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Dalbergia odorifera Essential Oil Protects against Myocardial Ischemia through Upregulating Nrf2 and Inhibiting Caspase Signaling Pathways in Isoproterenol-Induced Rats

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 338-347页

作者： Can-ho.g Wang Bao gong Hui Meng Yu-Lan Wu Xiang-Sheng Zhao Jian-he Wei Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of Bioactive Substances and Resources Utilization of Chinese herbal Medicine Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular *** study aimed to determine the potential myocardial protective effect and possible mechanism of action of *** ife ra essential oil(DOEO).Materials and Methods:The essential oil of *** was extracted by *** cardioprotective effects of DOEO were examined by histopathological observation,myocardial enzyme detection,peroxidation,anti-oxidant level detection,and related protein *** compounds in the blood were identified by gas chromatography-mass ***:These results showed that DOEO had significant myocardial cell protection,with IC50 values ranging from 17.64 to 24.78μg/mL in *** to the myocardial ischemia group,the DOEO pretreatment groups had lower levels of myocardial injury,creatinine kinase,lactate dehydrogenase,alanine transaminase,aspartate transaminase,hydrogen peroxide,and nitric oxide,and higher levels of glutathione and superoxide *** addition,DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase *** r,immunohistochemical e xperiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2(Nrf2)and heme oxygenase-1(ho-1)and reduced the expression of apoptotic caspases,including caspase 3 and caspase *** main components of the blood were transnerolidol and nerolidol ***,the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor-antioxidant response element(Nrf2-ARE)and caspase *** has a therapeutic effect on MI by inhibiting the oxidant and apoptotic ***:*** may be a potential candidate drug for treating myocardial ischemic injury.

关键词： Anti-apoptosis Anti-oxidation Dalbergia odorifera essential oil Isoproterenol Myocardial ischemia

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Central Composite Design for Optimized Extraction of Polysaccharides from Undaria pinnatifida

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Chemical Research in Chinese Universities 2012年第4期28卷 620-623页

作者： heO Hyo-jung ROW Kyung-ho Department of Chemical Engineering Inha University253 Yonghyun-DongNam-KuIncheon 402-751Korea

Response surface methodology was used to optimize the extraction conditions of polysaccharides from Undaria *** effects of three independent variables,extraction time,extraction temperature and ratio of water to raw material were investigated by a central composite *** experimental data were fitted to a second-order polynomial equation via multiple regression analysis and also examined with the appropriate statistical *** adjusted coefficient of determination（R^2Adj） for the model was *** optimum extraction yield of 30.78% was obtained when the extraction temperature was 95 °C,extraction time was 4.5 h,and the ratio of water to raw material was 35（mL/g）.Under these conditions,validation experiments were done and the mean extraction yield of polysaccharides was 30.79%,which was in good agreement with the predicted model value.

关键词： Undaria pinnatifida Optimization Extraction Polysaccharide Response surface methodology

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Purification of Astaxanthin from Laminaria japonica by Ionic Liquid-based Monolithic Cartridge

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Chemical Research in Chinese Universities 2012年第3期28卷 406-409页

作者： YOON Chang-hwan ROW Kyung-ho Department of Chemical Engineering Inha UniversityIncheon 402-751Korea

An effective and accurate method was developed for the extraction of astaxanthin from Laminariajapo- nica with subsequent separation by ionic liquid-based monolithic cartridge. The optimized extraction conditions in- cluding extraction solvent（ethanol）, extraction time（90 min） and ultrasonic power（75 W） were obtained by systema- tical investigation. Chromatographic analysis was performed on a C18 column with ultraviolet（UV） detection at 476 nm, and a solution consisting of methanol/acetonitrile/H2O/dichloromethane（83：6：6：5, volume ratio） was used as the mobile phase at a flow rate of 0.7 mL/min. After ionic liquid-based monolithic solid phase extraction, 17.82 μg/g as- taxanthin was obtained from Laminaria japonica. This ionic liquid-based monolithic cartridge exhibits high affinity and selectivity for astaxanthin, and it can be potentially used as the stationary phase of high performance liquid chromatography（HPLC）.

