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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Synergistic Effect of Graphdiyne-based Electrocatalysts

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Chemical Research in Chinese Universities 2021年第6期37卷 1242-1256页

作者： wong hon Ho SUN Mingzi HUANG Bolong Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARP.R.China

The synergistic effect can help improve the electrocatalyst performances by combining the advantages of individual *** particular,such an effect has been more important in the atomic *** this review,we have summarized the synergistic effect of N,X co-doping graphdiyne[X=B,S,F or transition metal(TM)]electrocatalysts and graphdiyne-based dual-atom catalyst(GDY-DAC).In general,the synergistic cooperation between two different dopants in co-doped GDY and adjacent active sites in GDY-DAC not only promotes their catalytic activity but also greatly enhances the thermodynamic stability of the *** the N,X co-doping GDY electrocatalysts,doping the heteroatoms like boron,sulphur,phosphorus,and fluorine with nitrogen can further tune the charge density distribution and electronic ***,the electron exchange between two doping atoms and GDY substrate has been discussed,where the TM-based GDY-DAC is a very promising catalyst for *** importantly,electronic interactions between different elements on GDY have been carefully *** the end,we have also supplied perspectives to the future developments of the GDY-based electrocatalysts.

关键词： Graphdiyne(GDY) Electrocatalyst Synergistic effect Dual-atom catalyst co-Doped GDY

Effective Common Chinese Herbal Medicines Used in Treating Chronic Cholecystitis with Liver-Gallbladder Dampness-Heat Syndrome: A Review of Clinical Studies in the Past 10 Years

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 8-20页

作者： Desmond Wei Kang Tee hon Foong wong Centrefor Complementary and Alternative Medicine International Medical UniversityKuala LumpurMalaysia

The objective of the study is to identify the effective common Chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome(CCLGDHS) through reviewing relevant clinical studies published in the past 10 years. Data were collected from Science Direct and Chinese National Knowledge Infrastructure. Data screening was carried out for the abstracts and full texts of the data. The top 15 Chinese herbal medicines with the highest occurring frequency were selected, statistically analyzed, and classified by their medicinal properties, actions, and indications according to the Chinese Pharmacopoeia 2015 edition. The top 15 effective common Chinese herbal medicines comprise Chai Hu, Huang Qin, Jin Qian Cao, Bai Shao, Yin Chen, Yu Jin, Chuan Lian Zi, Yan Hu Suo, Zhi Shi, Ban Xia, Bai Zhu, Pu Gong Ying, Gan Cao, Zhi Zi, and Qing Pi. The predominant natures were cold, cool, and warm. This combination can clear stagnant heat, warm Yang, and regulate Qi dynamics. In addition, bitter, pungent, and sweet were the predominant flavors. They can clear dampness-heat, regulate Qi dynamics to relieve cramps and pain, as well as tonify the deficiency. Along with entering the liver and gallbladder meridians, these herbal medicines also entered the spleen, stomach, and lung meridians to prevent potential disease transmission. The combinatorial medicinal actions of the effective common Chinese herbal medicine highlight the importance of the holistic concept of traditional Chinese medicine when treating CCLGDHS. In addition, the inclusion of activating blood to promote blood circulation, relieving cramps and alleviating pain, and tonifying the spleen and stomach represents a new finding in the treatment principle for CCLGDHS.

关键词： Chronic cholecystitis common Chinese herbal medicines liver-gallbladder dampness-heat syndrome traditional Chinese medicine treatment

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho hon Leung Hang Wai Lee Wing-tak wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

Cupping,the Past and Present Application

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Chinese Medicine and Culture 2018年第3期1卷 121-126页

作者： Xun Lin hon Foong wong Shih Chau Ng International Education College Shanghai University of Traditional Chinese MedicineChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityMalaysia

Cupping is a therapy in which a cup is applied to the skin surface to cause local congestion through negative *** has a long history in many places such as China,Greece,Egypt,and the Middle *** ancient Chinese used animal horns as their cupping instrument,whereas in modern days there are a wide variety of choices ranging from bamboo cup to glass *** is simple,inexpensive and yet has wide *** has shown that it can promote blood circulation,stimulate nerve and muscle *** terms of application methods,fire cupping,liquid cupping and vaccum cupping were *** five application techniques(flashing,retaining,moving,needle retention and bleeding)and precautions of cupping are also discussed in ***,pathological reactions observed during the cupping process can be used to support Chinese Medicine diagnosis.

