检索结果-南通市图书馆

AIE gel exhibiting continuous gradient fluorescence based on a polar-responsive AIE-gen

在线全文

学校读者我要写书评

暂无评论

SmartMat 2024年第2期5卷 83-92页

作者： Ziqing Hu Hanwei Zhang Hui Liu jinsa Li Xiaofan ji Ben Zhong Tang Key Laboratory of Materials Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdongChina

Traditional multicolor fluorescent hydrogels are generated through the assembly of discrete fluorescent hydrogels,which is not a complete integration much distinct from living *** the basis of aggregation-induced emission(AIE),a special solvent polar-responsive AIE molecule possessing a twisted intramolecular charge transfer(TICT)effect was *** incorporating it into the gel network,an AIE gel that displays continuous gradient fluorescence was ***,hydrogel A containing the solvent polar-responsive AIE-gen was prepared to show orange *** soaking in the organic solvents,the fluorescence color transition of hydrogel A ranging from orange to green occurred when being immersed in high-polarity organic solvents ascribed to the embedded AIE-gen owning TICT ***,hydrogel A was successively lifted up from organic *** to the different immersion time of each section for the hydrogel,the polarity difference ***,the produced gel B showed continuous gradient fluorescence ranging from orange to green under the irradiation of UV light.

关键词： aggregation-induced emission fluorescent hydrogel multicolor polar-responsiveness

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

粒径影响改性凹凸棒土抑制甲烷爆炸实验研究

工程热物理学报 2024年第6期45卷 1857-1862页

作者：陈凯峰杨克纪虹邢志祥蒋军成常州大学安全科学与工程学院、应急管理科学与工程学院常州213164 山东海科新源材料科技股份有限公司东营257000

自主搭建小尺寸半封闭可视化爆炸实验平台,探究不同粒径改性凹凸棒土粉体对甲烷爆炸的影响。研究结果表明:小粒径粉体的抑爆效果最好,使最大爆炸超压下降了36.05%,最大爆炸超压出现的时间延迟了17.5 ms,火焰传播速度峰值同比下降了24.50... 详细信息

自主搭建小尺寸半封闭可视化爆炸实验平台,探究不同粒径改性凹凸棒土粉体对甲烷爆炸的影响。研究结果表明:小粒径粉体的抑爆效果最好,使最大爆炸超压下降了36.05%,最大爆炸超压出现的时间延迟了17.5 ms,火焰传播速度峰值同比下降了24.50%。同时,借助高速摄影系统记录下爆炸全过程的视频图像,对火焰结构、锋面形状等进行分析。

关键词：改性凹凸棒土粉体甲烷抑爆粒度分布

在线全文

学校读者我要写书评

暂无评论

miR-613阻断宫颈癌进展及其机制

锦州医科大学学报 2024年第2期45卷 92-97页

作者：刘璐纪红锦州医科大学附属第一医院辽宁锦州121000

目的探讨miR-613对宫颈癌细胞进展的影响和作用机制。方法将HeLa细胞随机分为control组、NC组和miR-613过表达组。采用实时荧光定量聚合酶链式反应(RT-qPCR)检测宫颈癌HeLa细胞和正常宫颈E6E7细胞miR-613表达;采用细胞计数试剂(CCK-8)... 详细信息

目的探讨miR-613对宫颈癌细胞进展的影响和作用机制。方法将HeLa细胞随机分为control组、NC组和miR-613过表达组。采用实时荧光定量聚合酶链式反应(RT-qPCR)检测宫颈癌HeLa细胞和正常宫颈E6E7细胞miR-613表达;采用细胞计数试剂(CCK-8)检测各组宫颈癌HeLa细胞细胞增殖情况;采用克隆形成实验检测各组细胞克隆数;采用划痕实验检测各组细胞迁移情况;采用Transwell实验检测各组细胞侵袭情况;采用Western Blot实验β-连环蛋白肽(β-catenin)、波形蛋白(vimentin)、E-钙黏蛋白(E-cadherin)、c-Myc基因、基质金属蛋白酶9(matrix metalloproteinases 9,MMP9)蛋白相对表达量。结果miR-613在宫颈癌HeLa细胞中的相对表达量明显低于宫颈正常细胞(P0.05);与control组和NC组相比,miR-613过表达组HeLa细胞各时间点的OD(450 nm)值、克隆细胞数、迁移侵袭数、β-catenin、vimentin、c-Myc和MMP9相对表达量均明显下降,E-cadherin相对表达量明显上升(P<0.05)。结论miR-613可抑制宫颈癌增殖、迁移和侵袭等恶性生物学行为,从而阻断宫颈癌进展,该过程与miR-613抑制Wnt/β-catenin信号通路相关蛋白有关。

