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Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration

Neural Regeneration Research 2019年第7期14卷 1280-1288页

作者： holly m.howarth Turki Alaziz Brogan Nicolds Shawn O'Connor Sameer B.Shah Department of Bioengineering University of California Department of Orthopaedic Surgery University of California School of Exercise and Nutritional Sciences San Diego State University Research Service VA San Diego Healthcare System

End-to-end repair under no or low tension leads to improved outcomes for transected nerves with short gaps,compared to repairs with a ***,grafts are typically used to enable a tension-free repair for moderate to large gaps,as excessive tension can cause repairs to fail and catastrophically impede *** this study,we tested the hypothesis that unloading the repair interface by redistributing tension away from the site of repair is a safe and feasible strategy for end-to-end repair of larger nerve ***,we tested the hypothesis that such an approach does not adversely affect structural and functional *** this study,we used a rat sciatic nerve injury model to compare the integrity of repair and several regenerative outcomes following end-to-end repairs of nerve gaps of increasing *** addition,we proposed the use of a novel implantable device to safely repair end-to-end repair of larger nerve gaps by redistributing tension away from the repair *** data suggest that redistriubution of tension away from the site of repair enables safe end-to-end repair of larger gap *** addition,structural and functional measures of regeneration were equal or enhanced in nerves repaired under tension – with or without a tension redistribution device – compared to tension-free *** that repair integrity is maintained,end-to-end repairs under tension should be considered as a reasonable surgical *** animal experiments were performed under the approval of the Institutional Animal Care and Use Committee of University of California,San Diego(Protocol S11274).

关键词： tension biomechanics strain end-to-end repair peripheral nerve nerve regeneration

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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： holly Flyger Samantha J.Holdsworth Alistair J.Gunn Laura Bennet Hamid Abbasi mātai medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Brain Banking for Research into Neurodegenerative Disorders and Ageing

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Neuroscience Bulletin 2019年第2期35卷 283-288页

作者： Claire E.Shepherd holly Alvendia Glenda m.Halliday Neuroscience Research Australia and the University of New South Wales New York University Brain and mind Centre Sydney Medical School University of Sydney

Advances in cellular and molecular biology underpin most current therapeutic advances in *** advances for neurological and neurodegenerative diseases are hindered by the lack of similar specimens. It is becoming increasingly evident that greater access to human brain tissue is necessary to understand both the cellular biology of these diseases and their variation. Research in these areas is vital to the development of viable therapeutic options for these currently untreatable diseases. The development and coordination of human brain specimen collection through brain banks is evolving. This perspective article from the Sydney Brain Bank reviews data concerning the best ways to collect and store material for different research purposes.

关键词： Brain banking Brain donation Neurodegenerative diseases Human brain tissue processing

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Acyclic Complexes and Gorenstein Rings

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Algebra Colloquium 2020年第3期27卷 575-586页

作者： Sergio Estrada Alina Iacob holly Zolt Departamento de matematicas Universidad de MurciaMurcia 30100Spain Department of mathematical Sciences Georgia Southern University StatesboroGA 30460-8093USA

For a given class of modules A,let A be the class of exact complexes having all cycles in A,and dw(A)the class of complexes with all components in *** by GL the class of Gorenstein injective *** prove that the following are equivalent over any ring R:every exact complex of injective modules is totally acyclic;every exact complex of Gorenstein injective modules is in every complex in dw(GL)is dg-Gorenstein *** analogous result for complexes of flat and Gorenstein flat modules also holds over arb计rary *** the ring is n-perfect for some integer n≥0,the three equivalent statements for flat and Gorenstein flat modules are equivalent with their counterparts for projective and projectively coresolved Gorenstein flat *** also prove the following characterization of Gorenstein *** R be a commutative coherent ring;then the following are equivalent:(1)every exact complex of FP-injective modules has all its cycles Ding injective modules;(2)every exact complex of flat modules is F-totally acyclic,and every R-modulc m such that m^(+)is Gorenstein flat is Ding injective;(3)every exact complex of injectives has all its cycles Ding injective modules and every R-module m such that is Gorenstein flat is Ding *** R has finite Krull dimension,statements(1)-(3)are equivalent to(4)R is a Gorenstein ring(in the sense of Iwanaga).

