检索结果-南通市图书馆

Precision medicine in acute lymphoblastic leukemia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Medicine 2020年第6期14卷 689-700页

作者： Ching-hon Pui Departments of Oncology and Pathology St.Jude Children’s Research HospitalMemphisTN 38105USA

The cure rate of childhood acute lymphoblastic leukemia(ALL)has exceeded 90%in some contemporary clinical ***,the dose intensity of conventional chemotherapy has been pushed to its *** improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk *** with ETV6-RUNX1 or hyperdiploid>50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in *** with Philadelphia chromosome(Ph)-positive or Ph-like ALL with ABL-class fusion should be treated with ***3 profiling and other preclinical methods have identified several high-risk subtypes,such as hypodiplod,early T-cell precursor,immature T-cell,KMT2A-rearranged,Ph-positive and TCF-HLF-positive ALL,that may respond to BCL-2 inhibitor *** are other fusions or mutations that may serve as putative targets,but effective targeted therapy has yet to be *** other high-risk patients or poor early treatment responders who do not have targetable genetic lesions,current approaches that offer hope include blinatumomab,inotuzumab and CAR-T cell therapy for B-ALL,and daratumumab and nelarabine for *** the expanding therapeutic armamentarium,we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.

关键词： acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy

Flocking behavior of forest birds in hong Kong,South China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2017年第5期28卷 1097-1102页

作者： hon Kai Kwok Ecosystems Ltd

This paper reports observations of flocking behavior of birds in a well-protected secondary forest in Tai Po Kau Nature Reserve, hong Kong Special Administrative Region, China. A total of 1025 flocks including 5255 birds and 48 species were observed between October 2002 and November 2003. Most flocks consisted of only one species. The observed flocks averaged 1.79 +/- 0.05 (SE) species and 5.13 +/- 0.18 (SE) birds. The Japanese White-eye was the most numerous species and was present in 21.6% of the observed flocks. Seasonal trends in both flock size and number of species were similar to those in overall bird density and species richness in the study area reported in a previous study.

关键词： Forest bird Forest Flock Tai Po Kau Nature Reserve hong Kong special administrative region

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2015年第1期9卷 1-9页

作者： Ching-hon Pui Departments of Oncology and Pathology St. Jude Children's Research Hospital Memphis TN 38105 USA the University of Tennessee Health Science Center Memphis 7N 38105 USA

With the cure rate of childhood acute lymphoblastic leukemia （ALL） approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.

关键词： acute lymphoblastic leukemia genomics pharmacogenetics pharmacogenomics

A Guaranteed Cost Approach to Dynamic Output Feedback Control for Neutral-Type Markovian Jumping Stochastic Systems

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2021年第4期34卷 1487-1500页

作者： LI Yanbo kao Binghua XIE Jing kao Yonggui School of Information and Statistics Guangxi University of Finance and EconomicsNanning 530003China Department of Mathematics Harbin Institute of Technology(Weihai)Weihai 264209China School of Information and Control Engineering Qingdao University of TechnologyQingdao 266520China

This paper is devoted to investigating the dynamic output feedback(DOF)control problem of Markovian jump neutral-type stochastic systems with a guaranteed cost *** of the state and measurement equations contain time ***-dependent DOF controllers are first designed such that the closed-loop system is asymptotically stable in mean-square and an adequate performance level of this system is ***,sufficient conditions for the solvability of this problem are derived in the form of linear matrix inequalities(LMIs).A numerical example is presented to reveal the effectiveness of our findings.

关键词： Guaranteed cost control linear matrix inequality Markovian jump neutral stochastic systems output feedback control time delay

Asymptotic multistability and local S-asymptotic ω-periodicity for the nonautonomous fractional-order neural networks with impulses

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2021年第1期64卷 175-187页

作者： Yonggui kao Hui LI Department of Mathematics Harbin Institute of Technology at Weihai

This paper focuses on the investigation of asymptotic multistability and on local S-asymptoticω-periodicity for nonautonomous fractional-order neural networks(FONNs) with impulses. Several criteria on the existence, uniqueness, and invariant sets of nonautonomous FONNs with impulses are derived by constructing convergent sequences and comparison principles, respectively. In addition, using the Lyapunov direct method, some novel conditions of boundedness and local asymptotic stability of the FONNs discussed are obtained. Also, the sufficient conditions for local S-asymptotic ω-periodicities of the system are presented. Finally, a discussion using two examples verifies the validity of our findings, which imply that global asymptotic stability is a special case of asymptotic multistability.

