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A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic reticulum of rabbit skeletal muscle

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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano Yoshiyuki Hirayama Masayasu Hiraoka Akihiko Kuniyasu hitoshi nakayama Department of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

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Optimization and Development of New Badminton Machine with Launching Roller

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Journal of Mechanics Engineering and Automation 2012年第11期2卷 671-681页

作者： Shinobu Sakai Ryota Nobe Koetsu Yamazaki hitoshi nakayama School of Mechanical Engineering Kanazawa University Kanazawa 920-1192 Japan Machine Development Division JFE Steel Corporation Kawasaki 210-0868 Japan Development Division Sunaga Kaihatsu Co. Ltd. Ashikaga 326-0333 Japan

Shuttlecock used for badminton is light in mass so that its flight locus is strongly influenced by air. The highest launching velocity of the shuttlecock by professional badminton players exceeds speeds of over 83.3 m/s （300 km/hr）. In this study, a new badminton server machine was developed. The badminton machine can launch the shuttlecocks at wide range of speeds up to 52.8 m/s （190 km/hr） and with many shot types such as smash, clear and so on, which are easily achieved. The finite element models of a shuttlecock with feathers and the badminton machine were made, and the launching simulations of the shuttlecock were tried. The roller with a large diameter attained a higher speed of the shuttlecock than the small rollers for all kinds of launching conditions. The taper angles of the roller edge and the insert height of the shuttlecock relative to the roller surface were optimized for attaining the maximum shuttle speed by the response surface approach. After the optimization, the performance of the badminton machine had been improved about 7% as the shuttle speeds increase and the stress causing the shuttle deterioration decreased.

关键词： Badminton sports engineering finite element analysis shape optimization response surface methodology.

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Analysis of value of flexibility in Japan’s power system with increased VRE

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Clean Energy 2018年第1期2卷 37-44页

作者： Sumie nakayama hitoshi Azuma Suguru Fukutome Kazuhiko Ogimoto J-POWER/Electric Power Development Co. Ltd.6-15-1GinzaChuo-kuTokyo 104-8165Japan JP Business Service Corporation 2-2-18FukagawaKoto-kuTokyo 135-8451Japan Institute of Industrial Science Collaborative Research Center for Energy EngineeringThe University of Tokyo4-6-1KomabaMeguro-kuTokyo153-8585Japan

The growth of renewable energy has accelerated globally toward a low-carbon economy since the Paris Agreement entered into force in *** a result of the increase of variable renewable energy(VRE),namely solar PV and wind,power systems require more flexibility from conventional power plants with less power generation to regulate increased *** are sources of flexibility other than conventional power plants,including enhanced power networks,storage capacity and demand *** maximize economic utilization of VRE power generation,it is necessary to use the flexibility potential from all these *** Japan,the share of VRE has increased since the introduction of a feed-in tariff(FIT)and,in parallel,power market reform is *** has a unique power system of nine grids connected like a fish bone,making the uptake of an increasing share of VRE *** paper assesses the value of flexibility by source in Japan’s power system in *** analysis of different VRE scenarios is undertaken based on a newly developed production cost *** result of the simulation shows the quantitative impact of each source of flexibility to the generation cost and VRE curtailment and demonstrates the mechanism by which flexibility works to impact VRE curtailment.

关键词： component power demand and supply renewable energy flexibility Japan’s power system produc-tion cost model analysis

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Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi nakayama hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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Usefulness of noninvasive transient elastography for assessment of liver fibrosis stage in chronic hepatitis C

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World Journal of Gastroenterology 2006年第48期12卷 7768-7773页

作者： Tadashi Takeda Takahiro Yasuda Yuji nakayama Mika Nakaya Megumi Kimura Mariko Yamashita Ayumi Sawada Koji Abo Setsuko Takeda Hiroki Sakaguchi Susumu Shiomi hitoshi Asai Shuichi Seki Department of Hepatology Graduate School of Medicine Osaka City University Osaka Japan Central Clinical Laboratory Osaka City University Medical School Hospital Osaka Japan Department of Nuclear Medicine Graduate School of Medicine Osaka City University Osaka Japan hitoshi Asai Health Service Center Osaka Kyoiku University Osaka Japan

AIM：To evaluate the method of noninvasive transient elastography for assessment of histological stage of liver fibrosis in patients with chronic hepatitis C （CHC）.METHODS： Two hundred and thirty-seven patients with CHC were included in this study. Liver biopsy was performed under ultrasonography on 217 of the patients, excluding twenty with clear clinical evidence of liver cirrhosis. Fifty subjects without liver disease were enrolled as a control group （stage 0）. Twentyfive patients with sustained virological response （SVR） to interferon （IFN） therapy were also enrolled. These patients underwent liver biopsy before IFN therapy. Examination of liver stiffness （LS） was performed by elastography.RESISTS： Medians （50% levels） of LS were 4.1 （3.5-4.9）, 6.3 （4.8-8.5）, 8.8 （6.8-12.0）, 14.6 （10.5-18.6）, and 22.2 （15.4-28.0）, respectively, in the fibrosis stages 0-4 （P 〈 0.001）. LS was significantly correlated with four serum fibrosis markers. LS values in patients with SVR were 3.8 （3.5-5.6）, 5.2 （4.4-6.8）, 6.8 （6.1-7.6）, and 6.1 （3.6-7.9）, respectively, in the fibrosis stages 1-4. In all stages, LS for patients with SVR was significantly lower than that for patients who did not undergo IFN therapy. LS was significantly correlated with serum concentrations of hyaluronic acid, type Ⅳ collagen, type Ⅳ collagen 7S, and type Ⅲ procollagen N peptide.CONCLUSION： LS correlated well with the histological stage of fibrosis. Changes in liver fibrosis stage may thus be estimated noninvasively using transient elastography.

关键词： Hepatitis C virus Echography Fibrosis Stiffness Interferon

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局部消融术联合免疫治疗对实体恶性肿瘤的免疫效应

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癌症 2018年第10期37卷 439-446页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi nakayama hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

最近的综合研究表明肿瘤细胞周围的免疫微环境与肿瘤的进展、转移和对治疗的反应密切相关。而且,一些免疫治疗试验已取得了成功的结果,用于临床实践的免疫治疗药物也可以获得。为了增强其已证实的疗效,免疫治疗和消融术的联合使用已开... 详细信息

最近的综合研究表明肿瘤细胞周围的免疫微环境与肿瘤的进展、转移和对治疗的反应密切相关。而且,一些免疫治疗试验已取得了成功的结果,用于临床实践的免疫治疗药物也可以获得。为了增强其已证实的疗效,免疫治疗和消融术的联合使用已开始出现。局部消融作为一种替代治疗方案具有相当大的优势,尤其是其微侵袭特性。此外,局部消融在临床前和临床研究中也显示出免疫调节作用。虽然相应的机制尚不清楚,但局部消融结合免疫治疗已被建议用于治疗几种实体恶性肿瘤。本文对局部消融的免疫调节效应方面发表的文献进行了综述,包括立体定向放射治疗、冷冻消融、射频消融和高强度聚焦超声。我们还讨论了局部消融与免疫治疗联合使用的价值。局部消融有改善未来患者预后的潜力,但局部消融与免疫治疗联合使用的有效性和安全性有待进一步研究。

关键词：免疫疗法实体恶性肿瘤冷冻手术放射治疗立体定向放射治疗

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