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Neural Regeneration Research 2011年第17期6卷 1313-1315页

作者： Hyeok Gyu kwon Sung ho Jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The present study reported a 42-year-old male patient who underwent conservative management for a spontaneous intracerebral hemorrhage in the left corona radiata and the basal ganglia. The patient presented with complete weakness of the right upper and lower extremities at the onset of intracerebral hemorrhage; however, he showed progressive motor recovery to the level that he was able to extent the affected extremities against some resistance at 5 weeks after onset. The corticospinal tract of the affected （left） hemisphere connected to the left Broca＇s area at 3 weeks after onset as shown by diffusion tensor tractography. By contrast, this connection had disappeared at 5 weeks after onset as shown by diffusion tensor tractogaphy. Transcranial magnetic stimulation study showed that no motor evoked potential was elicited from the affected （left） hemisphere at 3 weeks after onset, but motor evoked potentials were elicited at 5 weeks after onset. These findings suggest that the connection between the injured corticospinal tract and Broca＇s area in this patient appears to be a compensation for severe motor weakness; consequently, the connection seems to disappear with motor recovery.

关键词： corticospinal tract Broca's area motor recovery stroke intracerebral hemorrhage neural regeneration

Recovery of an injured anterior cingulum to the basal forebrain in a patient with brain injury: a 4-year follow-up study of cognitive function

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Neural Regeneration Research 2016年第10期11卷 1695-1696页

作者： Sung ho Jang Hyeok Gyu kwon Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

~[he cingulum, a long neural tract extending from the orbitof- rontal cortex to the medial temporal lobe, obtains cholinergic innervation from three cholinergic nuclei in the basal fore- brain （the nucleus basalis of Meynert [Ch 4], the medial septal nucleus [Ch 1 ], and the vertical nucleus of the diagonal band [Ch 2]）, and is the passage of the medial cholinergic pathway which supplies cholinergic innervation from the basal forebrain to the cerebral cortex （Folstein et al., 1975; Selden et al., 1998; Lucas-Meunier et al., 2003）. Therefore, it is important for cog- nition, especially memory function （Selden et al., 1998）.

关键词： Recovery of an injured anterior cingulum to the basal forebrain in a patient with brain injury DTT MMSE Figure

The usefulness of diffusion tensor imaging in detection of diffuse axonal injury in a patient with head trauma

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Neural Regeneration Research 2012年第6期7卷 475-478页

作者： Hyeok Gyu kwon Sung ho Jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Diffuse axonal injury is the predominant mechanism of injuries in patients with traumatic brain injury. Neither conventional brain computed tomography nor magnetic resonance imaging has shown sufficient sensitivity in the diagnosis of diffuse axonal injury. In the current study, we attempted to demonstrate the usefulness of diffusion tensor imaging in the detection of lesion sites of diffuse axonal injury in a patient with head trauma who had been misdiagnosed as having a stroke. A 44-year-old man fell from a height of about 2 m. Brain magnetic resonance imaging （32 months after onset） showed leukomalactic lesions in the isthmus of the corpus callosum and the left temporal lobe. He presented with mild quadriparesis, intentional tremor of both hands, and trunkal ataxia. From diffusion tensor imaging results of 33 months after traumatic brain injury onset, we found diffuse axonal injury in the right corticospinal tract （centrum semiovale, pons）, both fomices （columns and crus）, and both inferior cerebellar peduncles （cerebellar portions）. We think that diffusion tensor imaging could be a useful tool in the detection of lesion sites of diffuse axonal injury in patients with head trauma.

关键词： traumatic brain injury diffuse axonal injury diffusion tensor imaging head trauma

Traumatic axonal injury of the medial lemniscus pathway in a patient with traumatic brain injury: validation by diffusion tensor tractography

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Neural Regeneration Research 2016年第1期11卷 130-131页

作者： Sung ho Jang Hyeok Gyu kwon Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Traumatic brain injury（TBI）is a common disability-causing neurological *** successful rehabilitation of TBI patients,a thorough evaluation of the presence and extent of neural injury is essential for determining the... 详细信息

关键词： tensor rehabilitation medial axonal disability traumatic thorough neurological radiata tracts

Neuroinflammation in neurodegenerative disorders:the roles of microglia and astrocytes

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Translational Neurodegeneration 2020年第4期9卷 535-546页

作者： Hyuk Sung kwon Seong-ho Koh Department of Neurology Hanyang University College of MedicineSeoulRepublic of Korea Department of Translational Medicine Hanyang University Graduate School of Biomedical Science&EngineeringSeoulRepublic of Korea

Neuroinflammation is associated with neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,ancamyotrophic lateral *** and astrocytes are key regulators of inflammatory responses in the central nervous *** activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxi(M1-phenotype microglia and A1-phenotype astrocytes)or neuroprotective(M2-phenotype microglia and A2-phenotype astrocytes).however,this dichotomized classification may not reflect the various phenotypes of microgliaand *** relationship between these activated glial cells is also very complicated,and the phenotypic distribution can change,based on the progression of neurodegenerative diseases.A better understanding of the rolesof microglia and astrocytes in neurodegenerative diseases is essential for developing effective *** this review,we discuss the roles of inflammatory response in neurodegenerative diseases,focusing on the contributions of microglia and astrocytes and their *** addition,we discuss biomarkers to measure neuroinflammation andstudies on therapeutic drugs that can modulate neuroinflammation.

