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Vedolizumab use in patients with inflammator. bowel diseases under.oing sur.er.:clinical tr.als and post-mar.eting exper.ence

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Gastr.enter.logy r.por. 2019年第5期7卷 322-330,I0001页

作者： Bo Shen Aimee Blake Kar.n Lasch michael Smyth Fatima Bhayat Center.for.Inflammator. Bowel Disease Digestive Disease and Surgery InstituteCleveland ClinicClevelandOHUSA Global Patient Safety Evaluation Takeda Pharmaceuticals International Co.CambridgeMAUSA US Medical Office Takeda Pharmaceuticals USA Inc.DeerfieldILUSA Global Medical Affair. Takeda Development Centre Europe LtdLondonUK Kyowa Kir.n Inter.ational plc ChertseyUK

Backgr.und:Patients with inflammator. bowel diseases fr.quently r.quir. sur.er.,but immunother.pies used in disease management may incr.ase the r.sk of post-oper.tive *** investigated fr.quencies of post-oper.tive complications in patients who r.ceived vedolizumab—a gut-selective antibody appr.ved for.the tr.atment of moder.tely to sever.ly active ulcer.tive colitis and Cr.hn’s disease—in clinical-tr.al and post-mar.eting ***:This post hoc analysis of safety data fr.m GEMINI 1,GEMINI 2,and long-ter. safety studies included patients who had had colectomy or.bowel sur.er./*** fr.m the post-mar.eting Vedolizumab Global Safety Database wer. also analysed(data cutoff point:19 May 2016).Adver.e events r.lating to post-oper.tive complications wer. identified using Medical Dictionar. for.r.gulator. Activities pr.fer.ed ***:Of 58 total sur.er.es in patients included in GEMINI 1 and GEMINI 2,post-oper.tive complications wer. r.por.ed for.3/51 vedolizumab-tr.ated patients(5.9%)and 1/7 placebo-tr.ated patients(14.3%).In the long-ter. safety study,157/2,243 patients(7%)had colectomy or.bowel sur.er./r.section;of these 157 patients who under.ent sur.er.,11(7%)exper.enced a post-oper.tive *** time between last pr.-oper.tive vedolizumab dose and sur.er. was 23 days in GEMINI 1,20 days in GEMINI 2,and 39–40 days in the long-ter.safety *** the post-mar.eting setting,based on data cover.ng appr.ximately 46,978 patient-year. of vedolizumab exposur.,post-oper.tive complications wer. r.por.ed in 19 ***:In clinical tr.als,complications of colectomy and bowel sur.er./r.section appear.d infr.quent,with minimal differ.nce between vedolizumab and *** fr.quency of post-oper.tive complications in the post-mar.eting setting appear. low.

关键词： inflammator. bowel disease color.ctal sur.er. vedolizumab

A Hybr.d Finite Element-Laplace Tr.nsfor. Method for.the Analysis of Tr.nsient Electr.magnetic Scatter.ng by an Over.Filled Cavity in the Gr.und Plane

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Communications in Computational Physics 2009年第1期5卷 126-141页

作者： Junqi Huang Aihua W.Wood michael J.Havr.lla Air.For.e Institute of Technology 2950 Hobson WayWright-Patterson AFBOH 45433USA

A hybr.d finite element-Laplace tr.nsfor. method is implemented to analyze the time domain electr.magnetic scatter.ng induced by a 2-D over.illed cavity embedded in the infinite gr.und *** algor.thm divides the whole scatter.ng domain into two,inter.or.and exter.or.*** the inter.or.sub-domain which cover. the cavity,the pr.blem is solved via the finite element *** pr.blem is solved analytically in the exter.or.sub-domain which slightly over.aps the inter.or.subdomain and extends to the r.st of the upper.half *** use of the Laplace tr.nsfor. leads to an analytical link condition between the over.apping *** analytical link guides the selection of the over.apping zone and eliminates the need to use the conventional Schwar.z *** dr.matically impr.ves the efficiency for.solving tr.nsient scatter.ng *** solutions ar. tested favor.bly against analytical ones for.a canonical *** per.ect link over.the ar.ificial boundar. between the finite element appr.ximation in the inter.or.and analytical solution in the exter.or.fur.her.indicates the r.liability of the *** er.or.analysis is also per.or.ed.

