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Challenges and Opportunities in the Practice of Chinese Medicine in Singapore

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Chinese Journal of Integrative Medicine 2024年第6期30卷 483-488页

作者： CHEW Sin yee National University hospital Singapore119074Singapore

According to the World Health Oranization(Who)Traditional Medicine Strategy 2014-2023,traditional medicine is defined as"the sum total of the knowledge,skill and practices based on the theories,beliefs,and experiences indigenous to different cultures,whether explicable or not,used in the maintenance of health as well as in the prevention,diagnosis,improvement or treatment of physical and mental illness.

关键词： theories prevention diagnosis

A prospective cohort of men with localized prostate cancer on active surveillance protocol in hong Kong,China:what did we learn?

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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-ho Ko Cindy Yeuk-Lam hong Samuel Chi-Hang yee Jeremy Yuen-Chun Teoh Samson Yun-Sang Chan ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter Ka-Fung Chiu SH ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH ho Urology Centre,Prince of Wales hospital,hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

Engineering behaviour of in situ cored deep cement mixed marine deposits subjected to undrained and drained shearing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1749-1760页

作者： Wei Li Chung yee Kwok Faculty of Engineering China University of GeosciencesWuhan430074China Department of Civil Engineering The University of Hong Kong999000Hong Kong SARChina

The deep cement mixing(DCM)is used to improve the capacity and reduce the settlement of the soft ground by forming cemented clay *** investigation on the mechanical behaviour of the DCM samples is limited to either laboratory-prepared samples or in-situ samples under unconfined *** this study,a series of drained and undrained triaxial shearing tests was performed on the in-situ cored DCM samples with high cement content to assess their mechanical *** is found that the drainage condition affects significantly the stiffness,peak and residual strengths of the DCM samples,which is mainly due to the state of excess pore water pressure at different strain levels,*** positive before the peak deviatoric stress and negative after the peak deviatoric stress,in the undrained *** slope of the failure envelope changes obviously with the confining pressures,being steeper at lower stress levels and flatter at higher stress *** strength parameters,effective cohesion and friction angle obtained from lower stress levels(c′0 andφ′0)are 400 kPa and 58°,respectively,which are deemed to be true for design in most DCM applications where the in-situ stress levels are normally at lower values of 50-200 ***,the computed tomography(CT)scanning system was adopted to visualize the internal structures of DCM *** is found that the clay pockets existing inside the DCM samples due to uneven mixing affect markedly their stress-strain behaviour,which is one of the main reasons for the high variability of the DCM samples.

关键词： Deep cement mixing(DCM) In-situ cored sample Triaxial shearing Drainage condition Confining pressure Computed tomography(CT)

Wan-yee Joseph Lau:the promoter of modernization and internationalization of Chinese surgery

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Oncology and Translational Medicine 2024年第1期10卷 1-3页

作者： Wan-yee Joseph Lau Faculty of Medicine The Chinese University of Hong KongHong KongChina

To my knowledge,there have been 3 books[1–3]and 2 book chapters written about me.[4–5]For those who are interested in the details of my life,please refer to these books/book *** title of this article is an English translation of the title of the book I refer to as reference 1,which I find appropriate to describe the role that I play in China.

关键词： please details translation

Low-thermal-budget electrically active thick polysilicon for CMOS-First MEMS-last integration

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Microsystems & Nanoengineering 2024年第3期10卷 395-407页

作者： Aron Michael Ian Yao-Hsiang Chuang Chee yee Kwok Kazuo Omaki UNSW SydneyNSW 2052Australia

