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Effects of AMD3100 subconjunctival injection on alkali burn induced corneal neovascularization in mice

International Journal of Ophthalmology(English edition) 2011年第1期4卷 44-48页

作者： liang-hong Peng, Lin Liu Department of Ophthalmology General Hospital of Guangzhou Military Command of PLA Guangzhou 510010 Guangdong Province China Department of Ophthalmology the First Affiliated Hospital of Second Military Medical University Shanghai 200433 China

AIM: To investigate the therapeutic effects of local and systemic administration of AMD3100 for alkali burn induced corneal neovascularization (CNV) in mice. METHODS: CNV was induced in vivo by alkaline burn of cornea in C57BL/6 mice. AMD3100 was administrated topically by subconjunctival injection or systemically by intraperitoneal injection for 7 days; balanced salt solution was administrated topically or systemically as a control respectively. Inflammatory index was evaluated by slit-lamp biomicroscopy and inflammatory cells infiltrated to cornea tissue were detected by histologic analysis at multiple time points. CNV was compared between the local and systemic treated mice 2 weeks after alkali burn, as quantified by CD34 immunostaining. Fluorescence-Activated Cell Sorter Analysis was used to investigate the mobilizing effects of EPC in mice after subconjunctival injected or intraperitoneal injected AMD3100. Immunohistochemistry was used to detect the expression of endothelial progenitor cells (EPC) marker proteins VEGFR2 and CD34. RESULTS: Three days after alkali burn, infiltration of inflammatory cells was found in corneal tissue. At the first 7 days of local injection group, the number of inflammatory cells was significantly lower than that in systemic injection group. CNV could be seen at the 7(th) day, and at the 14(th) day reached the peak, then started to decrease. The number of CNV in the subconjunctival injection group was 7.57 +/- 1.26 per 0.034mm(2), compared to a number of 14.87 +/- 2.21 per 0.034mm(2) in the control group (P<0.05). On the contrary, the number of CNV in the intraperitoneal injection group was a little higher than that in the control group, 16.34 +/- 1.53 per 0.034mm(2) vs 13.26 +/- 1.87 per 0.034mm(2). The research also showed that intraperitoneally, but not subconjunctivally injected AMD3100 could mobilize EPC. On the other hand, subconjunctival, but not intraperitoneally injected AMD3100 could reduce the expression of EPC marker pro

关键词： alkali burn corneal neovascularization AMD3100 inflammatory cells EPC

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Effects of Hydrogen Charging Time and Pressure on the Hydrogen Embrittlement Susceptibility of X52 Pipeline Steel Material

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 293-307页

作者： hong-Jiang Wan Xiao-Qi Wu hong-liang Ming Jian-Qiu Wang En-Hou Han School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering Northeastern UniversityShenyang110819China Institute of Corrosion Science and Technology Guangzhou510530China

The effects of hydrogen charging time and pressure on the hydrogen embrittlement(HE)susceptibility of X52 pipeline steel material are studied by slow strain rate tensile *** fracture morphologies of the specimens are observed by scanning electron *** HE susceptibility of the X52 pipeline steel material increases with an increase in both hydrogen charging time and hydrogen *** a charging time of 96 h,the HE susceptibility index reaches 45.86%,approximately 3.6 times that at a charging time of 0 ***,a charging pressure of 4 MPa results in a HE susceptibility index of 31.61%,approximately 2.5 times higher than that at a charging pressure of 0.3 MPa.

关键词： Hydrogen embrittlement X52 pipeline steel material Tubular specimen Hydrogen charging time Hydrogen charging pressure

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Evaluation on elevated-temperature stability of modified 718-type alloys with varied phase configurations

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International Journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1123-1132页

作者： Zhan Qiao Chong Li hong-jun Zhang hong-yan liang Yong-chang Liu Yong Zhang State Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science&EngineeringTianjin UniversityTianjin 300354China Key Laboratory of the Ministry of Education for Modern Metallurgy Technology North China University of Science and TechnologyTangshan 063210China Science and Technology on Advanced High Temperature Structural Materials Laboratory AEEC Beijing Institute of Aeronautical MaterialsBeijing 100095China

