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Sialoadenitis progression in nonobese diabetic mice and its correlation with expression of apoptosis-associated proteins in salivary glands and serum IgG levels

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Chinese Medical Journal 2007年第16期120卷 1426-1431页

作者： QI Ge hua hong GAO Yan LIN Qin YU Guang-yan Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing 100081 China Department of Traditional Chinese Medicine and Oral Medicine Peking University School and Hospital of Stomatology Beijing 100081 China Department of Oral Pathology Peking University School and Hospital of Stomatology Beijing 100081 China Department of Laboratory Examination Peking University School and Hospital of Stomatology Beijing 100081 China

Background Sjogren syndrome （SS） is an autoimmune disorder characterized by chronic lymphocytic infiltration and decreased secretion in salivary glands. Apoptosis is one of the possible mechanisms involved in acinar epithelial destruction in SS. The role of apoptosis in the initiation and effect phase of sialoadenitis is still controversial. The aim of this study was to observe the roles of apoptosis-associated proteins and serum IgG levels in sialoadenitis progression in nonobese diabetic （NOD） mice. Methods 2-, 5-, 10-, 15-, 20-week female NOD and matched BALB/c control mice were selected. Saliva and tear flow rate were measured. Serum IgG level was tested by enzyme-linked immunosorbent assay （ELISA）. Number of lymphocyte foci （NLF） in submandibular glands （SMGs） was counted under routine hematoxylin/eosin-stained sections. Expression of Fas, Bcl-2 and procaspase3 proteins as well as apoptotic cells in the SMGs were detected by immunohistochemical staining and by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling （TUNEL） assay respectively. Results Decreased stimulated total flow rate （STFR） and lymphocyte foci in SMGs were first observed in the 10-week NOD group. STFR was negatively correlated with NLF （P〈0.05）. Serum IgG in NOD mice was significantly higher than that of the control group （P〈0.05） and showed a positive correlation with NLF （P〈0.05）. Fas expression in SMGs acinar cells in NOD mice increased with age and was significantly higher compared with that in the control group. Bcl-2 expression and procaspase3 expression in SMG acinar cells in each NOD group were lower compared with those of the age-matched control mice. Conclusion Abnormal expression of Fas and Bcl-2 in the SMGs and higher level of serum IgG may contribute to the initiation of sialoadenitis and cause the glandular destruction in NOD mice.

关键词： nonobese diabetic (NOD) mice sialoadenitis apoptosis immunoglobulin G

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A PREDICTION SCHEME FOR THE PRECIPITATION OF SPR BASED ON THE DATA MINING ALGORITHM AND CIRCULATION ANALYSIS

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Journal of Tropical Meteorology 2019年第4期25卷 519-527页

作者： LI Chao SHI Da・wei CHEN Yu-tian ZHANG hong-hua GENG huan-tong WANG Peng Jiangsu Meteorological Observatory Nanjing 210008 China Meteorological Bureau of Lianyungang City Lianyungang 222000 China College of Geography Nanjing University of Information Science and TechnologyNanjing 210044 China College of Continuing Education Nanjing University of Infbnnation Science and TechnologyNanjing 210044 China

Based on the 74 circulation indexes provided by National Climate Center of China(NCC) and the 24 indexes compiled by National Oceanic and Atmospheric Administration(NOAA) of the US, the study used the C4.5 algorithm in data mining to establish a decision tree prediction model to predict whether the spring persistent rains(SPR) of 55 years(from 1961 to 2015) is more than the normal, and obtained 5 rules to determine whether the SPR is more than the normal. The accuracy rate of the test set, namely "whether the SPR is more than the normal", is 98.18%. After the evaluation of the model by conducting ten 10-fold cross validations to take the average value, the test accuracy rate gained is 84%. There are differences between the three types of years with a SPR more than the normal when it comes to intensity and distribution. In spring, they have respective anomalous 850 hPa monthly mean wind fields and water-vapor flux distribution, and 700 hPa forms the zone where the vertical speed is anomalously negative. As indicated by the results, the SPR prediction model based on the C4.5 algorithm has a high prediction accuracy rate, the model is reasonably and effectively constructed, and the decision rules take comprehensive factors into consideration. The anomalous rainfall and circulation distribution characteristics obtained based on the decision classification results provide new ideas and methods for the prediction of SPR.

