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Wedelolactone from Eclipta prostrata(L)*** inflammation and improves insulin resistance

Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 253-258页

作者： Trinh Tat Cuong Duong Duc Thien hoang hai yen Nguyen Anh Duc Trinh Quang Nam Do Viet Khanh Key Laboratory for Enzyme and Protein Technology Vietnam National University University of ScienceHanoiVietnam Faculty of Biology Vietnam National University University of ScienceHanoiVietnam Hanoi University of Pharmacy HanoiVietnam Vinschool HanoiVietnam

Objective:To evaluate the effects of wedelolactone,a major flavonoid from Vietnamese Eclipta prostrata(L)L.,on inflammation and insulin ***:Wedelolactone was extracted from the leaves of Vietnamese Eclipta prostrata(L.)*** methanol by *** effects of wedelolactone on lipopolysaccharide(LPS)-induced cytokine production,reactive oxygen species(ROS)generation,and nicotinamide adenine dinucleotide phosphate(NADPH)oxidase activities in Raw 264.7 cells were measured by enzyme-linked immunosorbent assay(ELISA),specific immunofluorescent dyes and luminometric analysis,*** addition,its effects on glucose uptake and the protein expression of insulin receptor substrate 1(IRS1)and glucose transporter 4(GLUT4)were examined in 3T3-L1 cells by immunofluorescent dyes and Western ***:Wedelolactone at 30μg/mL significantly inhibited LPS-induced production of tumor necrosis factor-α,interleukin(IL)-6,and IL-8(P<0.01)with no noticeable effects on IL-10 *** also reduced ROS generation and NADPH oxidase activities in LPS-stimulated Raw 264.7 cells(P<0.01).Furthermore,wedelolactone showed anti-insulin resistance activity,as evidenced by improved glucose uptake and the upregulated expression of IRS1 and GLUT4 in 3T3-L1 cells(P<0.01).Conclusions:Wedelolactone exhibits anti-inflammation and anti-insulin resistance effects,which may be used for the treatment of diabetes and inflammation-associated diseases.

关键词： Wedelolactone Eclipta prostrata Inflammatory responses Anti-insulin resistance Diabetes IRS1 GLUT4

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Locally weighted learning based hybrid intelligence models for groundwater potential mapping and modeling: A case study at Gia Lai province, Vietnam

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Geoscience Frontiers 2021年第5期12卷 54-68页

作者： hoang Phan hai yen Binh Thai Pham Tran Van Phong Duong hai Ha Romulus Costache Hiep Van Le Huu Duy Nguyen Mahdis Amiri Nguyen Van Tao Indra Prakash Department of Geography School of Social Sciences EducationVinh University182 Le DuanVinhNghe AnVietnam University of Transport Technology Hanoi 100000Viet Nam Institute of Geological Sciences Vietnam Academy of Science and Technology(VAST)84 Chua LangDong DaHanoiViet Nam Institute for Water and Environment Hanoi 100000Viet Nam Research Institute of the University of Bucharest 90-92 Sos.Panduri5th DistrictBucharestRomania National Institute of Hydrology and Water Management București-Ploiești Road97E1st District013686 BucharestRomania Faculty of Geography VNU University of ScienceVietnam National University334 Nguyen TraiHanoi 100000Viet Nam Department of Watershed&Arid Zone Management Gorgan University of Agricultural Sciences&Natural ResourcesGorgan ***Iran DDG(R)Geological Survey of India Gandhinagar 382010India

The groundwater potential map is an important tool for a sustainable water management and land use planning,particularly for agricultural countries like *** this article,we proposed new machine learning ensemble techniques namely AdaBoost ensemble(ABLWL),Bagging ensemble(BLWL),Multi Boost ensemble(MBLWL),Rotation Forest ensemble(RFLWL)with Locally Weighted Learning(LWL)algorithm as a base classifier to build the groundwater potential map of Gia Lai province in *** this study,eleven conditioning factors(aspect,altitude,curvature,slope,Stream Transport Index(STI),Topographic Wetness Index(TWI),soil,geology,river density,rainfall,land-use)and 134 wells yield data was used to create training(70%)and testing(30%)datasets for the development and validation of the *** statistical indices were used namely Positive Predictive Value(PPV),Negative Predictive Value(NPV),Sensitivity(SST),Specificity(SPF),Accuracy(ACC),Kappa,and Receiver Operating Characteristics(ROC)curve to validate and compare performance of *** show that performance of all the models is good to very good(AUC:0.75 to 0.829)but the ABLWL model with AUC=0.89 is the *** the models applied in this study can support decision-makers to streamline the management of the groundwater and to develop economy not only of specific territories but also in other regions across the world with minor changes of the input parameters.

