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A SEMI-ANALYTICAL SOLUTION FOR CHARACTERISTICS OF A DAMRESERVOIR SYSTEM WITH ABSORPTIVE RESERVOIR BOTTOM

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Journal of Hydrodynamics 2008年第6期20卷 727-734页

作者： LI Shang-ming liang hong LI Ai-min School of Civil Engineering and Architecture Nanchang University Nanchang 330031 China

In this study, a semi-analytical formulation based on the Scaled Boundary Finite Element Method （SBFEM） was proposed and used to obtain the solution for the characteristics of a two-dimensional dam-reservoir system with absorptive reservoir bottom in the frequency domain. For simplicity, the dam with arbitrary upstream faces was assumed to be rigid and was subjected to a horizontal ground acceleration, while the reservoir with absorptive bottom was assumed to be semi-infinite. The reservoir was divided into two sub-domains： a near-field sub-domain and a far-field sub-domain. The near-field sub-domain with arbitrary geometry was modelled by the Finite Element Method （FEM）, while the effects of the far-field sub-domain which was assumed to be horizontal were described by a semi-analytical formation. The semi-analytical formulation involved the effect of absorptive reservoir bottom, as well as the radiation damping effect of a semi-infinite reservoir. A FEM/SBFEM coupling formulation was presented to solve dam-reservoir coupled problems. The accuracy and efficiency of the coupling formulation were demonstrated by computing some benchmark examples. Highly accurate results are produced even if the near-field sub-domain is very small.

关键词： dam-reservoir interaction absorptive bottom SBFEM Hydraulic pressure FEM/SBFEM coupling formulation

Engine Multi-Body with Flexible Crankshaft Modeling and Numerical Simulation

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Journal of China University of Mining and Technology 2005年第4期15卷 361-365页

作者： LIU Yong-hong WANG hong GU hong-liang ZHANG You-yun Theory of Lubrication ＆ Bearing Institute Xi＇an Jiaotong University Xi＇an Shanxi 710049 China Taiyuan Branch of China Coal Research Institute Taiyuan Shanxi 030006 China

A multi-body model of engine system with flexible crankshaft was presented in this paper to analyze the dynamic behavior of an internal combustion engine. The flexible crankshaft structural dynamics was coupled with the main beating hydrodynamic lubrication in this model by a system approach. An application of an 14 engine was given to show this sophisticated simulation model and to predict the loads and the orbit plots in the journal beatings by the dynamic response of the multi-body engine system with flexible crankshaft. The numerical results show the capabilities and significance of the flexible crankshaft in this system. The objective of the research is to provide the scientific guidance for design and maintenance of the internal combustion engine.

关键词： engine piston-crankshaft system virtual prototype multi-body coupling

Water model experiments of multiphase mixing in the top-blown smelting process of copper concentrate

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International Journal of Minerals,Metallurgy and Materials 2016年第12期23卷 1369-1376页

作者： hong-liang Zhao Pan Yin Li-feng Zhang Sen Wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Green Recycling and Extraction of Metal Beijing 100083China Chambishi Copper Smelter Ltd. Beijing Representative OfficeBeijing 100029China

We constructed a 1：10 cold water experimental model by geometrically scaling down an Isa smelting furnace. The mixing processes at different liquid heights, lance diameters, lance submersion depths, and gas flow rates were subsequently measured using the conductivity method. A new criterion was proposed to determine the mixing time. On this basis, the quasi-equations of the mixing time as a function of different parameters were established. The parameters of the top-blown smelting process were optimized using high-speed photography. An excessively high gas flow rate or excessively low liquid height would enhance the fluctuation and splashing of liquid in the bath, which is unfavorable for material mixing. Simultaneously increasing the lance diameter and the lance submersion depth would promote the mixing in the bath, thereby improving the smelting efficiency.

关键词： copper smelting multiphase flow mixing water modeling

The Reverse Holder Classes in Martingale Setting

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Wuhan University Journal of Natural Sciences 2004年第3期9卷 273-277页

作者： Zuo hong-liang Liu Pei-de School of Mathematics and Statistics Wuhan UniversityWuhan 430072HubeiChina

In martingale setting, it has been shown thatA p weights can be factorized in terms ofA 1 weights. This factorization benefits many problems very much. In this paper, the new class of RH∞ plays the same role for RH s , which makes the reverse H?lder inequalities hold with exponents>1, that the classA 1 does forA p class. Therefore, the Jones' factorization theorem forA p weights was extended to include some information about the reverse H?lder classes. And it is the most convenient object in weight theory indeed. Key words martingale space - minimal function - weight inequality - reverse H?lder class CLC number O 221. 4 Foundation item: Supported by the National Natural Science Foundation of China (19771063)Biography: Zuo hong-liang (1976-), male, Ph. D candidate, research direction: martingale theory.

