检索结果-南通市图书馆

Biomaterials Translational 2024年第1期5卷 59-68页

作者： Huaxin Yang Mengjia Zheng Yuyue Zhang Chaochang Li Joseph ho Chi Lai Qizheng Zhang Kannie WY Chan Hao Wang Xin Zhao Zijiang Yang Chenjie Xu Department of Biomedical Engineering City University of Hong KongHong Kong Special Administrative RegionChina Center for Pluripotent Stem Cell Research and Engineering Research Institute of TsinghuaGuangzhouGuangdong ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

A composite scaffold composed of a porous scaffold and hydrogel filling can facilitate engraftment,survival,and retention in cell transplantation *** study presents a composite scaffold made of poly(ε-caprolactone)(PCL)and methacrylated hyaluronic acid(MeHA)hydrogel and describes the corresponding physical properties(surface area,porosity,and mechanical strength)and host response(angiogenesis and fibrosis)after subcutaneous ***,we synthesise MeHA with different degrees of substitution and fabricate a PCL scaffold with different ***,we construct a series of PCL/MeHA composite scaffolds by combining these hydrogels and *** experiments with mice,the scaffold composed of 3%PCL and 10-100 kDa,degree of substitution 70%MeHA results in the least fibrosis and a higher degree of *** study highlights the potential of PCL/MeHA composite scaffolds for subcutaneous cell transplantation,given their desirable physical properties and host response.

关键词： angiogenesis cell transplantation hyaluronic acid poly(ε-caprolactone) scaffold

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第9期14卷 748-757页

作者： Beom K Choi Do Y Lee Don g Lee Young H Kim Seon-Hee Kim ho S Oh Chungyong Han Byoung S Kwon Cancer Immunology Branch Division of Cancer BiologyNational Cancer CenterGoyangGyeonggi 10408Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752Korea Immune Cell Production Unit Program for Immunotherapeutic ResearchNational Cancer CenterGyeonggi 10408Korea Eutilex Catholic University School of MedicineSeoul 06591Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA

4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T *** these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid *** found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and *** with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid ***-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty *** also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB *** increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,*** conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.

关键词： AMPK CD8^(+)T cells 4-1BB(CD137) LKB1 metabolism

In-situ observations of novel single-atom thick 2D tin membranes embedded in graphene

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2021年第3期14卷 747-753页

作者： Xiaoqin Yang Huy Q.Ta Wei Li Rafael g.Mendes Yu Liu Qitao Shi Sami Ullah Alicja Bachmatiuk Jinping Luo Lijun Liu Jin-ho Choi Mark H.Rummeli School of Energy and Power Engineering Xi’an Jiaotong UniversityNo.28Xianning West RoadXian710049China

There is ongoing research in freestanding single-atom thick elemental metal patches,including those suspended in a two-dimensional(2D)material,due to their utility in providing new structural and energetic insight into novel metallic 2D *** pores have shown promise as support systems for suspending such *** study explores the potential of Sn atoms to form freestanding stanene and/or Sn patches in graphene *** atoms were deposited on graphene,where they formed novel single-atom thick 2D planar clusters/patches(or membranes)ranging from 1 to 8 atoms within the graphene *** of three or more atoms adopted either a star-like or close-packed structural *** functional theory(DFT)calculations were conducted to look at the cluster configurations and energetics(without the graphene matrix)and were found to deviate from experimental observations for 2D patches larger than five *** was attributed to interfacial interactions between the graphene pore edges and Sn *** presented findings help advance the development of single-atom thick 2D elemental metal membranes.

关键词： in-situ transmission electron microscopy Sn atoms planar cluster graphene vacancy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于无线信道直接加密的物理层安全通信技术

网络安全技术与应用 2024年第10期 67-70页

作者：石煜昊唐杰王睿斐文红 PIN Han-ho Shih Yu Chang 电子科技大学四川611731 University of Waterloo Ontario Canada N2L3G1

本文提出了一种新的基于无线信道直接加密的物理层安全通信技术。不同于传统的基于物理信道的密钥生成技术通常向合法通信双方将无线信道量化,再进行密钥协商,从而在合法通信双方生成两个完全相同的比特串作为上层密码算法加密的密钥。... 详细信息

本文提出了一种新的基于无线信道直接加密的物理层安全通信技术。不同于传统的基于物理信道的密钥生成技术通常向合法通信双方将无线信道量化,再进行密钥协商,从而在合法通信双方生成两个完全相同的比特串作为上层密码算法加密的密钥。本文的方案中通过提取合法双方的无线信道特征的量化后的比特,通过设计的轻量级加解密算法直接对物理层比特进行加密。相比传统方案,本方案避免了物理层密钥分发的密钥协商过程,大大提升了密钥生成速率。其基本原理是合法通信双方在物理层直接用不同的密钥直接对已编码比特信息加密,而合法接收方仍然可以通过信道译码得到较低的误码率从而恢复信源比特信息,而非法窃听者由于密钥比特和合法通信双方不一致而无法解密。通过实验验证,验证了在信息传输过程中信道差错率低于5*10^-2情况下,该模型能够在保证窃听者无法解密的同时能够实现合法通信者以平均正确率99.6%接收。此外,通过修改编码的参数,本文找到了不同信噪比下最为合适的传输效率。本文的方案可在对物理层信号进行安全增强的同时兼容上层安全加解密算法,具有广泛的应用前景。

