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Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 205-215,I0005页

作者： Tan-To Cheung Rong Liu Federica Cipriani Xiaoying Wang Mikhail Efanov David Fuks Gi-hong Choi Nicholas L.Syn Charing C.N.Chong Fabrizio Di Benedetto Ricardo Robles-Campos Vincenzo Mazzaferro Fernando Rotellar Santiago Lopez-Ben James O.Park Alejandro Mejia Iswanto Sucandy Adrian K.H.Chiow Marco V.Marino Mikel Gastaca Jae hoon lee TPeter Kingham Mathieu D’hondt Sung hoon Choi Robert P.Sutcliffe ho-Seong Han Chung-Ngai Tang Johann Pratschke Roberto I.Troisi Go Wakabayashi Daniel Cherqui Felice Giuliante Davit L.Aghayan Bjorn Edwin Olivier Scatton Atsushi Sugioka Tran Cong Duy Long Constantino Fondevila Mohammad Abu Hilal Andrea Ruzzenente Alessandro Ferrero Paulo Herman Kuo-Hsin Chen Luca Aldrighetti Brian K.P.Goh International robotic and laparoscopic liver resection study group investigators Department of Surgery Queen Mary HospitalThe University of Hong KongHong Kong SARChina Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Digestive Oncologic and Metabolic SurgeryInstitute Mutualiste MontsourisUniversite Paris DescartesParisFrance Division of Hepatopancreatobiliary Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoulKorea Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong Kong SARChina HPB Surgery and Liver Transplant Unit University of Modena and Reggio EmiliaModenaItaly Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de la ArrixacaIMIB-ARRIXACAMurciaSpain HPB Surgery Hepatology and Liver TransplantationFondazione IRCCS Istituto Nazionale Tumori di MilanoMilanItaly HPB and Liver Transplant Unit Department of General SurgeryClinica Universidad de NavarraUniversidad de NavarraPamplonaSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Hepatobiliary and Pancreatic Surgery Unit Department of SurgeryDr.Josep Trueta HospitalIdIBGiGironaSpain Hepatobiliary Surgical Oncology Department of SurgeryUniversity of Washington Medical CenterSeattleWAUSA The Liver Institute Methodist Dallas Medical CenterDallasTXUSA AdventHealth Tampa Digestive Health InstituteTampaFLUSA Hepatopancreatobiliary Unit Department of SurgeryChangi General

Background:The use of laparoscopic(LLR)and robotic liver resections(RLR)has been safely performed in many institutions for liver tumours.A large scale international multicenter study would provide stronger evidence and insight into application of these techniques for huge liver tumours≥10 ***:This was a retrospective review of 971 patients who underwent LLR and RLR for huge(≥10 cm)tumors at 42 international centers between ***:One hundred RLR and 699 LLR which met study criteria were *** comparison between the 2 approaches for patients with huge tumors were performed using 1:3 propensity-score matching(PSM)(73 vs.219).Before PSM,LLR was associated with significantly increased frequency of previous abdominal surgery,malignant pathology,liver cirrhosis and increased median *** PSM,RLR and LLR was associated with no significant difference in key perioperative outcomes including media operation time(242 vs.290 min,P=0.286),transfusion rate rate(19.2%vs.16.9%,P=0.652),median blood loss(200 vs.300 mL,P=0.694),open conversion rate(8.2%vs.11.0%,P=0.519),morbidity(28.8%vs.21.9%,P=0.221),major morbidity(4.1%vs.9.6%,P=0.152),mortality and postoperative length of stay(6 vs.6 days,P=0.435).Conclusions:RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent *** was no significant difference in perioperative outcomes after RLR or LLR.

关键词： Laparoscopic liver resection(LLR) robotic liver resection(RLR) hepatocellular carcinoma colorectal liver metastases huge

甲族第六型柯赛奇(Coxsackie)病毒引起之恒河猴实验性病毒性腮腺炎

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微生物学报 1964年第1期 17-23页

作者：孙望楚雷文绪罗惠蓉吴惠英李河民卫生部药品生物制品检定所

柯赛奇病毒（Coxsackie Virus、简称C病毒）是人类常见的肠道病毒之一,按其所致乳小白鼠病理变化的特征而分为甲、乙二族,每族又包括抗原性不同的许多毒株型（甲族24型,乙族6型）。本病毒在临床上除能引起新生儿心肌炎、脑心肌炎、心包... 详细信息

柯赛奇病毒（Coxsackie Virus、简称C病毒）是人类常见的肠道病毒之一,按其所致乳小白鼠病理变化的特征而分为甲、乙二族,每族又包括抗原性不同的许多毒株型（甲族24型,乙族6型）。本病毒在临床上除能引起新生儿心肌炎、脑心肌炎、心包炎、脑炎、脑膜脑炎、麻庳型脊髓前角灰白质炎、无菌性脑膜炎、Guillain-Barre氏综合症、肺炎、夏季流感、三日热、流行性肌痛及疱疹性咽峡炎等疾病外,howlett等氏曾于1957年察见了4名由甲族C病毒所致之腮腺炎伴有疱疹性咽峡炎综合症的病例,在他们的喉嗽液及唾