Low-thermal-budget,electrically active,and thick polysilicon films are necessary for building a microelectromechanical system(MEMS)on top of a complementary metal oxide semiconductor(CMOS).however,the formation of these polysilicon films is a challenge in this ***,for the first time,the development of in situ phosphorus-doped silicon films deposited under ultrahigh-vacuum conditions(~10^(−9)Torr)using electron-beam evaporation(UHVEE)is *** process results in electrically active,fully crystallized,low-stress,smooth,and thick polysilicon films with low thermal *** crystallographic,mechanical,and electrical properties of phosphorus-doped UHVEE polysilicon films are *** films are compared with intrinsic and boron-doped UHVEE silicon *** spectroscopy,X-ray diffraction(XRD),transmission electron microscopy(TEM)and atomic force microscopy(AFM)are used for crystallographic and surface morphological *** curvature,cantilever deflection profile and resonance frequency measurements are employed to study the mechanical properties of the ***,resistivity measurements are conducted to investigate the electrical properties of the *** vertical,high-aspectratio micromachining of UHVEE polysilicon has been developed.A comb-drive structure is designed,simulated,fabricated,and characterized as an actuator and inertial sensor comprising 20-μm-thick in situ phosphorus-doped UHVEE films at a temperature less than 500°*** results demonstrate for the first time that UHVEE polysilicon uniquely allows the realization of mechanically and electrically functional MEMS devices with low thermal budgets.

关键词： budget thick thermal

Blade Wrap Angle Impact on Centrifugal Pump Performance:Entropy Generation and Fluid-Structure Interaction Analysis

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 109-137页

作者： Hayder Kareem Sakran Mohd Sharizal Abdul Aziz Chu yee Khor School of Mechanical Engineering Universiti Sains MalaysiaEngineering CampusNibong TebalPenang14300Malaysia Chemical Engineering Department Faculty of EngineeringAl-Muthanna UniversityMuthanna66001Iraq Faculty of Mechanical Engineering&Technology Universiti Malaysia Perlis(UniMAP)ArauPerlis02600Malaysia

The centrifugal pump is a prevalent power equipment widely used in different engineering patterns,and the impeller blade wrap angle significantly impacts its performance.A numerical investigation was conducted to analyze the influence of the blade wrap angle on flow characteristics and energy distribution of a centrifugal pump evaluated as a low specific speed with a value of *** study investigates six impellermodels that possess varying blade wrap angles(95°,105°,115°,125°,135°,and 145°)that were created while maintaining the same volute and other geometrical *** investigation of energy loss was conducted to evaluate the values of total and entropy generation rates(TEG,EGR).The fluid-structure interaction was considered numerically using the software tools ANSYS Fluent and *** elastic structural dynamic equation was used to estimate the structural response,while the shear stress transport k–ωturbulence model was utilized for the fluid domain *** findings suggest that the blade wrap angle has a significant influence on the efficiency of the *** impeller featuring a blade wrap angle of 145°exhibits higher efficiency,with a notable increase of 3.76%relative to the original *** in the blade wrap angle impact the energy loss,shaft power,and pump *** model with a 145°angle exhibited a maximum equivalent stress of 14.8MPa and a total deformation of 0.084 *** results provide valuable insights into the intricate flow mechanism of the centrifugal pump,particularly when considering various blade wrap angles.

关键词： Centrifugal pump blade wrap angle entropy generation theory fluid-structure interaction hydraulic performance

Translating bacteriophage-derived depolymerases into antibacterial therapeutics:Challenges and prospects

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Acta Pharmaceutica Sinica B 2024年第1期14卷 155-169页

作者： honglan Wang Yannan Liu Changqing Bai Sharon Shui yee Leung School of Pharmacy the Chinese University of Hong KongHong Kong SARChina Emergency Medicine Clinical Research Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory Shenzhen University General HospitalShenzhen University Clinical Medical AcademyGuangdong 518055China

Predatory bacteriophages have evolved a vast array of depolymerases for bacteria capture and *** depolymerases are enzymes responsible for degrading diverse bacterial surface *** are exploited as antibiofilm agents and antimicrobial adjuvants while rarely inducing bacterial resistance,making them an invaluable asset in the era of antibiotic *** depolymerases have been investigated preclinically,with evidence indicating that depolymerases with appropriate dose regimens can safely and effectively combat different multidrug-resistant pathogens in animal infection ***,some formulation approaches have been developed for improved stability and activity of ***,depolymerase formulation is limited to liquid dosage form and remains in its infancy,posing a significant hurdle to their clinical translation,compounded by challenges in their applicability and *** development must address these obstacles for clinical ***,after unravelling the history,diversity,and therapeutic use of depolymerases,we summarized the preclinical efficacy and existing formulation findings of recombinant ***,the challenges and perspectives of depolymerases as therapeutics for humans were assessed to provide insights for their further development.

