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S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis

Bone Research 2019年第4期7卷 424-436页

作者： Haemin kim Bongjun kim Sang Il kim Hyung joon kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee kim Department of Cell and Developmental Biology BK21 Program and DRISeoul National UniversitySeoulKorea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Cancer Biology Seoul National University College of MedicineSeoulKorea Department of Oral Physiology BK21 PLUS Projectand Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanKorea Interdisciplinary Program in Bioinformatics Seoul National University College of Natural SciencesSeoulKorea Department of Biomedical Sciences Seoul National University Graduate SchoolSeoulKorea

Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer *** between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and ***-derived factors play fundamental roles in this form of *** identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer *** subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor *** S100A4 stimulated osteoclastogenesis in vitro and bone loss in *** medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate ***,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown *** addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in *** together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.

关键词： S100A4 breast metastatic

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MicroRNAs in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2011年第7期17卷 817-827页

作者： Jong Y Park James Helm Domenico Coppola Donghwa kim Mokenge Malafa Seung joon kim Division of Cancer Prevention and Control Moffitt Cancer Center FL 33612 United States Gastrointestinal Tumor Program Moffitt Cancer Center FL 33612 United States Department of Anatomic Pathology Moffitt Cancer Center FL 33612 United States Department of Molecular Oncology MoffittCancer Center FL 33612 United States Department of Internal Medicine Collegeof Medicine the Catholic University of Korea Seoul 137-040South Korea

Ductal adenocarcinoma of the pancreas is a lethal cancer for which the only chance of long-term survival belongs to the patient with localized disease in whom a potentially curative resection can be done. Therefore, biomarkers for early detection and new therapeutic strategies are urgently needed. miRNAs are a recently discovered class of small endogenous non-coding RNAs of about 22 nucleotides that have gained attention for their role in downregulation of mRNA expression at the post-transcriptional level. miRNAs regulate proteins involved in critical cellular processes such as differentiation, proliferation, and apoptosis. Evidence suggests that deregulated miRNA expression is involved in carcinogenesis at many sites, including the pancreas. Aberrant expression of miRNAs may upregulate the expression of oncogenes or downregulate the expression of tumor suppressor genes, as well as play a role in other mechanisms of carcinogenesis. The purpose of this review is to summarize our knowledge of deregulated miRNA expression in pancreatic cancer and discuss the implication for potential translation of this knowledge into clinical practice.

关键词： MicroRNAs Pancreatic cancer

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Fault area estimation using traveling wave for wide area protection

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Journal of Modern Power Systems and Clean Energy 2016年第3期4卷 478-486页

作者： Jae-Won LEE Won-Ki kim joon HAN Won-Hyeok JANG Chul-Hwan kim Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Daewoo Shipbuilding&Marine Engineering Co. Ltd.GeojeRepublic of Korea Electrical and Computer Engineering Department University of Illinois at Urbana-ChampaignChampaignILUSA

As the increasing number of Phasor Measurement Units(PMUs) are deployed, wide area protection in power systems has been gaining interest. In particular, fault detection, fault classification and fault area estimation are essential to reduce the damage of faults, and even prevent catastrophic cascades of failures. In this paper, we present a scheme for fault area estimation using PMUs and traveling wave theory. The purpose of this paper is to formulate a scheme for fault area estimation by calculating the approximate fault location based on traveling wave *** research has targeted at reliable operation of wide transmission system through the estimation of fault *** verify the suggested scheme, the various simulations are performed in practical Korean power transmission *** simulation results show that the proposed scheme has a good performance with high accuracy for estimating fault area.

关键词： Fault area estimation Phasor measurement unit(PMU) Transmission line system Traveling wave Wide area protection

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β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh kim Ji Min kim Eun Jeong Cho Chang Ohk Sung joon kim Se Jin Jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

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Topically administered bevacizumab had longer standing anti-angiogenic effect than subconjunctivally injected bevacizumab in rat corneal neovacularization

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 588-591页

作者： Jae Yong kim Dong Yoon kim Eun-Soon kim Myoung joon kim Hungwon Tchah Department of Ophthalmology University of Ulsan College of MedicineAsan Medical Center

AIMTo compare the effect of topically administered and subconjunctivally injected bevacizumab on experimental corneal neovascularization in rats for two weeks after treatment.

关键词： corneal neovascularization bevacizumab topical and subconjunctival administration

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Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

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World Journal of Gastroenterology 2018年第16期24卷 1708-1724页

作者： Yu-Min Choi So-Young Lee Bum-joon kim Department of Microbiology and Immunology Biomedical Sciences Liver Research Institute and Cancer Research Institute Seoul National University College of Medicine

The annual number of deaths caused by hepatitis B virus(HBV)-related disease, including cirrhosis and hepatocellular carcinoma(HCC), is estimated as 887000. The reported prevalence of HBV reverse transcriptase(RT) mutation prior to treatment is varied and the impact of preexisting mutations on the treatment of na?ve patients remains controversial, and primarily depends on geographic factors, HBV genotypes, HBe Ag serostatus, HBV viral loads, disease progression, intergenotypic recombination and co-infection with HIV. Different sensitivity of detection methodology used could also affect their prevalence results. Several genotype-dependent HBV RT positions that can affect the emergence of drug resistance have also been reported. Eight mutations in RT(rtL80I, rtD134N, rtN139K/T/H, rtY141F, rtM204I/V, rtF221Y, rtI224V, and rtM309K) are significantly associated with HCC progression. HBe Ag-negative status, low viral load, and genotype C infection are significantly related to a higher frequency and prevalence of preexisting RT mutations. Preexisting mutations are most frequently found in the A-B interdomain of RT which overlaps with the HBs Ag "a" determinant region, mutations of which can lead to simultaneous viral immune escape. In conclusion, the presence of baseline RT mutations can affect drug treatment outcomes and disease progression in HBVinfected populations via modulation of viral fitness and host-immune responses.