关键词：腮腺炎丁型疮疡病毒性 Coxsackie 恒河猴猕猴流腮病毒

Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

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Cancer Communications 2023年第8期43卷 951-955页

作者： hoi-Hin Kwok Huiyu Li Jiashuang Yang Junyang Deng Nerissa Chui-Mei lee Timmy Wing-Kuk Au Alva Ko-Yung Sit Michael Kuan-Yew Hsin Stephanie Kwai-Yee Ma LydiaWai-Ting Cheung Luc Girard Junya Fujimoto Ignacio Ivan Wistuba Boning Gao John Dorrance Minna David Chi-Leung Lam Department of Medicine Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong SARP.R.China Nancy B.and Jake L.Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexasUSA Cardiothoracic Surgical Department Queen Mary HospitalHong Kong SARP.R.China School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARP.R.China Department of Translational Molecular Pathology Division of Pathology/Lab MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTexasUSA

Dear Editor,Non-small cell lung carcinoma(NSCLC)accounts for more than 85%of all lung cancers[1].Lung adenocarcinomas(ADCs)arising from never-smokers have been frequently found to be associated with oncogenic driver mutations,including anaplastic lymphoma kinase(ALK)*** microtubule-associated protein-like 4(EML4)is the most common fusion partner of the ALK gene[2].Tyrosine kinase inhibitors(TKIs)are currently the first-line treatment for advanced EML4-ALKrearranged lung ADC.

关键词： lung adenocarcinoma Lung

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Cr-Si粉末冶金工艺及其物理-力学性能

粉末冶金材料科学与工程 2007年第6期12卷 374-379页

作者：谭中雄张世贤李世钦杨怡芳梁诚何信弘薄慧云国立成功大学材料科学及工程学系国立台立科技大学资源及材料系中山科学研究院

粉末冶金制作法主要有热压(HP)、热等静压(HIP)及常压烧结(Sinter)三种。采用热压及热等静压法可以很容易地得到高致密化的高温金属硅化物,但若要进行大尺寸的产品烧结,必须提升生产设备的规格和能力,例如加大热压机力吨位、扩大热压炉... 详细信息

粉末冶金制作法主要有热压(HP)、热等静压(HIP)及常压烧结(Sinter)三种。采用热压及热等静压法可以很容易地得到高致密化的高温金属硅化物,但若要进行大尺寸的产品烧结,必须提升生产设备的规格和能力,例如加大热压机力吨位、扩大热压炉腔体等,致使设备投资及生产成本相对昂贵。所以大部分厂商宁可采用常压烧结法,虽然该法的高致密化工艺条件不易控制,却因可以制作大尺寸金属硅化物,加上设备投资及生产成本相对降低,使许多大厂已投入相当大的人力和物力在开发此工艺。该文作者试用不同真空烧结温度,造成Cr-Si合金粉末烧结性质的差异,探讨稳定而可大量生产的可行性;并通过对温度的控制,来改善Cr-Si的物理性质与力学性质。结果表明,提高烧结温度会使Cr-Si合金产生部分液相烧结的现象,从而使孔隙率显著下降;但显微结构也随之有偏析与晶粒粗化的现象。

关键词：热压热等静压烧结 Cr-Si合金偏析

MINI TASTE COOL BRITANNIA

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城市漫步（GBA版） 2014年第5期 56-56页

作者： TOM lee DIXON ChoW(图) 不详

People love to poke fun at the United Kingdom for lacking a solid culinary traditi *** some one to name a British dish and they'll probably come up with fish and chips,or perhaps sausage rolls,but little *** those who... 详细信息

关键词： perhaps COOL BRI

A continuous quality improvement project to reduce medication error in the emergency department

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世界急诊医学杂志(英文) 2013年第3期4卷 179-182页

作者： Sara BC lee Larry LY lee Richard SD Yeung Jimmy TS Chan Emergency Department Alice Ho Miu Ling Nethersole Hospital

BACKGROUND:Medication errors are a common source of adverse healthcare incidents particularly in the emergency department(ED) that has a number of factors that make it prone to medication *** project aims to reduce medication errors and improve the health and economic outcomes of clinical care in hong Kong ***:In 2009,a task group was formed to identify problems that potentially endanger medication safety and developed strategies to eliminate these ***:Responsible officers were assigned to look after seven error-prone *** were proposed,discussed,endorsed and promulgated to eliminate the problems identified.A reduction of medication incidents(Ml) from 16 to 6 was achieved before and after the improvement ***:This project successfully established a concrete organizational structure to safeguard error-prone areas of medication safety in a sustainable manner.