关键词： Phage-derived polysaccharide depolymerases Bacteriophage proteins Bacterial capsules Polysaccharide capsules Antibiotic resistance Biofilms Antibacterial therapy Antimicrobial adjuvants Combination treatment

Effect of non-uniform swelling on coal multiphysics during gas injection: The triangle approach

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1362-1372页

作者： Yifan Huang Jishan Liu Yaoyao Zhao Derek Elsworth yee-Kwong Leong Department of Chemical Engineering School of EngineeringThe University of Western Australia35 Stirling HighwayWA 6009Australia State Key Laboratory of Coal Resources & Safe Mining China University of Mining& TechnologyBeijing100803China Department of Energy and Mineral Engineering G3 Centre and Energy InstituteThe Pennsylvania State UniversityUniversity ParkPA16802USA

In current dual porosity/permeability models,there exists a fundamental assumption that the adsorption-induced swelling is distributed uniformly within the representative elementary volume (REV),irrespective of its internal structures and transient ***,both internal structures and transient processes can lead to the non-uniform *** this study,we hypothesize that the non-uniform swelling is responsible for why coal permeability in experimental measurements is not only controlled by the effective stress but also is affected by the adsorption-induced *** propose a concept of the swelling triangle composed of swelling paths to characterize the evolution of the non-uniform swelling and serve as a core link in coupled multiphysics.A swelling path is determined by a dimensionless volumetric ratio and a dimensionless swelling *** swelling paths have the same start and end point,and each swelling path represents a unique swelling *** swelling path as the diagonal of the triangle represents the case of the uniform swelling while that as the two perpendicular boundaries represents the case of the localized *** paths of all intermediate cases populate inside the *** corresponding relations between the swelling path and the response of coal multiphysics are established by a non-uniform swelling *** define this method as the triangle approach and corresponding models as swelling path-based *** proposed concept and models are verified against a long-term experimental measurement of permeability and strains under constant effective *** results demonstrate that during gas injection,coal multiphysics responses have a close dependence on the swelling path,and that in both future experiments and field predictions,this dependence must be considered.

关键词： Transient process Heterogeneity Swelling triangle Swelling path Non-uniform swelling coefficient

Characterization of sand convective motions at a vertical wall subjected to long-term cyclic loading

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Fundamental Research 2024年第2期4卷 334-343页

作者： Dawei Guan Jialong Li yee-Meng Chiew Jisheng Zhang Key Laboratory of Ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210024China College of Harbour Coastal and Offshore EngineeringHohai UniversityNanjing 210024China Shanghai Investigation Design and Research Institute Co.LtdShanghai 200335China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore

By conducting a two-dimensional experimental study,this paper aims to enhance the understanding of the mechanism of sand convective motions in the vicinity of a wall subjected to long-term cyclic lateral *** experimental tests were conducted in a rectangular sandbox with a transparent front-wall,through which the process of sand particle motions could be recorded by using a high-resolution digital *** images were processed with a high time-resolved PIV(Particle Image Velocimetry)*** on the experimental data,this work(1)presents the sand flow field in the convective zones;(2)provides means to describe the convection mechanism;(3)proposes the relationships between the loading conditions and dimensions of the region with intense sand movement;and(4)elaborates the similarity of the sand flow velocity structure within the sand convective zones.

关键词： Vibration Soil/structure interaction Deformation Particle image velocimetry Laboratory tests