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Journal of China University of Geosciences 2009年第1期20卷 77-84页

作者： ho-shing yu Emmy T Y Chang Institute of Oceanography National Taiwan UniversityTaipei

We examine slope profile types and variations in slope gradient and slope refief with depth for both passive and active margins in the northern most South China Sea. The passive South China margin is characterized by an exponential slope profile, mainly associated with clustered slope-confined canyons. The active Taiwan margin shows a linear-like shape with great variations along the lower slope. Fewer canyons occur on the Taiwan margin, and hence the influence of canyon incision on slope morphology is relatively less significant. Quantitative analyses of slope curvature, slope gradient and square root of relief variance are useful statistical parameters to explain characteristics and variability of morphology of the slope of the South China margin, but not for the Kaoping slope on the Taiwan side. On the active Taiwan margin, tectonic activities are dominant over sediment deposition and surface erosion, producing a slope profile quite different from those of passive margins of the Middle Atlantic, KwaZulu-Natal, South Africa where failure on slope and accompanying canyon incision are the dominant processes shaping the slope morphology.

关键词： slope morphology canyon statistical analysis continental margin South China Sea.

Physiographic and geological characteristics of shelves in north and west of Taiwan

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Science China Earth Sciences 2001年第8期44卷 696-707页

作者：俞何兴周颖蔚 1. Institute of Oceanography Taiwan University 106 Taipei China

In north of Taiwan the East China Sea Shelf extends from the coastline of China's Mainland to the southern Okinawa Trough, showing a shelf-slope-basin bathymetric profile. Sea floor of the East China Sea Shelf is generally smooth and flat. It is wide (230 km) and relatively shallow with an average shelf-break depth of 120 m, reflecting the effect of Quaternary glaciation about 15000 years ago. The Pliocene-Quaternary East China Sea Shelf is underlain by thin sequences of about 1000 m thick shallow marine sediments mainly derived from China, forming an eastward dipping sedimentary wedge due to regional tilting and subsidence and representing the youngest part of the Cenozoic rift margin in southeastern China. The Taiwan Strait Shelf has two phases in development: one is the early phase of the Paleo-cene-Miocene rift margin and the other is the late stage of the Pliocene-Quaternary foreland sedi-mentation. It is a foreland shelf and its present morphology results from the combined effects of tectonic subsidence and sedimentation overprinting that of the Late Pleistocene glaciation about 15000 years ago.Southeast of the Taiwan Strait Shelf lies the very narrow Kaoping Shelf along the southwest-ern Taiwan coast. The island shelf is a short, narrow and shallow shelf (100 km long, 20 km wide and 80 m deep). Progradation of Quaternary orogenic sediments from the Taiwan orogen forms the present island shelf off southwest Taiwan. The shelf represents the early stage of foreland basin sedimentation.The transition from a passive margin shelf (East China Sea Shelf), a foreland shelf (Taiwan Strait Shelf) to an island shelf (Kaoping Shelf) along the strike of the fold-and-thrust belt of Taiwan mainly reflects the oblique collision between the Luzon Arc and the Chinese margin from Pliocene to the present. The accompanying uplift of Taiwan orogen, foreland-basin sedimentation, and sea level changes contribute to the formation of these three different shelves adjacent to Taiwan.

关键词： Taiwan shelf foreland basin glaciation

台湾西南部岸外陆坡上页岩底辟控制的枋寮峡谷的发育

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海洋地质译丛 1996年第1期 35-42页

作者： ho-shing yu 陶铮

1 引言台湾西南部岸外陆坡有几个峡谷。从北到南,这些峡谷是澎湖、高雄、高屏和枋寮(图1)。它们已被知道了60多年。因为没有充分的由现代海洋地球物理和地质方法所取得的资料,它们中的没有一个被很好了解。例如,这些峡谷的沉积过程被... 详细信息

1 引言台湾西南部岸外陆坡有几个峡谷。从北到南,这些峡谷是澎湖、高雄、高屏和枋寮(图1)。它们已被知道了60多年。因为没有充分的由现代海洋地球物理和地质方法所取得的资料,它们中的没有一个被很好了解。例如,这些峡谷的沉积过程被了解很少,因为从这些峡谷中没有取得为沉积分析用的沉积岩芯。这些峡谷的一般地质评述已由yu和Lu(1994)给出。枋寮峡谷(据海岸城市命名)切割了海岸线之南的陆架约20km(图1)。直到现在,仅有一篇出版的文章专门涉及了枋寮峡谷(yu等,1991)。根据有限的测深资料和穿过枋寮峡谷的3.5Hz回声图,yu等(1991)没有辨认出下峡谷分支成由南北向底辟侵入造成的两段。因此,他们的关于枋寮峡谷的地貌和成因的结论仅是部分正确的。本文详细地描述了枋寮峡谷的地貌,并把地貌与页岩底辟体的局部上升关联起来,然后利用新取得的测深资料和多道地震反射剖面讨论此峡谷的成因。