关键词： Neuroinflammation Neurodegenerative diseases Microglia Astrocytes

Recovery of an injured corticospinal tract during the early stage of rehabilitation following pontine infarction

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Neural Regeneration Research 2016年第3期11卷 519-520页

作者： Sung ho Jang Hyeok Gyu kwon Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaemyungdong

Motor weakness is a common and important sequela of stroke,and motor recovery is mostly achieved within 3 months following stroke（Jorgensen et al.,1995;Fujii and Nakada,2003）,suggesting the importance of active rehabilitation during the early stage of *** studies have reported on neurological recovery during this period,however,little is known about pontine infarction（Jang et al.,2007;kwon and Jang,2012;kwon

关键词： rehabilitation injured weakness neurological mostly infarct transcranial stimulation hemisphere minutes

Recovery of injured cingulum in a patient with traumatic brain injury

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Neural Regeneration Research 2015年第2期10卷 323-324页

作者： Sung ho Jang Seong ho Kim Hyeok Gyu kwon Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Neurosurgery College of Medicine Yeungnam University

The cingulum is the neural fiber bundle that connects the basal forebrain and medial temporal lobe. The cingulum contains the medial cholinergic pathway, which originates from the basalis nucleus of Meynert in the basal forebrain. Therefore, it is important for memory function （Malykhin et al., 2008; hong and Jang, 2010）. In the past, identification of the cingulum on conventional brain MRI has been impossible because it cannot discern the cingulum from other adjacent structures. Diffusion tensor tractography （DTT）, derived from diffusion tensor imaging （DTI）, allows three-dimensional visualization and estimation of the cingulum （Malykhin et al., 2008）.

关键词： TBI Recovery of injured cingulum in a patient with traumatic brain injury

High resolution aerosol optical thickness retrieval over the Pearl River Delta region with improved aerosol modelling

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Science China Earth Sciences 2009年第10期52卷 1641-1649页

作者： WONG ManSing NIChoL Janet LEE kwon ho Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic University Earth System Science Interdisciplinary Center University of Maryland (UMD)

Aerosol retrieval algorithms for the MODerate Resolution Imaging Spectroradiometer (MODIS) have been developed to estimate aerosol and microphysical properties of the atmosphere, which help to address aerosol climatic issues at global scale. however, higher spatial resolution aerosol products for urban areas have not been well researched mainly due to the difficulty of differentiating aerosols from bright surfaces in urban areas. Here, a new aerosol retrieval algorithm using the MODIS 500 m resolution images is described, to retrieve aerosol properties over hong Kong and the Pearl River Delta region. The rationale of our technique is to first estimate the aerosol reflectance by decomposing the top-of-atmosphere reflectance from surface reflectance and Rayleigh path reflectance. For the determination of surface reflectance, a modified Minimum Reflectance Technique (MRT) is used, and MRT images are computed for different seasons. A strong correlation is shown between the surface reflectance of MRT images and MODIS land surface reflectance products (MOD09), with a value of 0.9. For conversion of aerosol reflectance to Aerosol Optical Thickness (AOT), comprehensive Look Up Tables (LUT) are constructed, in which aerosol properties and sun-viewing geometry in the radiative transfer calculations are taken into account. Four aerosol types, namely mixed urban, polluted urban, dust, and heavy pollution, were derived using cluster analysis on three years of AERONET measurements in hong Kong. Their aerosol properties were input for LUT calculation. The resulting 500 m AOT images are highly correlated (r = 0.89) with AERONET sunphotometer observations in hong Kong. This study demonstrates the applicability of aerosol retrieval at fine resolution scale in urban areas, which can assist the study of aerosol loading distribution and the impact of localized and transient pollution on urban air quality. In addition, the MODIS 500 m AOT images can be used to study cross-boundary aeroso

关键词： aerosol retrieval aerosol optical thickness AERONET MODIS satellite image

Neuralgic amyotrophy with hourglass-like constrictions:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6728-6735页

作者： Mi-Hyeon Bang Ha-Lim Song Seok Hahn Wanil Kim Hwan-kwon Do Department of Physical Medicine and Rehabilitation Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Department of Radiology Haeundae Paik HospitalInje University College of MedicineBusan 48108South Korea Division of Biochemistry Department of Convergence Medical ScienceInstitute of Medical ScienceGyeongsang National University College of MedicineJinju 52727South Korea Department of Physical Medicine and Rehabilitation Dongnam Institute of Radiological and Medical SciencesBusan 46033South Korea

BACKGROUND Neuralgic amyotrophy(NA)is a rare disease with sudden upper limb pain followed by affected muscle *** most commonly affected area in NA is the upper part of the brachial plexus,and the paraspinal muscles are rarely affected(1.5%),making these cases difficult to distinguish from cervical *** SUMMARY A 76-year-old male presented to the emergency department with left hip pain *** undergoing left femoral neck fracture surgery,he experienced sudden left shoulder pain for 10 days with subsequent left arm *** spine computed tomography revealed mild right asymmetric intervertebral disc bulging with a decreased C5-6disc *** weeks later,an electrodiagnostic study confirmed brachial plexopathy findings involving the cervical *** resonance neurography was performed for a differential *** enhancement was identified at the upper trunk of the brachial plexus,including the C5 nerve root.A suprascapular nerve hourglass-like focal constriction(HLFC)was also identified,confirming *** being diagnosed with NA,the patient received 15 mg prednisolone,twice daily,for 3 *** therapy was initiated,including left arm strengthening exercises and electrical stimulation *** shoulder muscle strength significantly improved one CONCLUSION NA's unique features like HLFC and paraspinal involvement are crucial for accurate diagnosis,avoiding confusion with cervical radiculopathy.

关键词： Neuralgic amyotrophy Cervical radiculopathy hourglass-like focal constriction Paraspinal muscle Magnetic resonance neurography Case report

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP