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Pictet-spengler/transamination cascade reaction of indoles for modular synthesis of marinoquinoline analogues

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Green Synthesis and Catalysis 2024年第4期5卷 310-314页

作者： Jinjin Chen Pingyu Jiang Xinping Liu Huawen Huang Guojiang mao Guo-Jun Deng Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan411105China School of Pharmaceutical Science Hengyang Medical SchoolUniversity of South ChinaHengyang421001China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007China

The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analoguesthrough three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage of *** metal-free protocol exhibits very broad functional group tolerance with up to quantitative yields. Preliminarystudies on the antitumor activity of the resultant marinoquinoline analogues reveal that the indolyl-attachedpyrrolo[2,3-c]quinoline product (5d) shows great potential (IC50 of 0.32 μg/mL to HeLa cells) as a promisinganticancer agent in clinic.

关键词： Pictet-spengler reaction Indole ring-expansion N1-C2 cleavage Indole Marinoquinoline analogues

An integrated classification method for thematic mapper imagery of plain and highland terrains

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第6期9卷 858-866页

作者： Shan-long LU Xiao-hua SHEN Le-jun ZOU Chang-jiang LI Yan-jun mao Gui-fang ZHANG Wen-yuan WU Ying LIU Zhong ZHANG Department of Earth Sciences Zhejiang University Hangzhou 310027 China Zhejiang Land and Resources Information Center Hangzhou 310007 China Zhejiang Climate Center Hangzhou 310017 China

The classification of thematic mapper imagery in areas with strong topographic variations has proven problematic in the past using a single classifier, due to the changing sun illumination geometry. This often results in the phenomena of identical object with dissimilar spectrum and different objects with similar spectrum. In this paper, an integrated classification method that combines a decision tree with slope data, tasseled cap transformation indices and maximum likelihood classifier is introduced, to find an optimal classification method for thematic mapper imagery of plain and highland terrains. A Landsat 7 ETM+ image acquired over Hangzhou Bay, in eastern China was used to test the method. The results indicate that the performance of the inte- grated classifier is acceptably good in comparison with that of the existing most widely used maximum likelihood classifier. The integrated classifier depends on hypsography (variation in topography) and the characteristics of ground truth objects (plant and soil). It can greatly reduce the influence of the homogeneous spectrum caused by topographic variation. This integrated classifier might potentially be one of the most accurate classifiers and valuable tool for land cover and land use mapping of plain and highland terrains.

关键词： Image classification Land cover and land use Thematic mapper imagery Plain and highland terrains Integratedclassification method

Portal vein embolization combined with ex vivo liver resection and autotransplantation: A novel treatment strategy for end-stage and metastatic hepatic alveolar echinococcosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 210-216页

作者： Qiang Guo mao-Lin Wang Kai Zhong Jia-Long Li Tie-Min Jiang Hao Wen Tuerganaili Aji Ying-Mei Shao Department of Hepatobiliary and Echinococcosis Surgery Digestive and Vascular Surgery CenterFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Clinical Medical Research Center of Echinococcosis and Hepatobiliary Disease of Xinjiang Uygur Autonomous Region Urumqi 830054China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityUrumqi 830054China

Alveolar echinococcosis(AE)is a lethal parasitic disease caused by Echinococcus multilocularis larvae,and more than 90%of pri-mary AE lesions occur in the *** of the affected individ-uals remain asymptomatic and the disease is often diagnosed at an advanced *** infection may spread to organs adjacent to the liver or distant locations,eventually causing end-stage multi-ple organ *** metastasis of AE is the most fatal with an inci-dence rate of 0.2%[1].