关键词： Laminariajaponica Astaxanthin Extraction Ionic liquid Cartridge

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No evidence of superconductivity in a compressed sample prepared from lutetium foil and H_(2)/N_(2) gas mixture

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Matter and Radiation at Extremes 2023年第4期8卷 76-80页

作者： Shu Cai Jing guo Haiyun Shu Liuxiang Yang Pengyu Wang Yazhou Zhou Jinyu Zhao Jinyu Han Qi Wu Wenge Yang Tao Xiang ho-kwang Mao Liling Sun Institute of Physics Chinese Academy of SciencesBeijing 100190China Center for High Pressure Science and Technology Advanced Research 100094 BeijingChina University of Chinese Academy of Sciences Beijing 100190China

A material described as lutetium–hydrogen–nitrogen(Lu-H-N in short)was recently claimed to have“near-ambient superconductivity”[Dasenbrock-gammon et al.,Nature 615,244–250(2023)].If this result could be reproduced by other teams,it would be a major scientific ***,we report our results of transport and structure measurements on a material prepared using the same method as reported by Dasenbrock-gammon et *** x-ray diffraction measurements indicate that the obtained sample contains three substances:the facecentered-cubic(FCC)-1 phase(Fm-3m)with lattice parameter a=5.03Å,the FCC-2 phase(Fm-3m)with a lattice parameter a=4.755Å,and Lu *** two FCC phases are identical to the those reported in the so-called near-ambient ***,we find from our resistance measurements in the temperature range from 300 K down to 4 K and the pressure range 0.9–3.4 gPa and our magnetic susceptibility measurements in the pressure range 0.8–3.3 gPa and the temperature range down to 100 K that the samples show no evidence of *** also use a laser heating technique to heat a sample to 1800 XC and find no superconductivity in the produced dark blue material below 6.5 *** addition,both samples remain dark blue in color in the pressure range investigated.

关键词： resistance superconductivity ambient

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Chemical interaction motivated structure design of layered metal carbonate hydroxide/MXene composites for fast and durable lithium ion storage

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Journal of Energy Chemistry 2021年第12期30卷 633-641,I0015页

作者： Huibin guan Hanna he Tianbiao Zeng Chuho.g Zhang State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065Sichuan.China

Rational architecture design has turned out to be an effective strategy in improving the electrochemical performance of electrode materials for ***,an elaborate structure that could simultaneously endow active materials with promoted reaction reversibility,accelerated kinetic and restricted volume change still remains a huge ***,a novel chemical interaction motivated structure design strategy has been proposed,and a chemically bonded Co(CO_(3))_(0.5)OH·0.11 H_(2)O@MXene(CoCH@MXene)layered-composite was fabricated for the first *** such a composite,the chemical interaction between Co^(2+)and MXene drives the growth of smaller-sized CoCH crystals and the subsequent formation of interwoven CoCH wires sandwiched in-between MXene *** unique layered structure not only encourages charge transfer for faster reaction dynamics,but buffers the volume change of CoCH during lithiation-delithiation process,owing to the confined crystal growth between conductive MXene layers with the help of chemical ***,the sandwiched interwoven CoCH wires also prevent the stacking of MXene layers,further conducive to the electrochemical performance of the *** a result,the as-prepared CoCH@MXene anode demonstrates a high reversible capacity(903.1 mAh g^(-1)at 100 mA g^(-1))and excellent cycling stability(maintains 733.6 mAh g^(-1)at1000 mA g^(-1)after 500 cycles)for lithium ion *** work highlights a novel concept of layerby-layer chemical interaction motivated architecture design for futuristic high performance electrode materials in energy storage systems.

关键词： Chemical interaction motivated structure design Layer-by-layer structure Metal carbonate hydroxide Few-layer MXene Fast and durable lithium ion storage

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TheRMODYNAMIC MODELINg OF NANOSCALE FERROELECTRIC SYSTEMS

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Acta Mechanica Solida Sinica 2009年第6期22卷 524-549页

作者： Yue Zheng Biao Wang Chung-ho Woo State Key Laboratory of Optoelectronic Materials and Technologiez/Institute of Optoelectronic and FunctionalComposite Materials School of Physics and Engineering Sun Yat-sen University Guangzhou 510275 China Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong SAR China

Thermodynamic models formulated based on the Landau free-energy expansion are popular and well suited to studies involving properties of the ferro/para-electric transition, or near it. Indeed, the general nature of thermodynamics, from which the strength of the model is derived, allows a valid model to be constructed based on simple functional forms with parameters fitted to experiments, by passing the mechanistic complexity. Despite inaccuracy due to the neglect of fluctuations, this approach has been proven effective and powerful for recent research development of ferroelectrics in nanoscale. Efforts in some important works have recently faced much challenge, when free-energy contributions have to be incorporated to account for the presence of depolarization fields, surfaces and other defects. To minimize the problems with mechanistic obscurity, it is of paramount importance that the electromagnetics, mechanics and thermodynamics involved are accounted for explicitly and with full self-consistency. It is important that the free-energy functional of nanoscale ferroelectric systems, such as ferroelectric thin films （FTF）, bilayers （FB）, superlattices （FS）, nanowires （FNW）, nanotubes （FNT） and tunneling junctions （FTJ） etc., must be derived thermodynamically from first principles.

