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Metic.lously engineered three-dimensional-printed sc.ffold with mic.oarc.itec.ure and c.ntrolled peptide release for enhanc.d bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang J. Fatima k. Zhou X. He c. Shanghai Engineering Researc. c.nter of Nano-Biomaterials and Regenerative Medic.ne College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defec.s requires superior mec.anic.l strength, a feat that a single hydrogel sc.ffold c.nnot ac.ieve. The objec.ive is to seamlessly integrate optimal mic.oarc.itec.ure, mec.anic.l robustness, vasc.larisation, and osteoinduc.ive biologic.l responses to effec.ively address these c.itic.l load-bearing bone defec.s. To c.nfront this c.allenge, three-dimensional (3D) printing tec.nology was employed to prepare a polyc.prolac.one (Pc.)-based integrated sc.ffold. Within the voids of 3D printed Pc. sc.ffold, a methac.ylate gelatin (GelMA)/methac.ylated silk.fibroin (SFMA) c.mposite hydrogel inc.rporated with parathyroid hormone (PTH) peptide-loaded mesoporous silic. nanopartic.es (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/Pc. (PM@GS/Pc.) sc.ffold. The feasibility of fabric.ting this func.ional sc.ffold with a c.stomised hierarc.ic.l struc.ure was c.nfirmed through metic.lous c.emic.l and physic.l c.arac.erisation. c.mpression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the c.mposite sc.ffold. Additionally, in vitro angiogenesis potential of PM@GS/ Pc. sc.ffold was evaluated through Transwell and tube formation assays using human umbilic.l vein endothelium, revealing the superior c.ll migration and tube network.formation. The alizarin red and alk.line phosphatase staining assays using bone marrow-derived mesenc.ymal stem c.lls c.early illustrated robust osteogenic.differentiation properties within this sc.ffold. Furthermore, the bone repair potential of the sc.ffold was investigated on a rat femoral defec. model using mic.o-c.mputed tomography and histologic.l examination, demonstrating enhanc.d osteogenic.and angiogenic.performanc.. This study presents a promising strategy for fabric.ting a mic.oenvironment-matc.ed c.mposite sc.ffold for bone tissue engineering, providing a potential solution for effec.ive bone defec. repair. © 2024, c.inese Medic.l Multimedia Press c. Ltd. All rights reserve

关键词： angiogenesis bone regeneration methac.ylated gelatin methac.ylated silk.fibroin osteogenesis PTH

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Fish-on-c.ips:unveiling neural proc.ssing of c.emic.ls in small animals through prec.se fluidic.c.ntrol

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Neural Regeneration Researc. 2024年第11期19卷 2351-2353页

作者： Samuel k.H.Sy ho k. Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li k. Shing Institute of Health Sc.enc.s Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Elec.ric.l and Elec.ronic.Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanc.d Biomedic.l Instrumentation c.nter Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret k.L.c.eung Researc. c.nter for Management of Park.nsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-c.uen Researc. c.nter of Brain Degenerative Diseases in c.inese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald c.0}a Neurosc.enc. Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Prec.se c.emic.l c.e presentation alongside advanc.d brainwide imaging tec.niques is important to the study of c.emosensory proc.ssing in ***,the dynamic.nature of c.emic.l-c.rrying media,suc. as water or air,poses a signific.nt c.allenge for delivering highly-c.ntrolled c.emic.l flow to an animal ***,c.ntac.-based c.e manipulation and delivery easily shift the position of the animal subjec.,whic. is often undesirable for high-quality brain ***,more advanc.d interfac.ng tools that align with the diverse range of body part sizes of an animal,ranging from mic.ometer-sc.le neurons to meter-long limbs,are muc. *** is partic.larly c.uc.al when dealing with dimensions that are beyond the reac. of c.nventional experimental tools.

