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Safety threshold of intravitreal clonidine in rabbit's eyes

International Journal of Ophthalmology(English edition) 2018年第1期11卷 25-30页

作者： homayoun nikkhah Kiumars Heidari Garfami Mozhgan Rezaei Kanavi Ebrahim Mohammad Nashtaei Saeed Karimi Masoud Soheilian Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Torfeh Eye Hospital Shahid Beheshti University of Medical Sciences Ocular Tissue Engineering Research Center Shahid Beheshti University of Medical Sciences Labbafinejad Medical Center Shahid Beheshti University of Medical Sciences

AIM： To determine the safe dose of intravitreal clonidine（IVC）, a potential drug for neuroprotection and angiogenesis inhibition in rabbits. METHODS： A total of 28 rabbits were divided into four groups. Three groups received IVC with concentrations of 15（Group A）, 25（Group B）, and 50（Group C） g/0.1 m L and the control group（Group D） received 0.1 m L balanced salt solution（BSS）. To investigate IVC safety, electroretinography（ERG） was performed at baseline, then at 1, 4 and 8 wk after injection. After last ERG, all rabbits were euthanized, their eyes were enucleated and subjected to routine histopathological evaluation, immunohistochemistry for glial fibrillary acidic protein（GFAP） and terminal deoxynucleotidyl transferase d UTP nick end labeling（TUNEL） ***： Based on ERG, histopathology, GFAP and TUNEL assay findings, 15 g IVC was determined as the safe dose in rabbit eyes. While, the results of routine histopathology and TUNEL assay were unremarkable in all groups, toxic effects attributed to 25 and 50 g IVC were demonstrated by ERG and GFAP tests. CONCLUSION： Totally 15 g clonidine is determined as the safe dose for intravitreal injection in rabbits. Contribution of IVC in neuroprotection and inhibition of angiogenesis deserve more studies.

关键词： clonidine intravitreal injection electroretinography glial fibrillary acidic protein TUNEL assay

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Impact of coronary artery bypass grafting surgery on the chorioretinal biomicroscopic characteristics

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World Journal of Clinical Cases 2023年第28期11卷 6754-6762页

作者： Mansoor Shahriari homayoun nikkhah Mohammad Parsa Mahjoob Nazanin Behnaz Shahriar Barkhordari Kasra Cheraqpour Department of Ophthalmology Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Torfe Medical CenterTehran ***Iran Cardiovascular Diseases Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Ophthalmology Farabi Eye HospitalTehran ***Iran

BACKGROUND Most patients with cardiovascular disorders suffer from coronary artery diseases,which can be treated successfully using coronary artery bypass grafting(CABG).One of the unpleasant events following CABG is postoperative vision loss(POVL).Vulnerability of retinal vessels to hemodynamic changes,an expectable event following CABG,may contribute to the development of POVL,which might be associated with the changes in the choroidal and retinal *** To investigate postoperative changes in chorioretinal and peripapillary nerve fiber layer(NFL)thickness,and progression of diabetic and hypertensive retinopathy after *** In this prospective,cross-sectional study,49 eyes in 25 candidates for CABG underwent both ophthalmic and cardiovascular examinations within 6 mo prior to and 9 mo after *** Among the study participants,56%were male with a mean age of 62.84 years±10.49 years(range 33–80 years).Diabetes mellitus was observed in eight participants(32%).None of the patients suffered from postoperative anterior or posterior ischemic optic neuropathy,central retinal artery occlusion,and cortical *** mean value of the preoperative best corrected visual acuity was 0.11±0.10 logMAR(range,0–0.4),which worsened to 0.15±0.08 logMAR(range,0–0.4)after CABG(P=0.031).No significant difference was observed between the preand postsurgical choroidal(P=0.853)and macular(P=0.507)thickness,NFL thickness in the subfoveal(P>0.999)and peripapillary areas(P=0.659),as well as the severity of diabetic and hypertensive *** CABG may reduce visual acuity without affecting ocular *** vision reduction might be attributable to molecular or cellular variations,changes in visual pathway function,or central nervous system.