关键词： Application cupping history

Prevalence, correlates, attitude and treatment seeking of erectile dysfunction among type 2 diabetic Chinese men attending primary care outpatient clinics

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Asian Journal of Andrology 2014年第5期16卷 755-760,I0010页

作者： Wai hon Lo Sau Nga Fu Carlos King Ho wong Ee San Chen Department of Family Medicine and Primary Health Care Kowloon West Cluster Hospital Authority Hong Kong China Department of Family Medicine and Primary Care Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Linguistics School of Humanities University of Hong Kong Hong Kong China

To investigate the prevalence, correlates, attitude and treatment seeking behavior of erectile dysfunction （ED） in type 2 diabetes mellitus （T2DM） patients in the primary care setting, a multi-center cross-sectional survey using a structured anonymous self-administered questionnaire was performed in 10 general outpatient clinics. Of the 603 subjects （91% response rate）, the prevalence of ED men, as defined by the International Index of Erectile Function, was 79.1%. Most subjects had mild ED （28.9%）, followed by mild-to-moderate ED （27.9%）, then moderate ED （13.4%） and severe ED （9%）. Nearly 55% of those with ED did not consider themselves as having ED. Less than 10% of them had ever sought medical treatment, although 76.1% of them wished to receive management from doctor（s） should they be diagnosed with ED. They considered the most important management from doctors to be clinical assessment （41.7%）, followed by management of potential underlying cause （37.8%）, referral to specialist （27.5%）, education （23.9%）, prescription of phosphodiesterase type 5 inhibitors （16.9%） and referral to ~：ounseling service （6.7%）. The prevalence of ED was strongly associated with subjects who thought they had ED （odds ratio （OR） = 90.49 （20.00-409.48, P 〈 0.001）） and were from the older age group （OR = 1.043 （1.011-1.076, P = 0.008））. In conclusion, ED is highly prevalent among T2DM men. The majority of them wanted management from doctors should they have ED, but only a minority would actually voice out the request. Screening of ED among T2DM men using structural questionnaire allowed the diagnosis of more than half of the ED cases, which otherwise would have gone undiagnosed.

关键词： diabetes mellitus erectile dysfunction prevalence risk factors

Element-free Galerkin (EFG) method for analysis of the time-fractional partial differential equations

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Chinese Physics B 2012年第1期21卷 46-51页

作者： Ge hon-Xia Liu Yong-Qing cheng Rong-Jun Faculty of Science Ningbo UniversityNingbo 315211China Ningbo Institute of Technology Zhejiang UniversityNingbo 315100China

The present paper deals with the numerical solution of time-fractional partial differential equations using the element-free Galerkin （EFG） method, which is based on the moving least-square approximation. Compared with numerical methods based on meshes, the EFG method for time-fractional partial differential equations needs only scattered nodes instead of meshing the domain of the problem. It neither requires element connectivity nor suffers much degradation in accuracy when nodal arrangements are very irregular. In this method, the first-order time derivative is replaced by the Caputo fractional derivative of order α（0 〈 α≤ 1）. The Galerkin weak form is used to obtain the discrete equations, and the essential boundary conditions are enforced by the penalty method. Several numerical examples are presented and the results we obtained are in good agreement with the exact solutions.

关键词： element-free Galerkin (EFG) method meshless method time fractional partial differential equations

Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis

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Asian Journal of Andrology 2016年第5期18卷 716-722页

作者： Nan Li Chris KC wong C Yan cheng The Mary M. Wohlford Laboratory for Male Contraceptive Research Center for Biomedical Research Population Council 1230 York Avenue New York 10065 USA Department of Biology Hong Kong Baptist University Hong Kong China

Plastins are a family of actin binding proteins （ABPs） known to cross-link actin microfilaments in mammalian cells, creating actin microfilament bundles necessary to confer cell polarity and cell shape. Plastins also support cell movement in response to changes in environment, involved in cell/tissue growth and development. They also confer plasticity to cells and tissues in response to infection or other pathological conditions （e.g., inflammation）. In the testis, the cell-cell anchoring junction unique to the testis that is found at the Sertoli cell-cell interface at the blood-testis barrier （BTB） and at the Sertoli-spermatid （e.g., 8-19 spermatids in the rat testis） is the basal and the apical ectoplasmic specialization （ES）, respectively. The ES is an F-actin-rich anchoring junction constituted most notably by actin microfilament bundles. A recent report using RNAi that specifically knocks down plastin 3 has yielded some insightful information regarding the mechanism by which plastin 3 regulates the status of actin microfilament bundles at the ES via its intrinsic actin filament bundling activity. Herein, we provide a brief review on the role of plastins in the testis in light of this report, which together with recent findings in the field, we propose a likely model by which plastins regulate ES function during the epithelial cycle of sDermatogenesis via their intrinsic activity on actin microfilament organization in the rat testis.

关键词： actin binding proteins actin bundling proteins cytoskeleton F-actin fimbrins plastins seminiferous epithelial cycle spermatogenesis testis