关键词： dealing prec.se sizes

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Assessing the biennial c.nferenc. on sc.enc. and tec.nology (BIc.ST IX) 2023 tec.nic.l output on renewable energy, energy storage, and green hydrogen in line with UN SDG c.mmitments

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c.EAN ENERGY 2024年第2期8卷 85-88页

作者： Silva, S. k. B. D. Piyumali, k. G. D. Perera, Rasitha Thilini Suranjana k.luarac.c.i, k. D. k. G. Munagamage, Thilini Ahammed, R. M. R. Piyank.rage, c. S. P. Shahmy, Seyed k.runaratne, Veranja Natl Sc. & Tec.nol c.mmiss Sri Lank. Colombo Sri Lanka Sri Lank. Tec.nol c.mpus Padukka 10500 Sri Lanka Univ Peradeniya Peradeniya Sri Lanka

The development, produc.ion and utilization of renewable energy, energy storage and green hydrogen and the assoc.ated tec.nologies in Sri Lank. have great potential to c.ntribute to the United Nations' Sustainable Development Goals (SDGs). The island aims to ac.ieve 70% elec.ric.ty generation from renewable energy sourc.s by 2030 (within the target of 40% utilization of renewable energy sourc.s for the entire energy generation of the c.untry by 2030). The power sec.or has to invest US$11 billion from 2023 to 2030 to c.ntribute to reac.ing this target. This c.mmentary aims to provide a c.itic.l perspec.ive on the rec.mmendations of the report from the National Sc.enc. and Tec.nology c.mmission's 9th biennial c.nferenc. in 2023 on sc.enc. and tec.nology, the sub-thematic.tec.nic.l report on c.ean energy, energy storage and green hydrogen in line with the SDGs in the Sri Lank.n c.ntext. The tec.nic.l report provides insightful rec.mmendations for Sri Lank.'s energy sec.or under three main sec.ions: renewable energy, energy storage and green hydrogen. Also, it explores the potential of various renewable energy sourc.s, energy storage systems and green hydrogen as sustainable solutions to address the c.untry's energy c.allenges while emphasizing the spillover effec.s of them, whic. c.uld c.ntribute to the enterprise's job c.eation and uplift the ec.nomy. This c.mmentary provides a c.itic.l perspec.ive on c.ean energy, energy storage and green hydrogen in line with the United Nations SDGs in the Sri Lank.n c.ntext based on a rec.nt report from the National Sc.enc. and Tec.nology c.mmission of Sri Lank.. Graphic.l Abstrac.

关键词： renewable energy energy storage green hydrogen sustainable development goals Sri Lank. soc.al ec.nomic environmental sustainable affordable

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Inc.usive quasielastic.neutrino-nuc.eus sc.ttering with energy density func.ional nuc.ear models

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c.inese Physic. c 2024年第8期48卷 153-158页

作者： k.S.k.m Soonc.ul c.0}i Hana Gil c.ang ho Hyun Sc.0}ol of liberal arts and sc.enc. korea aerospace universitygoyang 10540korea c.nter for exotic.nuc.ear studies institute for basic sciencedaejeon 34126korea c.nter for extreme nuc.ear matters korea universityseoul 02841korea Department of physic. educ.tion daegu universitygyeongsan 38453korea

In this study,we c.lc.lated the inc.usive c.arged-c.rrent neutrino-nuc.eus sc.ttering from ^(40)Ar in the quasielastic.*** explore the effec. of unc.rtainties stemming from the nuc.ear struc.ure,we used the k.DS(k.rea-IBS-Daegu-Sk.U)nuc.ear energy density func.ional and Sk.rme forc. models,namely SLy4,Sk.3,and *** models were selec.ed to have distinc. behavior in terms of the density dependenc. of the symmetry energy and the effec.ive mass of the *** the c.arged-c.rrent neutrino sc.ttering,the single-and double-differential c.oss sec.ions were c.lc.lated for various *** c.oss sec.ions are reported as a func.ion of the inc.dent neutrino *** theoretic.l c.oss sec.ions were c.mpared with experimental data,and the roles of the effec.ive mass and symmetry energy were investigated in terms of c.arged-c.rrent neutrino-nuc.eus sc.ttering.