关键词：物理层密钥信息加密纠错编码密钥生成效率

在线全文

学校读者我要写书评

暂无评论

基于深度学习的物理层安全性能预测

网络安全技术与应用 2024年第9期 44-47页

作者：王爱文唐杰罗洪宇文红 PIN Han-ho Shih Yu Chang 电子科技大学四川611731 University of Waterloo Ontario Canada N2L3G1

本论文提出了一种基于合法信道的实时变化准确预测窃听者信道强度,从而增强通信安全性的创新方法。利用长短时记忆(LSTM)神经网络,训练一个模型来预测信道的实时振幅。通过网络中已知非授权用户的位置信息以及授权用户的信道信息来建立... 详细信息

本论文提出了一种基于合法信道的实时变化准确预测窃听者信道强度,从而增强通信安全性的创新方法。利用长短时记忆(LSTM)神经网络,训练一个模型来预测信道的实时振幅。通过网络中已知非授权用户的位置信息以及授权用户的信道信息来建立一个LSTM模型,并利用该模型来预测非授权用户的信道强度。实验证明,这种方法可以准确预测窃听信道的强度,从而防止非授权用户获取通信活动信息,提升了通信安全性。

关键词：未授权用户合法信道实时预测物理层安全信道增益

Assessment of the kinetic–frictional model for dense granular flow

在线全文

学校读者我要写书评

暂无评论

Particuology 2008年第1期6卷 50-58页

作者： Boon ho Ng Mojtaba ghadiri Institute of Particle Science&Engineering University of LeedsLeeds LS2 9JTUK

This paper aims to quantitatively assess the application of kinetic-frictional model to simulate the motion of dry granular materials in dense condition, in particular, the annular shearing in Couette configuration. The weight of frictional stress was varied to study the contribution of the frictional stress in dense granular flows. The results show that the pure kinetic-theory-based computational fluid dynamics （CFD） model （without frictional stress） over-predicts the dominant solids motion of dense granular flow while adding frictional stress [Schaeffer, D. g. （1987）. Instability in the evolution equations describing incompressible granular flow. Journal of Differential Equations, 66（1）, 19-50] with the solids pressure of [Lun, C. NTK., Savage, S. B., Jeffrey, D. J., ＆ Chepurniy, N. （1984）. Kinetic theories for granular flow： Inelastic particles in Couette flow and slightly inelastic particles in a general flow field. Journal of Fluid Mechanics, 140, 223-256] in the CFD model improves the simulation to better conform available experimental results. The results also suggest that frictional stress transmission plays an important role in dense granular flow and should not be neglected in granular flow simulations. Compatible simulation results to the experimental data are seen by increasing the weight of frictional stress to a factor of 1.25-1.5. These improved simulation results suggest the current constitutive relations （kinetic-frictional model） need to be improved in order to better reflect the real dense granular flow.

关键词： gas-solids flow CFD Constitutive relations Couette flow Kinetic theory Kinetic-frictional model

Mineralogical, REE-geochemical and fluid inclusion studies on some uranium occurrences, gabal gattar, Northeastern Desert, Egypt

在线全文

学校读者我要写书评

暂无评论

Chinese Journal Of geochemistry 2011年第4期30卷 430-443页

作者： El-Feky M.g. Nuclear Materials Authority

Altered granite occurrences (gII and gV) at gabal (g.) gattar are the most important mineralized rocks hosting U-mineralization in Egypt. This mineralized granite is affected by multi-stage hydrothermal alteration proc-esses along brittle structures. This alteration comprises pre-ore alkali-metasomatism and ore-stage hydrothermal hematitization, silicification, kaolinitization, fluoritization, carbonatization and episyenitization. Autoradiographic examination indicates that primary uranium mineralization is present as massive or disseminated ores along tectonic fractures, interstitially in granular minerals, and as cements of breccias. Uraninite, pitchblende and coffinite are the main primary minerals, while uranophane and kasolite are the secondary ones. galena, chalcopyrite, pyrrohtite and pyrite are the most abundant sulphides in association with uranium mineralizations. Hydrothermal alterations at the gII occurrence exhibit an increase in Ni, Cu, Zn, Pb, Mo, Nb, Rb beside HREEs and a decrease in Ba, Co, Sr, and V, while alterations at the gV occurrence show enrichment in Ni, Cu, Pb, Mo, Nb, Y, HREEs and depletion in Zn, Ba, Co, Rb, Sr, and V. Hydrothermal alteration during the late magmatic stage is also identified through the development of unusual REE patterns and fractionation of ratios like Zr/Hf and Y/ho out of the CHARAC (Charge Radius Con-trolled) range. Non-chondritic Y/ho ratio at gV is of larger value than chondritic one which may result from wa-ter-rock interaction or print from the encompassing sedimentary rocks. Fluid inclusion studies on quartz and fluorite revealed that temperatures of the mineralizing fluids range between 126 and 240℃ at pressure ≤0.5×108 Pa and give salinity values ranging between 1 wt% and 7.8 wt% NaCl equivalent.

