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Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： Dong jiang Yi Qian Yi-Jun Gu Ru Wang Hua Yu Hui Dong Dong-Yu Chen Yan Chen Hao-Zheng jiang Bi-bo Tan Min Peng Yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of College of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

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Effects of Ta content on microstructure and oxidation behavior of AlCoCrFeNiYTax high entropy alloy

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Rare Metals 2024年第9期43卷 4462-4475页

作者： Cang Gu Jun-Hao Hu Jian-bo Song Cheng Xu Ming-Yu Hu Yu-Xuan Zhang jiang Tian Chao Li Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and Technology Department of Physics Hong Kong Baptist University

The oxidation behavior of the Al Co Cr Fe Ni YTaxhigh entropy alloy（HEA） doped with different Ta contents at 1100 °C is investigated. In this study, different reasons for the spallation of the oxide scales of HEAs without/with excessive Ta addition after 1000 h of oxidation are discussed, and the most suitable Ta doping content for this HEA is explored, in which the HEA exhibits both an exceptionally low oxidation rate, and the formation of oxide scales composed of intact a-Al2O3. Meanwhile, it is found that the addition of Ta can effectively inhibit the phase transition of β phase, which makes the surface of the oxide scale smoother. By combining our experimental results with Wagner–Hauffe theory, the influence of Ta drag effect on oxide scale growth is explained, which provides some theoretical guidance for the subsequent design of Al Co Cr Fe Ni HEAs, and can lead to the development of thermal barrier coatings at higher service temperature.

关键词： Al2O3 scales Elements diffusion High-entropy alloy Oxidation

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Cl- ions accelerating interface charge transfer in a Si/In2S3 Faradaic junction photocathode for solar seawater splitting

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Science China Chemistry 2024年第9期67卷 2923-2929页

作者： Jun Luo Ruotong Bao hongzheng Dong Ye Fu Dongjian jiang bo Wang Yuzhan Zheng Qiong Wang Wenjun Luo Zhigang Zou Eco-materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University National Laboratory of Solid State Microstructures and Department of Physics Nanjing University

Photoelectrocatalytic seawater splitting is a promising low-cost method to produce green hydrogen in a large scale. The effects of Cl-ions in seawater on the performance of a photoanode have been reported in previous studies. However, few researches have been done on the roles of Cl-ions in a photocathode. Herein, for the first time, we find that Cl-ions in the electrolyte improve the photocurrent of a Si/In2S3photocathode by 50% at-0.6 VRHE. An in-situ X-ray photoelectron spectroscopy（XPS） characterization combined with the time-of-flight secondary-ion mass spectrometry by simulating photoelectrochemical conditions was used to investigate the interface charge transfer mechanism. The results suggest that there is an In2+3S3–x（OH）2xlayer on the surface of In2S3in the phosphate buffer solution（PBS） electrolyte, which plays a role as an interface charge transfer mediator in the Si/In2S3photocathode. The In2+3S3–x（OH）2xsurface layer becomes In2+3S3–x（Cl）2xin the PBS electrolyte with NaCl and accelerates the charge transfer rate at the In2S3/electrolyte interface. These results offer a new concept of regulating interface charge transfer mediator to enhance the performance of photoelectrocatalytic seawater splitting for hydrogen production.

关键词： solar hydrogen production interface charge transfer mechanism coupled electron and ion transfer in-situ XPS characterization In2+3S3–x(OH)2x surface layer

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Chlorinated Thiazole-Based Low-Cost Polymer Donors for High Efficiency Binary and Ternary Organic Solar Cells

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CCS Chemistry 2024年第7期6卷 1757-1766页

作者： Hao Lu Hang Wang Guangliu Ran Wenlong Liu Hao Huang Xiaolin jiang Yahui Liu Xinjun Xu Zhishan bo College of Materials Science and Engineering Qingdao UniversityQingdao 266071 College of Textiles&Clothing State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071 Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875 Department of Physics and Applied Optics Beijing Area Major Laboratory Beijing Normal UniversityBeijing 100875