Inconel 718 is a Ni–Fe-based superalloy widely used in aerospace engines because of its excellent mechanical ***,the inferior stability of theγ″phase limits the application of Inconel 718,which coarsens rapidly at temperatures greater than 650°*** improving the temperature tolerance of Inconel 718 requires optimization of the phase configuration via modification of the alloy’s chemical *** the aforementioned objective,this work was conducted to study the precipitation behavior and thermal stability of the strengthening phases with various structures in modified Inconel 718 alloys by tailoring the Al/Ti *** increasing Al/Ti ratio,three particle configurations were formed:γ′/γ″composite,isolatedγ′,andγ′/γ″/γ′composite *** results of aging tests demonstrate that the isolatedγ′and theγ′/γ″/γ′composite structure exhibited better thermal stability at temperature as high as 800°*** isolatedγ′exhibited a reduced coarsening rate compared with theγ′/γ″/γ′composite particles because the isolatedγ′phase was rich in Al,Ti,and ***,theγ′/γ″composite particles coarsened and decomposed rapidly during aging at temperatures greater than 700°C because of the lower stability resulting from the larger number ofγ″*** obtained results provide necessary data for the compositional optimization of novel 718-type alloys.

关键词： Inconel 718 structure thermal stability interface

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A density functional theory study on the interaction between UO_2^(2+) and the carbamoylphosphoramidic acid ligand for uranium extraction from seawater

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Nuclear Science and Techniques 2018年第6期29卷 128-140页

作者： Xiao-Jing Guo Cheng Li Jiang-Tao Hu hong-Juan Ma hong-liang Qian Shanghai Institute of Applied Physics Chinese Academy of Sciences School of Engineering China Pharmaceutical University

Phosphorylurea molecules, which contain both phosphoryl and carbonyl groups, are considered efficient extractants for UO_2^(2+). This study aims to explain the complexation of UO_2^(2+)with carbamoylphosphoramidic acid(CPO), a simple model for phosphorylurea, for ligand design for uranium recovery from seawater using density functional theory calculations, natural bond order analysis,and the quantum theory of atoms in molecules. The results showed that, when CPO acts as a monodentate ligand, the affinity of phosphoryl for UO_2^(2+)is stronger than that of carbonyl, and CPO coordinates with UO_2^(2+)through the phosphoryl oxygen atom. When CPO serves as a bidentate ligand, both the phosphoryl and carbonyl oxygen atoms connect to UO_2^(2+), and the U–O(carbonyl) bond plays a more important role than the U–O(phosphoryl) bond in the interaction between UO_2^(2+)and CPO. This paradox may be caused by the significant charge transfer from the U–O(carbonyl) p bond orbital to the C–N σ antibond orbital of the bidentate CPO. The NH spacer between the phosphoryl and carbonyl groups could ensure the delocalization of the electron system of the molecule. The bidentate binding motif is favored by entropy and opposed by enthalpy, while the monodentate binding motif is favored by enthalpy and opposed by entropy. Ultimately, the bidentate binding motif is more favorable than the monodentate one. As expected, the interaction between UO_2^(2+)and the deprotonated CPO is stronger than that between UO_2^(2+)and the neutral CPO. Comparing the interaction between UO_2^(2+)and CPO with that between UO_2^(2+)and Nphenylcarbamoylphosphoramidic acid(Ph CPO), formed by replacing one hydrogen atom from the terminal nitrogen atom of CPO with a phenyl group, the phenyl substituent at the terminal nitrogen atom of Ph CPO shows a slightly negative effect on the interaction between UO_2^(2+)and Ph CPO.