关键词： martingale space minimal function weight inequality reverse Holder class

Time and Location Aware Points of Interest Recommendation inLocation-Based Social Networks

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Journal of Computer Science & Technology 2018年第6期33卷 1219-1230页

作者： Tie-Yun Qian Bei Liu liang hong Zhen-Ni You School of Computer Science Wuhan University Wuhan 430072 China SchooI of Information Management Wuhan University Wuhan 430072 China

The wide spread of location-based social networks brings about a huge volume of user check-in data, whichfacilitates the recommendation of points of interest （POIs）. Recent advances on distributed representation shed light onlearning low dimensional dense vectors to alleviate the data sparsity problem. Current studies on representation learningfor POI recommendation embed both users and POIs in a common latent space, and users＇ preference is inferred basedon the distance/similarity between a user and a POI. Such an approach is not in accordance with the semantics of usersand POIs as they are inherently different objects. In this paper, we present a novel translation-based, time and locationaware （TransTL） representation, which models the spatial and temporal information as a relationship connecting users andPOIs. Our model generalizes the recent advances in knowledge graph embedding. The basic idea is that the embedding ofa 〈time, location〉 pair corresponds to a translation from embeddings of users to POIs. Since the POI embedding shouldbe close to the user embedding plus the relationship vector, the recommendation can be performed by selecting the top-kPOIs similar to the translated POI, which are all of the same type of objects. We conduct extensive experiments on tworeal-world ***. The results demonstrate that our TransTL model achieves the state-of-the-art performance. It is alsomuch more robust to data sparsity than the baselines.

关键词： point of interest (POI) recommendation, location-based social network (LBSN), time and location aware

Arteriovenous thrombotic events in a patient with advanced lung cancer following bevacizumab plus chemotherapy: A case report

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World Journal of Clinical Cases 2022年第19期10卷 6507-6513页

作者： Ying Kong Xiao-Cheng Xu liang hong Department of Oncology The First People’s Hospital of Xiaoshan DistrictXiaoshan Affiliated Hospital of Wenzhou Medical UniversityHangzhou 311200Zhejiang ProvinceChina

BACKGROUND In driver gene-negative non-small cell lung cancer patients who relapse following radical resection,combination chemotherapy using bevacizumab and platinumbased dual drugs is known to increase both progression-free and overall *** initially includes bevacizumab,and if patients are able to tolerate it,bevacizumab can continue to be utilized until disease *** is a recombinant humanized monoclonal neutralizing antibody that acts against vascular endothelial growth factor(VEGF).Various anti-VEGF monoclonal antibodies,such as bevacizumab,can increase the risk of arterial *** data indicate that VEGF-targeted treatment does not significantly increase the risk of venous thromboembolism events,except for *** SUMMARY A 55-year-old man underwent radical resection for cancer of the right *** months following surgery,multiple metastases were observed in his left ***,six cycles of bevacizumab combined with pemetrexed/carboplatin chemotherapy was *** evaluation continued to be partial relief according to RECIST 1.1 standards,and no noticeable adverse reactions were *** three cycles of maintenance therapy using a combination of bevacizumab and pemetrexed,the patient developed dizziness and *** patient was diagnosed with acute cerebral infarction and pulmonary embolism following head magnetic resonance imaging,computed tomography(CT)angiography,and chest enhanced *** the patient received lowmolecular-weight heparin anticoagulation and other treatment,the patient eventually died of respiratory failure 1 mo *** case report may offer some insight into fatal arteriovenous embolism,which has not been previously *** combined with chemotherapy may also increase the risk of arteriovenousthromboembolism. Accordingly, patients who receive angiogenesis inhibitor therapy should becarefully selected. Furthermore, close monitoring a

关键词： Cerebral infarction Pulmonary embolism Bevacizumab Chemotherapy Non-small cell lung cancer Case report

Comparative proteomes change and possible role in different pathways of micro RNA-21a-5p in a mouse model of spinal cord injury