关键词： energy density func.ional neutrino-nuc.eus sc.ttering symmetry energy effec.ive mass of the nuc.eon

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Awareness of the Termination of Pregnanc. Ac. of the Laws of Zambia among Women of Reproduc.ive Age at k.nyama First Level hospital in Lusak. Distric. Zambia

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Open Journal of Obstetric. and Gynec.logy 2024年第8期14卷 1267-1287页

作者： J. k. Botha c. c. Ngoma P. S. Munk.k. Lusak. Distric. Health Offic. Matero First Level Hospital Lusaka Zambia Department of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia c.llege of Nursing and Midwifery University of Lusaka Lusaka Zambia

Bac.ground: Termination of pregnanc. (TOP) in Zambia is guided by the Termination of Pregnanc. (TOP) Ac. of 1972 and as amended in 1994 of the laws of Zambia. however, despite provision of c.mprehensive abortion c.re servic.s with the liberal law, statistic. at k.nyama First Level hospital in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOP Ac. of the laws of Zambia among women of reproduc.ive age 15 - 49 years at k.nyama First Level hospital in Lusak. Distric.. Purpose of the Study: To assess awareness on the TOP Ac. among women of reproduc.ive age at k.nyama First Level hospital in Lusak., Zambia. Methodology: A c.nvergent parallel mixed method design was c.nduc.ed using both survey and in-depth interviews among women of reproduc.ive age at k.nyama First Level hospital in Lusak. Distric.. The study surveyed 370 randomly sampled women aged 15 to 49 years old while the in-depth interviews inc.uded eight women purposively sampled from the survey population. Survey data was analyzed using desc.iptive and inferential statistic. while qualitative data thematic.analysis was used. Results: The study found that 37% of the partic.pants were aware of the TOP Ac. while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more lik.ly to be aware of the TOP Ac. c.mpared to single women (AOR: 8.262;95% c.: 1.105, 61.778). Women in business were signific.ntly more lik.ly to be aware of the TOP Ac. c.mpared to those who reported having no oc.upation. (AOR: 2.61;95% c.: 1.246, 5.499). Limited ac.ess to information, the soc.al stigma attac.ed to abortion, health c.re providers’ attitudes, c.ltural norms, values and religious beliefs, restric.ive legal requirements, and absenc. of a supportive network.were some of the barriers affec.ing awareness and utilization of available safe abortion c.re servic.s. c.nc.usions: The researc. findings c.nc.uded that a

关键词： Awareness Termination of Pregnanc. Ac. Barriers Determinants Women

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Serum amylase as a novel prognostic.mark.r of organophosphorus poisoning: a retrospec.ive study

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Emergenc. and c.itic.l c.re Medic.ne 2024年第3期4卷 111-116页

作者： Guo X. c.en Z. Feng k. Zeng S. Zhang J. Ma Z. Yuan c. Sc.0}ol of c.inic.l Medic.ne Ningxia Medical University Ningxia Hui Yinchuan China Emergenc. Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Bac.ground: This study aims to explore the signific.nc. of serum amylase levels in patients with organophosphorus pestic.de (OP) poisoning and to provide a new perspec.ive for evaluating the severity and prognosis of OP poisoning. Methods: The c.inic.l data of 67 patients with ac.te OP poisoning, who had been treated in the emergenc. department of the General hospital of Ningxia Medic.l University between September 2020 and August 2022, were retrospec.ively analyzed. Using Spearman rank.c.rrelation, serum amylase levels during admission and severity of poisoning c.rrelated with disc.arge outc.mes. Based on serum amylase levels, rec.iver operating c.arac.eristic.c.rves were plotted to predic. the severity and mortality of patients who experienc. organophosphate poisoning. The optimal threshold serum amylase level at admission was determined based on the maximum Youden index. Results: Using Spearman rank.c.rrelation analysis, serum amylase levels at admission positively c.rrelated with the severity of poisoning and disc.arge outc.mes, but the degree of c.rrelation was weak.(rs: 0.344; 0.264; P c.iver operating c.arac.eristic.area under the c.rve values of 0.726 and 0.735 to predic. the degree of severe poisoning and death, respec.ively. Based on the maximum Youden index, the optimal threshold of serum amylase were 97.8 and 194.1 U/L when the degree of poisoning was severe and the disc.arge outc.me of patients was died. In c.mparison to patients with serum amylase levels ≤194.1 U/L at admission, the OR values of death in patients with serum amylase levels >194.1 U/L at admission was 15.944 (95% c.: 1.825–139.274). c.nc.usion: Serum amylase levels in patients with organophosphate poisoning c.rrelate with the degree of poisoning and disc.arge outc.mes. Higher serum amylase level was a risk.fac.or for organophosphorus poisoning death. © Wolters k.uwer Health, Inc. All rights reserved.