关键词： spring persistent rains data mining C4.5 algorithm prediction model model analysis

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房地产估价的区间数灰色模糊法

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湖南大学学报（自然科学版） 2012年第10期39卷 27-30页

作者：吴红华赖华勇湖南大学土木工程学院湖南长沙410082

考虑到房地产价格影响因素的不确定性和客观区间性,提出了基于市场比较的房地产估价的区间数灰色模糊法.该方法在房地产估价时引入了区间数,并且用灰色系统方法选择影响房地产价格的主要因素,最后利用模糊综合判断方法获得房地产价格的... 详细信息

考虑到房地产价格影响因素的不确定性和客观区间性,提出了基于市场比较的房地产估价的区间数灰色模糊法.该方法在房地产估价时引入了区间数,并且用灰色系统方法选择影响房地产价格的主要因素,最后利用模糊综合判断方法获得房地产价格的评估结果.算例表明,该方法有较高的精度,并具有有效性和实用性.

关键词：房地产估价区间数灰色模糊系统

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An application to detect the edge and texture of the flower by canny algorithm

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通讯和计算机（中英文版） 2009年第10期6卷 81-83页

作者： ZHANG Li-hong ZHANG Yan-hua Department of Computer Science Shandong University of Technology Zibo 255049 China

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Obstetric Outcomes in Chinese Women with Endometriosis： A Retrospective Cohort Study

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Chinese Medical Journal 2015年第4期128卷 455-458页

作者： hong Lin Jin-hua Leng Jun-Tao Liu Jing-He Lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Background：The effect of endometriosis on obstetric outcomes is still *** aim of our study was to determine the association between endometriosis and adverse obstetric outcomes in a cohort of Chinese ***：A retrospective cohort study was undertaken to compare obstetric outcomes between 249 women with endometriosis and 249 women without *** women were nulliparous and achieved singleton pregnancies *** with endometriosis were diagnosed during surgery and confirmed *** ratios （ORs） and 95％ confidence intervals （CIs） of measures of obstetric outcomes were ***：Women with endometriosis showed significantly increased risks of preterm labor （adjusted OR,2.42; 95％ CI,1.05-5.57）,placenta previa （adjusted OR,4.51; 95％ CI,1.23-16.50）,and cesarean section （adjusted OR,1.93; 95％ CI,1.31-2.84）.No significant differences were observed in the incidence of pregnancy-induced hypertension,fetal growth restriction,small for gestational age,placental abruption,or luteal support in the first trimester between the two ***：Women with endometriosis are at a higher risk of preterm labor,placenta previa,and cesarean section during pregnancy and need additional care.

关键词： Endometriosis Pregnancy Outcome Premature Birth

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Genome-wide analysis of Nilaparvata lugens nymphal responses to high-density and low-quality rice hosts

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Insect Science 2013年第6期20卷 703-716页

作者： Ding-Bang Hu Bing-Qing Luo Jie Li Yu Han Ting-Ru Jiang Jia Liu Gang Wu hong-Xia hua Yan-Fei Xiong Jun-Sheng Li Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and Technology Huazhong Agricultural University Wuhan 430070 Department of Biology College of Science Wuhan University of Technology Hubei 430070 State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Chaoyang China

The brown planthopper （BPH） Nilaparvata lugens is an economically impor- tant pest on rice plants. In this study, the higher population density and yellow-ripe stage of rice plants were used to construct adverse survival conditions （ASC） against BPH nymphs. Simultaneously, the low population density and tillering stage of rice plants were used to establish a suitable survival condition （SSC） as a control. Solexa/Illumina sequencing was used to identify genes of BPH nymphs responding to ASC. Significantly longer duration development of BPH nymphs and significantly lower brachypterous ratio of BPH adults were observed by ASC compared with SSC. A total of 2 544 differentially expressed genes （DEGs） were obtained and analyzed by BLASTx, Gene Ontology and KEGG Orthology. Gene ontology analysis revealed that the DEGs were mainly involved in categories of cell, cell part, cellular process, binding, catalytic, organelle and metabolic processes. 1138 DEGs having enzyme commission numbers were assigned to different metabolic pathways. The largest clusters were neurodegenerative diseases （137, 12.0%）, followed by carbohy- drate metabolism （113, 9.9%）, amino acid metabolism （94, 8.3%）, nucleotide metabolism （76, 6.7%）, energy metabolism （64, 5.6%）, translation （60, 5.3%）, lipid metabolism （58, 5.1%）, and folding, sorting and degradation （52, 4.6%）. Expressing profile of 11 DEGs during eight nymphal developmental stages of BPH were analyzed by quantitative real- time polymerase chain reaction. The 11 genes exhibited differential expression between ASC and SSC during at least one developmental stage. The DEGs identified in this study provide molecular proof of how BPH reconfigures its gene expression profile to adapt to overcrowding and low-quality hosts.