关键词：陆坡页岩底辟控制枋寮峡谷峡谷

Modular Design Using Sustainable Luminescent Materials in Energy-Saving Reflective Cat’s Eyes for Public Road Safety Planning

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Journal of Renewable Materials 2022年第5期10卷 1415-1437页

作者： Lung-Yin Lin yu-shing Chang Department of Industrial Design National Kaohsiung University of Science and TechnologyKaohsiung82445Taiwan Department of Business Administration National Taichung University of Science and TechnologyTaichung404Taiwan

Recently,there has been a global movement toward environmental protection and energy conservation through the design and development of new products in accordance with sustainable *** this study,rare earth luminescent materials were used owing to their active light emission and ***,solar lightemitting diode lights and car-light reflection were utilised to increase the recognition and reliability of reflective cat *** with carbon reduction,this can save energy and enhance road *** study considered the Theory of Inventive Problem Solving and a literature review to analyse the issues in existing ***,expert interviews were conducted to screen projects and develop product design ***,the ratio of light-storage materials was experimentally determined and the prototypes *** cat’s eye addresses the shortcomings identified in previous analyses of existing *** applied energy storage environmental protection materials,together with material proportioning(which balanced warning efficiency against cost-effectiveness)to develop diversified modular kits;these were flexible in terms of quantity and easily *** study achieved four key objectives:(1)reducing the research and development costs of the manufacturer;(2)offering buyers a diverse suite of products;(3)responding to a need to improve diverse road user safety;and(4)reducing government procurement costs for safety warning *** results provide a reference for the creative modular design of energy-saving products for public road safety planning in various industries.

关键词： Sustainable luminescent materials modular design TRIZ expert interview diverse road safety

Isolated right coronary artery bypass grafting via minimally invasive approach in two elderly patients with failed percutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第7期19卷 555-558页

作者： An shing Ang Ilias Skaltsiotis Theodore Kofidis Hee Hwa ho Department of Cardiology Tan Tock Seng HospitalSingapore Department of Cardiac Thoracic and Vascular SurgeryNational University HospitalNational University Health SystemSingapore

Coronary artery bypass grafting(CABG)tra-ditionally involves revascularization of the left anterior descending artery(LAD)as it is usually of greater prognostic value.[1]Isolated CABG for non-LAD lesions have also been descri-bed in ***,these were often in the setting of re-do CABG[2,3]or in patients with isol-ated right sided coronary lesion and concomitant valvular heart disease.

关键词： coronary bypass patients

Gut microbiota in cancer initiation,development and therapy

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Science China Life Sciences 2025年

作者： Ruyi Zhang Xiang Zhang Harry Cheuk Hay Lau Jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

Cancer has long been associated with genetic and environmental factors,but recent studies reveal the important role of gut microbiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific microorganisms *** microbiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish microecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut microbiota may help manage side effects of cancer *** research is crucial to understand better how gut microbiota can be used to improve cancer prevention and treatment outcomes.

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Beyond images: Emerging role of Raman spectroscopy-based artificial intelligence in diagnosis of gastric neoplasia

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Chinese Journal of Cancer Research 2022年第5期34卷 539-542页

作者： Khek yu ho Department of Medicine National University of SingaporeSingapore 119228Singapore

White-light endoscopy with tissue biopsy is the gold standard interface for diagnosing gastric neoplastic ***, misdiagnosis of lesions is a challenge because of operator variability and learning curve issues. These issues have not been resolved despite the introduction of advanced imaging technologies, including narrow band imaging, and confocal laser endomicroscopy. To ensure consistently high diagnostic accuracy among endoscopists,artificial intelligence(AI) has recently been introduced to assist endoscopists in the diagnosis of gastric *** endoscopic AI systems for endoscopic diagnosis are mostly based upon interpretation of endoscopic images. In real-life application, the image-based AI system remains reliant upon skilful operators who will need to capture sufficiently good quality images for the AI system to analyze. Such an ideal situation may not always be possible in routine practice. In contrast, non-image-based AI is less constraint by these requirements. Our group has recently developed an endoscopic Raman fibre-optic probe that can be delivered into the gastrointestinal tract via the working channel of any endoscopy for Raman measurements. We have also successfully incorporated the endoscopic Raman spectroscopic system with an AI system. Proof of effectiveness has been demonstrated in in vivo studies using the Raman endoscopic system in close to 1,000 patients. The system was able to classify normal gastric tissue, gastric intestinal metaplasia, gastric dysplasia and gastric cancer, with diagnostic accuracy of >85%. Because of the excellent correlation between Raman spectra and histopathology, the Raman-AI system can provide optical diagnosis, thus allowing the endoscopists to make clinical decisions on the spot. Furthermore, by allowing nonexpert endoscopists to make real-time decisions as well as expert endoscopists, the system will enable consistency of care.