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Neural Regeneration Research 2020年第6期15卷 1102-1110页

作者： Almaghalsa-Ziad Mohammed hong-Xia Du hong-liang Song Wei-Ming Gong Bin Ning Tang-hong Jia Department of Spinal Surgery Jinan Central Hospital Affiliated to Shandong University

Our previous study found that microRNA-21 a-5 p(miR-21 a-5 p)knockdown could improve the recovery of motor function after spinal cord injury in a mouse model,but the precise molecular mechanism remains poorly *** this study,a modified Allen's weight drop was used to establish a mouse model of spinal cord injury.A proteomics approach was used to understand the role of differential protein expression with miR-21 a-5 p knockdown,using a mouse model of spinal cord injury without gene knockout as a negative control *** found that after introducing miR-21 a-5 p knockdown,proteins that played an essential role in the regulation of inflammatory processes,cell protection against oxidative stress,cell redox homeostasis,and cell maintenance were upregulated compared with the negative control *** Encyclopedia of Genes and Genomes pathway enrichment analysis identified enriched pathways in both groups,such as the oxidative phosphorylation pathway,which is relevant to Parkinson's disease,Huntington's disease,Alzheimer's disease,and cardiac muscle *** also found that miR-21 a-5 p could be a potential biomarker for amyotrophic lateral sclerosis,as miR-21 a-5 p becomes deregulated in this *** results indicate successful detection of some important proteins that play potential roles in spinal cord *** the relationship between these proteins and the recovery of spinal cord injury will provide a reference for future research of spinal cord injury *** experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Shandong University of China on March 5,2014.

关键词： bioinformatics biomarker inflammation micro RNA mitochondria mouse pathway analysis proteomics spinal cord injury stathmin

Temperature Characteristics of Monolithically Integrated Wavelength-Selectable Light Sources

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Chinese Physics Letters 2013年第10期30卷 211-213页

作者： HAN liang-Shun ZHU hong-liang ZHANG Can MA Li liang Song WANG Wei Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

The temperature characteristics of monolithically integrated wavelength-selectable light sources are experimentally *** wavelength-selectable light sources consist of four distributed feedback(DFB)lasers,a multimode interferometer coupler,and a semiconductor optical *** oscillating wavelength of the DFB laser could be modulated by adjusting the device operating temperature.A wavelength range covering over 8.0 nm is obtained with stable single-mode operation by selecting the appropriate laser and chip *** thermal crosstalk caused by the lateral heat spreading between lasers operating simultaneously is evaluated by oscillating-wavelength *** thermal crosstalk approximately decreases exponentially as the increasing distance between lasers.

关键词： temperature interferometer crosstalk

One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles

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Chinese Science Bulletin 2009年第15期54卷 2620-2626页

作者： ZHANG Qin HUANG RongFu GUO liang-hong State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences ChineseAcademy of Sciences Beijing 100085 China

Silica nanoparticles are most commonly modified with amino-silanes, followed by post-modification activation for protein immobilization. In this work, epoxy-functionalized silica nanoparticles were prepared by modification with glycidyloxypropyl trimethoxysilane (GPTMS) for direct protein immobilization. Silica nanoparticles possessed an average size of 46 nm, but increased to 63 nm after GPTMS modification. Reaction time, reaction temperature and GPTMS content had no significant effect on particle size. Zeta potential of SiO2 changed from ?26mV to +38mV after modification. Fourier-transformed infrared spectroscopy revealed alkyl C-H bending and stretching bands at 2944 cm-1, 1343 cm-1 and 1465 cm-1, respectively, for the modified nanoparticles. Fluorescein cadaverine was found to bind to GPTMS-modified SiO2, but not to bare SiO2, indicating the chemical reactivity of epoxy groups on the modified nanoparticle with amines. Finally, fluorescently labeled bovine serum albumin (BSA) was used as a model protein to investigate the capacity of epoxy-SiO2 nanoparticles for protein immobilization. The results showed that more proteins were immobilized on the particle with longer reaction time, higher NaCl concentration, lower pH, and less GPTMS content. More importantly, proteins bound to epoxy-SiO2 nanoparticle were highly stable. Under optimized reaction conditions, as much as 25 mg BSA/g nanoparticle was covalently attached to the nanoparticle. The epoxy silane modification of silica nanoparticles offers a reactive surface for one-step and high-density protein immobilization.

关键词：二氧化硅制备方法反应条件纳米粒子