关键词： Locally weighted learning Hybrid models Groundwater potential GIS Vietnam

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Impact of microplastics and nanoplastics on liver health:Current understanding and future research directions

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World Journal of Gastroenterology 2024年第9期30卷 1011-1017页

作者： Chun-Cheng Chiang Hsuan Yeh Ruei-Feng Shiu Wei-Chun Chin Tzung-hai yen School of Medicine University of PittsburghPittsburghPA 15213United States Pittsburgh Liver Research Center University of PittsburghPittsburghPA 15213United States Division of Experimental Pathology Department of PathologyUniversity of PittsburghPittsburghPA 15213United States Division of Endocrinology Department of PediatricsUniversity of PittsburghPittsburghPA 15213United States Center of Excellence for The Oceans National Taiwan Ocean UniversityKeelung 20224Taiwan Institute of Marine Environment and Ecology National Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Materials Science and Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalTaoyuan 333TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina

With continuous population and economic growth in the 21st century,plastic pollution is a major global ***,the health concern of microplastics/nanoplastics(MPs/NPs)decomposed from plastic wastes has drawn public attention only in the recent *** article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ,which is one of the primary routes that MPs/NPs enter human *** interrelated mechanisms including oxidative stress,hepatocyte energy re-distribution,cell death and autophagy,as well as immune responses and inflammation,were also *** addition,the disturbance of microbiome and gut-liver axis,and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease,steatohepatitis,liver fibrosis,and cirrhosis were briefly ***,we discussed potential directions in regard to this trending topic,highlighted current challenges in research,and proposed possible solutions.

关键词： Microplastics Nanoplastics Liver Reactive oxidative species Cell death Autophagy Innate immunity Metabolic dysfunction-associated fatty liver disease Gut-liver axis

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Improved flood susceptibility mapping using a best first decision tree integrated with ensemble learning techniques

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Geoscience Frontiers 2021年第3期12卷 333-342页

作者： Binh Thai Pham Abolfazl Jaafari Tran Van Phong hoang Phan hai yen Tran Thi Tuyen Vu Van Luong Huu Duy Nguyen Hiep Van Le Loke Kok Foong University of Transport Technology Ha Noi 100000Viet Nam Research Institute of Forests and Rangelands Agricultural ResearchEducation and Extension Organization(AREEO)TehranIran Institute of Geological Sciences Vietnam Academy of Sciences and Technology84 Chua Lang StreetDong daHa NoiViet Nam Department of Geography School of Social EducationVinh UniversityViet Nam Department of Resource and Environment Management School of Agriculture and ResourcesVinh UniversityViet Nam Faculty of Geography VNU University of Science334 Nguyen TraiHa NoiViet Nam Institute of Research and Development Duy Tan UniversityDa Nang 550000Viet Nam Department for Management of Science and Technology Development Ton Duc Thang UniversityHo Chi Minh CityViet Nam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityViet Nam

Improving the accuracy of flood prediction and mapping is crucial for reducing damage resulting from flood *** this study,we proposed and validated three ensemble models based on the Best First Decision Tree(BFT)and the Bagging(Bagging-BFT),Decorate(Bagging-BFT),and Random Subspace(RSS-BFT)ensemble learning techniques for an improved prediction of flood susceptibility in a spatially-explicit manner.A total number of 126 historical flood events from the Nghe An Province(Vietnam)were connected to a set of 10 flood influencing factors(slope,elevation,aspect,curvature,river density,distance from rivers,flow direction,geology,soil,and land use)for generating the training and validation *** models were validated via several performance metrics that demonstrated the capability of all three ensemble models in elucidating the underlying pattern of flood occurrences within the research area and predicting the probability of future flood *** on the Area Under the receiver operating characteristic Curve(AUC),the ensemble Decorate-BFT model that achieved an AUC value of 0.989 was identified as the superior model over the RSS-BFT(AUC=0.982)and Bagging-BFT(AUC=0.967)models.A comparison between the performance of the models and the models previously reported in the literature confirmed that our ensemble models provided a reliable estimate of flood susceptibilities and their resulting susceptibility maps are trustful for flood early warning systems as well as development of mitigation plans.