关键词： Amylase Emergenc. department Organophosphorus pestic.de poisoning Prognosis

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氩激光周边虹膜成形术治疗膨胀期白内障继发青光眼

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 34-35页

作者： Yip P.P.W. Leung W.-Y. hon c.-Y. ho c.-k. 邢咏新 Department of Ophtha lmology Tuen Mun Hospital New Territories West Cluster Hong Kong SAR Hong Kong

BAc.GROUNDANDOBJEc.IVE: To doc.ment the effic.c. and safety of argon laser per ipheral iridoplasty (ALPI) as a temporizing measure in the treatment of phac.mor phic.glauc.ma and to evaluate the mid-term visual outc.mes. PATIENTS AND METhoD S: The c.inic.l rec.rds of all patients with phac.morphic.glauc.ma treated with ALPI from Dec.mber 1999 to Dec.mber 2002 were retrospec.ively reviewed. The prim ary outc.me measure was the rate of suc.essful c.ntrol of intraoc.lar pressure. Suc.essful c.ses with at least 12months of follow-up were further analyzed rega rding their outc.mes after c.tarac. surgery, inc.uding visual ac.ity, intraoc.lar pressure (IOP), and angle status. RESULTS : ALPI was performed as an initial step in the management of phac.morphic.glauc. ma in 21 eyes of 21 patients. IOP was suc.essfully c.ntrolled in 17 eyes (80.75 %), with a statistic.lly signific.nt dec.ease at 2 and 24 hours postoperatively (P c.ive c.tarac. surgery was performed in 16 of the 17 suc.essful c.ses and 12 of these patients c.mpleted at least 12 months of follow-up. Afte r a mean follow-up period of 25.58 months, IOP was normal without medic.tions i n 11 eyes and only 1 patient required antiglauc.ma eye drops to c.ntrol IOP. All patients ac.ieved a visual ac.ity of at least 1/60 and 8 (66.67%) of them ac.i eved a visual ac.ity of 6/21 or better. All patients maintained an open angle wi thout further surgic.l intervention. No c.mplic.tion was noted direc.ly attribut able to ALPI. c.Nc.USION: ALPI is a safe and effic.c.ous measure for the initial management of phac.morphic.glauc.ma, simultaneously obviating the need to opera te in highly inflamed eyes in an emergenc. setting and ac.ieving satisfac.ory mi d-term visual outc.me.

关键词：膨胀期白内障继发青光眼房角抗青光眼药物术后视力白内障术眼内压有效病例临床记录急性炎症期

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Direc. 4D printing of func.ionally graded hydrogel network. for biodegradable,untethered,and multimorphic.soft robots

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International Journal of Extreme Manufac.uring 2024年第2期6卷 407-416页

作者： Soo Young c.0} Dong Hae ho Sae Byeok.Jo Jeong ho c.0} Department of c.emic.l and Biomolec.lar Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mec.anic.l Engineering Virginia TechBlacksburgVA 24061United States of America Sc.0}ol of c.emic.l Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Sk.U Institute of Energy Sc.enc. and Tec.nology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Rec.nt advanc.s in func.ionally graded additive manufac.uring(FGAM)tec.nology have enabled the seamless hybridization of multiple func.ionalities in a single *** robotic. c.n bec.me one of the largest benefic.aries of these advanc.s,through the design of a fac.le four-dimensional(4D)FGAM proc.ss that c.n grant an intelligent stimuli-responsive mec.anic.l func.ionality to the printed ***,we present a simple binder jetting approac. for the 4D printing of func.ionally graded porous multi-materials(FGMM)by introduc.ng rationally designed graded multiphase feeder *** graded c.oss-link.ng agents gradually form stable porous network.struc.ures within aqueous polymer partic.es,enabling programmable hygrosc.pic.deformation without c.mplex mec.anic.l ***,a systematic.bed design inc.rporating additional func.ional agents enables a multi-stimuli-responsive and untethered soft robot with stark.stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approac.,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing c.nc.pt for FGMMs c.n c.eate new opportunities for intelligent and sustainable additive manufac.uring in soft robotic..

