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World Journal of Emergency Medicine 2024年第3期15卷 223-228页

作者： Ji ho Lee Dong Hun Lee Byung Kook Lee Seok Jin ryu Department of Emergency Medicine Chonnam National University HospitalGwangju 61469Republic of Korea Department of Emergency Medicine Chonnam National University Medical SchoolGwangju 61469Republic of Korea

The global incidence rates of in-hospital cardiac arrest(IHCA)range from1.2 to 9.0 per1,000 hospitalized patients,as per the National Cardiac Arrest Database.[1] While IHCAs tend to exhibit superior 30-day survival rates relative to out-of-hospital cardiac arrests (OHCA) due to situational advantages,such as immediate access to medical personnel and treatments.

关键词： patients cardiac IHC

Comparison of sequential and 7-,10-,14-d triple therapy for Helicobacter pylori infection

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World Journal of Gastroenterology 2012年第19期18卷 2377-2382页

作者： Hyuk Soon Choi hoon Jai Chun sang hoon Park Bora Keum Yeon Seok Seo Yong Sik Kim Yoon-Tae Jeen Soon ho Um hong Sik Lee Chang Duck Kim ho sang ryu Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori(***) infection with that of triple therapy of varying ***:The 460 patients enrolled in this study had ***-associated gastritis or a gastric or duodenal *** screening,***-infected patients were randomly assigned to receive either conventional triple therapy for 7,10 or 14 d,or a new 10-d sequential *** of the 4 treatment groups included 115 *** outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and ***:The overall eradication rate was 81.0%,and eradication rates were 75.7% for 7-d conventional triple therapy,81.9% for 10-d conventional triple therapy,84.4% for 14-d conventional triple therapy,and 82.0% for 10-d sequential *** intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy(P = 0.416 and P = 0.405,respectively).CONCLUSION:There are no significant differences between 10-d sequential eradication therapy for *** and any duration of standard triple treatment in Korean patients.

关键词：疗法三联感染幽门螺旋杆菌幽门螺杆菌十二指肠协议分析治疗

A novel cleansing score system for capsule endoscopy

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World Journal of Gastroenterology 2010年第7期16卷 875-880页

作者： Sung Chul Park Bora Keum Jong Jin Hyun Yeon Seok Seo Yong Sik Kim Yoon Tae Jeen hoon Jai Chun Soon ho Um Chang Duck Kim ho sang ryu Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Anam HospitalInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

AIM:To suggest a new cleansing score system for small bowel preparation and to evaluate its clinical ***:Twenty capsule endoscopy cases were reviewed and small bowel preparation was assessed with the new scoring *** the assessment,two visual parameters were used:proportion of visualized mucosa and degree of *** frames from small bowel images were serially selected and scored at 5-min *** correlation coefficient(ICC)was obtained to assess the reliability of the new scoring *** efficacy evaluation and validation,scores of our new scoring system were compared with another previously reported cleansing grading ***:Concordance with the previous system,inter-observer agreement,and intra-patient agreement were excellent with ICC values of 0.82,0.80,and 0.76,*** intra-observer agreements at four-week intervals were also *** cutoff value of adequate image quality was found to be ***:Our new scoring system is simple,efficient,and can be considered to be applicable in clinical practice and research.

关键词： Capsule endoscopy Cleansing score system

Sensitivity of the suspected blood indicator:An experimental study

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世界胃肠病学杂志：英文版 2012年第31期18卷 4169-4174页

作者： Sung Chul Park hoon Jai Chun Eun Sun Kim Bora Keum Yeon Seok Seo Yong Sik Kim Yoon Tae Jeen hong Sik Lee Soon ho Um Chang Duck Kim ho sang ryu Division of Gastroenterology and Hepatology Department of Internal MedicineKangwon National University School of MedicineChuncheon 200-722South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 136-705South Korea