关键词： Medication error Medication safety Continuous Quality Improvement(CQI)

Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

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World Journal of Gastroenterology 2013年第45期19卷 8366-8372页

作者： Chao-Sheng Liao Yu-Min Lin Hung-Chuen Chang Yu-Hung Chen lee-Won Chong Chun-Hao Chen Yueh-Shih Lin Kuo-Ching Yang Chia-Hui Shih Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan School of Medicine Fu Jen Catholic University New Taipei City 24205 Taiwan Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan Health Management Center Shin Kong Wu HoSu Memorial Hospital Taipei 111 Taiwan Chang Gung Institute of Technology School of Nursing Tao-Yuan 333 Taiwan

AIM:To determine the role of the fecal immunochemical test(FIT),used to evaluate fecal hemoglobin concentration,in the prediction of histological grade and risk of colorectal ***:We enrolled 17881 individuals who attended the two-step colorectal cancer screening program in a single hospital between January 2010 and October *** was recommended to the participants with an FIT of≥12 ngHb/mL *** classified colorectal lesions as cancer(C),advanced adenoma(AA),adenoma(A),and others(O)by their colonoscopic and histological *** linear regression analysis adjusted for age and gender was used to determine the association between the FIT results and colorectal tumor *** risk of adenomatous neoplasia was estimated by calculating the positive predictive values for different FIT ***:The positive rate of the FIT was 10.9%(1948/17881).The attendance rate for colonoscopy was 63.1%(1229/1948).The number of false positive results was *** these 1229 cases,the numbers of O,A,AA,and C were 759,221,201,and 48,*** analysis revealed a positive association between histological grade and FIT concentration(β=0.088,P0.95,P<0.001).CONCLUSION:Higher FIT concentrations are associated with more advanced histological *** prediction for colorectal neoplasia based on individual FIT concentrations is significant and may help to improve the performance of screening programs.

关键词： Colorectal cancer Fecal immunochemical test Screening Risk prediction Performance

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RCA在发药错误不良事件中的应用

现代医院管理 2020年第5期18卷 87-90页

作者：褚雪玲陆中奎宁晓明陈萍萍刘绮才李合幼广东医科大学附属第三医院佛山市顺德区龙江医院广东省佛山市528318 昆山长泰医疗企业管理有限公司护理部江苏省昆山市215300

目的探讨根本原因分析法在门诊药房发药错误不良事件的应用,减少发药错误发生。方法回顾性分析医院门诊药房发药错误1例不良事件,通过时间序列表及原因树分析,归纳出发药错误的近端原因,找出根本原因,确立问题为“四查十对”未落实、药... 详细信息

目的探讨根本原因分析法在门诊药房发药错误不良事件的应用,减少发药错误发生。方法回顾性分析医院门诊药房发药错误1例不良事件,通过时间序列表及原因树分析,归纳出发药错误的近端原因,找出根本原因,确立问题为“四查十对”未落实、药品名称相近、特殊人群安全用药意识不足、高峰时段排班不合理、人员沟通不到位,拟定改善策略:严格执行医疗核心制度、加强药学人员培训、定期盘点药品、弹性排班及完善配药流程、高峰时段管理等,并对整改效果进行确认。结果门诊药房实施RCA管理后,通过在系统及过程方面加强质量管理,2019年度未发生发药错误不良事件。结论通过RCA管理可有效减少发药错误不良事件,提高患者的用药安全和满意度。

关键词：发药错误不良事件根本原因分析法药事管理用药安全

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西57号街公寓

城市环境设计 2019年第2期118卷 228-239页

作者： David Brown Aleksander Tokarz Alessandro Ronfini Alessio Valmori Alvaro Mendive Benjamin Schulte Birk Daugaard Celine Jeanne Christoffer Gotfredsen Daniel Sundlin Dominyka Mineikyte Eivor Davidsen Felicia Guldberg Florian Oberschneider Soren Grunert Gabrielle Nadeau Gül Ertekin ho Kyung lee hongyi Jin Julian Liang Julianne Gola Laura Youf Lucian Racovitan Marcella Martinez Maria Nikolova Maya Shopova Mitesh Dixit Nicklas A.Rasch Ola Hariri Riccardo Mariano Steffan Heath Stanley Lung Tara Hagan Thilani Rajarathna Tyler Polich Valentina Mele Valerie Lechene Xu Li Yi Li Aaron Hales Alessandro Ronfini Brian Foster Christoffer Gotfredsen Francesca Portesine ho Kyung lee hongyi Jin Ivy Hume Jenny Chang Lauren Turner Mina Rafiee Rakel Karlsdottir Tara Hagan Thomas Fagan Tiago Barros Valentina Mele Iwan Baan 朱翰林

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开... 详细信息

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开阔,让较低的夕阳也能照进街区深处,并优雅地为一旁的Helena Tower保留河景。建筑的形式随着观察者的位置而不断变换。从西侧的高速公路上看,它

关键词： Section 局部剖面图