关键词： Coronary artery bypass grafting Nerve fiber layer Diabetic retinopathy Hypertensive retinopathy

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Incidence and risk factors of retinopathy of prematurity and utility of the national screening criteria in a tertiary center in Iran

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1330-1336页

作者： Milad Khorshidifar homayoun nikkhah Alireza Ramezani Morteza Entezari NarsisDaftarian Hamid Norouzi Mansoor Shahiari Mitra Radfar Ramin Norinia Saeed Karimi Clinical Research Development Unit of Torfe Medical Center Shahid Beheshti University of Medical SciencesTehran***Iran Department of Ophthalmology Imam Hossein HospitalShahid Beheshti University of Medical SciencesTehran***Iran Ophthalmic Research Center Shahid Beheshti University ofMedical SciencesTehran16666Iran Ophthalmic Epidemiology Research Center Shahid BeheshtiUniversity of Medical SciencesTehran16666Iran

AIM: To determine the incidence and risk factors of retinopathy of prematurity(ROP) and the sensitivity of current screening criteria in a tertiary eye center in Tehran, Iran. METHODS: In a cross-sectional observational study, neonates weighing ≤2000 grams at birth or born <34 wk gestational age(GA) and all other infants at risk of ROP admitted to the neonatal intensive care unit(NICU) or referred to our ROP clinic were investigated. The incidence of ROP and severe ROP(i.e. patients needing treatment) were determined. The associations between risk factors and the development and severity of ROP were assessed. We also examined the sensitivity of the current national screening guideline in Iran. RESULTS: Among 207 infants, the incidence of ROP and severe ROP was 33.3% and 11.1%, respectively. Mean GA and birth weight(BW) were significantly lower in ROP vs non-ROP infants(29±2 wk vs 33±3 wk, P<0.001;1274±489 g vs 1916±550 g, P<0.001, respectively). Univariate analysis displayed significant association between ROP incidence and GA, BW, NICU admission period, blood transfusion, surfactant usage, sepsis, intraventricular hemorrhage and patent ductus arteriosus(P<0.05 for all). BW [relative risk(RR): 0.857(0.711-0.873), P<0.001], GA [RR: 0.788(0.711-0.873), P<0.001] and blood transfusion [RR: 1.888(0.995-3.583), P=0.052] were independent ROP risk factors. The sensitivity of country-specific screening guidelines was 95.7% and 100% for overall and severe ROP detection, respectively. CONCLUSION: ROP incidence is relatively high in Iran. Identifying ROP risk factors results in more accurate screening and reduces the risk of irreversible vision loss. The ROP screening criteria utilized in Iran are efficient at the present time.

关键词： retinopathy of prematurity incidence risk factors screening Iran

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玻璃体腔组织纤溶酶原激活剂治疗玻璃体黄斑粘连（英文）

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国际眼科杂志 2018年第2期18卷 219-225页

作者： Saeed Karimi Masoud Soheilian homayoun nikkhah Azadeh Haseli Mofrad Shahid Beheshti医科大学 Torfeh眼科医院眼科研究中心伊朗德黑兰*** Shahid Beheshti医科大学 Labbafinejad眼科医院眼科研究中心伊朗德黑兰*** Shahid Beheshti医科大学 Torfe临床研究发展部伊朗德黑兰***

目的:评估仅玻璃体腔注射组织纤溶酶原激活剂(TPA)对玻璃体黄斑牵引以及玻璃体腔注射TPA和贝伐单抗对视网膜血管疾病的改善作用。方法:前瞻性研究。对24例24眼患者进行干预性系统研究。其中5眼玻璃体黄斑牵引综合征(VMT),19眼视网膜血... 详细信息