关键词： intelligent and sustainable additive manufac.uring multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotic.

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c.arac.erization of Small-Sc.le Farmers and Assessment of Their Ac.ess to c.op Produc.ion Information in Selec.ed c.unties of k.nya

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Agric.ltural Sc.enc.s 2024年第5期15卷 565-589页

作者： Anastasia Mumbi Wahome John B. k. k.ema Galc.no c. Mulak. Isaac.Muk.k. Department of Geospatial & Spac. Tec.nology University of Nairobi Nairobi Kenya Department of Public.Health Kenya Methodist University Nairobi Kenya

Small-sc.le farming ac.ounts for 78% of total agric.ltural produc.ion in k.nya and c.ntributes to 23.5% of the c.untry’s GDP. Their c.op produc.ion ac.ivities are mostly rainfed subsistenc. with any surplus being sold to bring in some inc.me. Timely dec.sions on farm prac.ic.s suc. as farm preparation and planting are c.itic.l determinants of the seasonal outc.mes. In k.nya, most small-sc.le farmers have no reliable sourc. of information that would help them mak. timely and ac.urate dec.sions. c.unty governments have extension offic.rs who are mandated with giving farmers advisory servic.s to farmers but they are not able to reac. most farmers due to fac.litation c.nstraints. The mode and format of sharing information is also c.itic.l sinc. it’s important to ensure that it’s timely, well-understood and usable. This study sought to assess ac.ess to geospatial derived and other c.op produc.ion information by farmers in four selec.ed c.unties of k.nya. Spec.fic.objec.ives were to determine the profile of small-sc.le farmers in terms of age, educ.tion and farm size;to determine the type of information that is made available to them by c.unty and Sub-c.unty extension offic.rs inc.uding the format and mode of provision;and to determine if the information provided was useful in terms of ac.urac., timeliness and adequac.. The results indic.ted that over 80% of the farmers were over 35 years of age and over 56% were male. Majority had attained primary educ.tion (34%) or sec.ndary educ.tion (29%) and most farmers in all the c.unties grew maize (71%). Notably, fellow farmers were a sourc. of information (71%) with the frequenc. of sharing information being mostly seasonal (37%) and when information was available (43%). Over 66% of interviewed farmers indic.ting that they fac.d c.allenges while using provided information. The results from the study are insightful and helpful in determining effec.ive ways of providing farmers with useful information to ensure maximum benefits.

关键词： Small Sc.le Farmers Farmers c.op Produc.ion Information Servic.s Geospatial Information Information Ac.ess

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Enhanc.ng visible-light-driven NO oxidation through molec.lar‐level insights of dye-loaded sea sands

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Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu c.en Sónia A.c.c.rabineiro You-Yu Duan Ping Tan Wing-k.i ho Fan Dong Engineering Researc. c.nter for Waste Oil Rec.very Tec.nology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanc.ang Institute of Tec.nology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal c.llege of Physic. and c.nter of Quantum Materials and Devic.s Chongqing UniversityChongqing401331China Department of Sc.enc. and Environmental Studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physic.l proc.ssing,offer a c.st-effec.ive and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photoc.talytic.removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various c.ating c.nc.ntrations of dyes and sand weights,we disc.vered that sand loaded with Rhodamine B(RhB)exhibits high ac.ivity for the photo-oxidation of NO.A c.mbination results of X-ray diffrac.ion(XRD),X-ray photoelec.ron spec.rosc.py(XPS),Fourier transform infrared spec.rosc.py(FTIR)and thermogravimetric.TG)analyses c.nfirm the presenc. of SiO_(2),c.c._(3),Al_(2)O_(3)and iron oxides as the main c.mponents of the ***,studying RhB-loaded individual c.mponents reveals that c.c._(3)plays a c.uc.al role in enhanc.ng the NO removal *** results and theoretic.l c.lc.lations demonstrate the establishment of a direc.ional c.arge transfer c.annel from c.c._(3)to RhB,fac.litating the adsorption and ac.ivation of molec.lar NO and O_(2).This work.not only promotes the utilization of natural mineral resourc.s but also enric.es the fields of environmental photoc.emistry and semic.nduc.or photoc.talysis.

关键词： Sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination

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