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Magnetic resonance image-guided versus ultrasound-guided high-intensity focused ultrasound in the treatment of breast cancer

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Chinese Journal of Cancer 2013年第8期32卷 441-452页

作者： Sheng Li pei-hong Wu State Key Laboratory of Oncology in South China Department of Medical Imaging & Interventional Radiology Sun Yat-sen University Cancer Center

Image-guided high-intensity focused ultrasound (HIFU) has been used for more than ten years, primarily in the treatment of liver and prostate cancers. HIFU has the advantages of precise cancer ablation and excellent protection of healthy tissue. Breast cancer is a common cancer in women. HIFU therapy, in combination with other therapies, has the potential to improve both oncologic and cosmetic outcomes for breast cancer patients by providing a curative therapy that conserves mammary shape. Currently, HIFU therapy is not commonly used in breast cancer treatment, and efforts to promote the application of HIFU is expected. In this article, we compare different image-guided models for HIFU and reviewed the status, drawbacks, and potential of HIFU therapy for breast cancer.

关键词：高强度聚焦超声超声治疗引导模式乳腺癌磁共振成像 HIFU 前列腺癌美容效果

Decomposition behavior of titanium hydride treated by surface oxidation

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Rare Metals 2015年第1期34卷 28-33页

作者： hong-Jie Luo Hao Lin pei-hong Chen Guang-Chun Yao School of Materials and Metallurgy Northeastern University Engineering Technology Research Centre of Ministry of Education for Materials Advanced Preparation

Titanium hydride attracts more attention as foaming agent in the fabrication of cellular metal materials. In order to meet most aluminum casting alloy＇s melting properties, the heat treatment processes for Till2 particles were investigated in a rotating device. In the present work, the most two important dynamic parameters, the treating temperature and oxidation interval, were taken under consideration. The decomposition behavior of titanium hydride was measured by differential scanning calorimetry （DSC） and the residual hydrogen content, morphologies and phase conversion were also characterized by hydrogen determinator, scanning electron microscopy （SEM）, and X-ray diffractometer （XRD）, respectively. The results show that the effect of temperature on the formation of oxidation film and decomposition behavior of Till2 is more significant than that of oxidation time. The onset temper- ature and peak value of Till2 decomposition shift from left to right through elevating temperature and extending time. Heat treatment process for Till2 at 500 ℃ between 1 and 5 h in air is favorable for preparing aluminum foam.

关键词： Titanium hydride Oxidation treatment Thermal decomposition Aluminum foam

Investigation on A Resistance-Type Porosity Model and the Experimental Coefficients

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China Ocean Engineering 2019年第4期33卷 468-476页

作者： ZHAO pei-hong SUN Da-peng WU Hao State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology

The mathematical model based on the Volume-Averaged/Reynolds-Averaged Navier Stokes (VARANS) equations has been adopted in recent years to generally simulate the interaction between waves and porous structures. However, it is still hard to determine the two experimental coefficients (α and β) included in VARANS equations. In the present study, VARANS equation is adopted to describe the flow inside and outside the porous structures uniformly, with applying the volume averaged k ε model to simulate the turbulence effect. A new calibration method is used to evaluate the accuracy of numerical simulation of wave motion on porous seabed with different coefficients, by taking the wave damping rate as an index. The calibration is achieved by completing a simulation matrix on two calibration cases. A region can be found in the parameter space to produce a lower error, which means that the simulation results are better consistent with the experimental results.

关键词： porous media VARANS equations wave damping rate perforated caisson rubble-mound foundation

Neural Explainable Recommender Model Based on Attributes and Reviews

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Journal of Computer Science & Technology 2020年第6期35卷 1446-1460页

作者： Yu-Yao Liu Bo Yang hong-Bin pei Jing Huang Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012China College of Computer Science and Technology Jilin UniversityChangchun 130012China

Explainable recommendation, which can provide reasonable explanations for recommendations, is increasingly important in many fields. Although traditional embedding-based models can learn many implicit features, resulting in good performance, they cannot provide the reason for their recommendations. Existing explainable recommender methods can be mainly divided into two types. The first type models highlight reviews written by users to provide an explanation. For the second type, attribute information is taken into consideration. These approaches only consider one aspect and do not make the best use of the existing information. In this paper, we propose a novel neural explainable recommender model based on attributes and reviews (NERAR) for recommendation that combines the processing of attribute features and review features. We employ a tree-based model to extract and learn attribute features from auxiliary information, and then we use a time-aware gated recurrent unit (T-GRU) to model user review features and process item review features based on a convolutional neural network (CNN). Extensive experiments on Amazon datasets demonstrate that our model outperforms the state-of-the-art recommendation models in accuracy of recommendations. The presented examples also show that our model can offer more reasonable explanations. Crowd-sourcing based evaluations are conducted to verify our model's superiority in explainability.

关键词： recommender system explainable recommendation review usefulness attribute usefulness

The number of tumor-free axillary lymph nodes removed as a prognostic parameter for node-negative breast cancer

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Chinese Journal of Cancer 2014年第11期33卷 569-573页

作者： Fei Gao Ni He pei-hong Wu Department of Interventional Radiology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine

Recently, there has been controversy about the relationship between the number of lymph nodes removed and survival of patients diagnosed with lymph node-negative breast cancer. To assess this relationship, 603 cases of lymph node-negative breast cancer with a median of 126 months of follow-up data were studied. Patients were stratified into two groups(Group A, 10 or fewer tumor-free lymph nodes removed; Group B, more than 10 tumor-free lymph nodes removed). The number of tumor-free lymph nodes in ipsilateral axillary resections as well as 5 other disease parameters were analyzed for prognostic value. Our results revealed that the risk of death from breast cancer was significantly associated with patient age, marital status, histologic grade, tumor size, and adjuvant therapy. The 5- and 10-year survival rates for patients with 10 or fewer tumor-free lymph nodes removed was 88.0% and 66.4%, respectively, compared with 69.2% and 51.1%, respectively, for patients with more than 10 tumor-free lymph nodes removed. For patients with 10 or fewer tumor-free lymph nodes removed, the adjusted hazard ratio(HR) for risk of death from breast cancer was 0.579(95% confidence interval, 0.492-0.687, P < 0.001), independent of patient age, marital status, histologic grade, tumor size, and adjuvant therapy. Our study suggests that the number of tumor-free lymph nodes removed is an independent predictor in cases of lymph node-negative breast cancer.

