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Prediction of cyclic large plasticity for prestrained structural steel using only tensile coupon tests

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Frontiers of Structural and Civil Engineering 2013年第4期7卷 466-476页

作者： Liang-Jiu JIA Tsuyoshi KOYAMA hitoshi KUWAMURA Department of Architecture School of Engineeringthe University of TokyoTokyo 113-8656Japan

Cold-formed steel members,which experience complicated prestrain histories,are frequently applied in structural *** paper aims to predict cyclic plasticity of structural steels with tensile and compressive *** and cyclic tests on hourglass specimens with tensile and compressive prestrain are conducted,and compared with numerical simulations using the Chaboche *** approaches are taken in the *** first requires only the monotonic tensile test data from the prestrained steels,and the second requires both the monotonic tensile test data from the virgin steel and the prestrain *** first approach slightly overestimates the compressive stress for specimens with tensile prestrain,while the second approach is able to accurately predict the cyclic plasticity in specimens with tensile and compressive prestrain.

关键词： cyclic plasticity prestrain Chaboche model mild steel

Treatment strategy for pancreatic head cancer with celiac axis stenosis in pancreaticoduodenectomy:A case report and review of literature

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World Journal of Gastroenterology 2022年第8期28卷 868-877页

作者： Eiji Yoshida Yasutoshi Kimura Takuro Kyuno Ryoko Kawagishi Kei Sato Tsuyoshi Kono Takehiro Chiba Toshimoto Kimura hitoshi Yonezawa Osamu Funato Makoto Kobayashi Kenji Murakami Akinori Takagane Ichiro Takemasa Department of Surgery Hakodate Goryoukaku HospitalHakodate City 040-8611Japan Department of Surgery Surgical Oncology and ScienceSapporo Medical UniversitySapporo City 060-8543HokkaidoJapan Department of Diagnostic Radiology Hakodate Goryoukaku HospitalHakodate City 040-8611Japan

BACKGROUND During pancreaticoduodenectomy in patients with celiac axis(CA)stenosis due to compression by the median arcuate ligament(MAL),the MAL has to be divided to maintain hepatic blood flow in many ***,MAL division often fails,and success can only be determined *** overcome this problem,we performed endovascular CA stenting preoperatively,and thereafter safely performed *** present this case as a new preoperative treatment strategy that was *** SUMMARY A 77-year-old man with a diagnosis of pancreatic head cancer presented to our department for *** assessment revealed CA stenosis caused by *** performed endovascular stenting in the CA preoperatively because we knew that going into the operation without a strategy could lead to ischemic ***-antiplatelet therapy(DAPT)–which is needed when a stent is inserted–was then administered in parallel with neoadjuvant chemotherapy(NAC).This allowed us to administer DAPT for a sufficient period before the main pancreaticoduodenectomy procedure while obtaining therapeutic effects from *** stomach-preserving pancreaticoduodenectomy was *** operation did not require any unusual techniques and was performed ***,the patient progressed well,without any ischemic ***,curative resection was confirmed,and the patient had no recurrence or complications due to ischemia up to six months *** Preoperative endovascular stenting,with NAC and DAPT,is effective and safe prior to pancreaticoduodenectomy in potentially resectable pancreatic cancer.

关键词： Pancreaticoduodenectomy Celiac axis stenosis Median arcuate ligament Endovascular stenting Pancreatic head cancer Case report

The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations

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Astrodynamics 2020年第4期4卷 377-392页

作者： Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda Institute of Space and A stronautical Science Japan A erospace Exploration AgencySagamihara 252-5210Japan The Graduate University for Aduanced Studies Hayama 240-0193Japan Research and Development Directorate Japan Aerospace Exploration AgencySagamihara 252-5210Japan University of Liverpool Liverpool L693BXUK Chiba Institute of Technology Narashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan

The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are *** was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary *** weighted least-squares batch filter is used for the orbit estimator of *** orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small *** system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking *** the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the *** example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar *** large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of *** the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by *** type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before.