关键词： totally acyclic complex Gorenstein injective module Gorenstein projective module Gorenstein flat module Ding injective module

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Consequences of redefining Alzheimer＇s disease in terms of amyloid burden without regard to cognitive decline

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Neural Regeneration Research 2018年第12期13卷 2098-2099页

作者： Stephen R.Robinson holly m.Brothers maya L.Gosztyla School of Health and Biomedical Sciences RMIT University Bundoora Victoria Australia Institutefor Breathing and Sleep Austin Health Heidelberg VictoriaAustralia Department of Psychology The Ohio State University ColumbusOH USA Department of Neuroscience the Ohio State UniversityColumbus OH USA

Alzheimer＇s disease（AD）redefined：For the past century,AD has been defined as a disease of progressive cognitive decline paired with a burden of amyloid-β（Aβ）plaques and pathologic tau tangles in the hippocampus and ***,a recent Framework paper jointly sponsored by the National Institute on Aging and the Alzheimer＇s Association（Jack et al.,2018）proposes new classification guidelines for AD,which,if adopted,will have profoundconsequences for the future management of AD.

关键词： AD Consequences of redefining Alzheimer’s disease in terms of amyloid burden without regard to cognitive decline

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Transient gene expression in western white pine using agroinfiltration

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Journal of Forestry Research 2020年第5期31卷 1823-1832页

作者： Zhenguo ma Jun-Jun Liu Arezoo Zamany holly Williams Canadian Forest Service Natural Resources Canada506 West Burnside RoadVictoriaBC V8Z 1M5Canada

A method for transient gene expression was developed for western white pine(WWP,Pinus monticola *** ***)using reporter gene uidA encodingβ-glucuronidase(GUS).GUS was transiently expressed in cross sections of primary and secondary needles,cotyledons,and current and second year stems of WWP via vacuum-infiltration with Agrobacterium *** assays of cross sections of secondary needles showed stronger blue color indicating GUS expression at day 1 and 2 than on other days post agroinfiltration(dpa).GUS activity expressed inside WWP cells was confirmed using light *** fluorometric assays,GUS expression was high at 1 dpa and lasted until 4 dpa in detached secondary needles,while similarly high expression levels only lasted until 2 dpa in attached secondary needles then dropped *** the length of GUS-staining zones varied among different WWP organs and between growth and dormant seasons,all tested WWP tissues using the protocol had high levels of transient GUS ***,heterologous candidate genes or endogenous silencing can be expressed in various WWP tissues or organs using this agroinfiltration *** current protocol for efficient transient gene expression will aid functional genomics study of WWP and its pathogens and related conifer species.

关键词： Agrobacterium Agroinfiltration β-glucuronidase Transient gene expression Western white pine

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Identification of predictive mRI and functional biomarkers in a pediatric piglet traumatic brain injury model

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Neural Regeneration Research 2021年第2期16卷 338-344页

作者： Hongzhi Wang Emily W.Baker Abhyuday mandal Ramana m.Pidaparti Franklin D.West holly A.Kinder Department of Statistics University of GeorgiaAthensGAUSA Regenerative Bioscience Center University of GeorgiaAthensGAUSA Department of Animal and Dairy Science University of GeorgiaAthensGAUSA College of Engineering University of GeorgiaAthensGAUSA

Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(mRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant mRI biomarkers and predict functional outcomes using mRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric mRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the mRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if mRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant mRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia I

关键词： controlled cortical impact gait analysis linear regression magnetic resonance imaging motor function pediatric pig model principal component analysis traumatic brain injury

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Howl variation across Himalayan, North African, Indian, and Holarctic wolf clades： tracing divergence in the world＇s oldest wolf lineages using acoustics

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Current Zoology 2017年第3期63卷 341-348页

作者： Lauren HENNELLY Bilal HABIB holly ROOT-GUTTERIDGE Vicente PALACIOS Daniela PASSILONGO Department of Animal Ecology and Conservation Biology Wildlife Institute of India Dehradun India Department of Biology Syracuse University New York 13210 USA Cavanilles Institute for Biodiversity and Evolutionary Biology University of Valencia Avenue de Blasce Ibanez Valencia 46010 Spain Ricerca sulla Selvaggina e sui miglioramenti Ambientali a Fini Faunistici (C.I.R.Se.m.A.E) Piazzale delle Cascine 18 Firenze 1-50144 Italy

