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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi Wu Hao Liu Chen Zhang Bo Chen hon.-Yi Zhang zhen.Hua Chen Yao-Bo Huang Xue-Qing ye Ya-Hua Yuan Yu-Xia Duan Jun He Jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

Aurora B promotes the CENP-T–CENP-W interaction to guide accurate chromosome segregation in mitosis

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Journal of Molecular Cell Biology 2024年第2期16卷 11-23页

作者： Wei Liu zhen.Dou Chunyue Wang Gangyin Zhao Fengge Wu Chunli Wang Felix Aikhionbare Mingliang ye Divine Mensah Sedzro zhen.e Yang Chuanhai Fu Zhikai Wang Xinjiao Gao Xuebiao Yao Xiaoyu Song Xing Liu MOE Key Laboratory for Cellular Dynamics Center for Advanced Interdisciplinary Science and Biomedicine of IHMUniversity of Science and Technology of China School of Life SciencesHefei 230027China Keck Center for Cellular Dynamics and Organoids Plasticity AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics and Chemical Biology Hefei National Research Center for Interdisciplinary Sciences at the MicroscaleHefei 230026China National Chromatographic Research and Analysis Center Chinese Academy of SciencesDalian 116023China

Accurate chromosome segregation in mitosis depends on kinetochores that connect centromeric chromatin to spindle *** are captured by individual microtubules via a kinetochore constitutive centromere-associated network(CCAN)during chromosome *** contains 16 subunits,including CENP-W and ***,the molecular recognition and mitotic regulation of the CCAN assembly remain ***,we revealed that CENP-W binds to the histone fold domain and an uncharacterized N-terminal region of *** B phosphorylates CENP-W at threonine 60,which enhances the interaction between CENP-W and CENP-T to ensure robust metaphase chromosome alignment and accurate chromosome segregation in *** findings delineate a conserved signaling cascade that integrates protein phosphorylation with CCAN integrity for the maintenance of genomic stability.

关键词： mitosis kinetochore Aurora B CENP-T CENP-W phosphorylation

Cytokine release syndrome triggered by programmed death 1 blockade(sintilimab)therapy in a psoriasis patient:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3555-3560页

作者： Ming-Hui Zhou Min-Feng ye zhen.Xing Zhang Feng Tao Yu Zhang Department of Gastrointestinal Surgery Shaoxing People’s HospitalShaoxing 312000Zhejiang ProvinceChina School of Medicine Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina

BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse ***,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blockade has significantly prolonged overall survival,marking a pivotal advancement comparable to the impact of Herceptin over the past two *** the therapeutic benefits of ICIs are evident,the increasing use of immunotherapy has led to an increase in immune-related adverse *** SUMMARY This article presents the case of a patient with advanced gastric cancer and chronic plaque *** sintilimab therapy,the patient developed severe rashes accompanied by cytokine release syndrome(CRS).Fortunately,effective management was achieved through the administration of glucocorticoid,tocilizumab,and acitretin,which resulted in favorable *** Glucocorticoid and tocilizumab therapy was effective in managing CRS after PD-1 blockade therapy for gastric cancer in a patient with chronic plaque psoriasis.

关键词： Cytokine release syndrome Programmed death 1 blockade Sintilimab Psoriasis Gastric cancer Case report

基于固有频率的运动冗余并联机构位置逆解优选方法

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机械工程学报 2024年第13期60卷 297-307页

作者：吴震李秦川叶伟浙江理工大学机械工程学院杭州310018 浙江交通职业技术学院杭州311112

运动冗余并联机构在规避奇异、增大工作空间、提升机构性能等方面具有显著优势,但运动冗余并联机构位置逆解不唯一,需要考虑性能指标进行优选。提出一种运动冗余并联机构位置逆解优选新方法。首先,基于闭环矢量法和全局独立广义位移坐标... 详细信息

运动冗余并联机构在规避奇异、增大工作空间、提升机构性能等方面具有显著优势,但运动冗余并联机构位置逆解不唯一,需要考虑性能指标进行优选。提出一种运动冗余并联机构位置逆解优选新方法。首先,基于闭环矢量法和全局独立广义位移坐标法,对运动冗余并联机构进行运动学和弹性动力学建模。其次,选用机构的第一阶固有频率(基频)为弹性动力学性能指标,对于动平台某个确定的输出位姿,运用粒子群优化算法,根据基频最大得到运动冗余并联机构的最优位置逆解。然后,利用多项式拟合技术,建立最优位置逆解与动平台输出位姿参数的响应面映射模型,获得动平台在不同输出位姿下的最优位置逆解。最后,以运动冗余2PUPR-PRPU并联机构(P:移动副,U:虎克铰,R:转动副)为例应用了所提的方法,通过位置逆解优选前后机构的基频对比证明该方法的有效性。

