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禽流感病毒非结构蛋白1单克隆抗体的制备及其特异性分析

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现代免疫学 2007年第6期27卷 493-498页

作者：丁细霞 hoi-wah tsoi 陈伟俊丘立文王压娣廖志勇袁国勇车小燕南方医科大学珠江医院临床医学基础研究所广州510282 香港大学微生物系

为研制禽流感病毒(H5N1)非结构蛋白1(NS1)的特异性单克隆抗体(mAb),并鉴定其特异性,本研究在分别表达了具有良好抗原性的A/Vietnam/1194/04(H5N1)-NS1和A/HongKong/486/97(H5N1)-NS1重组蛋白基础上,用A/Viet-nam/1194/04(H5N1)-NS1蛋白免疫BALB/c小鼠,取其脾细胞与小鼠骨髓瘤细胞进行融合,间接ELISA筛选阳性的杂交瘤细胞,并结合免疫荧光和免疫印迹对抗体的特异性进行鉴定,通过竞争抑制实验对单抗识别的抗原位点进行分析。结果共获得19株能识别4个H5N1-NS1蛋白不同抗原位点的mAb,亚类测定显示,5株为IgG2a、1株为IgG2b,另外13株为IgG1。这些mAb均与A/Vietnam/1194/04(H5N1)-NS1和A/HongKong/486/97(H5N1)-NS1重组蛋白特异性结合,免疫荧光检测均与A型流感病毒(H1N1和H3N2)有交叉反应,而与B型流感病毒无交叉现象。表明成功获得特异性针对H5N1-NS1蛋白的mAb,为进一步研究禽流感病毒NS1蛋白的结构与功能奠定基础。

关键词：禽流感病毒(H5N1) 非结构蛋白单克隆抗体

COVID-19 risk prediction scores for mortality:A validation study from the National Registry of COVID-19 in China

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Chinese Medical Journal 2024年第6期137卷 743-745页

作者： Sui Peng Kelvin KF tsoi Jianfeng Wu Steve HL Yim Haibo Wang Qian Zhou Han Xiao Zongpeng Weng Bin Li Ming Kuang Jianyan Long Joseph JY Sung Haipeng Xiao Clinical Trials Unit The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Stanley Ho Big Data Decision Analytics Research Centre The Chinese University of Hong KongHong Kong 999077China JC School of Public Health and Primary Care The Chinese University of Hong KongHong Kong 999077China Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Geography and Resource Management The Chinese University of Hong KongHong Kong 999077China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Liver Surgery The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Department of Endocrinology Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510080China

To the Editor:Coronavirus disease 2019(COVID-19)has evolved into a global pandemic,with over 700 million confirmed cases worldwide and still mounting.^([1])The clinical impact of this pandemic is immense,given the wide spectrum of disease manifestation,ranging from mild respiratory symptoms to severe pulmonary *** high-risk individuals,especially during their initial encounters in clinics and hospital emergency services,is crucial to provide timely effective ***,the timely risk stratification of COVID-19 patients in the emergency room can greatly benefit both infected individuals and healthcare professionals.^([2])This study aims to identify features of serious COVID-19 infection at presentation that may lead to mortality of the patients.

关键词： mortality respiratory prediction

Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application

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Regenerative Biomaterials 2020年第1期7卷 119-127页

作者： Yuqing Zhang Danni Sun Jun Cheng James Kit Hon tsoi Jiang Chen School and Hospital of Stomatology Fujian Medical UniversityFuzhou 350002FujianChina Stomatological Key Laboratory of Fujian College and University Fujian Medical UniversityFuzhou 350002FujianChina Faculty of Dentistry Dental Materials ScienceDivision of Applied Oral Sciences and Community Dental CareThe University of Hong KongHong Kong SARChina Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016ShaanxiChina

Binary titanium–niobium(Ti–Nb)alloys have recently been attracted due to low Young’s moduli and non-toxic *** study explores the influence of low Nb content(0–25 wt%)on the comprehensive parameters of tensile stress–strain relationships(ultimate strength(rUTS),yield strength(r0.2)and elastic modulus(E)),surfaces properties(Vickers microhardness,surface roughness(Ra),water contact angle(WCA),X-ray diffraction(XRD)and scanning electron microscopy(SEM)),corrosion resistance(in artificial saliva and lactic acid)and biological properties(cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts)of Ti–xNb alloys(x紏5,10,15,20 and 25 wt%),with using commercially pure grade 2 titanium(cp-Ti)as *** results shown that all the Ti–xNb alloys comprised atb Ti alloy phases,such that the b phase increased correspondingly with the increased amount of Nb in the alloy,as well as the reduction of E(69–87 GPa).Except Ti–5Nb,all other Ti–xNb alloys showed a significantly higher hardness,increased rUTS and r0.2,and decreased WCA compared with *** corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid *** cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour,but the proliferation rate of the Ti–5Nb alloy was lower than other *** overall,binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance,while Ti–5Nb should be used with caution.