关键词： polymerase hepatocellular carcinoma reverse transcriptase preexisting mutations hepatitis B virus

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Surface Tension and Temperature Effect on Entrapment of Bubbles and Particles in Continuous Casting of Steel

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Journal of Iron and Steel Research International 2011年第S2期18卷 220-226页

作者： Sang-Min Lee Sang-joon kim Hae-Geon Lee Graduate Institute of Ferrous Technology Pohang University of Science and Technology 31 San Pohang kyoungbuk Korea

The entrapment behavior of Ar bubbles onto the solidifying front of molten steel in the continuous casting mold was investigated. The dynamic model of bubble and particle entrapment was developed in order to consider the effect of surface tension gradient induced forces(Marangoni force) due to the gradient of sulfur concentration and temperature. The numerical analysis and water model experiment were performed to apply the present model for various conditions. The calculation result is compared with experimental results and plant data in continuous casting mold as well. It shows that the thermal Marangoni force could play an important role and this model predicts the bubble behavior in the vicinity of solid/liquid interface more precisely.

关键词： bubble continuous casting surface tension gradient marangoni force

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Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases

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World Journal of Gastroenterology 2021年第37期27卷 6161-6179页

作者： Satya Priya Sharma Ki Tae Suk Dong joon kim Institute for Liver and Digestive Diseases Hallym University College of MedicineChuncheon 24252South Korea

Liver-gut communication is vital in fatty liver diseases,and gut microbes are the key regulators in maintaining liver *** alcohol abuse and persistent overnutrition create dysbiosis in gut ecology,which can contribute to fatty liver *** this review,we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease *** also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.

关键词： Fatty liver disease Alcoholic fatty liver disease Non-alcoholic fatty liver disease Gut microbiome Dysbiosis

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A Study of the Gas Flow through Air Jet Loom

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Journal of Thermal Science 2007年第2期16卷 159-163页

作者： Heuy-Dong kim Chae-Min Lim Ho-joon Lee Doo-Hwan Chun School of Mechanical Engineering Andong National University388Songcheon-dongAndong 760-749KoreaE-mail:kimhd Korea Textile Machinery Research Institute 300Sampoong-dongKyeongsan 712-210Korea

Air jet loom, as one of the shuttleless looms, transports a yam into warps using viscosity and kinetic energy of an air jet. Performance of this picking system depends on the ability of instantaneous inhalation/exhaust, configuration of nozzle, operation characteristics of a check valve, etc. In the recent past, many studies have been reported on the air jet discharged from a nozzle exit, but studies for understanding the flow field characteristics associated with shear layer and shock wave/boundary layer interaction in the nozzle were not conducted enough. In this paper, a computational study was performed to explain the flow field in the air jet nozzle with an acceleration tube and validated with previous experimental data available. The results obtained from the computational study show that, in the supersonic flow regime, the flow field depends significantly on the length of acceleration tube. As nozzle pressure ratio increases, drag force acting on the string also increases. For a longer acceleration tube, the total pressure loss is large, owing to the frictional loss.

关键词： compressible flow nozzle shear layer shock wave air jet loom shuttleless loom

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Enhancement of photoresponsive electrical characteristics of multilayer MoS2 transistors using rubrene patches

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Nano Research 2015年第3期8卷 790-800页

作者： Eun Hei Cho Won Geun Song Cheol joon Park Jeongyong kim Sunkook kim Jinsoo Joo Department of Physics Korea University Seou1136-713 R. O. Korea Department of Electronics and Radio Engineering Institute for Laser Engineering Kyung Hee University Yongin Gyeonggi-do 446-70 I R. O. Korea Center for Integrated Nanostructure Physics (CINAP) Institute for Basic Science (IBS) Department of Energy Science Sungkyunkwan University Suwon 440-746 R. O. Korea

Multilayer MoS2 is a promising active material for sensing, energy harvesting, and optoelectronic devices owing to its intriguing tunable electronic band structure. However, its optoelectronic applications have been limited due to its indirect band gap nature. In this study, we fabricated a new type of phototransistor using multilayer MoS2 crystal hybridized with p-type organic semiconducting rubrene patches. Owing to the outstanding photophysical properties of rubrene, the device characteristics such as charge mobility and photoresponsivity were considerably enhanced to an extent depending on the thickness of the rubrene patches. The enhanced photoresponsive conductance was analyzed in terms of the charge results of the nanoscale laser confocal time-resolved PL measurements. transfer doping effect, validated by the microscope photoluminescence （PL） and

关键词： MoS2 rubrene transistor photoresponsivity charge transfer

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