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维持性血液透析患者衰弱与焦虑、抑郁的相关性

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实用医学杂志 2024年第18期40卷 2612-2617页

作者：刘洪梅周华红陈翔鸠洪国保吴雄彬梁燕娟李春婷郑美娣赖月琴刘璠娜暨南大学附属顺德医院肾内科广东佛山528305 暨南大学附属第一医院肾内科广州510630

目的了解维持性血液透析(MHD)患者衰弱的现状,并探究衰弱与焦虑、抑郁的相关性。方法收集2023年1月至2024年1月在暨南大学附属顺德医院肾内科接受MHD的101例患者的一般资料、临床数据和血液生化数据。采用FRAIL量表评估衰弱状况,根据... 详细信息

目的了解维持性血液透析(MHD)患者衰弱的现状,并探究衰弱与焦虑、抑郁的相关性。方法收集2023年1月至2024年1月在暨南大学附属顺德医院肾内科接受MHD的101例患者的一般资料、临床数据和血液生化数据。采用FRAIL量表评估衰弱状况,根据其分为“衰弱组”和“非衰弱组”(包括虚弱前期和无衰弱的参与者)。同时采用GAD-7、PHQ-9量表评估焦虑、抑郁现状。使用单因素分析及logistic回归方法探究衰弱与焦虑、抑郁的相关性及其他可能的影响因素。结果 101例MHD患者中,衰弱组29例(28.71%),非衰弱组72例(71.29%),其中抑郁42例(41.58%),焦虑25例(24.75%)。衰弱组中抑郁患病率65.52%,焦虑患病率55.17%。衰弱组和非衰弱组之间的年龄、握力值、有无运动、脑卒中及冠心病患病情况、有无焦虑抑郁、铁蛋白、CRP方面差异均有统计学意义(P <0.01)。通过多因素回归分析发现,抑郁、焦虑、无运动,患脑卒中,高铁蛋白浓度是MHD患者衰弱的独立危险因素(P <0.05)。结论 MHD患者中,衰弱与抑郁、焦虑及缺乏运动密切相关,且脑卒中和高铁蛋白浓度亦是衰弱的独立危险因素。

关键词：维持性血液透析衰弱焦虑抑郁

A Bifunctional-Blocker-Aided Hybridization Chain Reaction Lighting-Up Self-calibrating Nanocluster Fluorescence for Reliable Nucleic Acid Detection

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Journal of Analysis and Testing 2024年第2期8卷 160-169页

作者： Dan Zhang guobao Zhou hongyan Yang Yi Wang Lijun Shen Yuxuan Qiu Lei Li Longhua Guo College of Chemistry and Materials Science Zhejiang Normal UniversityJinhua321004China Jiaxing Key Laboratory of Molecular Recognition and Sensing College of BiologicalChemical Sciences and EngineeringJiaxing UniversityJiaxing314001China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou314000China

In this work,we proposed a ratiometric silver nanoclusters(AgNCs)fluorescent assay by designing a bifunctional-blockeraided hybridization chain reaction(HCR).Hairpin probe 1(HP1)containing two special DNA fragments(5′-CAC CGC T-3′and 5′-ATT TGC CTT TTG GGG ACG GATA-3′)at two terminals creates a red-emitting AgNC nucleation sequence(rNS,5′-CAC CGC TAT TTG CCT TTT GGG GAC GGATA-3′).We found that the presence of a toehold fragment(5′-TGCCC-3′)in HP1 could silence the *** the addition of a target nucleic acid,HCR of HP1 and hairpin probe 2(HP2)could be initiated,resulting in the formation of long chain of DNA duplexes with multibranched *** the toehold fragment in HP1participated in generating duplexes,a strong emission of rNS-templated AgNCs was observed at 670 *** significantly,a bifunctional blocker was introduced not only to reduce the background red-emitting fluorescence but also to play as an internal green-emitting AgNCs nucleation *** the one hand,the blocker could increase the signal-to-noise-ratio of the constructed biosensor,and on the other hand,the blocker also helped to prepare ratiometric HCR-AgNCs assay with self-calibrating ability to strengthen its *** with the traditional HCR-AgNCs sensors,the developed ratiometric assay based on the bifunctional-blocker-aided HCR has higher reliability,which is important for the fabrication of biosensors in various fields for practical biosensing applications.