关键词： orbit determination optical navigation gravity measurements superior solar conjunction delta differential one-way ranging(delta-DOR)

Effects of Additional Glycine in Outpatients Being Treated for Urine Storage Disorders

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Open Journal of Urology 2021年第11期11卷 381-392页

作者： Kimio Sugaya hitoshi Oh-Oka Tetsuo yamada Masanobu Miyata Katsuhiro Ashitomi Katsumi Kadekawa Saori Nishijima Department of Urology Kitakami Central Hospital Okinawa Japan Southern Knights’ Laboratory Okinawa Japan Kobe Medical Center Kobe Japan yamada Urological Clinic Sagamihara Japan Kitanodai Clinic Kitahiroshima Japan Department of Urology Okinawa Hokubu Hospital Okinawa Japan Department of Urology Okinawa Kyodo Hospital Okinawa Japan

Objectives: This study aimed to determine whether additional glycine can improve urine storage symptoms in outpatients. Methods: We recruited 50 outpatients (15 females, 35 males) with an Overactive Bladder Symptom Score (OABSS) of 3 or more. Participants being treated for urine storage disorders took additional glycine for 8 weeks at a dose of 3 g twice a day. Outcome measures included blood pressure, the International Prostate Symptom Score (IPSS), OABSS, Nocturia Quality of Life (N-QOL) score, urination frequency, sleep latency, time until the first void at night, bladder pain, improvement in urinary symptoms assessed with the Global Self-Assessment (GSA), and adverse events. Results: In the OABSS, the number of nighttime voids, urgency to urinate, urgent incontinence, and total score were improved. Improvements were also found in the IPSS total score for urine storage items, blood pressure, IPSS-QOL, time to first void, bladder pain, and GSA score, but no changes were seen in the frequency of urination at night, sleep latency or N-QOL score. No adverse events were recorded. Conclusion: Oral glycine improves objective and self-assessed urine storage symptoms, blood pressure, and bladder pain.

关键词： Chronic Prostatitis Glycine Interstitial Cystitis Overactive Bladder Urine Storage Symptoms

Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第S1期 173-174页

作者： hitoshi Endou,Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

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中药放射增敏机制的研究进展

中医肿瘤学杂志 2024年第4期6卷 73-77,94页

作者：蒋磊胡莉钧潘玉艳周海俊郝卫强高潮岩桥均高桥淳子常州工程职业技术学院检验检测认证学院江苏常州213164 南京医科大学附属常州第二人民医院放疗科江苏常州213000 南京医科大学附属常州第二人民医院药学部江苏常州213003 岐阜大学应用生物科学部日本岐阜县岐阜市501-1193 早稻田大学信息、生产和系统研究科(IPS) 日本福冈县北九州市808-0135

放疗是癌症治疗重要的手段之一,然而高剂量放疗引起的放射性炎症和肿瘤放射抵抗严重影响了患者治疗的依从性和成功率。放射增敏剂可有效提高肿瘤细胞放射敏感性,促进射线对肿瘤细胞的杀伤作用,对临床至关重要。本文回顾近五年全球中药... 详细信息

放疗是癌症治疗重要的手段之一,然而高剂量放疗引起的放射性炎症和肿瘤放射抵抗严重影响了患者治疗的依从性和成功率。放射增敏剂可有效提高肿瘤细胞放射敏感性,促进射线对肿瘤细胞的杀伤作用,对临床至关重要。本文回顾近五年全球中药作为放射增敏剂的增敏机制及在癌症放疗中的潜在应用价值,筛选可作为新型放射增敏剂的候选中药。本文使用关键词对PubMed、Scopus、Google Scholar和中国知网等科学数据库进行检索,对相关基础和临床研究的数据和结果进行综述。研究发现国内外中药作为放射增敏剂的研究具有一定基础。单体、复方、草本提取物和新型纳米中药均展现了潜在的应用价值,放射增敏机制主要为调节癌症细胞凋亡途径或细胞周期阻滞相关的基因。

关键词：放疗放射增敏剂中草药

Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第A3期19卷 173-174页

作者： hitoshi Endou Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

The absorption, distribution and excretion of most of xenobiotics, drugs, environmental toxins and their metabolites are mediated by membrane transporters.

关键词：环境毒素调节机构输送机构分子水平

Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

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World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词：原发性直肠癌肝癌肉瘤病理组织学检查肝脏肿瘤化疗药物氟尿嘧啶