关键词：淋巴结肿大乳腺癌肿瘤阴性预后辅助治疗置信区间预测因子

A new remaining useful life estimation method for equipment subjected to intervention of imperfect maintenance activities

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Chinese Journal of Aeronautics 2018年第3期31卷 514-528页

作者： Changhua HU hong pei Zhaoqiang WANG Xiaosheng SI Zhengxin ZHANG College of Science High-Tech Institute of Xi'an

As the key part of Prognostics and Health Management（PHM）, Remaining Useful Life（RUL） estimation has been extensively investigated in recent years. Current RUL estimation studies considering the intervention of imperfect maintenance activities usually assumed that maintenance activities have a single influence on the degradation level or degradation rate, but not on *** at this problem, this paper proposes a new degradation modeling and RUL estimation method taking the influence of imperfect maintenance activities on both the degradation level and the degradation rate into account. Toward this end, a stochastic degradation model considering imperfect maintenance activities is firstly constructed based on the diffusion process. Then, the Probability Density Function（PDF） of the RUL is derived by the convolution operator under the concept of First Hitting Time（FHT）. To implement the proposed RUL estimation method,the Maximum Likelihood Estimation（MLE） is utilized to estimate the degradation related parameters based on the Condition Monitoring（CM） data, while the Bayesian method is utilized to estimate the maintenance related parameters based on the maintenance data. Finally, a numerical example and a practical case study are provided to demonstrate the superiority of the proposed method. The experimental results show that the proposed method could greatly improve the RUL estimation accuracy for the degrading equipment subjected to imperfect maintenance activities.

关键词： Convolution operator Diffusion process First hitting time Imperfect maintenance Remaining useful life

Clinical reasoning: a 20-year-old woman with coma and quadriplegia

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World Journal of Emergency Medicine 2023年第2期14卷 169-170页

作者： Shao-wei Zheng hong-hong pei Long-fei Pan Department of Emergency Medicine the Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China

Dear editor,Subacute combined degeneration(SCD) of the spinal cord, which is mainly caused by vitamin B12 deficiency, reveals damage in posterior and lateral columns and peripheral nerves. The CNS and cranial nerves are rarely involved except in children.[1,2]Spinal cord MRI abnormal long T1 and T2 signs in the posterior funiculus has specificity for the diagnosis.[3]There have been many case reports about SCD induced by nitrous oxide anaesthesia or entertainment.

关键词： nerves vitamin specificity

Depinning Dynamics of Two-Dimensional Charged Colloids on a Random Laser-Optical Substrate

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Communications in Theoretical Physics 2009年第5期51卷 938-940页

作者： CAO Yi-Gang WANG hong-Ling YANG Gang HAN hong-pei School of Physics and Engineering Zhengzhou University Zhengzhou 450001 China Information College of Electronic-Engineering Xuchang University Xuchang 310018 China

Using Langevin simulations, we. investigate the depinning dynamics of two-dimensional charged colloids on a random laser-optical substrate. With an increase in the strength of the substrate, we find a transition from crystal to smectic flows above the depinning. A power-law scaling relationship between average velocity and applied driving force could be obtained for both flows, and we find that the scaling exponents are no bigger than 1 for the crystal and are bigger than 1 for the smectic flows.

关键词： charged colloids laser-optical substrate depinning

Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第27期20卷 9090-9097页

作者： Ye Liu Rui Wei Tian-pei hong Department of Endocrinology and Metabolism Peking University Third Hospital

Glucagon-like peptide-1(GLP-1)-based therapies have demonstrated efficacy and safety in treating type 2 diabetes, which shares a similar pathophysiological mechanism with non-alcoholic fatty liver disease(NAFLD). Recent studies showed that glucose-induced GLP-1 secretion was decreased in patients with NAFLD and that the level of dipeptidyl peptidase-4, which inactivates intact GLP-1, was upregulated. Moreover, the expression of the GLP-1 receptor was downregulated in livers from patients with NAFLD, indicating an association of defective GLP-1 signalling with NAFLD. Notably, GLP-1-based therapies are reported to be effective in improving hepatic endpoints in patients with NAFLD, such as reducing hepatic fat content, hepatic steatosis and plasma transaminase levels, and preventing fibrosis. GLP-1-based therapies are beneficial for body weight control and glycaemic normalisation, which are important for the management of NAFLD. Moreover, clinical and preclinical studies showed that GLP-1-based agents might directly exert their actions on the liver through activation of functional GLP-1 receptors in *** possible mechanisms involve regulating gene expression that is associated with insulin resistance and lipid metabolism, and suppressing oxidative stress in the liver cells, thus preventing the development and progression of NAFLD. Based on these promising data, large-scale randomised controlled trials are warranted to assess the efficacy and safety of GLP-1-based therapies in treating NAFLD.

关键词： Non-alcoholic fatty liver disease Glucagon-like peptide-1 Dipeptidyl peptidase-4 Insulin resistance Oxidative stress Lipid metabolism