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Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： Shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren hong-Tao li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei li Jian-hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

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研究型大学教师参与教学改革的动力及其特征研究-基于符号互动理论分析的视角

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北京科技大学学报（社会科学版） 2025年第1期41卷 39-50页

作者：李虹北京科技大学文法学院北京100083

大学教学质量的提升需要不断探索教学改革,其具体执行靠一线教师,一线教师有动力参与其中是教学改革成功的关键。文章基于质性研究方法,采用访谈法、参与式观察法、实物收集法等收集资料;对18所研究型大学、共计11个一级学科的33位一线... 详细信息

大学教学质量的提升需要不断探索教学改革,其具体执行靠一线教师,一线教师有动力参与其中是教学改革成功的关键。文章基于质性研究方法,采用访谈法、参与式观察法、实物收集法等收集资料;对18所研究型大学、共计11个一级学科的33位一线教师进行深度访谈;运用Nvivo软件按照三级编码的操作程序和扎根理论的方法取径完成了理论建构。研究发现,大学教师参与教学改革包括不同主体主导因素、实践过程主导因素、目标结果主导因素和情境场景主导因素共四类32种动力因素。基于符号互动理论分析视角发现,研究型大学教师参与教.学改革的动力具有情境性、能动性和变化性特征,其动力因素具有多元性、矛盾性和复杂性特征,各个动力因素之间具有开放性、互动性和共生性特征。基于前述特征,政府、高校、二级学院教学管理者等需要营造积极的教学改革文化,发挥教学制度的正面效应,提供相应的教学支持保障。

关键词：研究型大学教师教学改革动力特征符号互动理论

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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao Sha liao Yu-Jiao Gao Xi Wang li-hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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纤维桩联合不同冠部修复方式修复穿髓型非龋性颈部缺损牙体的力学分析

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中国组织工程研究 2025年第4期29卷 866-871页

作者：陈倚珑张旭李红首都医科大学附属北京口腔医院北京市100050 北京市房山区良乡医院北京市102401

背景:使用纤维桩修复穿髓型非龋性颈部缺损可以改变牙齿的应力分布,显著降低患牙折裂风险,但关于纤维桩改善牙体抗折性的力学机制及穿髓型非龋性颈部缺损的最佳冠部修复方式尚有争论。目的:综述纤维桩修复穿髓型非龋性颈部缺损后的应力... 详细信息

背景:使用纤维桩修复穿髓型非龋性颈部缺损可以改变牙齿的应力分布,显著降低患牙折裂风险,但关于纤维桩改善牙体抗折性的力学机制及穿髓型非龋性颈部缺损的最佳冠部修复方式尚有争论。目的:综述纤维桩修复穿髓型非龋性颈部缺损后的应力分布模式,在各种受力状态下的抗折能力与断裂模式,以及纤维桩联合不同冠部修复方式的最新研究进展。方法:应用计算机在PubMed和中国知网数据库中检索2008年9月至2023年9月发表的相关文献,英文检索词为“non-carious cervical lesions,endodontically treated teeth restoration,endodontically treated teeth stress distribution”,中文检索词为“非龋性颈部缺损,根管治疗后牙体修复,根管治疗后牙齿应力分布”,最终纳入56篇文献进行分析。结果与结论:穿髓型非龋性颈部缺损根管治疗后,应用纤维桩修复可部分改善牙齿颈部应力,同时不会增加牙根纵裂的风险;使应力分布更加均匀,提高牙齿的抗折性。使用纤维桩修复的非龋性颈部缺损牙齿若折断,其断裂模式显示出有利的、可恢复的或可修复的断裂模式。纤维桩联合瓷贴面或贴面式嵌体可能会成为修复穿髓型非龋性颈部缺损的一种较理想微创修复方法。

关键词：非龋性颈部缺损穿髓型三维有限元分析纤维桩冠部修复应力分布抗折性折断模式

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锥形术CT测量分析下颌第一磨牙拟种植区剩余牙槽嵴的骨量

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中国组织工程研究 2025年第8期29卷 1572-1577页

作者：蔡尧昊郎律黎红浙江中医药大学口腔医学院杭州口腔医院浙江省杭州市310000 中国科学技术大学附属第一医院(安徽省立医院)口腔医学中心安徽省合肥市230002 浙江中医药大学口腔医学院杭州口腔医院萧山分院浙江省杭州市310000

背景:随着口腔领域的发展与进步,口腔种植技术逐渐成为替代传统义齿的主流选择。近年来,多种骨增量技术的成熟以及口腔数字化领域的不断发展,使种植适应证不断扩大,种植手术的成功率也越来越高。但是种植手术前使用锥形术CT对剩余牙槽... 详细信息

背景:随着口腔领域的发展与进步,口腔种植技术逐渐成为替代传统义齿的主流选择。近年来,多种骨增量技术的成熟以及口腔数字化领域的不断发展,使种植适应证不断扩大,种植手术的成功率也越来越高。但是种植手术前使用锥形术CT对剩余牙槽嵴骨量进行准确测量并且个性化制定合适的种植方案,成为一部分临床医师的难题。目的:采用锥形束CT对下颌第一磨牙拟种植区剩余牙槽嵴骨量进行测量分析,为优化下颌第一磨牙区种植方案的设计提供参考。方法:采用回顾性研究设计,纳入205例下颌第一磨牙缺失患者的锥形术CT影像,测量下颌第一磨牙拟种植区剩余牙槽嵴高度及宽度,并将剩余牙槽嵴形态分为Ⅰ、Ⅱ、Ⅲ、Ⅳ4类(Ⅱ、Ⅲ、Ⅳ类剩余牙槽嵴为骨量不足),统计分析下颌第一磨牙剩余牙槽嵴高度、宽度、形态频数分布,不同性别患者下颌第一磨牙剩余牙槽嵴高度和牙槽嵴顶宽度的差异,剩余牙槽嵴高度与剩余牙槽嵴顶宽度、剩余牙槽嵴底宽度的相关性,年龄与剩余牙槽嵴顶宽度、高度的相关性。结果与结论:①下颌第一磨牙拟种植区剩余牙槽嵴高度平均为(12.14±2.96)mm,其中0.05),男性下颌第一磨牙剩余牙槽嵴顶宽度宽于女性,差异有显著性意义(P0.05);④剩余牙槽嵴形态Ⅰ类占58.05%(119/205),Ⅱ类占9.27%(19/205),Ⅲ类占20.49%(42/205),Ⅳ类占12.19%(25/205),其中多数为Ⅲ类剩余牙槽嵴骨量不足,临床医生需要根据剩余牙槽嵴类型个性化设计最佳的种植方案。