关键词： ferroelectrics nanoscale thin film superlattice nanowire nanotube tunneling junction mechanical load

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Synchrotron refractive-index microradiography of human liver cancer tissue

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Chinese Science Bulletin 2005年第22期50卷 2657-2661页

作者： TONg Yongpeng ZHANg guilin LI Yan HWU Yeukuang TSAI Wenli JE Jung ho Margaritondo g YUAN Dong Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China Institute of Physics Academia Sinica Nankang Taipei China Department of Material Science and Engineering Pohang Universty of Science and Technology Pohang Korea IPA-Ecole Polytechnique Federale de Lausanne (EPFL) CH-1015 Lausanne Switzerland Shanghai CDC Shanghai 200336 China

Three human liver tissue samples (～5 mm × 40 mm × 20 mm) were excised from a cancer patient's liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the cancer area. Blood vessels with a diameter smaller than 20 μm could be identified. These findings were fully consistent with the histopathological examination of the same area. Microradiographs of the newly formed blood vessels at different angles were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic imaging for clinic diagnosis of liver cancer at the early stage.

关键词：肝癌同步加速器折射系数 X射线显微照相术组织病理学

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Signaling pathways and targeted therapy for myocardial infarction

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1009-1046页

作者： Qing Zhang Lu Wang Shiqi Wang ho.gxin Cheng Lin Xu gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi he Quan Wei Rehabilitation Medicine Center and Institute of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuanPR China Key Laboratory of Rehabilitation Medicine in Sichuan Province ChengduSichuanPR China National Clinical Research Center for geriatrics West China HospitalSichuan UniversityChengduSichuanPR China Aging and geriatric Mechanism Laboratory West China HospitalSichuan UniversityChengduSichuanPR China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuanPR China

Altho.gh the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high *** there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are *** of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem *** signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/ho-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TgF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,*** signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and ***,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel *** this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,*** as to repair and re-functionalize damaged hearts.

关键词： inflammation infarction instance

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A laboratory scale study on arsenic(V) removal from aqueous medium using calcined bauxite ore

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Journal of Environmental Sciences 2008年第6期20卷 683-689页

作者： Debasish Mohapatra Debaraj Mishra Kyung ho Park DAEIL Development Co. Ltd. Research and Development CenterAnsan 425 836 Korea. Minerals and Materials Processing Division Korea Institute of Geosciences and Mineral ResourcesDaejeon 305 350 Korea

The present work deals with the As（Ⅴ） removal from an aqueous medium by calcined refractory grade bauxite （CRB） as a function of solution pH, time, As（Ⅴ） concentration and temperature. The residual As（Ⅴ） was lowered from 2 mg/L to below 0.01 mg/L in the optimum pH range 4.0-7.0 using a 5 g/L CRB within 3 h contact time. The adsorption data fits well with Langmuir isotherm and yielded Langmuir monolayer capacity of 1.78 mg As（Ⅴ）/g of CRB at pH 7.0. Presence of anions such as silicate and phosphate decreased As（Ⅴ） adsorption efficiency. An increase temperature resulted a decrease in the amount of As（Ⅴ） adsorbed by 6%. The continuous fixed bed column study showed that at the adsorbent bed depth of 30 cm and residence time of 168 min, the CRB was capable of treating 340 bed volumes of As（V） spiked water （C0 = 2 mg/L） before breakthrough （Ce = 0.01 mg/L）. This solid adsorbent, altho.gh not reusable, can be considered for design of adsorption columns as an efficiency arsenic adsorption media.

关键词： adsorption As(Ⅴ) calcination adsorption isotherm column study

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Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

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Nano-Micro Letters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurelian Crunteanu Zhenming Xie georges Humbert Libo Ma Yuanyuan Wei Aude Brunel Barbara Bessette Jean-Christophe Orlianges Fabrice Lalloué Oliver gSchmidt Nanfang Yu ho-Pui ho Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Applied Physics and Applied Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Faculty of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer,monitoring treatment and detecting ***,a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change *** precisely engineering the configuration with atomically thin materials,the phase singularity has been successfully achieved with a significantly enhanced lateral position shift *** on our knowledge,it is the first experimental demonstration of a lateral position signal change>340μm at a sensing interface from all optical *** this enhanced plasmonic effect,the detection limit has been experimentally demonstrated to be 10^(-15) mol L^(−1) for TNF-α cancer marker,which has been found in various human diseases including inflammatory diseases and different kinds of *** as-reported novel integration of atomically thin ge_(2)Sb_(2)Te_(5) with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

关键词： 2D nanomaterials Cancer marker detection Phase singularity Surface plasmon

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