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Low-cost and cleanroom-free fabrication of microneedles

Microsystems & Nanoengineering 2018年第1期4卷 518-524页

作者： hojatollah rezaei nejad Aydin Sadeqi Gita Kiaee Sameer Sonkusale Department of Electrical and Computer Engineering Nano LabTufts UniversityMedfordMA 02155USA Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA

We present a facile,low-cost and cleanroom-free technique for the fabrication of microneedles using molds created by laser *** mold with high aspect ratios is achieved on acrylic sheet by engraving a specific pattern of crossover lines(COL)using CO2 laser *** COL pattern on the acrylic sheet creates a sharp conical shape in the center of the *** have shown that a variety of microneedle shapes with different heights and tip angles can be easily achieved by changing the number and the length of the ***(PDMS)microneedles were fabricated by casting the PDMS on the *** resulted PDMS microneedles are oxygen plasma treated and then *** PDMS layer is casted on PDMS microneedles and detached after *** silanization prevents those two layers of PDMS from bonding to each other and makes them easily *** detachment of the PDMS mold of microneedles,the mold is used to fabricate degradable polyvinyl alcohol microneedle patch suitable for transdermal drug *** release kinetics of the needles are also shown and discussed in order to prove the applicability of the needles.

关键词： drug delivery laser ablation microneedles

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Three dimensional printing of metamaterial embedded geometrical optics(MEGO)

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Microsystems & Nanoengineering 2019年第1期5卷 542-551页

作者： Aydin Sadeqi hojatollah rezaei nejad Rachel E.Owyeung Sameer Sonkusale Nano Lab Department of Electrical and Computer EngineeringTufts UniversityMedfordMA 02155USA Department of Chemical and Biological Engineering Tufts UniversityMedfordMA 02155USA

Three-dimensional printers have revolutionized many scientific fields with its low-cost,accessibility and ease of *** this paper,we show how stereolithography(SLA)based 3D printers can enable realization of innovative 3D optical devices formed through the fusion of metamaterials with geometrical optics or *** utilizes a combination of desktop SLA 3D printer and metal deposition/coating *** this approach,we present innovative metamaterial embedded optical components such as mushroom-type metamaterials,curved wide-angle metamaterial absorbers/reflectors and a frequency selective moth eye hemispherical *** a unique MEGO device formed through the fusion of a frequency selective metamaterial with an optical parabolic reflector has been demonstrated that combines their individual properties in a single *** fabricated MEGO devices operate in the millimeter wave frequency *** and measurement results using terahertz continuous-wave spectrometer validate their functionality and *** improving resolution in 3D printing,MEGO devices will be able to reach Terahertz and optical frequencies in the near future.

关键词： millimeter printing optics

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Manganese toxicity in the central nervous system: Decreeing of catecholamine in rat’s brains

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Health 2013年第12期5卷 2146-2149页

作者： Vahid Yousefi Babadi Leyla Sadeghi Esmaiel Amraie Mohammad rezaei Ali Akbar Malekirad Meghdad Abarghouei nejad Department of Biochemistry Faculty of Biological Science Tarbiat Modares University Tehran Iran Department of Biology Faculty of Sciences Payam Noor University Iran Department of Food Safety and Hygiene School of Public Health Tehran University of Medical Sciences Tehran Iran Meghdad.abarghouei.nejad@*** Payam Noor University Iran Physiology Research Center Isfahan Cardiovascular Research Center Isfahan Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran

Manganese is an essential metal in human that functions in many enzymes. In contrast excessive exposure to Mn results in neurotoxicity. Accumulation of manganese damages central nervous system and causes Parkinson disease like syndrome called manganism. Mn neurotoxicity has been suggested to involve an imbalance in catecholamine neurotransmitters. It hypothesized that Mn can obstruct catecholamine synthesis pathway by inhibition of Tyrosine hydroxylase. Previous studies demonstrated that chronic and acute dose of Mn has different possible effects on catecholamine synthesis. It’s assumed that an acute dose of manganese can kill dopaminergic cells. Therefore, we focused the effect of Mn in catecholamine concentration on the rat’s brain by MnCl2 injection intraperitoneally and analyzed their brains after the time interval. This study used different acute doses in short time courses and different chronic doses at different exposing times to investigate which of them (exposing dose or time) is more important in Mn toxic effect. Measurement of catecholamine concentration performed by fluorescence assay in acidic and oxidant environment.

关键词： Manganese Neurotoxicity Catecholamine Toxicology

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Evaluation of Abuse Drugs and Clinical Laboratory Tests Variations in Whole Blood ＆ Urine Samples of Abusers

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 69-76页

作者： Majid rezaei Basiri Mojgan Behshid Alireza Najafi Saleh Alilou Haniyeh Mohebbi-Kamali: Fatemeh Hosseindoust Marziyeh Mokhtari Valiyollah Watani Ladan Aminzadeh Fatemeh Seyed nejad Ashraf Razavi Ligha Saadat Department of Pharmacology and Toxicology School of Pharmacy Tabriz University of Medical Sciences Tabriz 51999 Iran Medical Education Research Center Tabriz University of Medical Sciences Tabriz 51999 Iran Department of Medical Surgical School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz 51999 Iran Forensic and Legal Medicine of Organization Tabriz 515 7733541 Iran Welfare Organization of East Azarbayjan Tabriz 5156935 761 Iran

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