In this work,novel D-A alternating polymers(PJ-1,PJ-2,and PJ-3)with chlorinated benzodithiophene and chlorinated thiazole units were synthesized via gradual *** polymers could be obtained readily through a few concise synthesis *** them,PJ-1 displayed desirable properties including energy levels,crystallinity,and charge transport *** binary and ternary organic solar cells(OSCs)fabricated based on PJ-1 displayed significant power conversion efficiency(PCE)of 15.02%and 19.12%,respectively,placing them among the highest reported for ternary ***,the PJ1-based devices also showcased one of the highest figure-of-merit values,indicating their promising potential for future *** study offers valuable insights and supports the development of costeffective and high-performance polymer donors for the generation of OSCs.

关键词： organic solar cells low-cost donor high efficiency low energy loss ternary blend strategy

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Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun jiang Su-Na Ye Yin-Hua Huang Yi-Wen Ou Ke-Yang Chen Jian-Su Chen Shi-bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

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Anomaly monitoring and early warning of electric moped charging device with infrared image

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Optoelectronics Letters 2024年

作者： Li Jiamin Han bo jiang Mingshun School of Control Science and Engineering Shandong University

Potential high-temperature risks exist in heat-prone components of electric moped charging devices， such as sockets， interfaces， and controllers. Traditional detection methods have limitations in terms of real-time performance and monitoring scope. To address this， a temperature detection method based on infrared image processing has been proposed: utilizing the median filtering algorithm to denoise the original infrared image， then applying an image segmentation algorithm to divide the image. After trimming the image boundaries， the corner detection algorithm is used to extract corner information from the image， acquiring the position of the rectangular selection area that includes all corners. Finally， the block partitioning algorithm is used for temperature detection of the selected area and to determine the type of fault in the charging device based on the threshold. Based on this method， an electric moped charging device monitoring and warning system using infrared images has been designed. Experimental results demonstrate that this monitoring system can effectively detect the location and temperature of the test area， display and transmit warning information in real time via software， and has a high accuracy rate. This system holds promise as a crucial tool for enhancing the safety of electric moped charging devices.

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Review of the Analysis and Suppression for High-frequency Oscillations of the Grid-connected Wind Power Generation System

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CES Transactions on Electrical Machines and Systems 2024年第2期8卷 127-142页

作者： bo Pang Qi Si Pan jiang Kai Liao Xiaojuan Zhu Jianwei Yang Zhengyou He the College of Electrical Engineering Southwest Jiaotong UniversityChengdu 610031China IEEE

High-frequency oscillation(HFO)of gridconnected wind power generation systems(WPGS)is one of the most critical issues in recent years that threaten the safe access of WPGS to the *** the WPGS can damp HFO is becoming more and more vital for the development of wind *** HFO phenomenon of wind turbines under different scenarios usually has different ***,engineers need to acquire the working mechanisms of the different HFO damping technologies and select the appropriate one to ensure the effective implementation of oscillation damping in practical *** paper introduces the general assumptions of WPGS when analyzing HFO,systematically summarizes the reasons for the occurrence of HFO in different scenarios,deeply analyses the key points and difficulties of HFO damping under different scenarios,and then compares the technical performances of various types of HFO suppression methods to provide adequate references for engineers in the application of ***,this paper discusses possible future research difficulties in the problem of HFO,as well as the possible future trends in the demand for HFO damping.

关键词： Damping method High-frequency oscillation Stability Wind power generation

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The m^(6)A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy

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Genes & Diseases 2024年第2期11卷 993-1008页

