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A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy

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Chinese Journal of Cancer Research 2020年第1期32卷 105-114页

作者： ho Kyoung Hwang Keita Wada Ha Yan Kim Yuichi Nagakawa Yosuke Hijikata Yota Kawasaki Yoshiharu Nakamura lip Seng Lee Dong Sup Yoon Woo Jung Lee Chang Moo Kang Division of HBP Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Korea Pancreatobiliary Cancer Clinic Yonsei Cancer CenterSeverance HospitalSeoul 03722Korea Department of Surgery Teikyo University School of MedicineTokyo 173-8605Japan Biostatistician Biostatistics Collaboration UnitDepartment of Biomedical Systems InformaticsYonsei University College of MedicineSeoul 03722Korea Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 160-8402Japan Department of Digestive Surgery Breastand Thyroid SurgeryGraduate School of Medical SciencesKagoshima UniversityKagoshima 890-0065Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 890-0065Japan Department of General Surgery Changi General HospitalSingapore 529889Singapore

Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. however, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term ***: The medical records of patients who underwent pancreatectomy following neoadjuvant treatment from January 2005 to December 2016 at Severance hospital were retrospectively reviewed. Medical records were collected from five international institutions from Japan and Singapore for external ***: A total of 113 patients were enrolled. The nomogram for predicting 1-year disease-specific survival was created based on 5 clinically detectable preoperative parameters as follows: age(year), symptom(no/yes), tumor size at initial diagnostic stage(cm), preoperative serum carbohydrate antigen(CA) 19-9 level after neoadjuvant treatment(howed good agreement between actual and predicted survival probabilities;the the Greenwood-Nam-D’Agostino(GND) goodness-of-fit test showed that the model was well calibrated(χ~2=8.24,P=0.5099). A total of 84 patients were used for external validation. When correlating actual disease-specific survival and calculated 1-year disease-specific survival, there were significance differences according to the calculated probability of 1-year survival among the three groups(P=0.044).Conclusions: The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of p

关键词： Pancreatic cancer neoadjuvant treatment pancreatectomy survival nomogram

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少年期上中切牙冠根指标的锥体束CT研究

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口腔医学 2019年第1期39卷 30-34页

作者：徐志明李媛吴可侯伟潘永初王林南京医科大学口腔疾病研究江苏省重点实验室南京医科大学附属口腔医院正畸科江苏南京210029

目的研究少年期上中切牙冠根长度,并探讨与之相关的硬组织测量指标。方法选取100例符合纳入标准的错牙合畸形患者的锥体束CT(CBCT)资料,运用MIMICS 17.0软件测量该100例患者的上中切牙冠根长度及与之相关的硬组织3D测量指标,运用SPSS 2... 详细信息

目的研究少年期上中切牙冠根长度,并探讨与之相关的硬组织测量指标。方法选取100例符合纳入标准的错牙合畸形患者的锥体束CT(CBCT)资料,运用MIMICS 17.0软件测量该100例患者的上中切牙冠根长度及与之相关的硬组织3D测量指标,运用SPSS 21.0统计软件对上中切牙冠根长度及相关硬组织3D测量指标进行Spearman相关性分析。结果少年期上中切牙:(1)根长与唇倾度和根尖唇侧牙槽骨厚度呈正相关;(2)冠根比与唇倾度以及根尖唇侧牙槽骨厚度呈负相关;(3)根尖唇侧牙槽骨厚度与唇倾度呈正相关,与冠根比呈负相关。结论少年期上中切牙根长、冠根比、唇倾度和根尖唇侧牙槽骨厚度之间存在相关性,对临床工作有指导意义。

关键词：少年期上中切牙冠根长度牙槽骨锥体束CT

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