关键词： fractional-order neural networks local S-asymptotic ω-periodicity asymptotic multistability impulse nonautonomous

Cyclic ADP-ribose and NAADP:fraternal twin messengers for calcium signaling

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2011年第8期54卷 699-711页

作者： hon Cheung LEE Department of Physiology University of Hong Kong

The concept advanced by Berridge and colleagues that intracellular Ca2+-stores can be mobilized in an agonist-dependent and messenger(IP3)-mediated manner has put Ca 2+-mobilization at the center stage of signal transduction *** the late 1980s,we showed that Ca2+-stores can be mobilized by two other messengers unrelated to inositol trisphosphate(IP 3) and identified them as cyclic ADP-ribose(cADPR),a novel cyclic nucleotide from NAD,and nicotinic acid adenine dinucleotide phosphate(NAADP),a linear metabolite of *** messenger functions have now been documented in a wide range of systems spanning three biological *** evidence indicates that the target of cADPR is the ryanodine receptor in the sarco/endoplasmic reticulum,while that of NAADP is the two pore channel in endolysosomes. As cADPR and NAADP are structurally and functionally distinct,it is remarkable that they are synthesized by the same *** are thus fraternal twin *** first identified the Aplysia ADP-ribosyl cyclase as one such enzyme and,through homology,found its mammalian homolog,*** knockout in mice confirms the important roles of CD38 in diverse physiological functions from insulin secretion,susceptibility to bacterial infection,to social behavior of mice through modulating neuronal oxytocin *** have elucidated the catalytic mechanisms of the Aplysia cyclase and CD38 to atomic resolution by crystallography and site-directed *** article gives a historical account of the cADPR/NAADP/CD38-signaling pathway and describes current efforts in elucidating the structure and function of its components.

关键词： cyclic ADP-ribose cADPR NAADP nicotinic acid adenine dinucleotide phosphate CD38 ADP-ribosyl cyclase Calcium mobilization and signaling

Stability of Coupled Impulsive Markovian Jump Reaction-Diffusion Systems on Networks

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2016年第5期29卷 1269-1280页

作者： LI Yanbo kao Yonggui School of Mathematical Sciences Guangxi Teachers Education University Department of Mathematics Harbin Institute of Technology (Weihai)

This paper is devoted to the investigation of stability for a class of coupled impulsive Markovian jump reaction-diffusion systems on networks(CIMJRDSNs). By using graph theory, a systematic method is provided to construct global Lyapunov functions for the CIMJRDSNs. Based on Lyapunov functions and stochastic analysis method, some novel stability principles associated with the topology property of the networks are established.

关键词： Coupled stochastic reaction-diffusion systems, impulsive, Markovian switching networks stability.

Applying a Step Approach Method in Solving the Multi-Frequency Radiation From a Complex Obstacle

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2016年第7期112卷 59-73页

作者： Jui-Hsiang kao Department of Systems Engineering and Naval Architecture National Taiwan Ocean UniversityKeelungTaiwanR.O.C

In this paper,a step approach method in the time domain is developed to calculate the radiated waves from an arbitrary obstacle pulsating with multiple *** computing scheme is based on the Boundary Integral Equation and derived in the time domain;thus,the time-harmonic Neumann boundary condition can be *** the present method,the values of the initial conditions are set to zero,and the approach process is carried forward in a loop from the first time step to the *** each time step,the radiated pressure on each element is *** several loops,the correct radiated pressures can be obtained.A sphere pulsating with a monopole frequency in an infinite acoustic domain is calculated *** result is compared with the analytical solution,and both of them are in good ***,a complex-shaped radiator is taken as the studied *** pulsating frequency of this case is multiple,and the waves propagate in half *** is shown that the present method can treat multiple-frequency pulsation well,even when the radiator is a complex shape,and a robust convergence can be attained quickly.

关键词： Step approach method Time domain Radiated waves Multiple frequencies Boundary integral equation Neumann boundary condition

Preface: Current research progress on mechanics of high speed rail

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2014年第6期30卷 846-848页

作者： Yujie we the Institute of Mechanics Chinese Academy of Sciences (CAS)

The construction and operation of high-speed rail（HSR）grid within the past two decades in China,in terms of the scale,may be possibly comparable to any national-wide construction in the history of China,even the Great *** counting railways with commercial train service at the speed of200 km/h,China has the world’s longest HSR network with over 19 369.8 km of track in service today and this number

关键词： high Current research progress on mechanics of high speed rail Preface