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Sheep numbers required for dry matter digestibility evaluations when fed fresh perennial ryegrass or forage rape

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Animal Nutrition 2017年第1期3卷 61-66页

作者： Xuezhao Sun Linda Krijgsman Garry C.Waghorn holly Kjestrup John Koolaard David Pacheco Grasslands Research Centre Agresearch Limited DairyNZ Limited

Research trials with fresh forages often require accurate and precise measurement of digestibility and variation in digestion between individuals, and the duration of measurement periods needs to be established to ensure reliable data are obtained. The variation is likely to be greater when freshly harvested feeds are given, such as perennial ryegrass(Lolium perenne L.) and forage rape(Brassica napus L.),because the nutrient composition changes over time and in response to weather conditions. Daily feed intake and faeces output data from a digestibility trial with these forages were used to calculate the effects of differing lengths of the measurement period and differing numbers of sheep, on the precision of digestibility, with a view towards development of a protocol. Sixteen lambs aged 8 months and weighing 33 kg at the commencement of the trial were fed either perennial ryegrass or forage rape(8/treatment group) over 2 periods with 35 d between measurements. They had been acclimatised to the diets, having grazed them for 42 d prior to 11 days of indoor measurements. The sheep numbers required for a digestibility trial with different combinations of acclimatisation and measurement period lengths were subsequently calculated for 3 levels of imposed precision upon the estimate of mean dry matter(DM) digestibility. It is recommended that if the standard error of the mean for digestibility is equal to or higher than 5 g/kg DM, and if sheep are already used to a fresh perennial ryegrass or forage rape diet,then a minimum of 6 animals are needed and 4 acclimatisation days being fed individually in metabolic crates followed by 7 days of measurement.

关键词： Sheep Digestibility Fresh forage Sample size

Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna LCarter Katie Hege Jay Yang Hasini AKalpage Yongwei Su holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering Laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AML)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AML and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AML by investigating molecular pathways uniquely relevant to AML cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AML cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AML *** addition,we describe clinical investigations that have led to FDA approval of new targeted AML therapies and ongoing clinical trials of novel therapies targeting AML survival *** also describe the complexity of targeting leukemia stem cells(LSCs)as an approach to addressing relapse and remission in AML and targetable pathways that are unique to LSC *** comprehensive review details what we currently understand about the signaling pathways that support AML cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

2016 the Year in Review

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城市漫步（上海版、英文） 2016年第12期 51-61页

作者： holly Li 不详

For many in the West,2016 will be remembered for Trump,Brexit,terrorism in Europe and an absur d number of pop culture deaths,from Bowie to Mohammed *** comparison,China had an unusually quiet ***,there were still a few goings-on in the world's most populous *** the next 10 pages we recap the best(and worst)of China's 2016 in the worlds of technology,social media,sport,fashion,food and arts.

关键词： remember unusual culture

Antioxidant properties and sensory evaluation of microgreens from commercial and local farms

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Food Science and Human Wellness 2020年第1期9卷 45-51页

作者： Libo Tan holly Nuffer Jiannan Feng Shu Hang Kwan Hsiangting Chen Xiao Tong Lingyan Kong Department of Human Nutrition and Hospitality Management University of AlabamaTuscaloosaAL 35487USA Department of Clothing Textile&Interior DesignUniversity of AlabamaTuscaloosaAL 35487USA

Microgreens are young and tender vegetables or herbs that provide attractive color,flavor,and *** purpose of this study was to evaluate the nutritional and sensory qualities of broccoli microgreens grown by different methods(hydroponically *** grown)and from different sources(commercial *** farm).No significant difference in total phenolic concentration and antioxidant capacity was found in all broccoli microgreens,but a significantly higher chlorophyll concentration was found in farm microgreens than the commercial ***,the soil-grown farm microgreens possessed a significantly higher vitamin C concentration than hydroponically-grown farm sample and commercial *** in the sensory study favored farm samples regardless of growing method,and their overall liking was significantly correlated with taste of the *** addition,six other microgreens from the local farm were analyzed for their nutritional *** conclusions suggested a potential for consumers to still benefit nutritionally by purchasing commercial microgreens at a lower cost;however,it may be worthwhile for consumers to purchase microgreens from local farms for a better sensory experience.

关键词： Microgreens Antioxidant Phenolic Chlorophyll Sensory Hydroponics

Microhabitat use by white-footed mice Peromyscus leucopus in forested and old-field habitats occupied by Morrow's honeysuckle Lonicera morrowii

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Current Zoology 2009年第2期55卷 111-122页

作者： Jennifer A. EDALGO holly M. McCHESNEY Jason P. LOVE James T. ANDERSON West Virginia University Division of Forestry and Natural Resources

