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Structural,mechanical and electronic properties of precipitates in Mg−Zn alloys

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2507-2520页

作者： Tian-zhi ZHANG Yang-zhen LIU Qing-yun FU Bai-song GUO Wei-hong jin Zhen-tao YU Institute of Advance Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Shaoguan Research Institute of jinan University Shaoguan 512027China Stomatological Hospital Southern Medical UniversityGuangzhou 510280China

To accelerate the development and design of magnesium(Mg)alloys,the structural and mechanical properties of important precipitates in Mg−Zn alloys were studied by experiments and density functional *** nano-indentation tests revealed that the hardness of the precipitates initially increased and then decreased with increasing Zn content,and was significantly higher than that of pure Mg and *** calculation results revealed that the precipitates stability initially increased and then decreased with increasing Zn *** bulk moduli of the precipitates increased,whereas their shear and Young’s moduli initially increased and then decreased with increasing Zn *** decreasing order of ductility for these compounds is MgZn_(2)>Mg21Zn_(2)5>Mg2Zn11>*** surface profiles of the compounds revealed that they are obvious *** the degree of covalency and bond length of covalent bonds initially increased and then decreased with increasing Zn content.

关键词： Mg−Zn alloy nano-indentation modulus hardness chemical bonding

Enhanced degradation of florfenicol by microscale SiC/Fe:Dechlorination via hydrogenolysis

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Chinese Chemical Letters 2024年第7期35卷 218-221页

作者： Yun-Fei Zhang Chun-Hui Zhang Jian-Hui Xu Lei Li Dan Li jin-hong Fan Jiale Gao Xin Quan Qi Wu Yue Zou Yan-Ling Liu Dongguan University of Technology School of Environment and Civil EngineeringDongguan 523830China State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Herein,the degradation of florfenicol(FLO)over zero-valent iron(ZVI)enhanced by SiC was systematically *** was found that 5 g/L of ZVI/SiC(1:3)at pH 3.0 could completely degrade 20 mg/L of FLO within 1 h,with a Kobsvalue of 0.0873 min^(-1),12.5 times greater than that of pure ZVI(0.0069 min^(-1)).Vibrating sample magnetometer(VSM)characterizations revealed that the use of SiC supporter reduces the magnetic intensity of ZVI,which mitigates iron particle agglomeration,increases Brunauer-Emmett-Teller(BET)surface area,and enhances FLO degradation ***,ZVI/SiC exhibits a much lower hydrogen evolution potential(HEP)and significantly higher corrosion currents compared to pure *** was proposed to undergo degradation via reductive dechlorination,involving a hydrogenolysis mechanism that entails the cleavage of theσ*** study provides new insights into the reduction hydrogenation mechanism of ZVI.

关键词： Zero-valent iron Silicon carbide Reductive dechlorination Hydrogenolysis Florfenicol

Heterophase junction engineering-induced Co spin-state modulation of CoSe_(2) for large-current hydrogen evolution reaction

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Rare Metals 2024年第6期43卷 2660-2670页

作者： Bao-Chai Xu Ya-Ping Miao Min-Qin Mao Dong-Lian Li Song Xie Wei-hong jin Shu Xiao jing Wen Zaenab Abd-Allah Zhi-Tian Liu Xiang Peng Paul K.Chu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China School of Textile Science and Engineering Xi'an Polytechnic UniversityXi'an 710048China Institute of Advanced Wear and Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of Safety Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Engineering Manchester Metropolitan UniversityManchester M156BHUK Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Efficient electrocatalysts are vital to large-current hydrogen production in commercial water splitting for green energy ***,a novel heterophase engineering strategy is described to produce polymorphic CoSe_(2)*** composition of the electrocatalysts consisting of both cubic CoSe_(2)(c-CoSe_(2))and orthorhombic CoSe_(2)(o-CoSe_(2))phases can be controlled *** results demonstrate that junction-induced spin-state modulation of Co atoms enhances the adsorption of intermediates and accelerates charge transfer resulting in superior large-current hydrogen evolution reaction(HER)***,the CoSe_(2)based heterophase catalyst with the optimal c-CoSe_(2)content requires an overpotential of merely 240 mV to achieve 1,000 mA·cm^(-2)as well as a Tafel slope of 50.4 mV·dec^(-1).Furthermore,the electrocatalyst can maintain a large current density of 1,500 mA·cm^(-2)for over 320 h without *** results reveal the advantages and potential of heterophase junction engineering pertaining to design and fabrication of low-cost transition metal catalysts for large-current water splitting.