关键词： Ratiometric fluorescence Hybridization chain reaction Silver nanocluster Biosensor Bifunctional blocker

Electrochemical and colorimetric dual-signal detection of Staphylococcus aureus enterotoxin B based on AuPt bimetallic nanoparticles loaded Fe-N-C single atom nanocomposite

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Food Science and Human Wellness 2024年第4期13卷 2025-2035页

作者： Huan Liang hongcheng Liu Haojian Lin guobao Ning Xiaokang Lu Siying Ma Fei Liu Hui Zhao Canpeng Li School of Chemical Science and Technology Yunnan UniversityKey Laboratory of Medicinal Chemistry for Natural ResourceMinistry of EducationKunming 650091China Institute of Quality Standard and Testing Technology Yunnan Academy of Agricultural ScienceSupervision and Testing Center for Farm Product QualityMinistry of AgricultureKunming 650223China State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China

Sensitive detection of Staphylococcus aureus enterotoxin B(SEB)is of importance for preventing food poisoning from threatening human *** this work,an electrochemical and colorimetric dual-signal detection assay of SEB was *** probe(Ab2/AuPt@Fe-N-C)was bound to SEB captured by Ab1,where the Ab2/AuPt@Fe-N-C triggered methylene blue degradation and resulted in the decrease of electrochemical ***,the probe catalyzed the oxidation of 3,3’,5,5’-tetramethyl biphenyl to generate a colorimetric absorbance at 652 *** the target was captured and formed a sandwich-like complex,the color changed from colorless to *** detection by colorimetric and electrochemical methods showed a linear relationship in the concentration ranges of 0.0002-10.0000 and 0.0005-10.0000 ng/mL,with limits of detection of 0.0667 and 0.1670 pg/mL,*** dual-signal biosensor was successfully used to detect SEB in milk and water samples,which has great potential in toxin detection in food and the environment.

关键词： Staphylococcus aureus enterotoxin Electrochemical immunosensor Colorimetric assay MOF@borophene composite Dual-functional Fe-N-C signal atom catalyst

One stone two birds:electrochemical and colorimetric dual-mode biosensor based on copper peroxide/covalent organic framework nanocomposite for ultrasensentive norovirus detection

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Food Science and Human Wellness 2024年第2期13卷 920-931页

作者： guobao Ning Quanmei Duan Huan Liang Huifang Liu Min Zhou Chunlan Chen Chong Zhang Hui Zhao Canpeng Li School of Chemical Science and Technology Yunnan UniversityKunming 650091China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China Kunming Customs Technology Center Kunming 650228China

Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the *** is urgent to identify the pathogenic microorganism of the diarrhea in short *** this work,we developed an electrochemical and colorimetric dual-mode detection for NoV based on the excellent dual catalytic properties of copper peroxide/COF-NH_(2)nanocomposite(CuO_(2)@COF-NH_(2)).For the colorimetric detection,NoV can be directly detected by the naked eye based on CuO_(2)@COF-NH_(2)as a laccase-like nonazyme using“peptide-NoV-antibody”recognition *** colorimetric assay displayed a wide and quality linear detection range from 1 copy/mL to 5000 copies/mL of NoV with a low limit of detection(LOD)of 0.125 copy/*** the electrochemical detection of NoV,CuO_(2)@COF-NH_(2)showed an oxidation peak of copper ion from Cu^(+)to Cu^(2+)using“peptide-NoV-antibody”recognition *** electrochemical assay showed a linear detection range was 1-5000 copies/mL with a LOD of 0.152 copy/***'s worthy to note that this assay does not need other electrical signal molecule,which provide the stable and sensitive electrochemial detection for *** electrochemical and colorimetric dual-mode detection was used to detect NoV in foods and faceal samples,which has the potential for improving food safety and diagnosing of NoV-infected diarrhea.

关键词： Norovirus Specific peptides Electrochemical and colorimetric assay Dual-mode Copper peroxide/covalent organic framework

Studies on a new molluscicide, bromoacetamide.

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中国寄生虫学与寄生虫病杂志 1983年第S1期 37-38页

作者： Zhu Dapei, Gu Jinrong, YinJiangye, hong guobao, Chen Pulin, Guo Yuanhua: Institute of Parasitic Diseases, China NCPM WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis

Of 823 acetamide group chemicals screened in the last 4 years, bromoacetamidehas been found to be the most promising one with high molluscicidal effect, relativelylow toxicity to fishes, and high solubility in water. ... 详细信息

关键词： Studies on a new molluscicide bromoacetamide

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萧萐父先生论方以智哲学勘评

中国哲学史 2024年第3期 58-64页

作者：蒋国保苏州大学哲学系

萧萐父先生是有独特慧识和风度的大哲学史家。他独具眼光的方以智哲学之论,对后学深入而正确地研究方以智哲学,主要具有三个方面的启迪:第一,他从铸造“新工具”意义上,称方以智为中国的弗朗西斯·培根,这启发我们如何具体作培根之“归... 详细信息

萧萐父先生是有独特慧识和风度的大哲学史家。他独具眼光的方以智哲学之论,对后学深入而正确地研究方以智哲学,主要具有三个方面的启迪:第一,他从铸造“新工具”意义上,称方以智为中国的弗朗西斯·培根,这启发我们如何具体作培根之“归纳法”与方以智之“质测”法的比较研究;第二,他从铸造“新工具”方面将方以智与徐光启并提,而又称徐光启为“中国的笛卡儿”,这给我们以笛卡儿“演绎法”的视角研究方以智“通几”法以点拔;第三,他关于王夫之矛盾观中“合二而一”内容及其基本含义的剖析,对于我们把握方(以智)王(夫之)辩证法思想方面的根本差异,从而深刻认识中国辩证法思想形态的独特性(不局限于讲“一分为二”,而是进一步讲“一分为三”《合二而一》),具有重要的启发价值。

