检索结果-南通市图书馆

Preoperative defining system for pancreatic head cancer considering surgical resection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第26期22卷 6076-6082页

作者： Seok Jeong Yang ho kyoung hwang Chang Moo Kang Woo Jung Lee Department of Surgery Ulsan University Hospital University of Ulsan College of Medicine Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer Center Institute of Gastroenterology Yonsei Severance Hospital

AIM: To provide appropriate treatment, it is crucial to share the clinical status of pancreas head cancer among multidisciplinary treatment ***: A retrospective analysis of the medical records of 113 patients who underwent surgery for pancreas head cancer from January 2008 to December 2012 was performed. We developed preoperative defining system of pancreatic head cancer by describing “resectability - tumor location - vascular relationship - adjacent organ involvement - preoperative CA19-9 (initial bilirubin level) - vascular anomaly”. The oncologic correlations with this reporting system were ***: Among 113 patients, there were 75 patients (66.4%) with resectable, 34 patients (30.1%) with borderline resectable, and 4 patients (3.5%) with locally advanced pancreatic cancer. Mean disease-free survival was 24.8 mo (95%CI: 19.6-30.1) with a 5-year disease-free survival rate of 13.5%. Pretreatment tumor size ≥ 2.4 cm [Exp(B) = 3.608, 95%CI: 1.512-8.609, P = 0.044] and radiologic vascular invasion [Exp(B) = 5.553, 95%CI: 2.269-14.589, P = 0.002] were independent predictive factors for neoadjuvant treatment. Borderline resectability [Exp(B) = 0.222, P = 0.008], pancreatic head cancer involving the pancreatic neck [Exp(B) = 9.461, P = 0.001] and arterial invasion [Exp(B) = 6.208, P = 0.010], and adjusted CA19-9 ≥ 50 [Exp(B) = 1.972 P = 0.019] were identified as prognostic clinical factors to predict tumor ***: The suggested preoperative defining system can help with designing treatment plans and also predict oncologic outcomes.

关键词： Preoperative defining system Pancreas head cancer Borderline resectable Adjusted CA19-9 Neoadjuvant therapy

Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第4期23卷 676-686页

作者： Eun-Ki Min Jae Uk Chong ho kyoung hwang Sang Joon Pae Chang Moo Kang Woo Jung Lee Yonsei University College of Medicine Seoul 03722 Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer CenterSeverance Hospital National Health Insurance Corporation Ilsan hospital

AIMTo investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma (PDAC).METhoDSFrom January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale (NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC were reviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early (POD 1, 2, 3) and late (POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic *** total of 212 patients were dichotomized into good pain control group (n = 162) and poor pain control group (n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival (OS) was observed in the group of patients receiving distal pancreatectomy (DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival (DFS) in the DP group (18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy (PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients’ perceived pain control was revealed as an independent risk factor of both DFS (HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS (HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic *** postoperative pain relief durin

关键词： Pancreatic cancer Pancreatectomy Survival Postoperative pain Recurrence

A nomogram to preoperatively predict 1-year disease-specific survival in resected pancreatic cancer following neoadjuvant chemoradiation therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2020年第1期32卷 105-114页

作者： ho kyoung hwang Keita Wada Ha Yan Kim Yuichi Nagakawa Yosuke Hijikata Yota Kawasaki Yoshiharu Nakamura Lip Seng Lee Dong Sup Yoon Woo Jung Lee Chang Moo Kang Division of HBP Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Korea Pancreatobiliary Cancer Clinic Yonsei Cancer CenterSeverance HospitalSeoul 03722Korea Department of Surgery Teikyo University School of MedicineTokyo 173-8605Japan Biostatistician Biostatistics Collaboration UnitDepartment of Biomedical Systems InformaticsYonsei University College of MedicineSeoul 03722Korea Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityTokyo 160-8402Japan Department of Digestive Surgery Breastand Thyroid SurgeryGraduate School of Medical SciencesKagoshima UniversityKagoshima 890-0065Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 890-0065Japan Department of General Surgery Changi General HospitalSingapore 529889Singapore