关键词： biomaterial titanium-niobium binary titanium alloys low Young’s modulus biocompatibility

Binary titanium alloys as dental implant materials—a review

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Regenerative Biomaterials 2017年第5期4卷 315-323页

作者： Xiaotian Liu Shuyang Chen James K.H.tsoi Jukka Pekka Matinlinna Department of Orthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China Dental Materials Science Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARP.R.China Department of Prosthodontics Tianjin Stomatological Hospital of Nankai UniversityTianjinP.R.China

Titanium(Ti)has been used for long in dentistry and medicine for implant *** the years,not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were *** aim of this review is to describe and compare the current literature on binary Ti alloys,including Ti-Zr,Ti-In,Ti-Ag,Ti-Cu,Ti-Au,Ti-Pd,Ti-Nb,Ti-Mn,Ti-Mo,Ti-Cr,Ti-Co,Ti-Sn,Ti-Ge and Ti-Ga,in particular to mechanical,chemical and biological parameters related to implant *** was searched using the PubMed and Web of Science databases,as well as google without limiting the year,but with principle key terms such as‘Ti alloy’,‘binary Ti’,‘Ti-X’(with X is the alloy element),‘dental implant’and‘medical implant’.Only laboratory studies that intentionally for implant or biomedical applications were *** to available literatures,we might conclude that most of the binary Ti alloys with alloying<20%elements of Zr,In,Ag,Cu,Au,Pd,Nb,Mn,Cr,Mo,Sn and Co have high potential as implant materials,due to good mechanical performance without compromising the biocompatibility and biological behaviour compare to cp-Ti.

关键词： binary Ti Ti alloy dental implant biocompatibility

Organic Solar Cells at Stratospheric Condition for High Altitude Platform Station Application

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Chinese Journal of Chemistry 2022年第24期40卷 2927-2932页

作者： Ram Datt Harrison Ka Hin Lee Guichuan Zhang Hin-Lap Yip Wing Chung tsoi SPECIFIC Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySwanseaSA18EN United Kingdom Department of Physics City University of Hong KongKowloonHong KongSARChina School of Semiconductor Science and Technology South China Normal UniversityFoshanGuangdong528225 China State Key Laboratory of Luminescent Materials and Devices South China University of Technology381 Wushan RoadGuangzhouGuangdong510640 China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina School of Energy and Environment City University of Hong KongKowloonHong KongChina Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong KongChina

High specific power or power to mass ratio is a critical concern of photovoltaic(PV)for aerospace *** solar cells(OSCs)have advantages such as high absorption coefficient,compatibility with flexible substrate,light-weight,***,recently OSCs achieved power conversion efficiency(PCE)over 20%with the incorporation of the non-fullerene based small molecule acceptor and high specific power is believed to be *** enter the market,high-altitude platform station(HAPS)is perhaps the first place to start *** this work,we explore and compare the in-situ performance of two high performing OSCs,using the same donor but different acceptors,in mimic HAPS environment where the pressure,temperature and the illumination conditions are *** found that the use of acceptor can result in substantial difference in the performance at low temperatures.

关键词： Organic solar cells Stratosphere High-altitude platform station Low-temperature physics Donor-acceptor systems

Review of current progress in hole-transporting materials for perovskite solar cells

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Journal of Energy Chemistry 2022年第5期31卷 330-386页

作者： Prerna Mahajan Bhavya Padha Sonali Verma Vinay Gupta Ram Datt Wing Chung tsoi Soumitra Satapathi Sandeep Arya Department of Physics University of JammuJammuJammu and Kashmir 180006India Department of Physics Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates SPECIFIC College of EngineeringSwansea University Bay CampusFabian WaySA18ENSwanseaUnited Kingdom Department of Physics Indian Institute of Technology RoorkeeUttarakhand 247667India

Recent advancements in perovskites’ application as a solar energy harvester have been astonishing. The power conversion efficiency(PCE) of perovskite solar cells(PSCs) is currently reaching parity(>25 percent), an accomplishment attained over past decades. PSCs are seen as perovskites sandwiched between an electron transporting material(ETM) and a hole transporting material(HTM). As a primary component of PSCs, HTM has been shown to have a considerable effect on solar energy harvesting, carrier extraction and transport, crystallization of perovskite, stability, and price. In PSCs, it is still necessary to use a *** perovskites are capable of conducting holes, they are present in trace amounts, necessitating the use of an HTM layer for efficient charge extraction. In this review, we provide an understanding of the significant forms of HTM accessible(inorganic, polymeric and small molecule-based HTMs), to motivate further research and development of such materials. The identification of additional criteria suggests a significant challenge to high stability and affordability in PSC.