关键词：萧萐父质测之学通几方以智合二而一一分为三

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唐代安南地方豪族与南疆区域形势

中国边疆史地研究 2024年第2期34卷 51-62,222页

作者：陈国保广西师范大学越南研究院、历史文化与旅游学院 541004

唐朝统一岭南以后,于南疆交通沿线设立州县,又对部落和地方豪族采取羁之治,并改交州都督府为安南都护府,作为管理南部边疆的最高军政机关。为了加强对南疆的控制,唐朝最终通过循序渐进的措施逐步将南部边疆纳入王朝国家整体性的统治秩... 详细信息

唐朝统一岭南以后,于南疆交通沿线设立州县,又对部落和地方豪族采取羁之治,并改交州都督府为安南都护府,作为管理南部边疆的最高军政机关。为了加强对南疆的控制,唐朝最终通过循序渐进的措施逐步将南部边疆纳入王朝国家整体性的统治秩序之中,始终在巩固统一和加强集权的双重协奏中不断调适着对南部边疆的管理政策,逐步推动着对南疆地方社会的整合。随着州县制度在南部边疆的日趋深入,土流矛盾亦在此消彼长的竞争博奔中演化为王朝国家权威与地方豪族之间的激烈冲突,并由此深刻影响着唐代安南都护府的治乱兴替。

关键词：唐代安南都护府豪族大姓南疆形势

Effects of Sodium Cyclohexyl Sulfamate on Growth and Development of Drosophila melanogaster

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Agricultural Biotechnology 2024年第4期13卷 65-69页

作者： Lei WEI Danni MA guobao JIANG Jiayu WU Na FENG College of Life Science and Food Engineering Shaanxi Xueqian Normal UniversityXi'an 710100China

[Objectives]This study was conducted to investigate the effects of different concentrations of sodium cyclohexyl sulfamate on the growth and development of Drosophila melanogaster.[Methods]Different concentrations of sodium cyclohexyl sulfamate were added to the culture medium,and the effects of different concentrations of sodium cyclohexyl sulfamate on the development time and weight of *** in various life stages were statistically analyzed.[Results]High concentration of sodium cyclohexyl sulfamate delayed the time of pupation and eclosion of ***,which made *** lose *** number of male *** in the first generation was much larger than that of female individuals,which indicated that the effect of sodium cyclohexyl sulfamate on male *** was greater than that of female *** a word,high concentration of sodium cyclohexyl sulfamate significantly inhibited the growth and development of ***.[Conclusions]This study provides some reference data for the research perspective of food additives and the safe use of sodium cyclohexyl sulfamate.

关键词： Drosophila melanogaster Sodium cyclohexyl sulfamate Pupation Eclosion

二氧化碳浓度增加和气候变暖导致太白山林线树木生长与氮有效性关系减弱

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Journal of Plant Ecology 2024年第1期17卷 148-164页

作者： Lelong Yin Xiaohong Liu Xiaomin Zeng Ziyi Wang guobao Xu Liangju Zhao Qiangqiang Lu Lingnan Zhang Xiaoyu Xing School of Geography and Tourism Shaanxi Normal UniversityXi'an 710119China State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi'an 710069China Key Laboratory of Soil Resource&Biotech Applications Shaanxi Academy of SciencesXi'an Botanical Garden of Shaanxi Province(Institute of Botany of Shaanxi Province)Xi'an 710061China Qinling National Botanical Garden Xi'an 710061China

全球气候变暖、大气二氧化碳浓度(C_(a))升高和氮有效性正对全球森林生态系统产生深远影响,尤其是在高海拔林线地区。本研究结合树木生长指标和树轮稳定同位素指标,探讨了太白山林线树种太白红杉(Larix chinensis)对环境胁迫的生理生态... 详细信息

全球气候变暖、大气二氧化碳浓度(C_(a))升高和氮有效性正对全球森林生态系统产生深远影响,尤其是在高海拔林线地区。本研究结合树木生长指标和树轮稳定同位素指标,探讨了太白山林线树种太白红杉(Larix chinensis)对环境胁迫的生理生态响应。研究结果表明,近60年来太白红杉的生长速度显著增加,且该林线树木生长对春季温度特别敏感。太白红杉的潜在水分利用效率(iWUE)的持续上升与大气二氧化碳浓度升高和气候变暖紧密相关,共同促进了树木的生长。1851-1964年,树轮δ^(15)N随树木生长速度的加快逐渐增大;1964年之后转变为不显著的下降,打破了原有的碳-氮平衡。分析结果表明,自20世纪60年代以来气候变暖和iWUE的迅速增加已经取代氮有效性成为树木生长的主要驱动因子。随着树木持续加速生长,氮有效性在未来可能会显著下降甚至供不应求。本研究深入揭示了植物对生长环境变化响应的生理生态机制,这将提高我们预测未来高海拔地区森林生态系统演变的能力。

关键词：树轮稳定同位素高山林线植被气候变暖 CO_(2)肥化效应太白山