关键词： gene expression low-quality host metabolic pathway Nilaparvata !ugens,overcrowding Solexa sequencing

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Efficacy and Safety of Unmanipulated Haploidentical Related Donor AIIogeneic Peripheral Blood Stem Cell Transplantation in Patients with Relapsed/Refractory Acute Myeloid Leukemia

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Chinese Medical Journal 2018年第7期131卷 790-798页

作者： Li-Ping Dou hong-hua Li Lu Wang Fei Li Wen-Rong huang Li Yu Dai-hong Liu Department of Hematology Chinese PLA General Hospital Medical School of Chinese PLA Beijing 100853 China

Background： Studies of haploidentical-related donor （HRD） stem cell transplantation using a combination of peripheral blood stem cells （PBSCs） and bone marrow as the graft have reported encouraging results for patients with hematological diseases. However, few studies specifically reported transplantation of only PBSCs from HRDs among patients with relapsed or refractory acute myeloid leukemia （AML）. Here, the long-term outcomes and side effects of unmanipulated HRD PBSC transplantation （HRD-PBSCT） for relapsed/refractory AML were analyzed. Methods： We performed a retrospective analysis of the outcomes in relapsed/refractory AML patients who underwent PBSCT from HRDs （n = 36）. Results： Thirty-one （86.1%） patients in the HRD-PBSCT group achieved platelet recovery. The cumulative incidence of acute graft-versus-host disease （aGVHD） in the HRD-PBSCT group was 40.00%, and the cumulative incidence of grades 2-4 aGVHD in this group was 13.33%. A total of 13 patients in the HRD-PBSCT group had recurrent disease at a median of 183 days after transplantation （range： 10-1700 days）, reaching cumulative incidences of relapse of 50.28% at 5 years. On multivariate analysis, donor age and patient age 〉40 years were independent risk factors for inferior disease-free survival or overall survival （P 〈 0.05）. The results of the present study demonstrate rapid and complete neutrophil engraftment, a low incidence of grade 2-4 aGVHD, and promising survival rates in patients after HRD-PBSCT. Thus, granulocyte colony-stimulating factor-primed PBSCs may be a reliable graft source in unmanipulated HRD-HSCT under myeloablative conditioning when no matched sibling donor is available. Conclusions： Our results support the feasibility, effectiveness, and tolerability of PBSCs as a graft source in unmanipulated HRD transplantation under myeloablative conditioning in patients with leukemia.

关键词： Acute Myeloid Leukemia Haploidentical Transplantation Peripheral Blood Stem Cell Transplantation Recurrence

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Effects of Ganoderma lucidum spores on sialoadenitis of nonobese tiabetic mice

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Chinese Medical Journal 2009年第5期122卷 556-560页

作者： QI Ge hua hong GAO Yan LIN Qin YU Guang-yan Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing 100081 China Department of Traditional Chinese Medicine and Oral Medicine Department of Oral Pathology Department of Laboratory Examination Department of Stomatology of Beijing Tongren Hospital Capital Medical University