关键词： Raman spectroscopy artificial intelligence gastric cancer diagnosis

A modest proposal for a new beginning: a Hippocratic Oath for S&T workers

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National Science Review 2015年第4期2卷 387-388页

作者： yu-Chi ho School of Engineering and Applied Sciences Harvard University

In the last 30 some years,Chinese scientiic research has seen tremendous growth,along with the miraculous economic and social *** an oversea Chinese scientist,I am very proud of the *** growths always come with some side issues that need to be addressed along the *** problem of scholarly misbehavior in China is well known and the systemic causes of the problem have also been extensively *** is no need for me to

关键词： A modest proposal for a new beginning a Hippocratic Oath for S&T workers

Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

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Neural Regeneration Research 2022年第10期17卷 2157-2165页

作者： Ming-Xi Li Jing-Wen Weng Eric S.ho shing Fung Chow Chi Kwan Tsang Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Special Administrative RegionChina Department of Biology and Department of Computer Science Lafayette CollegeEastonPAUSA

Injuries to the central nervous system(CNS)such as stroke,brain,and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon *** brain has a surprising intrinsic capability of recovering itself after ***,the hostile extrinsic microenvironment significantly hinders axon *** advances have indicated that the inactivation of intrinsic regenerative pathways plays a pivotal role in the failure of most adult CNS neuronal ***,substantial evidence has convincingly demonstrated that the mechanistic target of rapamycin(mTOR)signaling is one of the most crucial intrinsic regenerative pathways that drive axonal regeneration and sprouting in various CNS *** this review,we will discuss the recent findings and highlight the critical roles of mTOR pathway in axon regeneration in different types of CNS ***,we will demonstrate that the reactivation of this regenerative pathway can be achieved by blocking the key mTOR signaling components such as phosphatase and tensin homolog(PTEN).Given that multiple mTOR signaling components are endogenous inhibitory factors of this pathway,we will discuss the promising potential of RNA-based therapeutics which are particularly suitable for this purpose,and the fact that they have attracted substantial attention recently after the success of coronavirus disease 2019 *** specifically tackle the blood-brain barrier issue,we will review the current technology to deliver these RNA therapeutics into the brain with a focus on nanoparticle *** will propose the clinical application of these RNA-mediated therapies in combination with the brain-targeted drug delivery approach against mTOR signaling components as an effective and feasible therapeutic strategy aiming to enhance axonal regeneration for functional recovery after CNS injury.

关键词： axon sprouting axon regeneration brain targeted drug delivery CNS injury ischemic stroke mTOR nanoparticle neural circuit reconstruction PTEN RNA-based therapeutics

Diastereodivergent Hydrosilylative Enyne Cyclization Catalyzed by N-Heterocyclic Carbene-Ni(o)

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Chinese Journal of Chemistry 2021年第6期39卷 1587-1592页

作者： Meng yu Xuefeng Yong Weiwei Gao Chun-yu ho Guangdong Province Key Laboratory of Catalysis Department of ChemistrySouthern University of Science and Technology(SUSTech)1088 Xueyuon AvenueShenzhenGuangdong 518055China Shenzhen Grubbs Institute Deportment of ChemistrySouthern University of Science and Technology(SUSTech)1088 Xueyuan AvenueShenzhenGuangdong 518055China

Catalytic diastereodivergent hydrosilylative enyne cyclization with high generality and broad scope was achieved using electronic ac-tivated N-heterocyclic carbene-Ni(O)as a catalyst and R_(3)SiH as silane(IPr^(Cl),syn-:anti-selectivity from up to 98:2 to 7:93 by Z=0,NH ***,R^(1)=n-pentyl).Heterocycles bearing homoallylsilane rather than vinylsilane was obtained *** undesired yet highly competitive reactivity was suppressed,like direct hydrosilylation of alkene and alkyne ***,the homoallylsilane products could be reduced further in one-pot using IPr^(Me) as ligand and(EtO)_(3)SiH as silane under otherwise the same standard condition as the above,offering practical access to additional stereocenters and more diverse product structures from enynes.

关键词： N-Heterocyclic carbenes Enynes Diastereodivergent synthesis Hydrosilylation Hydroalkenylation