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Portal hypertensive colopathy in patients with liver cirrhosis

World Journal of Gastroenterology 2005年第20期11卷 3127-3130页

作者： Keiichi Ito Katsuya Shiraki Takahisa Sakai hitoshi Yoshimura Takeshi Nakano First Department of Internal Medicine Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507Japan

AIM: In patients with liver cirrhosis and portal hypertension, portal hypertensive colopathy is thought to be an important cause of lower gastrointestinal hemorrhage. In this study, we evaluated the prevalence of colonic mucosal changes in patients with liver cirrhosis and its clinical significance. METHODS: We evaluated the colonoscopic findings and liver function of 47 patients with liver cirrhosis over a 6-year period. The main cause of liver cirrhosis was post-viral hepatitis (68%) related to hepatitis B (6%) or C (62%) infection. All patients underwent upper gastrointestinal endoscopy to examine the presence of esophageal varices, cardiac varices, and congestive gastropathy, as well as a full colonoscopy to observe changes in colonic mucosa. Portal hypertensive colopathy was defined endoscopically in patients with vascular ectasia, redness, and blue vein. Vascular ectasia was classified into two types: type 1, solitary vascular ectasia; and type 2, diffuse vascular ectasia. RESULTS: Overall portal hypertensive colopathy was present in 31 patients (66%), including solitary vascular ectasia in 17 patients (36%), diffuse vascular ectasia in 20 patients (42%), redness in 10 patients (21%) and blue vein in 6 patients (12%). As the Child-Pugh class increased in severity, the prevalence of portal hypertensive colopathy rose. Child-Pugh class B and C were significantly associated with portal hypertensive colopathy. Portal hypertensive gastropathy, esophageal varices, ascites and hepatocellular carcinoma were not related to occurrence of portal hypertensive colopathy. Platelet count was significantly associated with portal hypertensive colopathy, but prothrombin time, serum albumin level, total bilirubin level and serum ALT level were not related to occurrence of portal hypertensive colopathy. CONCLUSION: As the Child-Pugh class worsens and platelet count decreases, the prevalence of portal hypertensive colopathy increases in patients with liver cirrhosis. A colonoscopi

关键词： Portal hypertensive colopathy Liver cirrhosis

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Suppression of postprandial blood glucose elevation by buckwheat(Fagpopyrum esculentum) albumin hydrolysate and identification of the peptide responsible to the function

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Food Science and Human Wellness 2022年第4期11卷 992-998页

作者： Kazumi Ninomiya Yusuke Yamaguchi Fumie Shinmachi hitoshi Kumagai Hitomi Kumagai Department of Food Science and Nutrition Kyoritsu Women’s University2-2-1 HitotsubashiChiyoda-kuTokyo 101-8347Japan College of Bioresource Sciences Nihon University1866 KameinoFujisawa-shi 252-0880Japan

The objective of this study is to evaluate the suppressive effect of buckwheat-albumin hydrolysate on postprandial hyperglycemia and identify the peptide responsible to the function. Buckwheat-albumin hydrolysate was prepared by using digestive enzymes and was orally administered to rats together with soluble starch. The blood was taken from the tail vein up to 90 min after oral administration to measure blood-glucose and plasma-insulin levels. The peptide with α-amylase inhibitory activity was purified from the buckwheathydrolysate by gel-filtration chromatography, α-amylase affinity chromatography, and high performance liquid chromatography(HPLC). The amino-acid sequence of the peptide was identified by a protein sequencer and was compared with that in the buckwheat-genome database. Buckwheat-albumin hydrolysate significantly suppressed the elevation of blood glucose level 15 min after starch administration. The amino-acid sequence of the peptide with α-amylase inhibitory activity was YVEPDCGNLGCCYHC in the parental protein of molecular mass 17.8 k Da and theoretical pI 4.77. The amino-acid sequence, molecular weight, and pI of the parental protein in buckwheat albumin were different from those of α-amylase inhibitor in wheat albumin. This study suggests that the novel α-amylase inhibitor identified in buckwheat albumin is a potential candidate for a functional food material to suppress postprandial blood glucose elevation.

关键词： Buckwheat-albumin hydrolysate Bioactive peptide α-Amylase inhibitor Postprandial hyperglycemia Type 2 diabetes

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Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第S1期 173-174页

作者： hitoshi Endou,Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

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Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第A3期19卷 173-174页

作者： hitoshi Endou Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

The absorption, distribution and excretion of most of xenobiotics, drugs, environmental toxins and their metabolites are mediated by membrane transporters.

关键词：环境毒素调节机构输送机构分子水平

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

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World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词： Leiomyosarcoma Rectal cancer Metastasis Chemotherapy Surgery

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Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

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World Journal of Gastroenterology 2005年第38期11卷 5966-5972页

作者： Yuichi Yamazaki Satoru Kakizaki Norio Horiguchi hitoshi Takagi Masatomo Mori Masahiko Negishi Department of Medicine and Molecular Science Pharmacogenetics Section

AIM： To investigate the precise roles of CAR in CCI4- induced acute hepatotoxicity. METHODS： To prepare an acute liver injury model, CCI4 was intraperitoneally injected in CAR＋/＋ and CAR-/- mice. RESULTS： Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR＋/＋ mice without PB. Administration of a CAR inducer, PB, revealed that CCl4-induced liver toxicity was partially inhibited in CAR-/- mice compared with CAR＋/＋ mice. On the other hand, androstanol, an inverse agonist ligand, inhibited hepatotoxicity in CAR＋/＋ but not in CAR./. mice. Thus, CAR activation caused CCl4 hepatotoxicity while CAR inhibition resulted in partial protection against CCl4-induced *** were no differences in the expression of CYP2E1, the main metabolizing enzyme for CCl4, between CAR＋/＋ and CAR./. mice. However, the expression of other CCI4-metabolizing enzymes, such as CYP2B10 and 3All, was induced by PB in CAR＋/＋ but not in CAR-/- mice. Although the main pathway of CCl4-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3All in the presence of activator or inhibitor. CONCLUSION： The nuclear receptor CAR modulates CCl4- induced liver injury via induction of CCl4-metabolizing enzymes in the presence of an activator. Our results suggest that drugs interacting with nuclear receptors such as PB might play critical roles in drug-induced liver injury or drug- drug interaction even though such drugs themselves are not hepatotoxic.