关键词：并联机构运动冗余位置逆解优选固有频率

Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

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World Journal of Hepatology 2024年第2期16卷 264-278页

作者： Hao Ouyang Hui Miao zhen.Li Duan Wu Si-Cheng Gao Yao-Yao Dai Xiao-Di Gao Hai-Sheng Chai Wei-ye Hu Jun-Feng Zhu Department of Liver Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 201203China

BACKGROUND Liver fibrosis is a formidable global medical challenge,with no effective clinical treatment currently *** granule(YHG)is a proprietary Chinese medicine comprising Scutellariae Radix and Lonicerae Japonicae *** is frequently used for upper respiratory tract infections,pharyngitis,as well as acute and chronic *** To investigate the potential of YHG in alleviating carbon tetrachloride(CCl4)-induced liver fibrosis in *** To induce a hepatic fibrosis model in mice,this study involved intraperitoneal injections of 2 mL/kg of CCl4 twice a week for 4 ***,liver fibrosis mice in the low dose of YHG(0.4 g/kg)and high dose of YHG(0.8 g/kg)groups were orally administered YHG once a day for 4 *** alanine/aspartate aminotransferase(ALT/AST)activity and liver hydroxyproline content were *** red and Masson's trichrome staining assay were *** polymerase chain reaction,western-blot and enzyme-linked immunosorbent assay were *** glutathione content,superoxide dismutase activity level,reactive oxygen species and protein carbonylation amount were *** The administration of YHG ameliorated hepatocellular injury in CCl4-treated mice,as reflected by decreased serum ALT/AST activity and improved liver histological *** also attenuated liver fibrosis,evident through reduced liver hydroxyproline content,improvements in Sirius red and Masson's trichrome staining,and lowered serum hyaluronic acid ***,YHG hindered the activation of hepatic stellate cells(HSCs)and ameliorated oxidative stress injury and inflammation in liver from CCl4-treated *** prompted the nuclear accumulation of nuclear factor erythroid 2-related factor 2(Nrf2)and upregulated the expression of Nrf2-dependent downstream antioxidant *** addition,YHG promoted mitochon.rial biogenesis in liver from CCl4-treated mice,as demonstrated by increased liver adenosine triphosphate content,

关键词： Yinhuang granule Liver fibrosis Hepatic stellate cells Oxidative injury Nuclear factor erythroid 2-related factor 2 Inflammation

Naphthalene diimide-based cathode interlayer material enables 20.2% efficiency in organic photovoltaic cells

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Science China Chemistry 2024年

作者： Yue Yu Jianqiu Wang Zhihao Chen Yang Xiao zhen.Fu Tao Zhang Haoyu Yuan Xiao-Tao Hao Long ye Yong Cui Jianhui Hou State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences School of Physics State Key Laboratory of Crystal Materials Shandong University Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Materials Science and Engineering Beijing University of Chemical Technology School of Materials Science and Engineering Tianjin University

Cathode interlayer(CIL) materials play an important role in improving the power conversion efficiency(PCE) of organic photovoltaic(OPV) cells. However, the current understanding of the structure-property relationship in CIL materials is limited, and systematic studies in this regard are scarce. Here, two new CIL materials, NDI-PhC 4 and NDI-PhC 6 were synthesized by varying the alkylamine chain length on the NDI-Ph core. Our investigation reveals a systematic variation in the physical and chemical properties of these materials with increasing alkylamine chain length. Specifically, we observe a sequential decrease in melting point and self-doping effect, accompanied by an enhancement in crystallinity. Among these CIL materials, NDI-PhC 4 has a notable balance across various performance metrics. It also exhibits excellent surface modification capabilities, leading to a low surface roughness. Consequently, OPV cells based on NDI-PhC 4 achieve a PCE of 20.2%, which is one of the highest reported efficiencies for OPV cells. In addition, the appropriate melting point of NDI-PhC 4 contributes to the excellent stability of OPV cells.