We quantified microhabitat use by white-footed mice Peromyscus leucopus in forest and old-field habitats occupied by Morrow＇ s honeysuckle Lonicera morrowii, an invasive exotic shrub imported from Japan. Microhabitat characteristics were compared between trails used by mice （ n = 124） and randomly selected trails （ n = 127） in 4 study plots located at Fort Necessity National Battlefield, Farmington, Pennsylvania, USA. We compared 10 mierohabitat variables between used and random trails using non-metric multidimensional scaling （NMDS） and classification and regression tree （CART） analysis. Trails used by mice were statistically different from randomly selected trails in both forested plots （ P 〈 0. 008） and old-field plots （ P 〈 0. 001 ）. In the forested plots, trails of white-footed mice were more often associated with a greater percent cover （% cover） of coarse woody debris （CWD） than were randomly selected trails. In the old-field plots, mouse trails were commonly characterized by having a lower % cover of exotic herbaceous vegetation, a greater % cover of shrubs, and a greater % cover of Morrow＇ s honeysuckle than randomly selected trails. Our study indicates that white-footed mice do not move randomly and prefer areas of high structural complexity, thereby showing significant microhabitat preference. The preference of white-footed mice for areas with a relatively high percent cover of Morrow＇s honeysuckle could 1 ） be a factor in the aggressive nature of the exotic honeysuckle shrub＇s spread throughout the Battlefield or 2） cause the shrub to spread even faster into adjacent areas not yet occupied by Morrow＇ s honeysuckle

关键词： Microhabitat selection Morrow' s honeysuckle Peromyscus White-footed mice Exotic species Seed distribution

Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model

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Neural Regeneration Research 2021年第2期16卷 338-344页

作者： Hongzhi Wang Emily W.Baker Abhyuday Mandal Ramana M.Pidaparti Franklin D.West holly A.Kinder Department of Statistics University of GeorgiaAthensGAUSA Regenerative Bioscience Center University of GeorgiaAthensGAUSA Department of Animal and Dairy Science University of GeorgiaAthensGAUSA College of Engineering University of GeorgiaAthensGAUSA

Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia I

关键词： controlled cortical impact gait analysis linear regression magnetic resonance imaging motor function pediatric pig model principal component analysis traumatic brain injury

THE INTERNATIONALIZATION OF THE LEGAL SERVICES MARKET： AN INTERNATIONAL WORKSHOP AT THE CENTER FOR COMMON LAW

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Frontiers of Law in China-Selected Publications from Chinese Universities 2016年第3期11卷 575-577页

作者： McKenzie, holly Univ Leeds Leeds LS2 9JT W Yorkshire England Great Britain China Ctr London England

On March 22, 2016, the Center for Common Law （CCL） at Renmin University of China Law School held a workshop entitled The Internationalization of the Legal Services Market. The workshop was jointly organized by the Great Britain China Centre （GBCC）, and was supported by the All China Lawyers Association （ACLA）, Beijing Lawyers Association, Shenzhen Lawyers Association, and the Law Society of England and Wales. It covered methods of and strategies for international cooperation in the legal profession and was attended by thirty practicing lawyers.

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基于内容分析法的生态旅游内涵辨析

生态学报 2006年第4期26卷 1213-1220页

作者：卢小丽武春友 holly Donohoe 大连理工大学管理学院辽宁大连116024 加拿大渥太华大学地理学院

随着生态旅游的流行与快速发展对生态旅游这个术语的概念也不断的增长扩散。由于缺乏对其内涵的科学认知和梳理,生态旅游概念的应用具有泛化的危险。不断涌现出的大量有关生态旅游的概念给学术研究和旅游管理带来了许多困惑。运用内容... 详细信息

随着生态旅游的流行与快速发展对生态旅游这个术语的概念也不断的增长扩散。由于缺乏对其内涵的科学认知和梳理,生态旅游概念的应用具有泛化的危险。不断涌现出的大量有关生态旅游的概念给学术研究和旅游管理带来了许多困惑。运用内容分析的方法对中外旅游文献近10～15a内有影响力的40个生态旅游概念进行了分析,提炼出生态旅游概念中最频繁出现的能代表其内涵的6个标准,它们是:以自然为基础、对保护的贡献、当地社区受益、环境教育、道德规范与责任和可持续性。通过对这些标准的识别,结合先前的生态旅游概念,本文对生态旅游的概念在操作层面上进行了重新架构,将生态旅游这一术语定义为:生态旅游是以可持续旅游和伦理道德规范原则为指导,在旅游过程中强调环境教育、影响管理和社区受益,并为其所依赖的环境保护做贡献的负责任的自然之旅。

关键词：生态旅游内容分析法概念架构

Beyond the Modern Facade- A Journey into Beijing's Hutongs

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China Today 2000年第2期49卷 31-35页

作者： holly Krambeck

"Thealleystwistandwindthro***:tinymarkets,noodleshops,oldmensittinginthewaningsun,childrenplaying,donkeycarts,strollinglovers,ancientgatewaystowalled-courtyards... 详细信息

"Thealleystwistandwindthro***:tinymarkets,noodleshops,oldmensittinginthewaningsun,childrenplaying,donkeycarts,strollinglovers,ancientgatewaystowalled-courtyards...

关键词： A Journey into Beijing’s Hutongs Beyond the Modern Facade