Objective: This study aimed to develop a nomogram to predict the 1-year survival of patients with pancreatic cancer who underwent pancreatectomy following neoadjuvant treatment with preoperatively detectable clinical parameters. Extended pancreatectomy is necessary to achieve complete tumor removal in borderline resectable and locally advanced pancreatic cancer. however, it increases postoperative morbidity and mortality rates, and should be balanced with potential benefit of long-term ***: The medical records of patients who underwent pancreatectomy following neoadjuvant treatment from January 2005 to December 2016 at Severance hospital were retrospectively reviewed. Medical records were collected from five international institutions from Japan and Singapore for external ***: A total of 113 patients were enrolled. The nomogram for predicting 1-year disease-specific survival was created based on 5 clinically detectable preoperative parameters as follows: age(year), symptom(no/yes), tumor size at initial diagnostic stage(cm), preoperative serum carbohydrate antigen(CA) 19-9 level after neoadjuvant treatment(howed good agreement between actual and predicted survival probabilities;the the Greenwood-Nam-D’Agostino(GND) goodness-of-fit test showed that the model was well calibrated(χ~2=8.24,P=0.5099). A total of 84 patients were used for external validation. When correlating actual disease-specific survival and calculated 1-year disease-specific survival, there were significance differences according to the calculated probability of 1-year survival among the three groups(P=0.044).Conclusions: The developed nomogram had quite acceptable accuracy and clinical feasibility in the decision-making process for the management of p

关键词： Pancreatic cancer neoadjuvant treatment pancreatectomy survival nomogram

Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2022年第2期42卷 179-183页

作者： Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn ho kyoung hwang Gi hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee Jae-ho Cheong Hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee Department of Systems Biology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Republic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryCHA Bundang Medical CenterCHA UniversitySeongnam 13496Republic of Korea Department of GI Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoul 03722Republic of Korea Division of Thoracic Surgery Michael E.DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030USA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902USA Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841Republic of Korea Department of Surgery The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)*** two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes.

关键词： therapeutic subtypes prognosis

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Immediate muscle strengthening by an end-effector type gait robot with reduced real-time use of leg muscles: A case series and review of literature

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第19期7卷 2976-2985页

作者： Chang ho hwang Department of Physical Medicine and Rehabilitation Ulsan University Hospital University of Ulsan College of Medicine Department of Biomedical Engineering School of Electrical EngineeringUniversity of Ulsan

BACKGROUND De-afferentation or non-weight bearing induces rapid cortical and spinalα-motor neuron *** supposed that an end-effector type gait robot(EEGR)could provide patients with a training condition that was specific enough to activate rapid cortical/spinal neuroplasticity,leading to immediate muscle *** electromyographic and biomechanical comparisons were *** To compare the electromyographic activities of the thigh and shank muscles and isometric peak torque(PT)before and after walking training on a floor or in the end-effector gait *** Twelve outpatients without ambulatory dysfunction were *** of two interventions(5-min training on a floor at a comfortable pace or training in an EEGR with non-weight bearing on their feet and 100%guidance force at 2.1 km/h)were randomly *** PT,maximal ratio of torque development,amplitude of compound motor action potential(CMAP),and area under the curve(AUC)were evaluated before and 10 min after both *** The degree of PT improvement of the dominant knee flexors was larger in the EEGR than on the floor(9.6±22.4 Nm/BW,Phose who trained on the floor(4.5±28.1 Nm/BW,Phowever,all electromyographic activities of the thigh and shank muscles(peak CMAP,mean and peak AUC)were significantly lower for the use of the EEGR than walking on the *** Immediate strengthening of the knee flexors and extensors was induced after the 5-min EEGR training,despite reduced muscular use.