关键词： organs echinococcosis metastasis

A forwarding graph embedding algorithm exploiting regional topology information

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Frontiers of Information Technology & Electronic Engineering 2017年第11期18卷 1854-1866页

作者： hong-chao HU Fan ZHANG Yu-xing mao Zhen-peng WANG National Digital Switching System Engineering & Technological R&D Center Zhengzhou 450002 China

Network function virtualization （NFV） is a newly proposed technique designed to construct and manage network fimctions dynamically and efficiently. Allocating physical resources to the virtual network function forwarding graph is a critical issue in NFV. We formulate the forwarding graph embedding （FGE） problem as a binary integer programming problem, which aims to increase the revenue and decrease the cost to a service provider （SP） while considering limited network resources and the requirements of virtual functions. We then design a novel regional resource clustering metric to quantify the embedding potential of each substrate node and propose a topology-aware FGE algorithm called ＇regional resource clustering FGE＇（RRC-FGE）. After implementing our algorithms in C＋＋, simulation results showed that the total revenue was increased by more than 50 units and the acceptance ratio by more than 15%, and the cost of the service provider was decreased by more than 60 units.

关键词： Network function virtualization Virtual network function Forwarding graph embedding

Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5096-5105页

作者： Juxian Sun Feifei mao Chang Liu Fan Zhang Dafeng Jiang Weixing Guo Lei Huo Liping Zhou Wan Yee Lau Jie Shi Shuqun Cheng Department of Hepatic Surgery VI Third Affliated Hospital of Naval Medical UniversityShanghaiChina Tongji University Cancer Center Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghaiChina Department of General Surgery Fujian Cancer HospitalFujan Medical UniversityFuzhouChina Department of Oncology Zhejiang Sian International HospitalJiaxingChina Department of Radiology Third Affliated Hospital of Naval Medical UniversityShanghaiChina Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinNew TerritoriesHong Kong SARChina

The majority of hepatocellular carcinoma(HCC)cases are diagnosed at an advanced ***,there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis(EHM).Systemic chemotherapy,such as FOLFOX4(infusions of fluorouracil,leucovorin,and oxaliplatin),has been reported for treating advanced HCC with EHM,but its effectiveness is very poor.

关键词： FOLFOX4 metastasis chemotherapy

City level CO_(2) and local air pollutants co-control performance evaluation: A case study of 113 key envir on mental protection cities in China

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Advances in Climate Change Research 2022年第1期13卷 118-130页

作者： Qing-Yong ZHANG Bo-Feng CAI Mu-Dan WANG Jun-Xia WANG You-Kai XING Guang-Xia DONG Zhen ZHANG Xian-Qiang mao School of Environment Beijing Normal University'Beijing 100875China Center for Climate Change and Environmental Policy Chinese Academy of Environmental PlanningBeijing 100012China China National Environmental Monitoring Centre Beijing 100012China Ministry of Transport Transport Planning and Research InstituteLaboratory of Transport Pollution Control and Monitoring TechnologyBeijing 100028China

‘Co-control',or synergistically reducing CO_(2)and local air polluta nt emissions,is an important strategy for cities to achieve'low carb on'and'blue sky'***,there were few studies to evaluate and compare the level of co-control of CO_(2) and local air pollutants in cities *** present study proposed qualitative and quantitative methods to evaluate the level of co-control of CO_(2)and three local air pollutant(SO_(2).NOX,and particulate matter PM)emissions in key environmental protection cities in China over two periods(2012-2015 and 2015-2018).Statistical analysis found that,though three local air pollutant emissions positively correlated with CO_(2) emission,no significantly positive correlation was found between local air pollutants emission reductions and CO_(2) emission reductions,indicating that co-control effects were poor in *** using the co-control effect coordinate system,qualitative evaluation showed that less than half of the sample cities could achieve co-control of the total amount of CO_(2) and local air *** employing the indicator of emission reduction equivalence(EReq),quantitative evaluation showed that the co-control level of the sample cities improved in 2015-2018 compared with *** regression analysis showed that,reducing coal consumption and economic development significantly enhanced the co-control performance of the observed *** present case study proved that the proposed methods for evaluation and comparison of the city co-control performance works well,and can be used in other countries and regions to promote global cities racing to carbon and local air pollutants co-control.