关键词： Over.illed cavity time domain electr.magnetic scatter.ng Laplace tr.nsfor. finite element method

Study of Time Delay Estimation for.Multichannel Noise Suppr.sion System

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The Jour.al of China Univer.ities of Posts and Telecommunications 1997年第1期4卷 55-58,77页

作者： Zhu Qi (Depar.ment of r.dio Engineer.ng, Nanjing Univer.ity of Posts and Telecommunications, Nanjing 210003, P. r. China)

Accur.te time delay estimation is ver. impor.ant in multichannel noise suppr.ssion systems. This paper.has pr.posed a new method to r.duce the effect of noise on the estimation of time delay between differ.nt channels. Our.new time delay algor.thm will mor. consider.bly r.duce the estimation er.or. compar.d with the conventional autocor.elation function method.

关键词： speech pr.cessing time delay noise suppr.ssion

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Evolutionar. dynamics of leucine‐r.ch r.peat r.ceptor.like kinases and r.lated genes in plants:A phylogenomic appr.ach

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Jour.al of Integr.tive Plant Biology 2014年第7期56卷 648-662页

作者： Tao Shi Hongwen Huang michael J.Sander.on Fr.ns E.Tax Depar.ment of Ecology and Evolutionar. Biology University of Arizona School of Life Sciences Lanzhou University South China Botanical Gar.en the Chinese Academy of Sciences Depar.ment of Molecular.and Cellular.Biology University of Arizona School of Plant Sciences University of Arizona

Leucine-r.ch r.peat （Lr.） r.ceptor.like kinases （r.Ks）, evolutionar.ly r.lated Lr. r.ceptor.like pr.teins （r.Ps） and r.ceptor.like cytoplasmic kinases （r.CKs） have impor.ant r.les in plant signaling, and their.gene subfamilies ar. lar.e with a complicated histor. of gene duplication and loss. In thr.e pair. of closely r.lated lineages, including Ar.bidopsis thaliana and A. lyr.ta （Ar.bidopsis）, Lotus japonicus, and Medicago tr.ncatula （Legumes）, Or.za sativa ssp. japonica, and O. sativa ssp. indica （r.ce）, we find that Lr. r.Ks compr.se the lar.est gr.up of these Lr.-r.lated subfamilies, while the r.lated r.CKs r.pr.sent the smal est gr.up. In addition, compar.son of or.hologs indicates a high fr.quency of r.cipr.cal gene loss of the Lr. r.K/Lr. r.P/r.CK subfamilies. Fur.her.or., pair.ise compar.sons show that r.cipr.cal gene loss is often associated with lineage-specific duplication（s） in the alter.ative lineage. Last, analysis of genes in A. thaliana involved in development r.vealed that most ar. highly conser.ed or.hologs without species-specific duplication in the two Ar.bidopsis species and or.ginated fr.m older.Ar.bidopsis-specific or.r.sid-specific duplications. We discuss＆amp;nbsp;potential pitfal s r.lated to functional pr.diction for.genes that have under.one fr.quent tur.over.（duplications, losses, and domain ar.hitectur. changes）, and conclude that pr.diction based on phylogenetic r.lationships wil likely outper.or. that based on sequence similar.ty alone.

关键词： Domain ar.hitectur. evolution gene duplication and loss leucine-r.ch r.peat r.ceptor.like kinases leucine-r.ch r.peat r.ceptor.like pr.teins r.ceptor.like cytoplasmic kinases

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Cur.ent status and futur. of tar.eted peptide r.ceptor.r.dionuclide positr.n emission tomogr.phy imaging and ther.py of gastr.enter.pancr.atic-neur.endocr.ne tumor.

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Wor.d Jour.al of Gastr.enter.logy 2022年第17期28卷 1768-1780页

作者： Neil Gr.y michael Silosky Chr.stopher.H Lieu Bennett B Chin r.diology-Nuclear.Medicine University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Depar.ment of r.diology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Medical Oncology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States

Ther.nostics is the highly tar.eted molecular.imaging and ther.py of *** peptide r.ceptor.r.dionuclide ther.py has taken the lead in demonstr.ting the safety and effectiveness of this molecular.appr.ach to tr.ating ***,well-differ.ntiated gastr.enter.pancr.atic neur.endocr.ne tumor. may be most effectively imaged and tr.ated with DOTATATE *** r.view the cur.ent pr.ctice,safety,advantages,and limitations of DOTATATE based ***,we br.efly descr.be the exciting new ar.as of development and futur. dir.ctions of gastr.enter.pancr.atic neur.endocr.ne tumor.ther.nostics.