目的:评估仅玻璃体腔注射组织纤溶酶原激活剂(TPA)对玻璃体黄斑牵引以及玻璃体腔注射TPA和贝伐单抗对视网膜血管疾病的改善作用。方法:前瞻性研究。对24例24眼患者进行干预性系统研究。其中5眼玻璃体黄斑牵引综合征(VMT),19眼视网膜血管疾病包括:糖尿病黄斑水肿(DME)眼,糖尿病性玻璃体出血(VH)眼,视网膜中央静脉阻塞(CRVO)和新生血管年龄相关性黄斑变性眼(AMD)。在注射前及注射1mo后分别进行视力,B超和OCT检查。3眼VMT接受玻璃体腔单次注射TPA50μg,2眼接受100μg注射。19例视网膜血管疾病患者接受玻璃体腔组织纤溶酶原激活剂(50μg)和贝伐单抗(1.25 mg)联合治疗。结果:纳入病例中男性10眼视网膜血管疾病和VMT患者平均年龄分别为56.8y和60.4y。纳入病例中男性10眼(41.7%),女性14眼(58.3%)。22眼(91.7%)晶状体眼,2眼(8.3%)人工晶状体眼。VMT和视网膜血管疾病的玻璃体后部脱离(PVD)分别为0(0/5)和57.8%(11/19)(P=0.04)。在改善最佳矫正视力(BCVA)和降低黄斑中心凹厚度(CMT)方面,与无PVD眼相比,有PVD眼改善更多。结论:在VMT患者中,单独玻璃体腔内注射TPA不能成功诱导玻璃体后部完全脱离。玻璃体腔联合注射TPA和贝伐单抗可引起视网膜血管疾病患者玻璃体后部脱离,提高最佳矫正视力以及降低黄斑中心凹厚度。

关键词：贝伐单抗玻璃体后部脱离组织纤维蛋白溶酶原激活剂

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活动性葡萄膜炎引起暂时性屈光度变化（英文）

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国际眼科杂志 2019年第10期19卷 1637-1642页

作者： Mahsa Zameni homayoun nikkhah Safa Rahmani Alireza Ramezani Mehdi Yaseri Masoud Soheilian Shahid Beheshti医科大学 Labbafinejad医疗中心眼科研究中心伊朗德黑兰*** Shahid Beheshti医科大学Torfeh医院眼科伊朗德黑兰*** 哈佛医学院 Massachusetts眼耳医院眼科美国波士顿60611 Shahid Beheshti医科大学眼科流行病研究中心伊朗德黑兰*** 德黑兰医科大学公共卫生学院流行病学与生物统计学系伊朗德黑兰*** Negah眼科医院伊朗德黑兰***

目的:评估活动性葡萄膜炎对屈光不正变化的影响。方法:这是一项前瞻性队列研究,纳入66例88眼活动性葡萄膜炎患者。受试者根据其疾病活动的解剖位置分为前、中、后和全葡萄膜炎。在活动期和静止期均行睫状肌麻痹验光,并对结果进行比较。... 详细信息

目的:评估活动性葡萄膜炎对屈光不正变化的影响。方法:这是一项前瞻性队列研究,纳入66例88眼活动性葡萄膜炎患者。受试者根据其疾病活动的解剖位置分为前、中、后和全葡萄膜炎。在活动期和静止期均行睫状肌麻痹验光,并对结果进行比较。结果:活动性前非肉芽肿性葡萄膜炎的球镜变化导致平均-0.25(0.77)D(95%CI:-0.5~0)的近视转变(P=0.039),在活动性中层葡萄膜炎中,平均+0.39(0.8)D(95%CI:0.09~0.69)的远视转变(P=0.003)。活动性中层葡萄膜炎的等效球镜的变化导致远视转变[+0.43(0.94)D,95%CI:0.08~0.79,P=0.005]。柱镜仅在全色素膜炎时有明显改变[-0.3(0.39)D,95%CI:-0.58^-0.02,P=0.043]。在多元分析中,我们发现疾病活动过程(急性与复发)和疾病活动的解剖位置对等效球镜变化具有统计学意义(分别为P=0.003和P=0.004)结论:活动性葡萄膜炎对屈光度有重要影响,该变化取决于具体的炎症发生部位。

关键词：前葡萄膜炎中间葡萄膜炎后葡萄膜炎全葡萄膜炎屈光不正

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