关键词： Co-control CO_(2)emission reduction Local air pollutant emission reduction:Performance evaluation Key environmental protection cities

金属材料声发射Kaiser效应的混沌特性分析

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振动与冲击 2017年第12期36卷 50-54页

作者：刘婷毛汉领黄振峰毛汉颖广西大学机械工程学院南宁530004 广西科技大学汽车与交通学院广西柳州542506

对金属材料进行反复加卸载的拉伸试验后通过多参数综合判定法确定Kaiser效应点。对金属材料Kaiser效应点进行混沌特性分析,包括关联维数以及Kolmogorov熵值。经分析发现,Kaiser点信号在一定的时间范围内具有混沌特征,并且Kaiser效应点... 详细信息

对金属材料进行反复加卸载的拉伸试验后通过多参数综合判定法确定Kaiser效应点。对金属材料Kaiser效应点进行混沌特性分析,包括关联维数以及Kolmogorov熵值。经分析发现,Kaiser点信号在一定的时间范围内具有混沌特征,并且Kaiser效应点信号的关联维数及Kolmogorov熵计算值比其前后一段时间内的计算值都低,说明Kaiser点处关联维数及Kolmogorov熵的降低意味着主损伤的发生。

关键词：金属声发射 Kaiseir效应混沌

建筑企业业绩考核“12384”法的实践与探索

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铁道工程学报 2019年第7期36卷 100-104页

作者：毛祥虎中国中铁股份有限公司

研究目的:当前,企业业绩考核的理论研究较多,但实际开展考核工作的可借鉴的经验较少,特别是建筑企业总部部门及员工的考核可借鉴的经验更少。本文围绕业绩考核的难点,结合建筑企业总部的特点,对某大型国有建筑企业的"12384"业绩考核方... 详细信息

研究目的:当前,企业业绩考核的理论研究较多,但实际开展考核工作的可借鉴的经验较少,特别是建筑企业总部部门及员工的考核可借鉴的经验更少。本文围绕业绩考核的难点,结合建筑企业总部的特点,对某大型国有建筑企业的"12384"业绩考核方法进行梳理,并提出一些有针对性的改进意见,对同类企业具有一定参考和借鉴意义。研究结论:(1)开展好业绩考核首先要有良好的组织保障,要建立从上到下全员参与的考核组织体系;(2)做好业绩考核工作要把握三个关键,即筹划精细、组织严密、执行规范;(3)要加强反馈沟通和结果运用,积极营造良好的业绩考核文化导向;(4)通过先述职再评议、规范评价打分取值空间、加强信息化技术运用、设置加分减分项目等方式,对优化业绩考核具有积极意义。

关键词：建筑企业总部业绩考核方法

Application of Mianzhu New Year Painting Art Style in Children’s Picture Books

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Advances in Humanities Research

Advances in Humanities Research 2023年第1期2卷 37-46页

作者： Chencheng mao Sharul Azim Sharudin City University Malaysia Malaysia

This paper analyzes the attraction of children's language learning and literacy through the collation of Chinese Mianzhu New Year's Paintings art style,analyzes the attraction of children's language learning and literacy through the reading of early children's New Year's Paintings art style picture books,summarizes the use of pre-school children's favorite picture book survey reports and data,and analyzes the case of the excellent picture book design that has won awards for integrating the Chinese traditional art style,and the result shows that Mianzhu New Year's Paintings art style has great potential to be explored in the field of picture *** results show that Mianzhu Nianhua art style in the field of picture books has great potential to be explored,and its artistic characteristics have strong extensibility and integration,and the use of saturated,bright colors combined with children's favorite picture book themes will be more attractive to children to read picture *** study provides a new design reference for the integration of traditional Chinese art styles with children's picture books,which can enhance children's language learning and literacy skills while promoting the traditional Chinese art of Mianzhu New Year's Paintings.

关键词： Mianzhu New Year painting traditional Chinese art style childhood picture book vibrant colors language learning literacy