关键词： Robotics Rehabilitation Muscles Neuronal plasticity Gait Knee

Nanograin network memory with reconfigurable percolation paths for synaptic interactions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第6期12卷 1040-1050页

作者： hoo-Cheol Lee Jungkil Kim Ha-Reem Kim kyoung-ho Kim Kyung-Jun Park Jae-Pil So Jung Min Lee Min-Soo hwang hong-Gyu Park Department of Physics Korea UniversitySeoul 02841Republic of Korea Department of Physics Jeju National UniversityJeju 63243Republic of Korea Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea

The development of memory devices with functions that simultaneously process and store data is required for efficient *** achieve this,artificial synaptic devices have been proposed because they can construct hybrid networks with biological neurons and perform neuromorphic ***,irreversible aging of these electrical devices causes unavoidable performance *** several photonic approaches to controlling currents have been suggested,suppression of current levels and switching of analog conductance in a simple photonic manner remain ***,we demonstrated a nanograin network memory using reconfigurable percolation paths in a single Si nanowire with solid core/porous shell and pure solid core *** electrical and photonic control of current percolation paths enabled the analog and reversible adjustment of the persistent current level,exhibiting memory behavior and current suppression in this single nanowire *** addition,the synaptic behaviors of memory and erasure were demonstrated through potentiation and habituation *** habituation was achieved using laser illumination on the porous nanowire shell,with a linear decrease in the postsynaptic ***,synaptic elimination was emulated using two adjacent devices interconnected on a single ***,electrical and photonic reconfiguration of the conductive paths in Si nanograin networks will pave the way for next-generation nanodevice technologies.

关键词： electrical percolation network

Is endoscopic ultrasonography still the modality of choice in preoperative staging of gastric cancer?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第38期20卷 13775-13782页

作者： Sung Wook hwang Dong ho Lee Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Seoul National University Bundang HospitalSeongnam

The treatment option for gastric cancer is usually based on preoperative staging by imaging modalities. Endoscopic ultrasonography (EUS) and computed tomography (CT) have been used as the diagnostic modality of choice in preoperative staging of gastric cancer. Magnetic resonance imaging (MRI) has been employed in several studies, and (18F) 2-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has emerged as a new promising imaging modality. The purpose of this article is to provide summarized information on preoperative staging using EUS, multi-detector row CT (MDCT), MRI and PET for gastric cancer. In T staging, both EUS and MDCT show high accuracy. MRI seemed to have better performance, but the number of MRI studies is limited. FDG-PET is not able to properly evaluate the depth of invasion. In N staging, the diagnostic accuracy of EUS, MDCT and MRI is not sufficient. In preoperative M staging, MDCT and FDG-PET showed similar diagnostic accuracies. FDG-PET/CT fusion could be expected to show better performance in the future. Physicians should keep in mind that each diagnostic modality has advantages and limitations and choose an appropriate diagnostic strategy tailored for each patient.

关键词： Gastric cancer Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography

A comparative study of interface reconstruction algorithms in molten metal flow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2013年第1期10卷 50-56页

作者： Young-Sim Choi Jun-ho hong ho-Young hwang e-Design Center Korea Institute of Industrial TechnologyIncheon 406-840Korea

In the present research,two numerical schemes for improving the accuracy of the solution in the flow simulation of molten metal were *** method is the Piecewise Linear Interface Calculation(PLIC) method and the other is the Donor-Acceptor(D-A) *** verify the module of the interface reconstruction algorithms,simple problems were *** these validations,the accuracy and efficiency of these two methods were compared by simulating various real *** the numerical simulation of free surface flow,it is possible for the PLIC method to track very accurately the interface between *** PLIC method,however,has the weak point in that a lot of computational time is required,though it shows the more accurate interface *** Donor-Acceptor method has enough effectiveness in the macro-observation of a mold filling sequence though it shows inferior ***,for the problems that need the accurate solution,PLIC is more appropriate than *** accuracy may cause less efficiency in numerical *** method between D-A method and PLIC method should be chosen depends on the product.

关键词： interface reconstruction DA PLIC molten metal flow accuracy volume of fluid method