关键词： Hole transporting material Perovskite solar cells Power conversion efficiency Stability

Down-conversion materials for organic solar cells:Progress,challenges,and perspectives

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Aggregate 2022年第3期3卷 59-79页

作者： Ram Datt Swati Bishnoi Harrison Ka Hin Lee Sandeep Arya Sonal Gupta Vinay Gupta Wing Chung tsoi Faculty of Science and Engineering Sustainable Product Engineering Centre for Innovative Functional Industrial CoatingsSwansea UniversityBay CampusFabian WaySwansea SA18ENUK Advanced Materials and Metrology Division Council of Scientific And Industrial Research-National Physical LaboratoryDr.K.S.Krishnan MargNew Delhi 110012India Department of Physics University of JammuJammuJammu and Kashmir 180006India Department of Conducting Polymers Institute of Macromolecular ChemistryCzech Academy of SciencesPrague 616206Czech Republic Department of Physics Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Organic solar cells(OSCs)in terms of power conversion efficiency(PCE)and operational lifetime have made remarkable progress during the last decade by improving the active layer materials and introducing new *** newly developed wide bandgap organic donor and low bandgap acceptor molecules covered the absorption from the visible to the near-infrared *** the incident high energy region(UV)is not in favor of *** absorption causes thermalization losses and photoinduced degradation,which hinders the PCE and lifetime of ***,lanthanide and non-lanthanide-based down-conversion(DC)materials have been introduced,which can effectively convert the high-energy photons(UV)to low-energy photons(visible)and resolve the spectral mismatch losses that limit the absorption of OSCs in high energy incident ***,the DC materials also protect the OSCs from UV-induced *** DC materials were also proposed to cross the Shockley-Queisser efficiency limit of the solar *** this review,the need for DC materials and their processing method for OSCs have been thoroughly ***,the main emphasis has been given to developing lanthanides and non-lanthanides-based DC materials for OSCs,their applications,and their impact on photovoltaic device performance,stability,and future perspectives.

关键词： down-conversion down-shifting lanthanides organic solar cells photostability

Candida albicans aspects of binary titanium alloys for biomedical applications

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Regenerative Biomaterials 2020年第2期7卷 213-220页

作者： Shuyang Chen James K.H.tsoi Peter C.S.Tsang Yeong-Joon Park Ho-Jun Song Jukka P.Matinlinna Dental Materials Science Division of Applied Oral Sciences&Community Dental CareFaculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China Department of Prosthodontics Tianjin Stomatological HospitalNo.75Dagu RoadHeping DistrictTianjin 300041People’s Republic of China Division of Restorative Dental Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital34 Hospital RoadHong Kong SARPeople’s Republic of China and 4 Department of Dental Materials and MRC for Hard-tissue Biointerface School of DentistryChonnam National UniversityGwangju 61186Republic of Korea

Titanium and its alloys are widely used in biomedical devices,***,due to its biocompati-bility and osseointegration *** fact,fungal(Candida spp.)infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the ***,this study evaluated the surface morphology,surface chemical composition and Candida albicans adhesion on specimens of 16 binary Tialloys(-5 wt%of any one of the alloy elements:Ag,AI,Au,Co,Cr,Cu,Fe,In,Mn,Mo,Nb,Pd,Pt,Sn,V and Zr)compared with cp-Ti,targeting to seek for the binary Ti-alloys which has the lowest *** *** albicans cultures were grown on the specimens for 48 h,and colony forming units(CFUs)and real-time polymerase chain reaction(RT-PCR)were used to evaluate the biofilm formation *** electron mi-croscopy and confocal laser scanning microscopy confirmed the formation of *** biofilm on all specimens'surfaces,such that CFU results showed Ti-Mo,Ti-Zr,Ti-AI and Ti-V have less *** formed on the surfaces than ***-PCR showed Ti-Zr and Ti-Cu have significantly higher *** DNA concentrations than Ti-AI and Ti-V(P<0.05),whereas Ti-Cu has even showed a statistically higher concentration than Ti-Au,Ti-Co,Ti-In and Ti-Pt(P<0.05).This study confirmed that Ti-Mo,Ti-Zr,Ti-AI and Ti-V have lower the occurrence of *** which might be clinically advantageous for medical devices,but Ti-Cu should be used in caution.

关键词： titanium binary titanium alloy C.albicans,fungal infection medical devices

Some Generalizations of Semimartingales in the Plane

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应用概率统计 1999年第3期 310-318页

作者： ALLANUS H.tsoi (Department of Mathematics, The Hong Kong University of Science and Technology Clear Water Bay, Hong Kong)

In this paper we introduce new classes of processes which are generalization of the V-processes and A-processes investigated by Brennan. Positive measures associated with some of these processes are also consodered. F... 详细信息

关键词： Math Some Generalizations of Semimartingales in the Plane