关键词：下颌第一磨牙剩余牙槽嵴形态锥形术CT 种植修复引导骨再生术牙槽骨劈开术骨移植术短种植体计算机辅助种植

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Interface engineering renders high-rate high-capacity lithium storage in black phosphorous composite anodes with excellent cycling durability

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Science China Chemistry 2020年第12期63卷 1734-1736页

作者： hong li Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and DevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Tianmu Lake Institute of Advanced Energy Storage Technologies Liyang 213300China

Electrode materials are key components of lithium ion batteries that dominate the upper-limit of batteries’ performance and its scope of applications. To date, anode materials are mainly modified natural graphite and artificial *** silicon-carbon composites start to be used recently in anode mixed with graphite in a weight ratio less than 10%. Energy density of li-ion battery is increased up to 300 Wh/kg in a cell level accordingly.

关键词： battery lithium durability

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基于海陆生态安全格局的生态修复关键区域识别——以辽西地区为例

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水土保持研究 2025年第1期32卷 285-293页

作者：蔡雨池李红刘兆顺吉林大学地球科学学院

[目的]识别出生态敏感性极高的辽西地区生态修复关键区域，为该地区国土空间生态修复工作提供科学参考。[方法]综合运用MSPA分析、景观连通性评价和电路理论等研究方法，尝试将陆域生态安全格局与海域生态安全格局相连接，识别辽西地区... 详细信息

[目的]识别出生态敏感性极高的辽西地区生态修复关键区域，为该地区国土空间生态修复工作提供科学参考。[方法]综合运用MSPA分析、景观连通性评价和电路理论等研究方法，尝试将陆域生态安全格局与海域生态安全格局相连接，识别辽西地区国土空间生态修复关键区域。[结果]（1）辽西地区共识别生态源地42个，面积为11 619.75 km2,生态源地多呈东北至西南的条带状分布，以林地及草地等土地利用类型为主。（2）生态廊道95条，其中一级廊道9条，二级廊道26条，三级廊道60条，全长778.30 km。（3）国土空间生态修复关键区域196处，其中生态夹点93处，生态障碍点103处。[结论]生态修复关键区识别是国土空间生态修复的重要基础与依据。在综合分析生态修复关键区域空间分布和土地利用现状特征基础上，提出了辽西地区针对性的国土空间生态修复策略。

关键词：生态修复关键区生态安全格局国土空间生态修复 MSPA 电路理论

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X-ray-activated UVA long persistent luminescence from defective fluoride elpasolites

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Journal of Rare Earths 2020年第2期38卷 124-129页

作者： Zhiyong li hong li hong-Tao Sun College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Long persistent phosphors have received significant attention owing to their attractive photophysical ***,we report a new long persistent phosphor exhibiting strong ultraviolet A(UVA)*** phosphors were synthesized by a solid-state reaction *** find that the obtained phosphors demonstrate super long UVA-afterglow emissions after irradiation by X-ray source,and the afterglow can last more than 50 h.A wide range of experimental characterizations indicate that the Tb^3+doped fluoride elpasolite phosphors are defective and some fluoride ions are replaced by oxygen ions,which creates electron traps with suitable trap *** results establish that Tb^3+can act as optical emitters in wide-bandgap hosts that can result in the UVA *** work enriches the bank of UV long persistent phosphors,and may stimulate more efforts for the design and synthesis of this kind of optical materials.

关键词： Cs2NaYF6:Tb^3+ Long persistent phosphor Afterglow Ultraviolet A X-ray irradiation Rare earths

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New insight of stabilizing electrode/electrolyte interphase:Regulating the specific adsorption of the inner Helmholtz plane

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Journal of Energy Chemistry 2020年第6期29卷 126-127,I0005页

作者： Wenjun li hong li Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Welion New Energy Technology Co.Ltd. Beijing 102402China Beijing Advanced Innovation Center for Materials Genome Engineering Institute of PhysicsChinese Academy of ScienceBeijing 100190China

Rechargeable lithium metal batteries own the highest energy density among all electrochemical energy storage *** metal anode in those cell system acts as paramount role in promoting high energy density[1].However,lithium anode tends to form dendrite morphology and exhibits huge volume expansion and high reactivity,which induces ultra-low columbic efficiency and out of tolerance cycle performance and even safety hazards[2,3].The lithium dendrite growth behavior is mainly decided by the high surface energy and diffusion barriers for li ions in lithium batteries which is ascribed to thermodynamics factors and uneven electronic field distribution[1,4,5].During the repeated plating/stripping process,the structure and components of solid–liquid interphase are significantly determined by the deposition thermodynamics and *** the recent years,advances in characterization technology and the development of high-performance computing method have driven the rapid exploration of the fundamental theory of solid–liquid interphase in lithium batteries.

关键词： lithium metal anode Stable SEI Inner Helmholtz plane Specific adsorption Solvation

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