AIM:To investigate whether suspected blood indicator(SBI) in capsule endoscopy(CE) is affected by background color and capsule passage ***:Experimental models of the small intestine constructed from paper in a variety of colors were used to simulate the background colors observed in CE *** background colors studied included very pale yellow,yellow,very pale magenta,light grayish pink,burnt sienna,and deep and dark brown,and red spots were attached inside *** endoscopic capsule was manually passed through the *** rate of detection of the red spots by the SBI was evaluated based on the colors of the models and the capsule passage velocities(0.5 cm/s,1 cm/s,and 2 cm/s).RESULTS:The rate of detection of the red spots by the SBI differed significantly according to the background color of the model(P < 0.001).Detection rates were highest for backgrounds of very pale magenta,burnt sienna,and yellow,in that *** were lowest for backgrounds of dark brown and very pale *** rate of detection of red spots by the SBI tended to decrease at rapid capsule passage velocities(1-2 cm/s) compared to slow velocities(0.5 cm/s) for backgrounds of very pale yellow(P = 0.042),yellow(P = 0.001),very pale magenta(P = 0.002),and burnt sienna(P = 0.001).No significant differences in the rate of detection were observed according to velocity for light grayish pink(P = 0.643) or dark brown(P = 0.396).CONCLUSION:SBI sensitivity was affected by background color and capsule passage velocity in the *** findings may facilitate the rapid detection of bleeding lesions by CE.

关键词：实验模型血液指标灵敏度通过速度背景颜色 SBI 检测率颜色模型

how good is cola for dissolution of gastric phytobezoars?

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World Journal of Gastroenterology 2009年第18期15卷 2265-2269页

作者： Beom Jae Lee Jong-Jae Park hoon Jai Chun Ji hoon Kim Jong Eun Yeon Yoon Tae Jeen Jae Seon Kim Kwan Soo Byun sang Woo Lee Jae Hyun Choi Chang Duck Kim ho sang ryu Young-Tae Bak Division of Gastroenterology Department of Internal MedicineKorea University College of MedicineSeoul 152-703South Korea

AIM:To evaluate the efficacy of cola treatment for gastric phytobezoars,including ***:A total of 17 patients(range:48 to 78 years) with symptomatic gastric phytobezoars treated with cola and adjuvant endoscopic therapy were *** liters of cola lavage(10 cases) or drink(7 cases) were initially used,and then endoscopic fragmentation was done for the remnant bezoars by using a lithotripsy basket or a polypectomy *** overall success of dissolving a gastric phytobezoars with using three liters of cola and the clinical and endoscopic findings were compared retrospectively between four cases of complete dissolution by using only cola and 13 cases of partial dissolution with ***:After 3 L of cola lavage or drinking,a complete dissolution of bezoars was achieved in four patients(23.5%),while 13 cases(76.5%) were only partially ***(4 of 6 cases) were observed more frequently than diospyrobezoars(0 of 11) in the group that underwent complete dissolution(P = 0.006).Gender,symptom duration,size of bezoar and method of cola administration were not significantly different between the two *** of 13 patients with residual bezoars were completely treated with a combination of cola and endoscopic ***:The rate of complete dissolution with three liters of cola was 23.5%,but no case of diospyrobezoar was completely dissolved using this ***,pretreatment with cola may be helpful and facilitate endoscopic fragmentation of gastric phytobezoars.

关键词：可口可乐胃癌辅助内镜治疗残余结石持续时间碎石篮工作组预处理

Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6987-6995页

作者： Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen hong Sik Lee hoon Jai Chun Chang Duck Kim ho sang ryu Department of Internal Medicine Korea University College of MedicineSeoul 136-705South Korea Department of Biostatistics Korea University College of MedicineSeoul 136-705South Korea

AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis ***:We included 154 consecutive patients in two treatment groups:the "add-on" group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the "switch/combination" group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as *** "switch/combination" group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the "add-on" group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the "add-on" group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the "add-on" group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment.

