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Molecular markers of systemic therapy response in urothelial carcinoma

Asian Journal of Urology 2021年第4期8卷 376-390页

作者： Francesco Claps Maria Carmen Mir homayoun zargar Department of Urology Fundacion Instituto Valenciano de OncologiaValenciaSpain Urological Clinic Department of MedicineSurgery and Health SciencesUniversity of TriesteTriesteItaly Department of Urology Royal Melbourne HospitalMelbourneVictoriaAustralia Department of Surgery University of MelbourneMelbourneVictoriaAustralia

Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer *** carcinoma is a very heterogeneous disease and responses to systemic therapies,and outcomes after radical cystectomy are difficult to *** in molecular biology such as next generation sequencing and whole genome or transcriptomic analysis provide promising platforms to achieve a full understanding of the biology behind the disease and can identify emerging predictive ***,the ability to categorize patients’risk of recurrence after curative treatment,or even predict benefit from a conventional or targeted therapies,represents a compelling challenge that may reshape both selection for tailored treatment and disease *** has been made but currently no molecular biomarkers are used in the clinical setting to predict response to systemic agents in either neoadjuvant or adjuvant settings highlighting a relevant unmet ***,we aim to present the emerging role of molecular biomarkers in predicting response to systemic agents in urothelial carcinoma.

关键词： Urothelial carcinoma Biomarkers Neoadjuvant chemotherapy Adjuvant chemotherapy Targeted therapies Precision oncology

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Squamous cell carcinoma of the scrotum: A look beyond the chimneystacks

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World Journal of Clinical Cases 2014年第11期2卷 654-660页

作者： Ritva Vyas homayoun zargar Rossella Di Trolio Giuseppe Di Lorenzo Riccardo Autorino Department of Dermatology University Hospitals Case Medical Center Cleveland OH 44106 United States Glickman Urological and Kidney Institute Cleveland Clinic Cleveland OU 44195 United States Unit of Medical Oncology and Innovative Therapy National Cancer Institute "Fondazione Giovanni Pascale" 80100 Napoli Italy Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology Division University Federico II 80100 Napoli Italy Urology Institute University Hospitals Case Medical Center Cleveland OH 44106 United States Urology Unit Second University of Naples80100 Naples Italy

Despite the low incidence, squamous cell carcinoma(SCC) remains the most common scrotal malignancy featuring a propensity for recurrence and metastasis. In recent years there has been a significant change in the epidemiology of scrotal SCC. Surgery is the mainstay of treatment for resectable disease. Sentinel lymph node dissection similar to algorithm for patients with penile SCC can reduce the morbidity of routine lymph node dissection. Emerging treatments for advanced and metastatic SCC are at the cusp of significantly changing management of this disease. We have performed a comprehensive review of scrotal SCC with a focus on these topics.

关键词： Squamous cell carcinoma Genital cancer Scrotal cancer

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