关键词： miR-613 宫颈癌作用机制 Wnt/β-catenin信号通路

Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第1期30卷 79-90页

作者： Qing-Qi hong Su Yan Yong-Liang Zhao Lin Fan Li Yang Wen-Bin Zhang Hao Liu He-Xin Lin jian Zhang Zhi-jian Ye Xian Shen Li-Sheng Cai Guo-Wei Zhang jia-Ming Zhu Gang ji jin-Ping Chen Wei Wang Zheng-Rong Li jing-Tao Zhu Guo-Xin Li Jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen 361001Fujian ProvinceChina Department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery The First Hospital Affiliated to Army Medical UniversityChongqing 400038China Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrmuqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastrointestinal Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004Fujian ProvinceChina Department of Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of General Surgery Unit 4 Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361021Fujian ProvinceChina Department of Gastrointestinal Nutrition and Hernia Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Gastrointestinal Surgery Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian Provin

BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned *** To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious *** In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation *** clinicopathological data and 30-d postoperative complications of gastric cancer patients were *** machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were *** The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical *** exhibited stable performance in external validation and is worthy of further promotion in more *** Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were *** hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.

关键词： Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阜新蒙古族自治县乡村振兴实践路径探讨

辽宁农业科学 2024年第3期 60-63页

作者：孙洪极内蒙古民族大学马克思主义学院内蒙古通辽028043

分析了阜新蒙古族自治县发展优势,总结了乡村振兴面临的困难:产业发展单一、集体经济发展内生动力不足、“空壳化”问题突出、农村基础设施薄弱。并提出了阜新蒙古族自治县乡村振兴路径:挖掘农业多功能性,拓宽产业融合路径;壮大农村集... 详细信息

分析了阜新蒙古族自治县发展优势,总结了乡村振兴面临的困难:产业发展单一、集体经济发展内生动力不足、“空壳化”问题突出、农村基础设施薄弱。并提出了阜新蒙古族自治县乡村振兴路径:挖掘农业多功能性,拓宽产业融合路径;壮大农村集体经济,增强内生动力;破解空壳化,带动“人才振兴”;提高基础设施水平,打造生态宜居乡村。

关键词：阜新乡村振兴路径

维普期刊数据库博看期刊

融合与变通:BOPPPS模式在英语教学设计中的应用

在线全文

学校读者我要写书评

暂无评论

齐齐哈尔高等师范专科学校学报 2024年第1期 141-144页

作者：蒋鸿基广西科技师范学院广西来宾546199

与PPP教学模式相比,BOPPPS教学模式有其独到的优势,有利于培育学生的英语学科核心素养。但在实际教学中,存在着BOPPPS模式应用浅显化和僵化问题。教师应当在该模式中融入真实-典型-交际三原则、VAK Learning学习者风格、Fcous on form... 详细信息

与PPP教学模式相比,BOPPPS教学模式有其独到的优势,有利于培育学生的英语学科核心素养。但在实际教学中,存在着BOPPPS模式应用浅显化和僵化问题。教师应当在该模式中融入真实-典型-交际三原则、VAK Learning学习者风格、Fcous on form重形式教学使该模式与教学内容深度融合,并灵活地调整BOPPPS教学模式的各个环节,使之为教学目标服务。

关键词： BOPPPS 英语教学应用

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng Ye Yunfei Deng Yue Gu Pengfei Liu jie Luo jiangqin Pu jingyu Chen Yu Huang Nanping Wang Yong ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of Pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:Pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).Pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and Yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and Yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan Zi-jie Li Zi-Yi Lin Shu-Qin ji William Ka Fai Tse Zhi-Qiang Meng Chang Liu Lei Li Shenzhen-hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

基于HP滤波和Wiener过程的柱塞泵剩余使用寿命预测

在线全文

学校读者我要写书评

暂无评论

航空动力学报 2024年第7期39卷 11-20页

作者：高文科王状状张曦文王圣垚冀宏深圳技术大学中德智能制造学院广东深圳518118 兰州理工大学能源与动力工程学院兰州730030 江苏凯恩特机械设备制造有限公司江苏泰州225300

柱塞泵的性能退化主要由关键摩擦副的泄漏加剧所致,通过理论分析关键摩擦副的泄漏量,引入等效间隙的退化率参数和工况因素建立了柱塞泵的总泄漏量计算模型.在考虑测量数据误差的情况下采用HP(Hodrick-Prescott)滤波方法滤除随机噪声,借... 详细信息

柱塞泵的性能退化主要由关键摩擦副的泄漏加剧所致,通过理论分析关键摩擦副的泄漏量,引入等效间隙的退化率参数和工况因素建立了柱塞泵的总泄漏量计算模型.在考虑测量数据误差的情况下采用HP(Hodrick-Prescott)滤波方法滤除随机噪声,借助柱塞泵总泄漏量计算模型结构,应用Wiener过程构建了滤波后的柱塞泵退化模型,并依此建立了其剩余使用寿命模型.模型分析结果表明:依据HP滤波分解方法所建的退化模型,柱塞泵工作900h失效概率小于1%,而未滤波数据所得失效概率为28%,HP滤波数据更符合实际情况.

关键词：轴向柱塞泵 HP滤波分解 Wiener过程性能退化剩余使用寿命预测