关键词： Heterophase junction Spin-state Hydrogen evolution reaction Large current electrochemical hydrogen production Water splitting

Herb pair of Huangqi-Danggui exerts anti-tumor immunity to breast cancer by upregulating PIK3R1

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Animal Models and Experimental Medicine 2024年第3期7卷 234-258页

作者： Hai-Xin Liu Li Lian Li-Li Hou Cai-Xia Liu jin-hong Ren Yuan-Biao Qiao Shi-Yuan Wen Qing-Shan Li College of Traditional Chinese Medicine and Food Engineering Shanxi University of Chinese MedicineTaiyuanChina Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation College of Traditional Chinese Medicine and Food EngineeringShanxi University of Chinese MedicineTaiyuanChina College of Basic Medical Sciences Shanxi Medical UniversityTaiyuanChina

Background:According to traditional Chinese medicine(TCM),drugs supplementing the vital energy,Qi,can eliminate tumors by restoring host *** objective of this study is to investigate the underlying immune mechanisms of anti-tumor activity associated with Qi-supplementing herbs,specifically the paired use of Huangqi and ***:Analysis of compatibility regularity was conducted to screen the combination of Qi-supplementing *** the MTT assay and a transplanted tumor mice model,the anti-tumor effects of combination TCMs were investigated in vitro and in *** content analysis and flow cytometry were then used to evaluate cellular immunity,followed by network pharmacology and molecular docking to dissect the significant active compounds and potential ***,the anti-tumor activity and the mechanism of the active ingredients were verified by molecular ***:There is an optimal combination of Huangqi and Danggui that,administered as an aqueous extract,can activate immunity to suppress tumor and is more effective than each drug on its own in vitro and in *** on network pharmacology analysis,PIK3R1 is the core target for the anti-tumor immunity activity of combined Huangqi and *** docking analysis shows 6 components of the combined Danggui and Huangqi extract(quercetin,jaranol,isorhamnetin,kaempferol,calycosin,and suchilactone)that bind to *** is the most important component against breast *** suchilactone/jaranol combination and,especially,the suchilactone/kaempferol combination are key for immunity enhancement and the anti-tumor effects of the ***:The combination of Huangqi and Danggui can activate immunity to suppress breast cancer and is more effective than the individual drugs alone.

关键词： anti-tumor Danggui Huangqi immunity

A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： hong-jin Liao Zhu Zhuo Qing Li Yoshihito Shiota Jonathan P.Hill Katsuhiko Ariga Zi-Xiu Lu Lu-Yao Liu Zi-Ang Nan Wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and Engineering Kyushu UniversityFukuoka 819-0395Japan World Premier International(WPI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

Electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular Photochromic X-ray induced Anion-directed folding Electron-deficient viologens

Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

五台山景区酒店从业者低碳认知与行为的差异及影响因素

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自然资源学报 2024年第7期39卷 1548-1574页

作者：程锦红王峥程占红山西师范大学历史与旅游文化学院太原030031 山西财经大学文化旅游与新闻艺术学院太原030006

厘清酒店从业者低碳认知与行为差异,对实现碳中和目标与推动景区酒店可持续发展具有重要的理论价值和实践意义。采用主成分分析、耦合协调度、配对样本T检验和地理探测器方法,探讨了五台山景区酒店从业者低碳认知与行为的差异及影响因... 详细信息

厘清酒店从业者低碳认知与行为差异,对实现碳中和目标与推动景区酒店可持续发展具有重要的理论价值和实践意义。采用主成分分析、耦合协调度、配对样本T检验和地理探测器方法,探讨了五台山景区酒店从业者低碳认知与行为的差异及影响因素。结果表明:(1)酒店从业者低碳认知和行为主要涉及低碳饮食、低碳住宿、低碳管理、低碳循环、低碳服务和低碳供应6个维度,而影响因素包含人地观、气候变化观、碳中和知识与方式、生态文化、低碳服务成本、低碳社会氛围与政策、低碳设施与条件7个维度。(2)根据酒店星级不同,将酒店从业者分为五星级、四星级、三星级、三星级以下及民宿从业者四组,且其低碳认知水平呈逐步下降趋势。(3)四组酒店从业者的低碳认知与行为均存在显著差异,在低碳认知方面,四组类型均表现为低碳饮食认知滞后,而在低碳行为方面,四组类型则均表现为低碳供应行为、低碳住宿行为、低碳管理行为、低碳循环行为和低碳服务行为滞后。(4)基于低碳认知与行为耦合协调的不同,五星级酒店从业者在低碳住宿、循环与供应维度均处于中级协调,而影响其协调的主导因素是人地观、低碳设施与条件。四星级酒店从业者在低碳供应维度处于初级协调,低碳住宿与循环维度则为中级协调,主要驱动力是低碳设施与条件、低碳服务成本、碳中和知识与方式。三星级酒店从业者在低碳供应维度处于初级协调,低碳住宿与循环维度则为中级协调,主要因素是生态文化、碳中和知识与方式。三星级酒店以下及民宿从业者在低碳循环和供应维度处于中级协调,主要影响因素是低碳服务成本、低碳社会氛围与政策。