Vocal divergence within species often corresponds to morphological, environmental, and genetic differences between populations. Wolf howls are long-range signals that encode individual, group, and subspecies differences, yet the factors that may drive this variation are poorly understood. Furthermore, the taxonomic division within the Canis genus remains contended and additional data are required to clarify the position of the Himalayan, North African, and Indian wolves within Canis lupus. We recorded 451 howls from the 3 most basal wolf lineages-Himalayan C. lupus chanco-Himalayan haplotype, North African C. lupus lupaster, and Indian C. lupus pallipes wolves-and present a howl acoustic description within each clade. With an additional 619 howls from 7 Holarctic subspecies, we used a random forest classifier and principal component analysis on 9 acoustic parameters to assess whether Himalayan, North African, and Indian wolf howls ex- hibit acoustic differences compared to each other and Holarctic wolf howls. Generally, both the North African and Indian wolf howls exhibited high mean fundamental frequency （F0） and short duration compared to the Holarctic clade. In contrast, the Himalayan wolf howls typically had lower mean F0, unmodulated frequencies, and short howls compared to Holarctic wolf howls. The Himalayan and North African wolves had the most acoustically distinct howls and differed significantly from each other and to the Holarctic wolves. Along with the influence of body size and environmental differences, these results suggest that genetic divergence and/or geographic distance may play an important role in understanding howl variation across subspecies.

关键词： acoustic variation Canis lupus geographic variation mammal communication.

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Towards designing telepresence robot navigation for people with disabilities

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International Journal of Intelligent Computing and Cybernetics 2014年第3期7卷 307-344页

作者： Katherine m.Tsui Eric mcCann Amelia mcHugh mikhail medvedev holly A.Yanco David Kontak Jill L.Drury Department of Computer Science University of Massachusetts LowellLowellMassachusettsUSA Assistive Technology Services Crotched Mountain Rehabilitation CenterGreenfieldNew HampshireUSA multimedia and Collaboration Department The MITRE CorporationBedfordMassachusettsUSA

Purpose–The authors believe that people with cognitive and motor impairments may benefit from using of telepresence robots to engage in social *** date,these systems have not been designed for use by people with disabilities as the robot *** paper aims to discuss these ***/methodology/approach–The authors conducted two formative evaluations using a participatory action design ***,the authors conducted a focus group(n¼5)to investigate how members of the target audience would want to direct a telepresence robot in a remote environment using *** authors then conducted a follow-on experiment in which participants(n¼12)used a telepresence robot or directed a human in a scavenger hunt ***–The authors collected a corpus of 312 utterances(first hand as opposed to speculative)relating to spatial ***,the analysis of the corpus supported several speculations put forth during the focus ***,it showed few statistically significant differences between speech used in the human and robot agent conditions;thus,the authors believe that,for the task of directing a telepresence robot’s movements in a remote environment,people will speak to the robot in a manner similar to speaking to another *** implications–Based upon the two formative evaluations,the authors present four guidelines for designing speech-based interfaces for telepresence ***/value–Robot systems designed for general use do not typically consider people with *** work is a first step towards having our target population take the active role of the telepresence robot operator.

关键词： Focus groups User studies Computer-mediated communication Design guidelines Human-robot interaction Spatial navigation command

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Growth of ZnO self-converted 2D nanosheet zeolitic imidazolate framework membranes by an ammoniaassisted strategy

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Nano Research 2018年第4期11卷 1850-1860页

作者： Yujia Li Lu Lin min Tu Pei Nian Ashlee J. howarth Omar K. Farha Jieshan Qiu Xiongfu Zhang State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116024 China International Institute for Nanotechnology Department of Chemistry Northwestern University 2145 Sheridan Road Evanston IL 60208 USA Center for Surface Chemistry and Catalysis KU Leuven-University ofLeuven Leuven Belgium Department of Chemistry Faculty of Science King Abdulaziz University Jeddah Saudi Arabia

Shaping crystalline porous materials such as metal organic frameworks （mOFs） and zeolites into two-dimensional （2D） nanosheet forms is highly desirable for developing high-performance molecular sieving membranes. However, conventional exfoliation-deposition is complex and challenging for the large-scale fabrication of nanosheet mOF tubular membranes. Here, for the first time, we report a direct growth technique by ZnO self-conversion and ammonia assistance to fabricate zeolitic imidazolate framework （ZIF） membranes consisting of 2D nanosheets on porous hollow fiber substrates; the membranes are suitable for large-scale industrial gas separation processes. The proposed fabrication process for ZIF nanosheet membranes is based on the localized self-conversion of a pre-deposited thin layer of ZnO in a ligand solution containing ammonium hydroxide as a modulator. The resulting ZIF 2D nanosheet tubular membrane is highly oriented and only 50 nm in thickness. It exhibits excellent molecular sieving performance, with high H2 permeance and selectivity for H2/CO2 separation. This technique shows great promise in mOF nanosheet membrane fabrication for large-scale molecular sieving applications.

关键词： nanosheet nanosheet membrane metal organic framework membrane oriented growth gas separation

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