关键词：相互作用理论学习海水密度抽取 CPO 铀苯基取代

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Contributions of source population and incubation temperature to phenotypic variation of hatchling Chinese skinks

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Current Zoology 2021年第3期67卷 245-253页

作者： hong-liang Lu Yan-Fu Qu hong Li Xiang Ji Hangzhou Key Laboratory for Animal Adaptation and Evolution College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121ZhejiangChina Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing 210023JiangsuChina College of Life and Environmental Sciences Wenzhou UniversityWenzhou 325035ZhejiangChina

Phenotypic plasticity and local adaptation are viewed as the main factors that result in between-population variation in phenotypic traits,but contributions of these factors to phenotypic variation vary between traits and between species and have only been explored in a few species of ***,we incubated eggs of the Chinese skink(Plestiodon chinensis)from 7 geographically separated populations in Southeast China at 3 constant temperatures(24,28,and 32℃)to evaluate the combined effects of dutch origin,source population,and incubation temperature on hatchling *** relative importance of these factors varied between *** all examined hatchling traits,including body mass,snout-vent length(SVL),tail length,head size,limb length,tympanum diameter,and locomotor speed,varied among populations and were affected by incubation *** for hatchling size(body mass and SVL)varied considerably among *** population explained much of the variation in hatchling body mass,whereas incubation temperature explained much of the variation in other examined *** results indicate that between-population variation in hatchling traits of *** likely reflects the difference in natural incubation conditions and genetic divergence.

关键词： egg incubation hatchling phenotype incubation temperature local adaptation Plestiodon chinensis source population

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On Edge Connectivity and Parity Factor

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Acta Mathematica Sinica,English Series 2015年第5期31卷 772-776页

作者： hong liang LU Wei WANG Yuqing LIN School of Mathematics and Statistic Xi'an Jiaotong University School of Electrical Engineering and Computer Science The University of Newcastle

By Petersen＇s Theorem, a bridgeless cubic graph has a 2-factor. Fleischner （Discrete Math., 101, 33-37 （1992）） has extended this result to bridgeless graphs of minimum degree at least three by showing that every such graph has an even factor without isolated vertices. Let me〉 0 be even and mo〉 0 be odd. In this paper, we prove that every me-edge-connected graph with minimum degree at least me ＋ 1 contains an even factor with minimum degree at least me and every （mo ＋ 1）- edge-connected graph contains an odd factor with minimum degree at least too, which further extends Fleischner＇s result. Moreover, we show that our results are best possible.

关键词： Edge connectivity parity factor

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Purification and Characterization of a Novel Hydrolase That Can Specifically Degrade the Polysaccharide Isolated from Green Seaweed Ulva prolifera

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Journal of Ocean University of China 2019年第1期18卷 185-192页

作者： LI Jiaxin ZHANG Pei hong liang LIU Chenguang College of Marine Life Sciences Ocean University of China

The extracellular polysaccharide hydrolase-producing strain EP-1 was isolated from seawater and identified as Paenibacillus pabuli. Furthermore, a homogeneous extracellular polysaccharide hydrolase from Paenibacillus pabuli EP-1 was purified by combining ion-exchange chromatography and size exclusion chromatography with a purification fold of 90.69 and recovery of 16.23%. Characterization of the purified polysaccharide hydrolase revealed a molecular mass of 38 k Da and optimum activity at 45℃ and pH 6.0. The polysaccharide hydrolase maintained its stability within a wide range of pH(3.0–12.0) and thermal stability when the temperature was below 50℃. The presence of Hg^(2+), Fe^(2+), Mn^(2+), Co^(2+) and SDS notably decreased hydrolase activity, and organic solvents such as formaldehyde, acetone, DMF and acetonitrile completely inhibited hydrolase activity. The purified hydrolase had no activity on agar, carrageenan, gellan gum, sodium alginate, or starch, but effectively hydrolyzed the polysaccharide from Ulva prolifera. The Km and Vmax values of this hydrolase were 43.84 mg m L^(-1) and 4.33 mg m L^(-1) min^(-1), respectively. The sequence analysis with quantitative time-of-flight mass spectrometry indicated that the hydrolase was an endoglucanase.

