients with advanced hepatocellular carcinoma(HCC)receiving antitumor ***:In this prospective,open-label,controlled,multicenter study,patients with advanced HCC at BCLC stage C and a brief fatigue inventory(BFI)score of≥4 were *** were assigned to the RsgB group(RsgB,10 mL twice daily)or the control group(with supportive care).Primary and secondary endpoints were the change in multidimensional fatigue inventory(MFI)score,and BFI and functional assessment of cancer therapy-hepatobiliary(FACT-Hep)scores at weeks 4 and 8 after *** events(AEs)and toxicities were ***:A total of 409 participants were enrolled,with 206 assigned to the RsgB *** week 4,there was a trend towards improvement,but the differences were not statistically *** week 8,the RsgB group exhibited a significantly lower MFI score(PsgB group showed significantly greater decrease in BFI and FACT-Hep scores at week 8(PsgB group experienced a significantly substantial decrease in MFI,BFI,and FACT-Hep scores at week *** serious drug-related AEs or toxicities were ***:RsgB oral solution effectively reduced CRF in patients with advanced HCC undergoing antitumor therapy over an eight-week period,with no discernible *** findings support the potential of RsgB oral solution as an adjunctive treatment for managing CRF in this patient population.

关键词： Cancer-related fatigue Hepatocellular carcinoma Renshenguben oral solution Efficacy Safety Ginseng

Endoscopic features and treatments of gastric cystica profunda

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World Journal of Gastroenterology 2024年第7期30卷 673-684页

作者： Zi-Han Geng Yan Zhu Pei-Yao Fu Yi-Fan Qu Wei-Feng Chen Xia Yang Ping-hong Zhou Quan-Lin Li Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Gastric cystica profunda(GCP)represents a rare condition characterized by cystic dilation of gastric glands within the mucosal and/or submucosal *** is often linked to,or may progress into,early gastric cancer(EGC).AIM To provide a comprehensive evaluation of the endoscopic features of GCP while assessing the efficacy of endoscopic treatment,thereby offering guidance for diagnosis and *** This retrospective study involved 104 patients with GCP who underwent endoscopic *** demographic and clinical data,regular patient followups were conducted to assess local *** Among the 104 patients diagnosed with GCP who underwent endoscopic resection,12.5%had a history of previous gastric *** primary site predominantly affected was the cardia(38.5%,n=40).GCP commonly exhibited intraluminal growth(99%),regular presentation(74.0%),and ulcerative mucosa(61.5%).The leading endoscopic feature was the mucosal lesion type(59.6%,n=62).The average maximum diameter was 20.9±15.3 mm,with mucosal involvement in 60.6%(n=63).Procedures lasted 73.9±57.5 min,achieving complete resection in 91.3%(n=95).Recurrence(4.8%)was managed via either surgical intervention(n=1)or through endoscopic resection(n=4).Final pathology confirmed that 59.6%of GCP cases were associated with *** analysis indicated that elderly males were more susceptible to GCP associated with ***,multivariate analysis identified lesion morphology and endoscopic features as significant risk *** analysis demonstrated no statistically significant difference in recurrence between GCP with and without EGC(P=0.72).CONCLUSION The findings suggested that endoscopic resection might serve as an effective and minimally invasive treatment for GCP with or without EGC.

关键词： Gastric cystica profunda Early gastric cancer Endoscopic features Endoscopic resection Endoscopy

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基于深度学习的微纳光纤自动制备系统

物理学报 2024年第10期73卷 212-220页

作者：刘鸿江刘逸飞谷付星上海理工大学光电信息与计算机工程学院上海200093

在微纳光纤拉锥制备过程中,对直径的大范围、高精度和动态实时性测量是实现低损耗传输和色散调控的关键.针对现有传统制备方法直径调控范围小、操作复杂及耗时长等问题,本文基于深度学习神经网络算法实现了微纳光纤自动检测系统.利用计... 详细信息

在微纳光纤拉锥制备过程中,对直径的大范围、高精度和动态实时性测量是实现低损耗传输和色散调控的关键.针对现有传统制备方法直径调控范围小、操作复杂及耗时长等问题,本文基于深度学习神经网络算法实现了微纳光纤自动检测系统.利用计算机视觉中的图像分割方法,通过制作高质量多尺度微纳光纤数据集,使用基于小目标检测改进的YOLOv8-FD算法对微纳光纤直径进行自动检测.在数据集中获得了平均均值精度高达mAP^(IoU=50)=0.975和mAP^(IoU=50_95)=0.765的性能参数.实验结果表明,该系统可实现微纳光纤直径462 nm—125μm范围,误差2.95%以内的测量和自动化制备,并随着光纤直径增长,误差逐渐缩小,且该系统光学成像单个像素分辨率为65.97 nm,平均检测时间为9.6 ms.本文工作适用于对微纳光纤的高精度实时测量和自动精确制备,为低损耗传输和色散可调的微纳光纤器件发展提供新的思路.

关键词：微纳光纤直径测量深度学习图像分割