Background Sjǒgren syndrome （SS） is a systematic autoimmune disease, on which traditional therapeutic agents show limited effect. More effective agents with longer-lasting and fewer side effects are needed in the clinic. The aim of this study was to investigate the effects of Ganoderma lucindum spores （GLS） on sialoadenitis of nonobese diabetic （NOD） mice. Methods Thirty-two female NOD mice were assigned randomly into 4 groups： low-dose GLS-treated （L-GLS） group and high-dose GLS-treated （H-GLS） group, a dexamethasone group, and a normal saline （NS） control group. Stimulated total saliva flow rate （STFR）, area of lymphocytic infiltration in submandibular glands and ratios of CD4^＋ and CD8^＋ T lymphocytes and B lymphocytes in peripheral blood as well as apoptosis of these subsets and serum IgG level were tested after 10 weeks of treatments. Differences among the groups were analyzed by one-way analysis of variance （ANOVA）, Student-Newman-Keuls Test （SNK） was used between each two groups and a P 〈0.05 was considered statistically significant. Results STFR of the high-dose GLS group increased significantly after a 10-week treatment compared with those of the NS control group （P 〈0.05）. The incidence of sialoadenitis in GLS-treated NOD mice groups showed no significant difference compared with the control group （P 〉0.05）, but the area of lymphocytic foci in both the H-GLS and L-GLS groups decreased significantly to 50% of the NS control group （P 〈0.05）; the ratio of CD4^＋/CD8^＋ T lymphocytes and apoptosis of B lymphocytes of NOD mice with sialoadenitis were less and apoptosis of CD4^＋ and CD8^＋ T lymphocytes were significantly increased compared with the control group （P 〈0.05）. After pretreatment with H-GLS before sialoadenitis onset, the ratio of CD4^＋/CD8^＋ T lymphocyte and the serum IgG levels of NOD mice decreased significantly （P 〈0.05）. Conclusions Pretreatment with H-GLS can relieve symptoms of sialoadenitis in NOD mice. GLS has some protective effects on sialoa

关键词： nonobese diabetes sialoadenitis ganoderma lucidum spores

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Highly Fluorescent Semiconducting Two-Dimensional Conjugated Polymer Films Achieved by Side-Chain Engineering Showing Large Exciton Diffusion Length

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CCS Chemistry 2023年第10期5卷 2366-2377页

作者： Yongshuai Wang Qing Zhang Xiao-Ze Li Zhibin Shu Yihan Zhang Can Gao Yang Li Hao Liu Chenguang Li hong-hua Fang hong-Bo Sun Xiaotao Zhang Wenping Hu huanli Dong Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100190 Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207 Department of Chemistry National University of SingaporeSingapore 117543 State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084 Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072

Semiconducting two-dimensional conjugated polymers(2DCPs)with strong fluorescence emission have great potential for various optoelectronic ***,it is enormously challenging to achieve this goal due to the significant compact interlayerπ-πstacking-induced quenching effect in these *** this work,we found that highly fluorescent semiconducting 2DCPs can be prepared through an effective side-chain engineering approach in which interlayer spacers are introduced to reduce the fluorescence quenching *** obtained two truxene-based 2DCP films that,along with-C6H13 and-C_(12)H_(25)alkyl side chains as interlayer spacers both demonstrate superior fluorescence properties with a high photoluminescence quantum yield of 5.6%and 14.6%,*** are among the highest values currently reported for 2DCP ***,an ultralong isotropic quasi-twodimensional exciton diffusion length constrained in the plane with its highest value approaching 110 nm was revealed by the transient photoluminescence microscopy technique,suggesting that theπ-conjugated structure in these truxene-based 2DCP films has effectively been *** work can enable a broad exploration of highly fluorescent semiconducting 2DCP films for more deeply fundamental properties and optoelectronic device applications.

关键词： two-dimensional conjugated polymer side-chain engineering enlarged interlayer distance strong fluorescence emission large exciton diffusion length

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＂Floating popliteus tendon injury＂ in a mutiple-ligament knee injury： one case report and arthroscopy-assisted reconstruction

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Chinese Medical Journal 2011年第23期124卷 4099-4101页

作者： ZHANG Jin FENG hua hong Lei WANG Xue-song ZHANG Hui Sports Medicine Service Beijing Jishuitan Hospital Beijing 100035 China

A patient with both a femoral attachment injury （peel-off injury） and musculotendinous junction avulsion of the popliteus, a so-called ＂floating popliteus tendon injury＂, received arthroscopy-assisted popliteus reconstruction. The injured ligaments were addressed in the same procedure, including mini-open direct repair of the femoral avulsed fibular collateral ligament （FCL）, suture repair of the grade 3 medial collateral ligament （MCL）, and reconstruction of the posterior cruciate ligament （PCL~.

关键词： arthroscopy posterolateral corner reconstruction popliteus

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