关键词：五台山景区低碳认知低碳行为影响因素

地震亚失稳过程中前兆异常演化的综合解释——以2014年鲁甸6.5级地震为例

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地震地质 2024年第3期46卷 513-535页

作者：蒋海昆邓世广姚琪宋金王锦红中国地震台网中心北京100045 中国地震局地震预测研究所北京100036

文中以2014年鲁甸6.5级地震为例,在亚失稳实验及理论指导下,基于震前地震活动及地球物理观测资料并结合地震成核数值模拟结果,综合分析前兆异常时空演化与亚失稳过程的关系,首次提供了一个可明确佐证亚失稳阶段震源区成核、震源区附近... 详细信息

文中以2014年鲁甸6.5级地震为例,在亚失稳实验及理论指导下,基于震前地震活动及地球物理观测资料并结合地震成核数值模拟结果,综合分析前兆异常时空演化与亚失稳过程的关系,首次提供了一个可明确佐证亚失稳阶段震源区成核、震源区附近协同化过程持续加剧的典型震例和观测事实。研究结果显示,依据大区域强震活动及流动重力观测,可判定鲁甸地震前研究区已处于高应力状态。在高应力背景判定的基础上,依据地震活动及地球物理观测前兆异常,可粗略判定鲁甸地震亚失稳过程可能起始于震前7、8个月,最突出的现象或判定指标是由震中附近小地震活跃所表征的断层应力状态由积累为主向释放为主的转变,以及由定点地球物理观测异常数量显著增加所表征的断层运动协同化现象,从地震成核的角度与成核后期核心弱化区扩张过程有关。之后至主震发生,还有2个时间节点需要关注:一是震前4、5个月,定点地球物理观测异常空间分布范围自震中附近向外围的明显扩展,显示断层变形的加速协同化;二是震前2个月之后,震中附近小地震活动开始减弱、微震活动及定点地球物理异常出现向震中的迁移收缩,与地震成核过程核心弱化区扩展之后的收缩过程相关联。

关键词：亚失稳阶段应力状态变化断层变形协同化鲁甸M 6.5地震小地震活动地球物理观测

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Neuroprotective effect of Naochuxue prescription(脑出血方) on intracerebral hemorrhage:inhibition of autophagy via downregulating high mobility group box-1

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Journal of Traditional Chinese Medicine 2024年第5期 944-953页

作者： jin hong WANG Xinna WANG Ruonan LI jinjian YU Junchao ZHAO Dexi ZHAI Lu College of Chinese medicine Changchun University of Chinese Medicine Department of Encephalopathy the Affiliated Hospital of Changchun University of Chinese Medicine College of nursing Changchun University of Chinese Medicine Research Center of Traditional Chinese Medicine the First Affiliated Hospital of Changchun University of Chinese Medicine

OBJECTIVE: To determine the molecular mechanisms underlying the neuroprotective effects of Naochuxue prescription(脑出血方,NCXP) in rats with intracerebral hemorrhage(ICH). METHODS: Sprague–Dawley rats were injected with collagenase to generate ICH models, which were then randomly divided into six groups, including control, sham, model, and three intervention groups. The intervention groups received different doses of NCXP(0.13, 0.26, and 0.52 g/kg) daily for 10 d. High-performance liquid chromatography(HPLC) was used to analyze the chemical characteristics of NCXP. The neurobehavioral outcomes of the rats were evaluated using neurological deficit scores(Zea Longa 5) and the corner turn test. Pathomorphological changes in perihematomal tissues after ICH were observed using hematoxylin and eosin staining. Immunohistochemistry(IHC) was used to detect the inflammation expression of interleukin 6(IL-6) and toll-like receptor 4(TLR4). High mobility group box-1(HMGB1), Beclin1, microtubule-associated protein 1 light chain 3 beta(LC3), and sequestosome 1(p62) were detected using real-time quantitative polymerase chain reaction and Western blotting in perihematomal tissues. RESULTS: HPLC showed that the NCXP had good stability. Rats with ICH had severe neurological function deficits compared to the control group. IHC results showed that NCXP significantly downregulated the expression of the inflammatory proteins IL-6 and TLR4. ICH rats treated with NCXP showed less neurological injury than the model group, accompanied by a significantly decreased expression of HMGB1, Beclin1, and LC3 and an increased expression of p62. CONCLUSIONS: The neuroprotective effect of NCXP alleviated inflammation and autophagy possibly by downregulating HMGB1 expression. However, further research on the signaling pathways is required to verify this hypothesis.

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