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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： ye Xu Chao Li Zhon.-Yu Yu Jiamin Wang Zhaoyang Liu Chao Jiang zhen.Feng Chen Xiaoyu Wu Ming-Xing Li hon. Yang Zhao-Xi Wang Jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

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用于气膜冷却的机器学习湍流模型

工程热物理学报 2024年第5期45卷 1324-1331页

作者：张振叶林苏欣荣袁新清华大学能源与动力工程系北京100084

在气膜冷却中,主流和射流的相互作用会产生三维涡系结构和湍流掺混,它们引起了温度的对流和湍流扩散输运。由于上述现象的三维特性,传统的湍流模型无法准确预测气膜冷却效果,限制了燃气轮机冷却结构的分析与设计水平。本文采用湍流模型... 详细信息

在气膜冷却中,主流和射流的相互作用会产生三维涡系结构和湍流掺混,它们引起了温度的对流和湍流扩散输运。由于上述现象的三维特性,传统的湍流模型无法准确预测气膜冷却效果,限制了燃气轮机冷却结构的分析与设计水平。本文采用湍流模型反演机器学习框架,基于流场关键位置的温度数据,对湍流普朗特数进行了具有空间分布的修正。所发展的机器学习湍流温度扩散模型可以显著降低冷却有效度的预测误差,且具有较好的泛化能力。

关键词：气膜冷却湍流模型机器学习

Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

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Food Science and Human Wellness 2024年

作者： Jun Zhou Ziyan Wang Zhixuan Zhang Jiaojiao Han Ying Feng Jing Zhang zhen.Zhang ye Li Tinghon. Ming Chenyang Lu Rixin Wang Xiurong Su School of Marine Science， Ningbo University Faculty of Food Science， Zhejiang Pharmaceutical College Key Laboratory of Aquacultural Biotechnology Ministry of Education， Ningbo University College of Life Sciences， Tonghua Normal University State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Ningbo University

Fructose consumption has risen dramatically in recent decades due to the use of sucrose and high fructose corn syrup in beverages and processed foods， contributing to rising rates of hyperuricemia. The purpose of this experiment was to explore the anti-hyperuricemia effects of an active oligopeptide (GPSGRP) derived from sea cucumber in fructose induced hyperuricemia mouse model， and to clarify the underlying mechanism in sight of gut microbiota and serum metabolites. Peptide GPSGRP treatment rebalanced uric acid metabolism and alleviated inflammatory response in mice. In addition， treatment with GPSGRP decreased the abundance of Bacteroides and Proteobacteria at the phylum level， Muribaculum， Prevotella and Bacteroides at the genus level， and inhibited the related pathways of purine metabolism and glycolysis/gluconeogenesis metabolism. Moreover， serum metabolites， including linoleic acid， indole and its derivatives， arachidonic acid and uridine， as well as related metabolic pathways， such as tricarboxylic acid cycle， ketone production and sugar production， were altered in response to GPSGRP treatment. This study provides a valuable reference for the application and development of marine biological peptides in uric acid management.

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竖井大直径空孔掏槽爆破的振动效应分析

工程爆破 2024年第3期30卷 160-168页

作者：朱振业中铁四局集团有限公司第七工程分公司合肥230032

大直径空孔对掏槽爆破及其振动效应有复杂的影响。以青岛地铁5号线沾化路竖井工程为背景,借助数值模拟与现场试验相结合等手段,揭示了直孔掏槽时大直径中空孔孔径和装药孔与中空孔距离的比值K对掏槽区破岩效果和地表振速响应规律的影响... 详细信息

大直径空孔对掏槽爆破及其振动效应有复杂的影响。以青岛地铁5号线沾化路竖井工程为背景,借助数值模拟与现场试验相结合等手段,揭示了直孔掏槽时大直径中空孔孔径和装药孔与中空孔距离的比值K对掏槽区破岩效果和地表振速响应规律的影响。研究结论表明:掏槽区爆破破岩和减振效果与K值之间存在显著的正相关性,且K值为1时大直径空孔掏槽爆破效果最为合理;采用大直径中空孔(Ф80 cm)掏槽,基于数码电子精确延时的逐孔起爆方式,可将实际工程地表质点峰值振速精准控制在0.3 cm/s以内;现场试验监测与数值模拟结果误差在8%左右,表明研究方法是合理可行的。研究结论能为城市闹市区地铁及竖井爆破振动有害效应精准控制提供依据和参考。

关键词：竖井工程破岩效果直孔掏槽大直径空孔振动效应