作者： Fangyi Yao Fangmin Zhong Junyao jiang Ying Cheng Shuai Xu Jing Liu Jin Lin Jing Zhang Shuqi Li Meiyong Li Yanmei Xu bo Huang Xiaozhong Wang jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Chronic myeloid leukemia(CML)is a common adult *** the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor *** N6-methyladenine(m^(6)A)modification plays an important regulatory role in various physiological and pathological ***1429 is a known m^(6)A regulator,but the biological role of KIAA1429 in CML is *** this study,we observed that the m^(6)A levels and KIAA1429 expression were significantly up-regulated in patients with blast phase ***,KIAA1429 regulated the total level of RNA m^(6)A modification in the CML cells and promoted the malignant biological behaviors of CML cells,including proliferation,migration,and imatinib *** KIAA1429 in CML cells reduced the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis,consequently inhibiting CML proliferation and drug efflux,ultimately increasing the sensitivity of CML cells to ***,the knockdown of RAB27B also inhibited the proliferation and drug resistance of CML cells and promoted their ***,a recently developed anti-cancer agent,suppressed the expression of KIAA1429 and CML cell proliferation and promoted cell *** also inhibited the tumorigenesis of CML cells in *** combined use of rucaparib and imatinib enhanced the sensitivity of CML cells to *** study provides evidence that elevated KIAA1429 expression in the blast phase of CML enhances the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis to up-regulate RAB27B expression,thereby promoting CML *** exerts inhibitory effects on KIAA1429 expression and thus reduces CML progression.

关键词： Chronic myeloid leukemia KIAA1429 N6-methyladenine RAB27B Rucaparib YTHDF1

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Regulating the dopant clustering in LiZnAs-based diluted magnetic semiconductor

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Chinese Physics B 2024年第5期33卷 617-623页

作者：贾子航周波姜振益张小东 Institute of Modern Physics Northwest UniversityXi'an 710069China Shaanxi Key Laboratory for Theoretical Physics Frontiers Northwest UniversityXi'an 710069China Department of Physics Chinese University of Hong KongHong Kong SARChina Beijing Computational Science Research Center Beijing 100193China

Tuning of the magnetic interaction plays the vital role in reducing the clustering of magnetic dopant in diluted magnetic semiconductors(DMS).Due to the not well understood magnetic mechanism and the interplay between different magnetic mechanisms,no efficient and universal tuning strategy is proposed at ***,the magnetic interactions and formation energies of isovalent-doped(Mn) and aliovalent(Cr)-doped LiZnAs are studied based on density functional theory(DFT).It is found that the dopant–dopant distance-dependent magnetic interaction is highly sensitive to the carrier concentration and carrier type and can only be explained by the interplay between two magnetic mechanisms,i.e.,superexchange and Zener’s p–d exchange ***,the magnetic behavior and clustering of magnetic dopant can be tuned by the interplay between two magnetic *** insensitivity of the tuning effect to U parameter suggests that our strategy could be universal to other DMS.

关键词： diluted magnetic semiconductor dopant distribution first-principles calculations

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地位满意度与印度的国际机制合作行为

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国际展望 2024年第4期16卷 125-146,169,170页

作者：姜波复旦大学国际关系与公共事务学院上海200043

近年来,印度愈发注重通过参与国际机制合作来提升本国的国际地位,并在不同的国际机制中展现出差异性的合作行为。既有研究缺乏对印度在不同机制中合作行为的比较,因此本文结合角色理论,在分析框架中引入“地位”这一变量来阐释印度的国... 详细信息

近年来,印度愈发注重通过参与国际机制合作来提升本国的国际地位,并在不同的国际机制中展现出差异性的合作行为。既有研究缺乏对印度在不同机制中合作行为的比较,因此本文结合角色理论,在分析框架中引入“地位”这一变量来阐释印度的国际机制合作行为。“地位满意度”是指一国在国际机制中的实际地位与预期地位的比较和匹配,不同的“地位满意度”将引发不同的国家角色建构,并最终导致特定的国家行为。案例分析表明,作为新兴崛起国的印度具有追求国际地位的强烈动机,其在联合国安全理事会、南亚国家区域合作联盟以及“印太经济框架”中分别建构了“变革者”“控制者”以及“有限合作者”的角色,并展现了相应的合作行为。研究表明,虽然印度对于参与国际机制合作乃至多边主义的态度日趋积极,但鉴于其一贯的自利做法,恐难以在国际机制合作中真正践行多边主义原则。

关键词：国际机制国际合作地位满意度国际地位印度

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