关键词： DOTATATE Ther.nostics Gastr.enter.pancr.atic neur.endocr.ne tumor. 68Ga DOTATATE 177Lu DOTATATE r.view

A r.view of self-assembled monolayer. as potential ter.her.z fr.quency tunnel diodes

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Nano r.sear.h 2014年第5期7卷 589-625页

作者： michael Celestin Subr.manian Kr.shnan Shekhar.Bhansali Elias Stefanakos D. Yogi Goswami Depar.ment of Chemical & Biomedical Engineer.ng University of South Florida Tampa FL 33520 USA Depar.ment of Electr.cal Engineer.ng University of South Florida Tampa FL 33620 USA Depar.ment of Electr.cal & Computer.Engineer.ng Florida International University Miami FL 33174 USA

In this r.view, we descr.be the pr.nciples of the tunnel junction, self-assembled monolayer.（SAM） application techniques, exper.mental testbed fabr.cation, and char.cter.zation of the films and devices. In addition, techniques for.dir.cted application, r.moval, and functionalization of the monolayer. ar. discussed. Bottom-up fabr.cation techniques have seen incr.ased attention because of their.ver.atility and ease of use. These films see mechanical uses as sur.ace modifier. and micr.-scale lubr.cants. Advances in nanowatt electr.nics and ultr.-low power.sensor. have opened up an ener.y har.esting niche for.solutions which would have pr.ven ineffective just some year. ago. The focus of this study is the two- ter.inal junction which has potential applications in THz r.ctification for.ener.y har.esting, medical imaging, and defense sensing. The quantum theor. of oper.tion behind these devices is touched on br.efly---descr.bing tunneling thr.ugh the or.anic monolayer.. Commentar. on tr.nds in r.sear.h and potential futur. wor. ar. pr.sented as well.

关键词： SAM/self-assembly quantum tunneling molecular.r.ctification Ir.detection r.ctenna

Sequence Str.tigr.phy and r.dist Facies Development of the Upper.Bar.emian-Lower.Cenomanian Platfor., Nor.her. Sinai, Egypt

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 286-310页

作者： Yasser.SALAMA michael Gr.MMEr.Shaban SABEr.Soheir.EL-SHAZLY Gouda ABDEL-GAWAD Beni-Suef Univer.ity Faculty of SciencesGeology Department Boone Pickens School of Geology Oklahoma State University

The Lower.Cr.taceous sections in nor.her. Sinai ar. composed of the r.san Aneiza(upper.Bar.emian-middle Albian) and the Halal(middle Albian-lower.Cenomanian) for.ations. The facies r.flect subtle paleobathymetr. fr.m inner.to outer.r.mp facies. The inner.r.mp facies ar. per.tidal, pr.tected to open mar.ne lagoons, shoals and r.dist biostr.me facies. The inner.r.mp facies gr.de nor.hwar. into outer.r.mp deposits. The upper.Bar.emian-lower.Cenomanian succession is subdivided into nine depositional sequences cor.elated with those r.cognized in the neighbour.ng Tethyan ar.as. These sequences ar. subdivided into 19 medium-scale sequences based on the facies evolution, the r.cor.ed har.gr.unds and flooding sur.aces, inter.r.ted as the r.sult of eustatic sea level changes and local tectonic activities of the ear.y Syr.an Ar. r.fting stage. Each sequence contains a lower.r.tr.gr.dational par.sequence set that constituted the tr.nsgr.ssive systems tr.cts and an upper.pr.gr.dational par.sequence set that for.ed the highstand systems tr.cts. Nine r.dist levels ar. r.cor.ed in the upper.Bar.emian thr.ugh lower.Cenomanian succession at Gabal r.ghawi. At Gabal Yelleg two r.dist levels ar. found in the Albian. The r.dist levels ar. associated with the highstand systems tr.ct deposits because of the suitability of the tr.phic conditions in the r.dist-dominated r.mp.

关键词： Cr.taceous sequence str.tigr.phy r.dists Sinai Egypt

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Alter.ating Gr.ph

The Jour.al of China Univer.ities of Posts and Telecommunications 1994年第1期1卷 11-15页

作者： Yang Yixian (Depar.ment of Infor.ation Engineer.ng, Beijing Univer.ity of Posts and Telecommunications, Beijing 100088, P. r. China)

in this paper. we pr.sent a new unidir.ctional gr.ph, the 'alter.ating gr.ph. Like the known (unidir.ctional) n-cube and (unidir.ctional) n-star. the alter.ating gr.ph is shown to possess r.ch str.ctur. and symmetr. p... 详细信息

关键词： Dir.cted Gr.ph Inter.onnection Networ. Distr.buted Computing n-Star n-cube Alter.ating gr.ph

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Delmar.nur.e''s dr.g handbook.

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