关键词：稀土元素地球化学流体包裹体铀矿化矿物学埃及全球信息基础设施东北部沙漠

基于比特的物理层人工噪声安全传输系统破解方法

在线全文

学校读者我要写书评

暂无评论

网络安全技术与应用 2024年第8期 33-36页

作者：罗洪宇唐杰王爱文文红 PIN Han-ho Shih Yu Chang 电子科技大学四川611731 University of Waterloo Ontario Canada N2L3G1

针对物理层人工噪声安全传输系统,提出了一种基于信息纬度的破解方法。在无线通信网络中,人工噪声(AN,Artificial Noise)被广泛用于增强物理层系统的安全性。尽管已有大量研究探讨使用人工噪声实现安全传输,然而现有方法多从通信信息论... 详细信息

针对物理层人工噪声安全传输系统,提出了一种基于信息纬度的破解方法。在无线通信网络中,人工噪声(AN,Artificial Noise)被广泛用于增强物理层系统的安全性。尽管已有大量研究探讨使用人工噪声实现安全传输,然而现有方法多从通信信息论的角度考虑安全性,且不考虑接收误比特率。本文提出的方法从信息比特层面出发,结合加解密思想,针对给定的接收误比特率和发送信息比特长度,提出了一种破译方法。通过理论分析和仿真实验,本文证明了该方法在破译复杂度上具有一定优势。

关键词：物理层安全传输人工噪声信息纬度破译方法接收误比特率

SMA molecular line survey towards the massive star-forming region g10.6-0.4in W31complex

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2018年第11期18卷 29-42页

作者： Wai-ho Wong Tao An Key Laboratory of Radio Astronomy Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Line surveys of complex molecules with millimeter and sub-millimeter telescopes are important for probing the physical and chemical environments of massive star forming regions(MSFRs).We present a molecular line survey with the Submillimeter Array(SMA) in the frequency ranges of 220.3–222.3 gHz and 230.3–232.3 gHz toward g10.6-0.4, the brightest star forming core in the W31 complex. Ninety-nine transitions from 22 molecular species and their isotopologues are identified. The moment 0 images of typical molecules show a compact core which is concentrated at the continuum peak position. Based on the local thermodynamic equilibrium assumption, the molecular line data are modeled. The rotational temperatures of those molecular species range from 96 to 178 K and their column densities range from 2.0×1014to 3.7×1017cm-2. The observational data suggest that all complex molecules are located in a warm environment. Chemical environments of the molecules are discussed. We compared molecular abundances and gas temperatures in g10.6-0.4 with those in other MSFRs, and found that gas temperatures and fractional abundances of specific molecules in g10.6-0.4 are similar to the typical MSFR W51 North, suggesting that there are similar physical and chemical environments in these two MSFRs.

关键词： stars: formation ISM: abundances ISM: individual objects: g10.6-0.4 ISM: molecules radio lines: ISM

Can radiotherapy finally “go live” in the management of liver metastases?

在线全文

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第9期6卷 1-9页

作者： Reggie g.John Francis ho.gokula K.Appalanaido Desiree Chen Jeremy Tey Yu Yang Soon Balamurugan A.Vellayappan Department of Radiation Oncology National University Cancer Institute SingaporeNational University HospitalSingapore 119228Singapore Advanced Medical and Dental Institute Universiti Sains MalaysiaBertamJln Tun Hamdan Sheikh TahirPulau Pinang 13200Malaysia.

Liver metastases can present synchronously or at different time *** systemic therapy continues to be the mainstay of treatment for patients with liver metastases,it is unlikely to completely eradicate the ***“metastectomy”for patients with limited metastatic burden,particularly from colorectal cancers,has been shown to improve ***,owing to medical co-morbidities or tumour location,not all patients are eligible for surgical *** recent years,there has been an increase in the use of non-surgical techniques,including high dose radiation using stereotactic body radiotherapy,or brachytherapy,to ablate liver *** purpose of this narrative review is to describe the role of radiotherapy in the management of liver metastases,both for local ablation and symptom *** will elaborate on the techniques used,patient selection process,expected outcomes and toxicities based on the current literature.

关键词： Radiotherapy stereotactic body radiotherapy liver metastases brachytherapy palliation