关键词： CAR Phenobarbital Cytochrome P450 CCl4 Drug-induced liver injury

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Ablation for Benign Liver Tumors:Current Concepts and Limitations

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 244-252页

作者： hitoshi Maruyama Maki Tobari Hiroaki Nagamatsu Tadashi Yamaguchi Shuichiro Shiina Department of Gastroenterology Juntendo UniversityTokyoJapan Center for Frontier Medical Engineering Chiba UniversityChibaJapan

Percutaneous ablation under imaging guidance is a curative treatment that can induce complete tumor necrosis with advantages of minimal invasiveness and a low risk of *** ablation,which includes radiofrequency ablation and microwave ablation,is a representative technique that has sufficient antitumor effects in cases of hepatocellular carcinoma with≤3 lesions measuring≤3 cm and preserved liver *** short-and long-term outcomes of patients are comparable with those achieved with surgical *** their nonmalignant nature,some benign liver tumors require treatment for symptoms caused by the presence of the tumor and/or continuous *** may be the treatment of choice because it has lower burden on patients than surgical *** review describes the recent concepts,progress,and limitations of ablation-based treatment for benign liver tumors.

关键词： Liver tumor Radiofrequency ablation Microwave ablation Benign

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Study on adsorption behavior of cesium using ammonium tungstophosphate(AWP)-calcium alginate microcapsules

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Science China Chemistry 2012年第9期55卷 1719-1725页

作者： WU Yan MIMURA hitoshi NIIBORI Yuichi OHNISHI Takashi KOYAMA Shinichi WEI YueZhou School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Graduate School of Engineering Tohoku University Aramaki-Aza-Aoba 6-6-01-2Sendai980-8579Japan Japan Atomic Energy Agency 4002 NaritaO-arai-machiIbaraki311-1393Japan

A functional microcapsule was prepared by encapsulating the fine crystalline ammonium tungstophosphate （AWP） in calcium alginate polymer （CaALG）. The characterization of AWP-CaALG microcapsule was examined by SEM and EPMA. The ad- sorption behavior of Cs（Ⅰ）, Rb（Ⅰ）, Sr（Ⅱ）, Pd（II）, Ru（Ⅲ）, Rh（Ⅲ）, La（Ⅲ）, Ce（Ⅲ）, Dy（Ⅲ） and Zr（IV） was investigated by the batch method. The batch experiments were carried out by varying the shaking times, HNO3 concentration, and initial concen- tration of metal ions. Relatively large K＋ values above 105 cm3/g for Cs（I） were obtained in the range of 0.1-5 M HNO3, re- sulting in a separation factor of Cs/Rb exceeding 102. In contrast, the K＋ values of Sr（II）, Pd（II）, Ru（Ⅲ）, La（Ⅲ）, Dy（Ⅲ）, Ce（Ⅲ） and Zr（IV） were considerably lower than 50 cm3/g. The K＋ value of Cs（1） decreased in the order of the coexisting ions, H＋〉 Na＋〉〉 NH4＋, and a linear relationship with a slop of about -1 was obtained between log Kd and log [NH4＋] （[NH4＋] 〉 0.01 M） The adsorption of Cs（I） was found to be controlled by chemisorption mechanism, and followed a Langmuir-type adsorption equation. A high uptake percentage of 99.4% for Cs（I） was obtained by using the dissolved solutions of spent fuel from FBR-JOYO （JAEA）.

关键词： cesium high level liquid waste (HLLW) ammonium tungstophosphate alginate microcapsule adsorption

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Effects of 0.4% ripasudil hydrochloride hydrate on morphological changes in rabbit eyes

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1637-1642页

作者： Bundit Limratchatamorn Ken Asakawa Kimiyo Mashimo Shigekazu Uga hitoshi Ishikawa Department of Ophthalmology Priest HospitalDepartment ofMedical ServicesMinistry of Public HealthBangkok10400Thailand Department of Ophthalmology School of MedicineKitasatoUniversityKanagawa252-0374Japan Department of Orthoptics and Visual Science School of AlliedHealth SciencesKitasato UniversityKanagawa252-0373Japan

We evaluated the cellular structure changes after continuous use of ripasudil hydrochloride hydrate in rabbit eyes which might affect its own efficacy and adverse effects. Two pigmented Dutch rabbits and 1 Japanese white rabbit were instilled with 0.4% ripasudil hydrochloride hydrate to the left eye twice daily. The right eye was observed as the control. Both eyes of all 3 rabbits were then enucleated for histopathologic examination by light and electron microscope at 1 mo in 1 of the pigmented Dutch rabbits, 3 mo in the other pigmented Dutch rabbit, and in the Japanese white rabbit after instillation. Microscopic observations showed increase intercellular space in trabecular meshwork, ciliary body, and iris stoma, increase pigmented granule number and size in iris epithelial cells, and decrease actin filament in iris muscle fiber cells. Consequently, ripasudil hydrochloride hydrate decreases the intraocular pressure by improving the conventional outflow and may also facilitate the unconventional outflow via intercellular space widening without serious side effects.

关键词： ripasudil hydrochloride hydrate actin filament side effect rabbit

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