关键词：阿德福韦酯慢性乙型肝炎联合治疗拉米夫定耐药 DNA水平多变量分析病毒学

Endoscopic submucosal tunnel dissection salvage technique for ulcerative early gastric cancer

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World Journal of Gastroenterology 2014年第27期20卷 9210-9214页

作者： Hyuk Soon Choi hoon Jai Chun Min ho Seo Eun Sun Kim Bora Keum Yeon Seok Seo Yoon Tae Jeen hong Sik Lee Soon ho Um Chang Duck Kim ho sang ryu Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Endoscopic submucosal dissection is an effective treatment modality for early gastric cancer(EGC), though the submucosal fibrosis found in ulcerative EGC is an obstacle for successful treatment. This report presents two cases of ulcerative EGC in two males, 73- and 80-year-old, with severe fibrosis. As endoscopic ultrasonography suggested that the EGCs had invaded the submucosal layer, the endoscopic submucosal tunnel dissection salvage technique was utilized for complete resection of the lesions. Although surgical gastrectomy was originally scheduled, the two patients had severe coronary heart disease, and surgeries were refused because of the risks associated with their heart conditions. The endoscopic submucosal tunnel dissection salvage technique procedures described in these cases were performed under conscious sedation, and were completed within 30 min. The complete en bloc resection of EGC using endoscopic submucosal tunnel dissection salvage technique was possible with a free resection margin, and no other complications were noted during the procedure. This is the first known report concerning the use of the endoscopic submucosal tunnel dissection salvage technique salvage technique for treatment of ulcerative EGC. We demonstrate that endoscopic submucosal tunnel dissection salvage technique it is a feasible method showing several advantages over endoscopic submucosal dissection for cases of EGC with fibrosis.

关键词： Endoscopy Early gastric cancer Endoscopic submucos

Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第15期14卷 2394-2400页

作者： Yeon Seok Seo Jin Nam Kim Bora Keum sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen hoon Jai Chun Chul Yong Kim Chang Duck Kim ho sang ryu Soon ho Um Department of Internal Medicine Korea University College of Medicine Seoul 136-705 Korea Department of Radiation Oncology Korea University College of Medicine Seoul 136-705 Korea

AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METhoDS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.

关键词：肝细胞癌放射治疗治疗反应生存率

Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

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World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen hong Sik Lee hoon Jai Chun Chang Duck Kim ho sang ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METhoDS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P holestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

Effects of dispersoid preforming via multistep sintering of oxide dispersion-strengthened CoCrFeMnNi high-entropy alloy

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Journal of Materials Science & Technology 2023年第9期140卷 187-200页

作者： SeungHyeok Chung Ji ho Shin ho Jin ryu Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Central Research Institute Korea Hydro and Nuclear Power Co.Ltd.(KHNP)Daejeon 34101Republic of Korea

Dispersoid formation and microstructural evolution in an oxide dispersion-strengthened CoCrFeMnNi high-entropy alloy(HEA)using a newly designed multistep sintering process are *** proposed multistep sintering consists of a dispersoid preforming heat treatment of as-milled 0.1 wt%Y_(2)O_(3)-CoCrFeMnNi high-entropy alloy powders at 800℃,followed by sintering at 800–1000℃ under uniaxial *** the conventional single-step sintered bulk,the coarsened BCC Y_(2)O_(3)dispersoids mainly form with an incoherent interface with the HEA *** contrast,finer FCC Y_(2)O_(3)dispersoids,an atypical form of Y_(2)O_(3),are formed in the matrix region after multistep *** of FCC Y_(2)O_(3)disper-soids is initiated on the favorable facet,the{111}plane of the austenitic matrix,with the formation of a semi-coherent interface with the matrix during the dispersoid preforming heat treatment and it maintains its refined size even after *** is found that dispersoid preforming prior to sintering appears promising to control the finer dispersoid formation and refined grain structure.

关键词： Oxide dispersion strengthening High-Entropy alloy Multistep sintering Dispersoid preforming Microstructure evolution Interfacial structure