关键词： characterization hydrolase polysaccharide purification Ulva prolifera

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Phase shifts of the paired wings of butterfly diagrams

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Research in Astronomy and Astrophysics 2010年第11期10卷 1177-1185页

作者： Ke-Jun Li hong-Fei liang Wen Feng National Astronomical Observatories / Yunnan Observatory CAS Kunming 650011 China Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Physics Yunnan Normal University Kunming 650093 China Research Center for Analysis and Measurement Kunming University of Science and Technology Kunming 652094 China

Sunspot groups observed by the Royal Greenwich Observatory/US Air Force/NOAA from 1874 May to 2008 November and the Carte Synoptique solar filaments from 1919 March to 1989 December are used to investigate the relative phase shift of the paired wings of butterfly diagrams of sunspot and filament activi- ties. Latitudinal migration of sunspot groups （or filaments） does asynchronously occur in the northern and southern hemispheres, and there is a relative phase shift between the paired wings of their butterfly diagrams in a cycle, making the paired wings spa- tially asymmetrical on the solar equator. It is inferred that hemispherical solar activity strength should evolve in a similar way within the paired wings of a butterfly diagram in a cycle, demonstrating the paired wings phenomenon and showing the phase rela- tionship between the northern and southern hemispherical solar activity strengths, as well as a relative phase shift between the paired wings of a butterfly diagram, which should bring about almost the same relative phase shift of hemispheric solar activity strength.

关键词： Sun activity - Sun general - Sun sunspots

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Scattering Theory for the Defocusing Fourth Order NLS with Potentials

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Acta Mathematica Sinica,English Series 2018年第4期34卷 773-786页

作者： hong liang FENG Hua WANG Xiao Hua YAO School of Mathematics and Statistics Central China Normal University Wuhan 430079 P. R. China School of Mathematics and Statistics and Hubei Province Key Laboratory of Mathematical Physics Central China Normal University Wuhan 430079 P. R. China

Based on the endpoint Strichartz estimates for the fourth order SchrSdinger equation with potentials for n ≥ 5 by [Feng, H., Softer, A., Yao, X.： Decay estimates and Strichartz estimates of the fourth-order Schr6dinger operator. J. Funct. Anal., 274, 605-658 （2018）], in this paper, the authors further derive Strichartz type estimates with gain of derivatives similar to the one in [Pausader, B.： The cubic fourth-order Schr6dinger equation. J. Funct. Anal., 256, 2473-2517 （2009）]. As their applications, we combine the classical Morawetz estimate and the interaction Morawetz estimate to establish scattering theory in the energy space for the defocusing fourth order NLS with potentials and pure power nonlinearity 1 ＋ 8/n〈 p 〈 1 ＋ 8/n-4 in dimensions n ≥ 7. n

关键词： Fourth order NLS potential morawetz estimate scattering

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The spatial-temporal pattern and influencing factors of negative air ions in urban forests, Shanghai, China

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Journal of Forestry Research 2014年第4期25卷 847-856页

作者： hong liang Xiaoshuang Chen Junguang Yin liangjun Da Department of Environmental Science East China Normal University Tiantong Forest Ecosystem National Research Station and Shanghai Key Laboratory for Ecology of Urbanization Process and Eco-restoration College of Landscape Architecture and Forestry Qingdao Agricultural University Kunshan Municipal Environmental Protection Bureau

Negative air ions are natural components of the air we breathe Forests are the main continuous natural source of negative air ions （NAI）. The spatio-temporal patterns of negative air ions were explored in Shanghai, based on monthly monitoring in 15 parks from March 2009 to February 2010. In each park, sampling sites were selected in forests and open spaces. The annual variation in negative air ion concentrations （NAIC） showed peak values from June to October and minimum values from December to January. NAIC were highest in summer and autumn, intermediate in spring, and lowest in winter. During spring and summer, NAIC in open spaces were significantly higher in rural areas than those in suburban areas. However, there were no significant differences in NAIC at forest sites among seasons. For open spaces, total suspended particles （TSP） were the dominant determining factor of NAIC in sum- mer, and air temperature and air humidity were the dominant determining factors of NAIC in spring, which were tightly correlated with Shanghai＇s ongoing urbanization and its impacts on the environment. R is suggested that urbanization could induce variation in NAIC along the urban-rural gradient, but that may not change the temporal variation pattern. Fur- thermore, the effects of urbanization on NAIC were limited in non-vegetated or less-vegetated sites, such as open spaces, but not in well-vegetated areas, such as urban forests. Therefore, we suggest that urban greening, especially urban forest, has significant resistance to theeffect of urbanization on NAIC.

关键词： negative air ion concentration spatial-temporal pattern urbanization urban ecosystem urban greening

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