关键词： Machine learning Ensemble learners Hybrid modeling

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Investigation of Polymorphisms in Coding Region of OsHKT1in Relation to Salinity in Rice

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Rice science 2016年第6期23卷 334-338页

作者： pham quynh-hoa tran xuan-an nguyen thi-nha-trang tran thi-thuy-anh hoang hai-yen nguyen thi-hong-van tang thi-hanh do thi-phuc Faculty of Biology VNU University of ScienceHanoi334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Agronomy Vietnam National University of AgricultureNgo Xuan Quang StreetTrau QuyGia LamHanoiVietnam

Rice （Oryza sativa） is sensitive to salinity, but the salt tolerance level differs among cultivars,which might result from natural variations in the genes that are responsible for salt tolerance. High-affinitypotassium transporter （HKTs） has been proven to be involved in salt tolerance in plants. Therefore, wescreened for natural nucleotide polymorphism in the coding sequence of OsHKT1, which encodes the HKTprotein in eight Vietnamese rice cultivars differing in salt tolerance level. In total, seven nucleotidesubstitutions in coding sequence of OsHKT1 were found, including two non-synonymous and five synonymoussubstitutions. Further analysis revealed that these two non-synonymous nucleotide substitutions （G50Tand T1209A） caused changes in amino acids （Gly17Val and Asp403Glu） at signal peptide and the loop ofthe sixth transmembrane domain, respectively. To assess the potential effect of these substitutions on theprotein function, the 3D structure of HKT protein variants was modelled by using PHYRE2 webserver. Theresults showed that no difference was observed when compared those predicted 3D structure of HKTprotein variants with each other. In addition, the codon bias of synonymous substitutions cannot clearlyshow correlation with salt tolerance level. It might be interesting to further investigate the functional roles ofdetected non-synonymous substitutions as it might correlate to salt tolerance in rice.

关键词： polymorphism salt stress OsHKT1 gene rice

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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： Nguyen Quang Thu Nguyen Tran Nam Tien Nguyen Thi hai yen Thuc-Huy Duong Nguyen Phuoc Long Huy Truong Nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim Dong Guk Kang Hyeon Gyu Lee yen hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan yen Thi hoang Creswell Jacob Dang Thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

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Successful containment of a COVID-19 outbreak in Bach Mai Hospital by prompt and decisive responses

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 234-235页

作者： Van Minh hoang Thi Phuong Thao Tran Thi Ngoc Phuong Nguyen Thi hai yen Nguyen Quang Tuan Nguyen Hanoi University of Public Health HanoiVietnam Bach Mai Hospital HanoiVietnam

In low-and middle-income countries,tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 *** Mai Hospital(BMH),one of the leading tertiary hospitals in Vietnam,is on the frontline in the fierce battle against *** letter aims to describe how BMH tackles the COVID-19 outbreak in the hospitallevel battle,which could support policymakers in time-management and well-preparation for this unpredictable pandemic.

关键词： prompt income policy

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Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges

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World Journal of Gastroenterology 2021年第26期27卷 4104-4142页

作者： Hsuan Yeh Chung-Cheng Chiang Tzung-hai yen Department of Nephrology Chang Gung Memorial Hospital and Chang Gung UniversityTaipei 105Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan

The population of patients with hepatocellular carcinoma(HCC)overlaps to a high degree with those for chronic kidney disease(CKD)and end-stage renal disease(ESRD).The degrees of renal dysfunction vary,from the various stages of CKD to dialysis-dependent ESRD,which often affects the prognosis and treatment choice of patients with *** addition,renal dysfunction makes treatment more difficult and may negatively affect treatment *** study summarized the possible causes of the high comorbidity of HCC and renal *** possible mechanisms of CKD causing HCC involve uremia itself,long-term dialysis status,immunosuppressive agents for postrenal transplant status,and miscellaneous factors such as hormone alterations and *** possible mechanisms of HCC affecting renal function include direct tumor invasion and hepatorenal ***,we categorized the risk factors that could lead to both HCC and CKD into four categories:Environmental toxins,viral hepatitis,metabolic syndrome,and vasoactive *** CKD and ESRD have been reported to negatively affect HCC prognosis,but more research is warranted to confirm ***,ESRD status itself ought not to prevent patients receiving aggressive *** study then adopted the well-known Barcelona Clinic Liver Cancer guidelines as a framework to discuss the indicators for each stage of HCC treatment,treatment-related adverse renal effects,and concerns that are specific to patients with pre-existing renal dysfunction when undergoing aggressive treatments against CKD and *** aggressive treatments include liver resection,simultaneous liver kidney transplantation,radiofrequency ablation,and transarterial ***,focusing on patients unable to receive active treatment,this study compiled information on the latest systemic pharmacological therapies,including targeted and immunotherapeutic *** on available clinical studies and Food and Drug Administration labe

关键词： Hepatocellular carcinoma Chronic kidney disease End-stage renal disease Hemodialysis Cancer prognosis Cancer therapeutics

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